DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and ptprq

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_021323628.1 Gene:ptprq / 555426 ZFINID:ZDB-GENE-050419-183 Length:2896 Species:Danio rerio


Alignment Length:1973 Identity:490/1973 - (24%)
Similarity:792/1973 - (40%) Gaps:518/1973 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 DPPPSIVWRKNGKKVSGTQSRYTVL-----EQPGGISILRIEPVRAGRDDAPYECVAENG----V 117
            |.||      .|..:..|.|....|     |:|.|  |:|:           ||....||    .
Zfish  1169 DSPP------RGLTIVKTTSSTATLSWSPPEKPNG--IIRM-----------YEISYTNGTYSNT 1214

  Fly   118 GDAVSADATL------TIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKN 176
            .::.||.|||      |.|  :.|...|.::..|.     ::..|:.|..   |...|       
Zfish  1215 VNSTSASATLRYLKPHTHY--NVTVRAFTLLGHGE-----QISETLQMLS---GEDVP------- 1262

  Fly   177 QTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPE 241
                  .:|.|.|                .||.:..:|:....|                  ||.
Zfish  1263 ------GSPPYDL----------------SYESIGSSSVNVSWS------------------PPL 1287

  Fly   242 TISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANY--TCIAA 304
            ..:.|:|..|              |::...::.|.....||    .:.|.|:::.|:|  :..||
Zfish  1288 LANGVILFYN--------------VEYWNATQSLNQTTHMP----YIVLSNLRKYAHYRISVQAA 1334

  Fly   305 STLG------QIDSVSVVK--------VQSLPTAPTDVQIS-EVTATSVRLEWSYKGPEDLQYYV 354
            :.:|      :|.:::.::        .|::|::|....|: :::.|.|.|.|.           
Zfish  1335 TQVGMGNHTSEILNITTLEDGECLLCFSQTVPSSPPKFLIARKLSDTEVELSWE----------- 1388

  Fly   355 IQYKPKNANQAFSEISGIITMYYVVRALSPYTEY------EFYVIAVNNIGRGPPSAPATCTTGD 413
               .|:.||   |||     :||:||..:..||:      ...|::|:..|:...|..:....||
Zfish  1389 ---APEEAN---SEI-----LYYIVRVWNLSTEFVANVTETSVVVSVDGPGQYNASVSSWTRLGD 1442

  Fly   414 FSFGG-------TKMESA----PRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPE 467
               ||       :.:|||    |::|....|:.||:.::|.||..|||.:..|.:|||.|:.:  
Zfish  1443 ---GGLLIYITFSTIESAPSDPPQDVVYTLLTISTVRLSWRPPNEPNGIIQYYTIYYTDNNTE-- 1502

  Fly   468 ASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTP---------------------- 510
              :..::..:.....:|:|.....|:|.:.:.||:|.|.:.:|                      
Zfish  1503 --YTERVPGSEHQLLLSDLQAGQDYSVWMSSSTSVGDGGLFSPSLNFTTLEDGQSPHSLRGEAQL 1565

  Fly   511 --------VQVKAQQGVPSQP-SNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAH 566
                    ...|....:||.| .|..||....|||.:.|..|...:.. |:|:|...:....   
Zfish  1566 CTTFPTDYTSKKIALKLPSGPVHNLSATIYSSTAVVISWDPPLEPNGR-VYYQLSLQEAGIT--- 1626

  Fly   567 HKRISNSEAYTLDGLYPDTL-----------YYIWLAARSQRGEGAT-TPPIPVRTKQ--YGAPP 617
            |..|:.:...|:.....||:           |.|.:...:..|.... |..:.:||.:  ..:||
Zfish  1627 HPSINRTVNMTITKTTTDTIYLFTKLRKYFPYIINVTPATSAGSAVNHTTMLHLRTDEDVPSSPP 1691

  Fly   618 RNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTS---IVLDELK 679
            .:.:....|||:|.:||. |||| :||.||.|.|..       ...:|...|.||   :||.||.
Zfish  1692 LSGSNKNLSSTSIQVSWF-PPVE-ANGEIIEYAVNL-------QGPSTSNKNYTSETHLVLSELT 1747

  Fly   680 RWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPG---DPQDVKATPLNSTSIHVSWKPPLEKDRN 741
            .:|.|.:.:.|.|.||.||   |::|....|..|   .|:::......:.|:.:.|:|..|.  |
Zfish  1748 PFTPYNLSIAAVTRVGTGP---PVVLSLHTDEAGPMSPPRNLTIFNHTANSVWLQWEPSPEP--N 1807

