DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and ptprja

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_005166490.1 Gene:ptprja / 559679 ZFINID:ZDB-GENE-030131-8301 Length:1766 Species:Danio rerio


Alignment Length:2040 Identity:441/2040 - (21%)
Similarity:744/2040 - (36%) Gaps:586/2040 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 CVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVM-----------LGSNLNLSCIAVGSP 262
            |:|:|:..| :|..||:.|       |...|..|...::           ..|..||:...:.|.
Zfish    56 CIAQNASFT-NSSQTNITV-------TGLLPGNTYFLIISCTSVCCENFSSNSTSNLTFTQLNST 112

  Fly   263 MPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTD 327
            ..:|.|   ::.|.|.|                                       ||....|..
Zfish   113 SVYVNW---TDQLIPTN---------------------------------------QSFTLRPEP 135

  Fly   328 V---QISEVTATSVRLEWS--Y-KGPEDLQYYVIQYKPKNA--NQAFSEISGIITMYYVVRALSP 384
            |   .::.:|.:|:.|.|:  | ..|    ||.:.:....|  ||...:||          :|||
Zfish   136 VFNLSVNSITVSSMILAWTPPYGSSP----YYKVAWVGNLAFTNQTSMQIS----------SLSP 186

  Fly   385 YTEYEFYV--IAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPET 447
            .|:|.|.|  :|.:|...|.|:|.:..|:          .:..:|:.|...::|::.:.|   ..
Zfish   187 GTKYNFNVTSVATDNSTEGRPTAISQNTS----------PAQVQNITVVNYTNSSVTVAW---TV 238

  Fly   448 PNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQ 512
            |:|.|..|.|..:|.| .|..:      ||:  ||:|.|.|..:|.:.|.:.:.:... :|..||
Zfish   239 PDGHVDSYTVNCSTQS-IPNIN------DNN--TTISSLPPGCLYNLTVTSISGVLTN-VSNIVQ 293

  Fly   513 VKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYW------------NDTYANQA 565
            ...:   |:.|...|.:....::::|.|:.|...|...|.|.:.:            ..|.:|..
Zfish   294 FATK---PNPPEAVRVSGQTFSSISLLWSTPLSMSGVAVSYGVSYVPVQPGVNLPLTQTTSSNMT 355

  Fly   566 HHKRISNSEAYTL----DGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIATS 626
            :...:.:...||:    :|:...:..:|.|.       |.|.|.|          .:|:.....|
Zfish   356 NITNLLSGTQYTITVVTNGVNNLSSSFINLI-------GYTVPKI----------VQNLAVSNVS 403

  Fly   627 STTISLSWLPPPVERSNG--RIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVL 689
            :.::||:||||     ||  .:..|.:....:|:      |......|..:.:|:..|:|..:|.
Zfish   404 TNSVSLTWLPP-----NGTSSLFSYNINISSLGQ------TFYTTSNSYQITQLQPGTQYNCYVT 457

  Fly   690 AGTSVGD--GPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPP-----LEKDRNGIIRGY 747
            .....|:  || |..|...|:   |....::||.|:.:|.|.:||.|.     .....||....|
Zfish   458 TLIVAGNISGP-SQFIQCNTK---PLPVSNLKAIPVGTTVILLSWTPSTALYLYNVSANGTWSTY 518

  Fly   748 HIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYS--------------IQVAALTRKG 798
            :      ..||.                 |||||.|...|:              :.::|.|..|
Zfish   519 N------SSEGA-----------------NVTGLTPGNNYTFTVITVANGLSSEPVTISAFTGLG 560

  Fly   799 DGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKE 863
                 .||::...|...                ::.::|..||   |.:..|..|..:.|..   
Zfish   561 -----KAIIISAIGNTQ----------------TMTVQWTPPA---GTVSLYSARILLMDGT--- 598

  Fly   864 EMLSGPQMTK---KRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQT 925
             :|:....||   ..|.:|..|.:|.. :..|....:.|::..:......||.|..|..    |:
Zfish   599 -VLNTKNQTKTTSMMFSDLLPGTQYSV-IVSSISGPVKQDSDSVTNATLPTPPGEISTT----QS 657

