DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and ptpn13

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_068072003.1 Gene:ptpn13 / 560883 ZFINID:ZDB-GENE-070410-72 Length:2525 Species:Danio rerio


Alignment Length:1887 Identity:382/1887 - (20%)
Similarity:630/1887 - (33%) Gaps:619/1887 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 MSNPRYSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPP-----TFSRP-- 239
            :|:.:||...|.:.:..|.|.:..|....:|.|:    ||:::..|.|...||     :.|.|  
Zfish   916 LSSLQYSDGMGAVSLSPSSEPELYKRMSYSEMSL----SKSSSSRVSVPSEPPYPGFSSSSNPRM 976

  Fly   240 -----------PET-----------------ISEVMLGS----NLNLSCIAVG----------SP 262
                       ||:                 .|:|:..|    |.:...|||.          ||
Zfish   977 KSRSHHNLGQLPESPEHRMVPFSSQSQSSMARSQVLASSHQRANSDTGSIAVARQQESLSVDDSP 1041

  Fly   263 MPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTD 327
            ....|.:|...|.:...:  .|:..:..::: .|:......||::|..||:. .|||:||:...:
Zfish  1042 RWSPKSLKKESDSSSCED--TGQAYVVGVSM-HSSGVPSTPASSIGITDSLK-KKVQALPSPERE 1102

  Fly   328 VQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYV 392
            :|       :|.|:      :|::|.:      .......|.||...:...:.:::|        
Zfish  1103 IQ-------TVNLK------KDVKYGL------GFQVVGGESSGRQDLGTFISSITP-------- 1140

  Fly   393 IAVNNIGRGPPSAPATCTTGD--FSFGGTKMESAPRNVQVRTLSSS----TMVITWEP-----PE 446
                   .||.........||  .|.....:||......|..|.|:    ::|:: :|     |:
Zfish  1141 -------GGPADLNGLLKPGDRLLSVNDVSLESLSHTTVVEMLQSAPDDVSLVVS-QPKERLFPD 1197

  Fly   447 TPNGQVTGYKVYYTTNSNQPEASWNSQMVDN----SELTTVSELTPHAIYTVRVQAYTSM----- 502
            :|:|     ..:|...:...|...:|...|:    |...|.|:.:|.  .::|..:.:|.     
Zfish  1198 SPSG-----AHHYNPATQIQELDMDSSSEDHTRSPSPPFTASKTSPP--QSIRQGSISSQDSKTE 1255

  Fly   503 GAG-------------PMSTPVQVKA---------QQGVPSQPSNFRATDIGETAVTLQWTKPTH 545
            .||             ||..||..:|         :...|:.|...|.....:....|:::....
Zfish  1256 SAGLQQTHLNGFHKNIPMEGPVAAQALPADIKPSIEAMPPALPPKTRKAKAADVPKELEYSDRGD 1320

  Fly   546 SSENIVHYELYWNDTYANQAH----HKRIS--------NSEAYTLDGLYPDTLYYIWLAARSQR- 597
            |..:        .|||:|...    .|.:|        ::.:..::.|:|..|:.|.|:..... 
Zfish  1321 SDMD--------EDTYSNSQDKLKTKKGVSPITITETLSASSPDVNSLHPGDLFDIELSKIDSSL 1377

  Fly   598 --------GEGATTPP-----------IPV-RTKQYGAPPRNITAIATSSTTISLSWLPPPVE-- 640
                    |:|.:...           ||. ..:|.|...:....:|.:..::..:.....||  
Zfish  1378 GISVTVLFGKGGSNTSLKHGGIYVKGVIPKGAAEQDGRIKKGDRVVAVNGKSLEGATHKQAVEML 1442

  Fly   641 RSNGRIIYYKVFFVEVGR--EDDEATTMTLNMTS-------------------IVLDELKRWTEY 684
            |..|::::   ..:|.|:  :|.....:|...||                   |..|     ..:
Zfish  1443 RDTGQVVH---LLMERGQPPKDSIHAPLTPQGTSEPQNKTVEEPSAPEKEYNFITAD-----NTF 1499

  Fly   685 KIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVS----WKPPLEKDRNGIIR 745
            .:.:|..|| |.|     .....:|.:||:       ||.|:.:.|.    .:|..|..|..:  
Zfish  1500 DVALLKNTS-GLG-----FSFSREEIIPGE-------PLGSSMVRVKKLFPGQPAAESGRIKV-- 1549

