DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and ptprja

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001129714.1 Gene:ptprja / 559679 ZFINID:ZDB-GENE-030131-8301 Length:1650 Species:Danio rerio


Alignment Length:1969 Identity:422/1969 - (21%)
Similarity:718/1969 - (36%) Gaps:560/1969 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 CVAENSMGTEHSKATNLYVKVRRVP---------------PTFSRPPETISEVMLGSNLNLSCIA 258
            |:|:|:..| :|..||:.| ...:|               ..||..|..:..:.:.:..| |.:.
Zfish    56 CIAQNASFT-NSSQTNITV-TGLLPGNTYFLIISCTSVCCENFSSSPAQVQNITVVNYTN-SSVT 117

  Fly   259 VGSPMP--HVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVS-VVKVQS 320
            |...:|  ||.  ..:.:.:.::...|..|...:.::.....|.....|..|.:.:|| :|:..:
Zfish   118 VAWTVPDGHVD--SYTVNCSTQSIPNINDNNTTISSLPPGCLYNLTVTSISGVLTNVSNIVQFAT 180

  Fly   321 LPTAPTDVQISEVTATSVRLEWSYKGPEDLQ----YYVIQYKP--KNANQAFSEISGIITMYYVV 379
            .|..|..|::|..|.:|:.|.||  .|..:.    .|.:.|.|  ...|...::.:. ..|..:.
Zfish   181 KPNPPEAVRVSGQTFSSISLLWS--TPLSMSGVAVSYGVSYVPVQPGVNLPLTQTTS-SNMTNIT 242

  Fly   380 RALSPYTEYEFYVI--AVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITW 442
            ..||. |:|...|:  .|||:           ::...:..|..:....:|:.|..:|::::.:||
Zfish   243 NLLSG-TQYTITVVTNGVNNL-----------SSSFINLIGYTVPKIVQNLAVSNVSTNSVSLTW 295

  Fly   443 EPPETPNGQVT-----------GYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRV 496
            .|   |||..:           |...|.|:||.|                 :::|.|...|...|
Zfish   296 LP---PNGTSSLFSYNINISSLGQTFYTTSNSYQ-----------------ITQLQPGTQYNCYV 340

  Fly   497 QAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTY 561
            .  |.:.||.:|.|.|.......|...||.:|..:|.|.:.|.||..|    .:..|.:..|.|:
Zfish   341 T--TLIVAGNISGPSQFIQCNTKPLPVSNLKAIPVGTTVILLSWTPST----ALYLYNVSANGTW 399

  Fly   562 ANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIATS 626
            :.      .::||...:.||.|...|...:...:   .|.::.|:.: :...|.....|.:...:
Zfish   400 ST------YNSSEGANVTGLTPGNNYTFTVITVA---NGLSSEPVTI-SAFTGLGKAIIISAIGN 454

  Fly   627 STTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNM---TSIVLDELKRWTEYKIWV 688
            :.|:::.|.||.     |.:..|....:.:    |.....|.|.   ||::..:|...|:|.:.|
Zfish   455 TQTMTVQWTPPA-----GTVSLYSARILLM----DGTVLNTKNQTKTTSMMFSDLLPGTQYSVIV 510

  Fly   689 LAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQE 753
               :|: .||........|...:|..|.::..|...:| :::||..||....   :..|.:    
Zfish   511 ---SSI-SGPVKQDSDSVTNATLPTPPGEISTTQSTNT-LNISWAQPLNMSS---VSYYFL---- 563

  Fly   754 LRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRP 818
            |:......:|....:.       ::|||.....|:|.:..:........|.::...|...|....
Zfish   564 LQYNNSTLINCSQNYT-------SLTGLNAGFPYNIIMWTVGAMNYSSSSKSLTAFTNPSVVTNV 621

  Fly   819 TVSLKIMEREPIVSIELEWER--PAQT-YGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLE 880
            ||: :..|    .|:.|.|::  |.|: |..|..|:...|..:|.....       ...:.:.|:
Zfish   622 TVN-EFTE----TSVTLSWQQNDPQQSGYSYLLNYKTINGTSNQTTVNN-------NTVKLEQLQ 674