  Fly   926 PDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYT 990
            .:.|.::|..|        :....|.::..:.:...:..|.:......|.|  |..:.:.:..:|
Zfish   658 TNTLNISWAQP--------LNMSSVSYYFLLQYNNSTLINCSQNYTSLTGL--NAGFPYNIIMWT 712

  Fly   991 KQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLD 1055
             .||..:|......|.........::.....:|.:..:.|:....:.....|.:.|         
Zfish   713 -VGAMNYSSSSKSLTAFTNPSVVTNVTVNEFTETSVTLSWQQNDPQQSGYSYLLNY--------- 767

  Fly  1056 DWQTKTVGLTESADLVN--------LEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLR 1112
                ||:..|.:...||        |:..:||.::|.|....|.....:.:|...:|..|. |:.
Zfish   768 ----KTINGTSNQTTVNNNTVKLEQLQSASQYNISIIALTPGGTKSDPQFITACSRPNRVN-NVS 827

  Fly  1113 AHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINEL 1177
            :..::..::.|||:.|::   .|..:|:   :|.|.:...:...:....|:|        |:..|
Zfish   828 SVALNVSTVRLSWARPLQ---YNQLVSY---QVLVSNCTKNSMNMSTSTEMI--------TVTNL 878

  Fly  1178 SPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGE----EILVILPQASEE 1238
            .|.|...:::.::.... ...|...:|.|..:..||        |||.:    .:||:.   |..
Zfish   879 QPGTLCQISIYSVACGL-LGQPVNTSVLTMPSTVQP--------VVNSQGSNNSLLVLW---SHP 931

  Fly  1239 YGPISHYYLVVVPE---DKSNLHKIPDQF----------LTDDLLPGRNKPERPNAPYIAAKFP- 1289
            .|.:..|.|.:..:   |.|.|:...:.:          .|..|...:...:..:...::|.:| 
Zfish   932 DGGLDMYILNISSDGWSDFSFLNSTENNYTFTQLKAATLYTVTLTTVKGSFQETSGAVVSATYPN 996

  Fly  1290 ----------------------QRSIPFTFH-------------------------LGSGDDYH- 1306
                                  |...|.:|:                         |.||..|: 
Zfish   997 SPGMITVLFKNTHSVLLHWDIAQNMTPGSFNYSLSFWSSKNNSLYLTPNNTLLLDGLQSGTPYNV 1061

  Fly  1307 --------NFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSL--DMREAPPGERPHRPD 1361
                    |..:..:    ||.:   ..:..|.|:|...|..:..:|:  .|.:.|         
Zfish  1062 SLATVGPLNLQSESM----RYNV---TTMPDPVKNLKVVSTTTNTISVTWKMVDVP--------- 1110

  Fly  1362 PNWPAEPEVSVNR------------NKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKT 1414
                 :..||||.            :..:|...:.: .:..||| .:|....:|:     |.|  
Zfish  1111 -----KYVVSVNNAVKITSSNNMTIHNLQPSTQYNI-SVQSSTF-DNTEGEAVCL-----QDC-- 1161

  Fly  1415 PDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQK--- 1476
            .|.|.|.....     .||..:.|:    ||.    ..:|   |:..:.|....|.|:.::|   
Zfish  1162 TDAAPVENVTC-----VGPNLTLPM----LNL----FWNH---PLGGYMNFEVNLSSSISEKTKN 1210

  Fly  1477 -------------FSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGS 1528
                         :|....::..|:..|..|.:.....:......:||...|..|......|:.|
Zfish  1211 LNYNFTGLKYNKTYSVTLRTLGCGKSSTVKNISCTTGFTNPVVPKITAASVSEQQYNKFALVIQS 1275

  Fly  1529 DYI---NANYC--------------DGYRKHNAYVATQGPLQETFVDFWRMCWELK---TATIVM 1573
            |..   |...|              |..:.:|..      |.:|:.|     |:.|   |...|:
Zfish  1276 DAFNDSNGTVCSYGLLVSSGSFDCLDNNQNYNQC------LLKTYDD-----WKAKQSDTFLAVV 1329

