DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and ptprz1b

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_073803012.1 Gene:ptprz1b / 553019 ZFINID:ZDB-GENE-050506-100 Length:1457 Species:Danio rerio


Alignment Length:1376 Identity:378/1376 - (27%)
Similarity:575/1376 - (41%) Gaps:286/1376 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   775 EFNVTGLQPDT--KYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEW 837
            ||::..|.|:.  ||.:...:||.....:....||.|...|:.                      
Zfish   216 EFSLLALLPENTEKYFMYNGSLTAPPCSENVEWIVFKNTVGIS---------------------- 258

  Fly   838 ERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETV 902
            |...:.:.|:.       ...||       |..|......|..|..:.:|         :||   
Zfish   259 ETQLEVFCEVM-------TMQQA-------GYAMLTDYLQNNYREQQQQF---------MGQ--- 297

  Fly   903 KIFQTPEGTPGGP-------PSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGL 960
             :|.:..||...|       |.|:....|....:.|||:.| |...:.:|.||.|.:.:.  .|.
Zfish   298 -VFSSYTGTEEVPAPMCSSEPQNVQADSQNFTGIVVTWERP-RAVYDTVIERYSVTYQRL--QGQ 358

  Fly   961 GSERNMTLRK------AVFTNLEENTEYIFRVRAYTKQG-AGPFSDKLIVETE-RDMGRAPMSLQ 1017
            ...:...|..      |:..||..|:.|:.:|.|....| .|..||::||:.. .|....|....
Zfish   359 NPPKQQYLTDGDQDVGAIIHNLLANSSYVVQVVALCMNGLTGKMSDQVIVDMPFEDPVNEPDPYG 423

  Fly  1018 AEATSEQTAEIWWEPVTSR---GKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQY 1079
            ..|.||:..|......:|:   |:.|          :.|    ...::.:|.|.|          
Zfish   424 DLAESEEYNEEHTSAPSSKPPPGRFL----------IRD----SGSSISITTSTD---------- 464

  Fly  1080 AVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMK 1144
                ...|...:.| :..:|||.|             .|...:|| .||::......:....|.:
Zfish   465 ----QPGFLFPVSR-TTPITVRRK-------------ITEESSLS-QPPVQNKSRKNETKRPANR 510

  Fly  1145 VFVDSQG-FSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPP--------- 1199
            :..|..| |.|:..| ..::..:..:.:.|.| ::|....|:.:.......|..||         
Zfish   511 LLPDDSGHFPQSNTV-VTDVYYEDVLNSSTTN-ITPTINNNLLIDQNTEKASTSPPKQPANESST 573

  Fly  1200 TKITVTTQMAAPQPMV----KPDFYGV------VNGEEILVILPQASEEYGPISHYYLVVVPEDK 1254
            ...|..:.::|...::    :|.|..|      .|.|.:|::                    .|.
Zfish   574 ANATTGSSLSASMKIISQTTQPLFNDVFVTATSFNNERVLMV--------------------SDA 618

  Fly  1255 SNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDD-YHNFTNRKLEREKR 1318
            ::|::...:..|..|..|            :|.||.......|. |||.. :....:|:.|.|:.
Zfish   619 TSLYESSTRSPTIILEEG------------SAHFPPSDGQGEFS-GSGSAIFLEELDREWELEQT 670

  Fly  1319 YRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPD----PNWPAEPEVS-------V 1372
            ......|.....|:..:...| |.|.....|||....:|...|    ..|.||.:..       :
Zfish   671 RMAPKNADPRKTQEENHEGLP-STFFFESEREASSTYKPQNQDFLSWVTWSAESDSGSGQGGSMI 734

  Fly  1373 NRNKDEPEILWVVLP--------------------------------LMVSTFIVSTALIVLCVV 1405
            ::.:|.|  :.:::|                                .:|...|||| |.|||:|
Zfish   735 SQTEDIP--IQLIIPKLNIQEENHAEASNSSPESRVGMVGGTETEKRAVVPLAIVST-LTVLCLV 796

