Protein Alignment Lar and ptprc

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: XP_073793929.1
• Gene: ptprc / 559154
• ZFINID: ZDB-GENE-050208-585
• Length: 1542
• Species: Danio rerio
• Alignment Length: 1980
• Identity: 444/1980 - (22%)
• Similarity: 701/1980 - (35%)
• Gaps: 644/1980 - (32%)

  Fly   149 RVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAEN 213
            |...:|..||:.|..: .|:|        |:.|.:|.:.:         .:..:|......|..|
Zfish     3 RFFAIGPLVLVLCLVL-YPSP--------TRTDENNSKET---------TTTTKDPSSTRTVENN 49

  Fly   214 SMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPE 278
            |..|..:|||
Zfish    50 STATTTNKAT------------------------------------------------------- 59

  Fly   279 NEMPIGRNVLQLINIQESANYTCIAASTLGQIDSV---SVVKVQSLPTAPTDVQISEVTATSVRL 340
                       :|....|.::|.|::.|....||.   :..:.....|:||  |.|.:|.:
Zfish    60 -----------VIEKASSPSHTLISSETTKTTDSTPTPTKAETTGFSTSPT--QTSIITTS---- 107

  Fly   341 EWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSA 405
                             ||..:..:.:...        ....:|.|.......:|.. ....|:.
Zfish   108 -----------------KPSGSTTSVNSAD--------THTTTPTTGETTNAASVKE-SNATPTT 146

  Fly   406 PATCTTG------DFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSN 464
            |.|....      :.|.|.|...||........||:.|...:....:||.|.::.:.....|:.:
Zfish   147 PKTSAESSSYKDQEASSGTTLPSSADLKTPSPNLSTLTNPSSLPLTKTPTGNISPHTQEKNTSIS 211

  Fly   465 QPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRAT 529
            .|..|..    .|:.:|:|:|...:.|              |..|||:....:...|:||:...:
Zfish   212 PPLTSHQ----QNTIITSVTEPNANPI--------------PSKTPVESIPDKVKASEPSSLMHS 258

  Fly   530 DIGETAVTLQW--------------TKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDG 580
            ......||...              |.|:.:|:.        |.|..:..:.:|  |::|.|
Zfish   259 TSPTPIVTTTSTGNNSENNNKANPPTSPSCTSQQ--------NTTNTSVCNTER--NNQANT--- 310

  Fly   581 LYPDTLYYIWLAARSQRGEGATTPPIPVRT--KQYG--APPRNITAIATSSTTISLSWLPPPVER 641
              |.|     .|..||:...:.|..:|.||  :|:.  ..|.|.|::..:.|.:..:...|||:.
Zfish   311 --PTT-----TALTSQQPSNSDTSGLPSRTIMQQHVIITTPVNDTSLPPNITLMQPTSPIPPVKT 368

  Fly   642 SNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILR 706
            ::            :|.:..|.|.. .|:|         |.|                :..||
Zfish   369 TS------------MGAKISEETCQ-YNIT---------WNE----------------TEAII-- 393

  Fly   707 TQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVV 771
            ....:|.:.:|.|    |.|.| :..|...|...|||                ..|..|.|.
Zfish   394 NVSSIPNNARDYK----NQTYI-IKLKHNTETISNGI----------------SPLKIPLKM--- 434

  Fly   772 DTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELE 836
                     |:|.|:|:|.|...|.||
Zfish   435 ---------LKPCTEYTIHVDNCTVKG-------------------------------------- 452

  Fly   837 WERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQET 901
                                     |....|....:|          ||       ..|.:|.:.
Zfish   453 -------------------------KNSFYSNDSESK----------EY-------TAIDVGDKQ 475

  Fly   902 VKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNM 966
            | .|:..:....|               |..            ||..|....:.|:..|  ::.:
Zfish   476 V-CFEDKKWNLTG---------------CAN------------ITAEDSCVQRSIEINL--DKCI 510

  Fly   967 TLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEI--- 1028
            ...|.:...::...:|                 ...:.|:.:....|::....:....|.||
Zfish   511 YAMKVLMPPVKPELKY-----------------NKTIPTKFEWSNKPLNKTRMSDCNDTFEIDCG 558

  Fly  1029 ----W----------WEPVTSRGKLLGYKIFYTMTAVEDL--DDWQTKTVGLTESADLVNLEKFA 1077
                |          .:..:..||...|..|...|:.:.|  .:|           ...||.:..
Zfish   559 GGKCWRLNQDAYLAPGKSYSCTGKYKYYNTFVNSTSTDILISCNW-----------SYTNLYEAV 612

  Fly  1078 QYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSW---SP-----PIRLTPV 1134
            .....:.:|..|              |.|....:..|..|....:.|.   ||     .|..|.|
Zfish   613 TNNSIVISRILN--------------PGDNCPGIIWHSFSATCQSESGKASSPVHGCDKINATTV 663

  Fly  1135 NYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPP 1199
            |.                                    |.||||.:|.|..::||
Zfish   664 NC------------------------------------TFNELSAYTEYKCSISA---------- 682

  Fly  1200 TKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLH---KIP 1261
                              .....:.||..:....|.::.|.|:.        .||.:::   :..
Zfish   683 ------------------HINSTIGGEPFVTRFIQRTKSYKPMF--------GDKKDVNVSGRSH 721

  Fly  1262 DQFLTDDLLPGRNKPERP-NAPYIAAKFPQRSIPFTFHL---GSGDDYHNFTN-----RKLEREK 1317
            :.||.:    .:|..|.. |.|        |.: :.|.|   |:.:.|:|..|     ..|....
Zfish   722 NSFLVN----CKNLTETQWNGP--------RGL-YQFELTSSGNTNKYNNSINCSFLFENLYYLT 773