  Fly   746 GYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKT 810
                                  .||:  |..|.|.|:..:::.: ::||  :|.|......:.:.
Zfish  1550 ----------------------GDVI--LRVNQTPLKGLSQHEV-ISAL--RGTGQEVTLHLCRP 1587

  Fly   811 PGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKR 875
            ..|:......::......|.....|:.:...:|....:..:...|..::||:..:|..|......
Zfish  1588 EQGILPEMDTAITTPVPSPRKQAHLQPQASPRTSSSPQESQRLLGPVEEALERLLLKSPSRRDSY 1652

  Fly   876 FD--------------NLERG----------VEYEFRV-----------------AGSNHIGIGQ 899
            .|              ||||.          |.||..:                 :..:...:..
Zfish  1653 SDSTDNDELEEAFRAANLERDSSAYQTPAERVSYEDEMDDTVQSAYYSSRQSMARSEDSRSDVNS 1717

  Fly   900 ETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSER 964
            .:::|..:| ..|.|...|     .:||.|     ||.                      |.:..
Zfish  1718 SSIRISASP-ALPEGDLLN-----PSPDPL-----PPP----------------------LPNPV 1749

  Fly   965 NMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETE-------RDMGRAPMSLQAEATS 1022
            |::|                           |..:.||.|.|       .|.|....:| .:.|.
Zfish  1750 NLSL---------------------------PEHEDLIPEVELKVSLVKSDKGSLGFTL-TKGTD 1786

  Fly  1023 EQ--TAEIWWEPVTSRGKLL-GYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIA 1084
            |.  ..:|..:|....|:|. |.:    |..|.:.|      |......::|||.:.|...|.:.
Zfish  1787 ENCYIHDIIQDPAKGDGRLRPGDR----MIMVNNTD------VSGMNHTEVVNLVRAAPKVVDLV 1841

  Fly  1085 ARFKNGLGRLSEKVTVRIKPEDVP-LNLRAHD--------------------------------- 1115
                  :||:.|.....|:...:| :..:.||                                 
Zfish  1842 ------VGRILEPPKPPIEAHLLPDITFQCHDESLGLVLDGGSDSALGVLYVKEIFPGSAAFEEG 1900

  Fly  1116 -------------VSTHSMTLSWSP---PIRLTPVNYKISFDAMKVFVDSQGFS--QTQIVPKRE 1162
                         |.|..:|||.|.   .:.|..::.|.:.|...||.|.:..|  ...|.||..
Zfish  1901 SLRHLDIIHYINGVPTQDLTLSESRRLLQLSLRNLSLKATRDGKPVFPDEEEISLLNNNISPKVS 1965

  Fly  1163 IILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDF----YGVV 1223
            ..:..|:.:...|||...:      ...|::             :......:.||..    :.|:
Zfish  1966 QSMNGYLHSSENNELEALS------GICPAE-------------EQIVKLELEKPPAGGLGFSVI 2011

  Fly  1224 NGEEILVILPQASEEYGPISHYYLVVVP---EDKSNLHKIPDQFL--TDDLLPG----------- 1272
            .||..:.:..               |.|   .|.:...::.|:.|  .|||:.|           
Zfish  2012 GGERGIFVKS---------------VTPGGTADIAGTLQVGDRLLKVNDDLMIGVSHAKAVTTIR 2061

  Fly  1273 -----------RNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAV 1326
                       |...:.||. |:.      .:|......:|       |..:..:..    |:..
Zfish  2062 KAKGLVQLIVSRPPDQMPNT-YLG------FLPLKSSTVNG-------NNDVSEDSG----VKTK 2108

  Fly  1327 VDTPQKHLYTSSP------------------------FSEFLSLDMREAPPGERPHRPDPNWPAE 1367
            :.||.:...:|||                        .||....|....|...........|..|
Zfish  2109 LQTPSEQSQSSSPPPLPPIDYDTGSLEKRKGTDTSADLSEDTDCDGSSLPEDSPETSRKAEWKEE 2173

  Fly  1368 ----------PEVSVNRNKDEPEILWVV--LPL--MVSTFIVSTALIVLCVVKRRRQPCKTPDQA 1418
                      |: |.:...||.||.|..  ||:  :.|.|.....::.              ::.
Zfish  2174 NVDAPLNDSAPQ-SSSGPLDEDEITWGSDDLPIENINSKFTEDGPIVT--------------EEE 2223