  Fly   881 RGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPP--------------SNITIRFQTPDVLCV 931
            ...:|...:              |..||.||...|.              |::.:...|   :.:
Zfish   675 SASQYNISI--------------IALTPGGTKSDPQFITACSRPNRVNNVSSVALNVST---VRL 722

  Fly   932 TWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVF--TNLEENTEYIFRVRAYTKQGA 994
            :|..|.:.::   :..|.|    .:.:...:..||:....:.  |||:..|  :.::..|: ...
Zfish   723 SWARPLQYNQ---LVSYQV----LVSNCTKNSMNMSTSTEMITVTNLQPGT--LCQISIYS-VAC 777

  Fly   995 G----PFSDKLIVETERDMGRAPMSLQ----AEATSEQTAEIWWEP----------VTSRGKLLG 1041
            |    |.:..::.        .|.::|    ::.::.....:|..|          ::|.    |
Zfish   778 GLLGQPVNTSVLT--------MPSTVQPVVNSQGSNNSLLVLWSHPDGGLDMYILNISSD----G 830

  Fly  1042 YKIF---------YTMTAVEDLDDWQTKTVGLT-------ESADLVNLEKFAQYAVAIAARFKNG 1090
            :..|         ||.|.::....:   ||.||       |::..|           ::|.:.|.
Zfish   831 WSDFSFLNSTENNYTFTQLKAATLY---TVTLTTVKGSFQETSGAV-----------VSATYPNS 881

  Fly  1091 LGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTP--VNYKISFDAMKVFVDSQGFS 1153
            .|    .:||..|             :|||:.|.|.....:||  .||.:||.:.|       .:
Zfish   882 PG----MITVLFK-------------NTHSVLLHWDIAQNMTPGSFNYSLSFWSSK-------NN 922

  Fly  1154 QTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPD 1218
            ...:.|...::|         :.|...|.|||:::.:..........:..|||.   |.|:..  
Zfish   923 SLYLTPNNTLLL---------DGLQSGTPYNVSLATVGPLNLQSESMRYNVTTM---PDPVKN-- 973

  Fly  1219 FYGVVNGEEILVILPQASEEYGPIS-HYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAP 1282
                         |...|.....|| .:.:|.||:...:::                     ||.
Zfish   974 -------------LKVVSTTTNTISVTWKMVDVPKYVVSVN---------------------NAV 1004

  Fly  1283 YIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPF----SEF 1343
            .|.:.                  :|.|...|:...:|.|.|:            ||.|    .|.
Zfish  1005 KITSS------------------NNMTIHNLQPSTQYNISVQ------------SSTFDNTEGEA 1039

  Fly  1344 LSL-DMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKR 1407
            :.| |..:|.|.|......||                    :.|| |::.|              
Zfish  1040 VCLQDCTDAAPVENVTCVGPN--------------------LTLP-MLNLF-------------- 1069

  Fly  1408 RRQPCKTPDQAAVTRPL---MAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERL 1469
                        ...||   |..::....:.|:..  :.||:...|:                  
Zfish  1070 ------------WNHPLGGYMNFEVNLSSSISEKT--KNLNYNFTGL------------------ 1102

  Fly  1470 KSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYI--- 1531
              ..|:.:|....::..|:..|..|.:.....:......:||...|..|......|:.||..   
Zfish  1103 --KYNKTYSVTLRTLGCGKSSTVKNISCTTGFTNPVVPKITAASVSEQQYNKFALVIQSDAFNDS 1165

  Fly  1532 NANYC--------------DGYRKHNAYVATQGPLQETFVDFWRMCWELK---TATIVMMTRL-- 1577
            |...|              |..:.:|..      |.:|:.|     |:.|   |...|:.|.:  
Zfish  1166 NGTVCSYGLLVSSGSFDCLDNNQNYNQC------LLKTYDD-----WKAKQSDTFLAVVKTNVSK 1219