  Fly  1318 RYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEIL 1382
            .|.|.:.|:....:..:.::|                                :..|..|...|.
Zfish   774 NYTIKITAINGHGKYSIVSTS--------------------------------TSTRYNDTAVIG 806

  Fly  1383 WVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTP--DQAAVTRPLMAADLGAGPTPSDPVDMRRLN 1445
            ::...::|::..:...|..:.::||:|   :||  |:..:|:||...         :|:
Zfish   807 FLAFLIVVTSIALLFVLYKIFLLKRKR---RTPEEDEICLTQPLRRV---------EPI------ 853

  Fly  1446 FQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPG--QQFTWDNSNLEHNKSKNRYAN 1508
                    :|...|..:...|    :::::.|..|::|| |.  ..:|...:....|:|||||.:
Zfish   854 --------YPEGLIDAYRTKI----ADESRLFMDEFQSI-PRIFNNYTIKEAKRPENQSKNRYVD 905

  Fly  1509 VTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVM 1573
            :..||::||.|.:  |..| |||||::.:||::...|:|.|||..||.||||:|.||.|::.|||
Zfish   906 ILPYDYNRVTLSS--GAYG-DYINASFIEGYQEPKKYIAAQGPKDETIVDFWQMMWEQKSSIIVM 967

  Fly  1574 MTRLEERTRIKCDQYWP--TRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDR-----REI 1631
            :||.||..::||.||||  .|.||.:....|.|...:....|.||...|.    |.|     |||
Zfish   968 VTRCEEGNKVKCAQYWPCLDRETEIFDDFVVKIKTEEHCPDYIIRHLVLA----NKREKASEREI 1028

  Fly  1632 KQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHE 1696
            ..:||.:|||||||..|...|:..||..:.....|||::|||||||||||.||.||:|:|.::.|
Zfish  1029 THIQFISWPDHGVPTDPGQLLKLRRRVNSFKNFFSGPIVVHCSAGVGRTGTYIGIDAMIESLEAE 1093

  Fly  1697 KIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETI 1761
            ..:||||.|..||.||..|||.|.|||.||.|::|....|.||:.....|:.|..:...:..|:|
Zfish  1094 NRVDIYGFVAKLRRQRCLMVQVEAQYILIHTALIEHNQFGETEILLSEFHSVLNTIREKQGNESI 1158

  Fly  1762 SGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRV------------------YL 1808
              ||:||:||...| :.....|.:...||.|||...::||:.:||                  |.
Zfish  1159 --MEIEFQKLPKFK-NWRTINTGSSEENKDKNRDSKVIPYDYNRVLFRLDIAGNQTSDPEDDTYS 1220

  Fly  1809 TPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREK 1873
            :.....|.::|:||||:|||..:.:.||||||:.:...:|..||::..:..|||||..:|.|::.
Zfish  1221 SDEEEEESNEYINASFLDGYWCQKSLIAAQGPLPNTTAEFLLMLYQQQTKTVVMLTDCQEDGKDL 1285

  Fly  1874 CFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGE 1938
            |.|||..|:.| :....::.....:.|.|..|..::...:......:.|:||:.|....:|::.:
Zfish  1286 CCQYWGDEKKV-FGDMEIEVKKTESFPTYVKRHLEIQSTKKNEILELDQYQFLKWKSNELPENAQ 1349

  Fly  1939 GFIDFI------GQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVR 1997
            ..|:.|      |:...:|:  .:..||.||||.|..|:|:|..|..:::....|.::||||.|:
Zfish  1350 ELIEMIKNIRENGKYDNSKK--NRSIPIVVHCSNGSSRTGLFCALWNLMDCSLTEKLVDVFQVVK 1412

  Fly  1998 ILRSQRPAMVQTEDQYHFCYRAALEYLGSF 2027
            .||.:|..||:|.:||.|.| ..||  |:|
Zfish  1413 NLRKERQGMVETFEQYQFLY-TTLE--GAF 1439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250	18/78 (23%)
		Ig strand B	157..161	CDD:409353	2/3 (67%)
		Ig strand C	170..174	CDD:409353	0/3 (0%)
		Ig strand E	192..196	CDD:409353	0/3 (0%)
		Ig strand F	206..211	CDD:409353	0/4 (0%)
		Ig strand G	218..221	CDD:409353	0/2 (0%)
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401	7/84 (8%)
		Ig strand A	237..239	CDD:409401	0/1 (0%)
		Ig strand A'	244..248	CDD:409401	0/3 (0%)
		Ig strand B	251..259	CDD:409401	0/7 (0%)
		Ig strand C	264..270	CDD:409401	0/5 (0%)
		Ig strand C'	272..274	CDD:409401	0/1 (0%)
		Ig strand D	277..281	CDD:409401	0/3 (0%)
		Ig strand E	286..291	CDD:409401	0/4 (0%)
		Ig strand F	298..305	CDD:409401	2/6 (33%)
		Ig strand G	309..318	CDD:409401	2/11 (18%)
		FN3	322..411	CDD:238020	14/88 (16%)
		FN3	<382..747	CDD:442628	80/388 (21%)
		FN3	712..810	CDD:238020	23/97 (24%)
		FN3	832..898	CDD:214495	6/65 (9%)
		FN3	<867..1269	CDD:442628	63/431 (15%)
		fn3	914..998	CDD:394996	9/83 (11%)
		R-PTPc-LAR-1	1498..1735	CDD:350401	116/243 (48%)
		R-PTP-LAR-2	1784..2021	CDD:350402	80/260 (31%)
ptprc	XP_073793929.1	None