  Fly  1419 AVTRPLMAADLGAGPTPSDPVDMRRLNF---QTPGMISHPPIPISEFANHIERLKSNDNQKFSQE 1480
            ..:.||:..      .|........||.   ...|:|.. .:|:.||.| ::.|:..|.....|.
Zfish  2224 LTSLPLVKV------VPDGHYTSTNLNTIVRMMRGLIEQ-KVPLQEFEN-LQNLRPLDECLIGQT 2280

  Fly  1481 YESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSD--YINANYCDGYRKHN 1543
            .|                 ||.||||.|:..:|.:||       ::|:|  |||||:.....|..
Zfish  2281 KE-----------------NKKKNRYKNIVPFDTTRV-------LLGNDGGYINANFIKMAVKDE 2321

  Fly  1544 A--YVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWP--TRGTETY-GQIFVT 1603
            :  |:|.||||..|..|||:|.||.|:..|.|||:..|..::||.:|||  .|..:.. .::.||
Zfish  2322 SFMYIACQGPLPTTLGDFWQMVWEQKSNVIAMMTQEVEGGKVKCQRYWPDTPRSPQMVDDRLQVT 2386

  Fly  1604 ITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGP 1668
            :.:.|.|..:.||..:|.....|:.:.:..|.:|.|||||.|..|...|.|:...|.:  ..|||
Zfish  2387 LVKDQHLDNFVIRLIELKDVQTNELQRVTHLNYTGWPDHGTPTQPEQLLTFISYMRHI--HLSGP 2449

  Fly  1669 VIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI 1733
            :|.|||||:||:|..|.||.:|..:..:...||...|..:|.||..|||||:||||.:..||..:
Zfish  2450 IITHCSAGIGRSGTLICIDVVLGLISKDADFDISDIVRTMRLQRQGMVQTEEQYIFCYQVILYVL 2514

  Fly  1734 IC 1735
            .|
Zfish  2515 RC 2516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250 11/45 (24%)
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353 1/3 (33%)
Ig strand F 206..211 CDD:409353 1/4 (25%)
Ig strand G 218..221 CDD:409353 0/2 (0%)
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401 24/125 (19%)
Ig strand A 237..239 CDD:409401 1/1 (100%)
Ig strand A' 244..248 CDD:409401 2/3 (67%)
Ig strand B 251..259 CDD:409401 2/7 (29%)
Ig strand C 264..270 CDD:409401 1/5 (20%)
Ig strand C' 272..274 CDD:409401 0/1 (0%)
Ig strand D 277..281 CDD:409401 0/3 (0%)
Ig strand E 286..291 CDD:409401 0/4 (0%)
Ig strand F 298..305 CDD:409401 0/6 (0%)
Ig strand G 309..318 CDD:409401 2/8 (25%)
FN3 322..411 CDD:238020 12/88 (14%)
FN3 <382..747 CDD:442628 83/466 (18%)
FN3 712..810 CDD:238020 19/101 (19%)
FN3 832..898 CDD:214495 15/106 (14%)
FN3 <867..1269 CDD:442628 85/513 (17%)
fn3 914..998 CDD:394996 11/83 (13%)
R-PTPc-LAR-1 1498..1735 CDD:350401 96/243 (40%)
R-PTP-LAR-2 1784..2021 CDD:350402
ptpn13XP_068072003.1 Protein Kinases, catalytic domain 48..225 CDD:473864
Ubl1_cv_Nsp3_N-like 600..694 CDD:475130
B41 605..809 CDD:214604
FERM_C_PTPH13 805..905 CDD:270008
PDZ1_PTPN13-like 1102..1193 CDD:467285 21/125 (17%)
PTN13_u3 1189..1366 CDD:465189 34/191 (18%)
PDZ2-PTPN13_FRMPD2-like 1364..1455 CDD:467254 14/93 (15%)
PDZ3_PTPN13_FRMPD2-like 1498..1587 CDD:467181 25/130 (19%)
PDZ4_PTPN13-like 1762..1845 CDD:467182 22/99 (22%)
PDZ5_PTPN13-like 1856..1942 CDD:467183 11/85 (13%)
PDZ5_DrPTPN13-like 1995..2072 CDD:467273 14/91 (15%)
PTPc-N13 2281..2514 CDD:350445 97/258 (38%)
Blue background indicates that the domain is not in the aligned region.

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