  Fly  1578 -EERTRI-----KCDQY----WPTRGTETYGQIFVTITETQE------LATYSIRTFQLCRQGFN 1626
             |..|.|     |.::|    ...:||..:..:..|:.|.::      .:.||:..:|       
Zfish  1220 SELETIIIGDGSKWNKYTNGELNAKGTYNFAIVAFTLLEVKDGKVDVSKSYYSVSAYQ------- 1277

  Fly  1627 DRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLE 1691
                                             ::|.||:..||...:||||.|...:||     
Zfish  1278 ---------------------------------SVTLPENPVVIGGAAAGVGVTVIIVVI----- 1304

  Fly  1692 RMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITE 1756
                     |.|.|.|.|.:|..:..:                     ||..:|...:...:..|
Zfish  1305 ---------IIGIVACTRKKRKEVSNS---------------------VPIHSLRNKVSDPIKVE 1339

  Fly  1757 P---------GETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIH 1812
            .         .::..|...||:.|..|.::.||.| |..|.||.|||..::|||:||||.|:.:.
Zfish  1340 DYEAYYKRQRADSFCGFAEEFEDLRPVGINQSKTV-AVFPENKAKNRYNNVLPYDSSRVKLSVLS 1403

  Fly  1813 GIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQY 1877
            . ...||:||:::.||..:..:||||||:.....||||::||.|...:|||||..|.||.||.:|
Zfish  1404 S-PFDDYINANYMPGYITKKEFIAAQGPLPGTVNDFWRLIWEKNVHTIVMLTKCNEQGRVKCEEY 1467

  Fly  1878 WPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFID 1942
            ||.|... :....|..|::..:..:.||:|:|.:.:....|:||.|.|..||:.|||::.|..|:
Zfish  1468 WPAEMKT-FSNLTVTTISDIPLEDWTLRDFEVKNMKTAEIRSVRHFHFTAWPDHGVPETTELLIN 1531

  Fly  1943 FIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMV 2007
            |...|.:..:::.:..|..|||||||||:|.||.:..::.:::.:||:||:..:..||..||.||
Zfish  1532 FRHLVREHMDEYSRHSPTLVHCSAGVGRTGTFIAIDRLIFQIERDGVVDVYGIIHDLRMHRPLMV 1596

  Fly  2008 QTEDQYHFCYRAALEYLGS 2026
            ||||||.|..:.|::.:.|
Zfish  1597 QTEDQYVFLNQCAMDIIKS 1615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250 7/18 (39%)
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353 1/1 (100%)
Ig strand G 218..221 CDD:409353 0/2 (0%)
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401 16/84 (19%)
Ig strand A 237..239 CDD:409401 1/1 (100%)
Ig strand A' 244..248 CDD:409401 0/3 (0%)
Ig strand B 251..259 CDD:409401 2/7 (29%)
Ig strand C 264..270 CDD:409401 3/7 (43%)
Ig strand C' 272..274 CDD:409401 0/1 (0%)
Ig strand D 277..281 CDD:409401 0/3 (0%)
Ig strand E 286..291 CDD:409401 1/4 (25%)
Ig strand F 298..305 CDD:409401 1/6 (17%)
Ig strand G 309..318 CDD:409401 3/9 (33%)
FN3 322..411 CDD:238020 23/96 (24%)
FN3 <382..747 CDD:442628 84/380 (22%)
FN3 712..810 CDD:238020 17/97 (18%)
FN3 832..898 CDD:214495 12/68 (18%)
FN3 <867..1269 CDD:442628 76/454 (17%)
fn3 914..998 CDD:394996 16/103 (16%)
R-PTPc-LAR-1 1498..1735 CDD:350401 49/274 (18%)
R-PTP-LAR-2 1784..2021 CDD:350402 98/236 (42%)
ptprjaNP_001129714.1 fn3 102..168 CDD:394996 10/68 (15%)
FN3 158..676 CDD:442628 130/608 (21%)
FN3 707..783 CDD:473895 14/88 (16%)
FN3 968..1031 CDD:214495 19/128 (15%)
PTP_tm 1157..1279 CDD:465889 26/172 (15%)
R-PTPc-J 1384..1611 CDD:350463 94/228 (41%)
Blue background indicates that the domain is not in the aligned region.

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