  Fly   742 GIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAI 806
            |:::.|.....||..:...:.|..   |.....|..  |.:|...|.|.|...||.|:||:.:  
Zfish  1808 GVVQLYGFRILELNTDSFRYQNSS---DASTQAELG--GFKPHNSYEISVCTFTRAGNGDQYS-- 1865

  Fly   807 VVKTPGGVPVRPTVSLKIMEREPIV--------SIELEWERPAQTYGELRGYRLRWG-VKDQA-- 860
                   :||..|.:..:.:....:        |:.:|||.|....||:..|.:|.| ::|:|  
Zfish  1866 -------LPVLFTTNESVSDAVGNLSCSGLDWDSVYMEWELPDHPNGEILYYLIRSGDLEDEAHP 1923

  Fly   861 -----LKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQE-------------------- 900
                 .....|:|          |.....|...||..|..|:|:|                    
Zfish  1924 VVLTHTVAHTLTG----------LSPHAFYLITVAAVNSAGVGEEANCSAHTPPESVVHKKGVNY 1978

  Fly   901 ------------------------------------TVKI---FQTPEGTPGGPPSNITIRFQTP 926
                                                |.||   |.:|...| ||..::|:...|.
Zfish  1979 VPFNVESFQAVQNCFFFCDVLASQSFLSLHSSLHSQTQKIQHCFLSPSAVP-GPSHSLTVTDVTS 2042

  Fly   927 DVLCVTWDPPTREHRNGIITRYDVQF----------HKKIDHGLGSE-----RNMTLRKAVFTNL 976
            |.:.|:|..|.  |..|::..|:|:.          .::::..:.::     ...|.| |..|:|
Zfish  2043 DSVSVSWQRPV--HVPGLLQGYNVEIEQLSRNCERQQQQVESCMEAQILEWVEGETTR-ATLTSL 2104

  Fly   977 EENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLG 1041
            .:..:|..||.|:|:.|||..|:.:..:|......||....:...|....:|.|:..:.......
Zfish  2105 LKYRQYRIRVVAFTRAGAGEPSEWIYTQTLAGNPDAPPGAISVVPSANGLKIEWDKPSVISGPTS 2169

  Fly  1042 YKI--------FYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGL------G 1092
            |.|        .|.:|.|...::.:|..||        ||..|..::|.|.| |...|      |
Zfish  2170 YIIDITALDGSGYNITLVRHSEEIRTVIVG--------NLSAFTLHSVTITA-FTGPLSNARRDG 2225

  Fly  1093 RLSEKVTVRI---KPEDVPLNLRAHDVSTHSMT---LSWSPPIRLTPVNYKISFDAMKVFVDSQG 1151
            :.||.|.:|.   :|:|.|.|:.. .|....:|   :::|||   ...|..||  |.:|.:...|
Zfish  2226 KASEPVLIRTLEDEPKDPPKNVTL-TVIPEEVTRVYVTFSPP---DEPNGNIS--AYRVDIYRNG 2284

  Fly  1152 FSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQM-AAPQPMV 1215
            .....|.....|...:...|..|:.|.....|::.::|: :...:.|.:::.|||.: |.|:|..
Zfish  2285 QLDFFINSLSVISNPNNTMTAIIDGLKGGFNYSIRIAAV-NGAGFGPSSEVHVTTGVKAPPKPKK 2348

  Fly  1216 KP----DFYGVV--NGEEILVILPQA--SEEYGPISHYYLVVVPE----DKSNLHKIPDQFLTDD 1268
            .|    :..||:  ..:.|.:.:|:.  ::::|||.... |:|.|    |..||......||   
Zfish  2349 TPRAALNSAGVIISTSKTITIEMPECFFTDDHGPIQKVQ-VIVSEPAVMDYGNLSNWKSVFL--- 2409

  Fly  1269 LLPGRNKPERPNAPYI---------AAKFPQR--SIPFTFHLGS-----GDDYHNFTNRKLEREK 1317
                     .|.|||:         ..|..:|  |...|:.:|.     .:|.....|..|:.:.
Zfish  2410 ---------HPTAPYLTDDGFLNPECPKNSERMSSSTKTYVIGEDEGCLSEDAETLCNGPLKPKT 2465

  Fly  1318 RYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNR--NKDEPE 1380
            .|....||   |..:..:|.|.:|:    .:|.|.                    :|  .:||..
Zfish  2466 HYVFKFRA---TNIRGQFTDSEYSD----KVRTAD--------------------DRLLTRDEQI 2503