  Fly  1574 MTRL---EERTRI-----KCDQY----WPTRGTETYGQIFVTITETQE------LATYSIRTFQL 1620
            .|.:   |..|.|     |.::|    ...:||..:..:..|:.|.::      .:.||:..:| 
Zfish  1330 KTNVSKSELETIIIGDGSKWNKYTNGELNAKGTYNFAIVAFTLLEVKDGKVDVSKSYYSVSAYQ- 1393

  Fly  1621 CRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIV 1685
                                                   ::|.||:..||...:||||.|...:|
Zfish  1394 ---------------------------------------SVTLPENPVVIGGAAAGVGVTVIIVV 1419

  Fly  1686 IDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQ 1750
            |              |.|.|.|.|.:|..:..:                     ||..:|...:.
Zfish  1420 I--------------IIGIVACTRKKRKEVSNS---------------------VPIHSLRNKVS 1449

  Fly  1751 KLLITEP---------GETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRV 1806
            ..:..|.         .::..|...||:.|..|.::.||.| |..|.||.|||..::|||:||||
Zfish  1450 DPIKVEDYEAYYKRQRADSFCGFAEEFEDLRPVGINQSKTV-AVFPENKAKNRYNNVLPYDSSRV 1513

  Fly  1807 YLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGR 1871
            .|:.:.. ...||:||:::.||..:..:||||||:.....||||::||.|...:|||||..|.||
Zfish  1514 KLSVLSS-PFDDYINANYMPGYITKKEFIAAQGPLPGTVNDFWRLIWEKNVHTIVMLTKCNEQGR 1577

  Fly  1872 EKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKS 1936
            .||.:|||.|... :....|..|::..:..:.||:|:|.:.:....|:||.|.|..||:.|||::
Zfish  1578 VKCEEYWPAEMKT-FSNLTVTTISDIPLEDWTLRDFEVKNMKTAEIRSVRHFHFTAWPDHGVPET 1641

  Fly  1937 GEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRS 2001
            .|..|:|...|.:..:::.:..|..|||||||||:|.||.:..::.:::.:||:||:..:..||.
Zfish  1642 TELLINFRHLVREHMDEYSRHSPTLVHCSAGVGRTGTFIAIDRLIFQIERDGVVDVYGIIHDLRM 1706

  Fly  2002 QRPAMVQTEDQYHFCYRAALEYLGS 2026
            .||.||||||||.|..:.|::.:.|
Zfish  1707 HRPLMVQTEDQYVFLNQCAMDIIKS 1731

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653 7/17 (41%)
Ig 159..228 CDD:299845 7/18 (39%)
I-set 234..318 CDD:254352 12/94 (13%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 9/67 (13%)
fn3 324..404 CDD:278470 25/89 (28%)
FN3 423..514 CDD:238020 24/90 (27%)
FN3 520..610 CDD:238020 20/105 (19%)
FN3 616..707 CDD:238020 23/94 (24%)
FN3 712..810 CDD:238020 26/116 (22%)
FN3 832..907 CDD:238020 16/77 (21%)
FN3 914..1005 CDD:238020 15/90 (17%)
FN3 1012..1101 CDD:238020 16/96 (17%)
fn3 1106..1198 CDD:278470 16/91 (18%)
PTPc 1476..1731 CDD:214550 54/308 (18%)
PTPc 1503..1731 CDD:238006 49/265 (18%)
PTPc 1763..2022 CDD:214550 107/258 (41%)
PTPc 1791..2022 CDD:238006 95/230 (41%)
ptprjaXP_005166490.1 fn3 135..197 CDD:278470 21/75 (28%)
fn3 218..284 CDD:278470 21/77 (27%)
FN3 298..>371 CDD:238020 13/72 (18%)
COG3979 391..543 CDD:226487 47/199 (24%)
fn3 394..469 CDD:278470 21/86 (24%)
fn3 480..550 CDD:278470 20/92 (22%)
fn3 565..631 CDD:278470 16/89 (18%)
fn3 732..806 CDD:278470 14/86 (16%)
fn3 825..899 CDD:278470 15/88 (17%)
FN3 1084..1147 CDD:214495 12/77 (16%)
PTPc 1471..1727 CDD:214550 107/258 (41%)
PTPc 1499..1727 CDD:238006 95/229 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.940

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