  Fly  1381 ILWVVLPLMVSTFIVSTALIVLCVVK--RRRQPCKT--PDQAAVTRP-------LMAADLGAGPT 1434
            ||.|:|...::.|::   ||:...||  ||::...|  |.||.:...       :..|||   ..
Zfish  2504 ILGVLLSFFLALFLI---LIIYGSVKIHRRKKEGGTYSPRQAEIIETKFKLDQLIAVADL---EL 2562

  Fly  1435 PSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPG--QQFTWDNSNL 1497
            ..:.:: |.|:::.    |..||....|..|:|.|.:|||.||.:|:..: |.  |.....:::|
Zfish  2563 KEEKIN-RLLSYRK----SLKPISKKSFLQHVEDLCANDNAKFQEEFAEL-PKLLQDLATSDADL 2621

  Fly  1498 EHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRM 1562
            ..|:||||:.|:..|::|||:|.:..|:.|||||||::..||...|.::||||||..|..|||||
Zfish  2622 PWNRSKNRFTNIKPYNNSRVKLLSEPGMPGSDYINASFVSGYLCPNEFIATQGPLPSTVADFWRM 2686

  Fly  1563 CWELKTATIVMMTRLEERTRIKCDQYWP--TRGTETYGQIFVTITETQELATYSIRTFQLCRQGF 1625
            .||..|.||||:|:..|:.||:|.||||  .:....:..|.:|.........:::|..::.|.| 
Zfish  2687 IWETGTKTIVMLTQCFEKGRIRCHQYWPEDNKPVTVFADIIITKLTEDVRPDWTVRALKVERHG- 2750

  Fly  1626 NDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSML 1690
             ....:....:|:||:||||:..:..:||::..|:....|:..::|||||||||||.:|.:|.::
Zfish  2751 -SYMIVHHFNYTSWPEHGVPESSSTLVQFVKAVRSNRGHENTTIVVHCSAGVGRTGVFIALDHLI 2814

  Fly  1691 ERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLIT 1755
            :.::..:.:||||.|..||::|..|||...||:|:|.:.|:                     |::
Zfish  2815 QHLRDHEFVDIYGLVAELRSERMCMVQNLAQYMFLHQSTLD---------------------LLS 2858

  Fly  1756 EPGETISGMEVEFKKLSNVKMDS 1778
            ..|.:.|...|.:..|.  ||||
Zfish  2859 AKGNSQSIWFVNYSALE--KMDS 2879

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 21/81 (26%)
I-set 36..129 CDD:254352 21/81 (26%)
IG_like 146..227 CDD:214653 11/80 (14%)
Ig 159..228 CDD:299845 10/68 (15%)
I-set 234..318 CDD:254352 17/99 (17%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 13/75 (17%)
fn3 324..404 CDD:278470 21/86 (24%)
FN3 423..514 CDD:238020 27/124 (22%)
FN3 520..610 CDD:238020 23/102 (23%)
FN3 616..707 CDD:238020 36/93 (39%)
FN3 712..810 CDD:238020 24/100 (24%)
FN3 832..907 CDD:238020 26/141 (18%)
FN3 914..1005 CDD:238020 26/105 (25%)
FN3 1012..1101 CDD:238020 25/102 (25%)
fn3 1106..1198 CDD:278470 21/94 (22%)
PTPc 1476..1731 CDD:214550 100/258 (39%)
PTPc 1503..1731 CDD:238006 92/229 (40%)
PTPc 1763..2022 CDD:214550 6/16 (38%)
PTPc 1791..2022 CDD:238006
ptprqXP_021323628.1 fn3 209..278 CDD:306538
FN3 301..363 CDD:328772
FN3 382..470 CDD:238020
FN3 475..569 CDD:238020
FN3 723..808 CDD:238020
FN3 829..>864 CDD:238020
FN3 <1033..1067 CDD:238020
FN3 1072..1161 CDD:238020
fn3 1170..1241 CDD:306538 23/91 (25%)
fn3 1264..1340 CDD:306538 23/127 (18%)
fn3 1368..>1410 CDD:306538 16/63 (25%)
FN3 1460..1549 CDD:238020 25/92 (27%)
FN3 1585..1670 CDD:214495 19/88 (22%)
FN3 1697..1768 CDD:238020 32/82 (39%)
FN3 1781..1872 CDD:238020 25/106 (24%)
fn3 1878..1958 CDD:306538 21/89 (24%)
FN3 2029..2133 CDD:238020 27/107 (25%)
FN3 2141..2235 CDD:238020 24/102 (24%)
FN3 2242..2338 CDD:238020 23/102 (23%)
UP_III_II 2354..>2491 CDD:297589 34/156 (22%)
PTPc 2599..2855 CDD:214550 100/258 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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