  Fly  1406 ---------KRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMI---SHPPIP 1458
                     :|..|          |......|..:....|.|        .||.::   .:..:|
Zfish   797 VLVGILIYWRRCFQ----------TAHFYVEDTNSARAISAP--------STPLLLPTEDNEALP 843

  Fly  1459 ISEFANHIERLKSNDNQKFSQEYESIEPGQQ----------FTWDNSNLEHNKSKNRYANVTAYD 1513
            :.:|..|:..|.:  |.|||:|:|.::...:          .|.|:||...|||||||.|:.|||
Zfish   844 VKDFVKHVADLHA--NHKFSKEFEILKESYEEIQGCTADMGITTDSSNHPDNKSKNRYINILAYD 906

  Fly  1514 HSRVQLPA---VEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMT 1575
            ||||:|..   .:|..| |||||||.||:.:..||:|.||||:.:..|||||.||.....|||:|
Zfish   907 HSRVKLSQNSDKDGKTG-DYINANYVDGFNQPKAYIAAQGPLKGSLEDFWRMIWEQNVGVIVMIT 970

  Fly  1576 RLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQL--------CRQGFNDRREIK 1632
            .|.|:.|.|||||||....|.||...||:..::.||.|::|||.|        .::|.:..|.:.
Zfish   971 NLVEKGRRKCDQYWPLENQEDYGCFLVTLKSSRTLAYYTLRTFTLRNVQIKKGSQKGRSQERTVL 1035

  Fly  1633 QLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEK 1697
            ...:|.|||.|||::..|.|.|:|........|.|||:|||||||||||.||||||||:::|.|.
Zfish  1036 HFHYTQWPDMGVPEYTLPLLSFIRTSSQARTAEMGPVVVHCSAGVGRTGTYIVIDSMLKQIKEEN 1100

  Fly  1698 IIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEP-GETI 1761
            .::|.|.:..:|.||||:||||:||:|||||::|||....|.|.:..:||::..||...| |:| 
Zfish  1101 TVNIMGFLKHIRTQRNYLVQTEEQYVFIHDALVEAIRSKETLVSSSLIHTYVSGLLTPGPAGKT- 1164

  Fly  1762 SGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFID 1826
             .:|.:||.:|......|.:.||....|..|||...::|.|.|||.|:...| |.|||:|||::.
Zfish  1165 -PLEKQFKLVSQSCAKQSDYTTALKESNVSKNRTACLMPVERSRVSLSAAAG-ESSDYINASYLL 1227

  Fly  1827 GYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWP-HERSVRYQYYV 1890
            |:.....:|..|.|:.:...|||||:|:||:.|:|.|.....|..|....||| .:..:..:.:.
Zfish  1228 GFHQSREFIVTQNPLPNTIHDFWRMIWDHNTQIIVSLPDTHNMSSEAECVYWPTKDEPISCETFT 1292

  Fly  1891 V-----DPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKT 1950
            |     |.:...|.....::.|.:...:|.....|.|||...||:...|.|  ...:.|..:.  
Zfish  1293 VSFRDEDSLNLSNEEPVLVQHFILEALKDDYVLEVHQFQSPRWPDPDSPIS--NCFELINIIR-- 1353

  Fly  1951 KEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHF 2015
            :|...::||:.:|...|...:|:|..|..::.::..|..:||:||.|::...||.:....:||.|
Zfish  1354 EESSRREGPVLIHDGCGGSSAGLFCALVTLVNQLDEENSVDVYQTARMINLMRPGVFNDVEQYQF 1418

  Fly  2016 CYRAALEYLGS 2026
            .|:|.|..:.:
Zfish  1419 LYKAILSLVST 1429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628
FN3 712..810 CDD:238020 10/36 (28%)
FN3 832..898 CDD:214495 9/65 (14%)
FN3 <867..1269 CDD:442628 86/439 (20%)
fn3 914..998 CDD:394996 24/97 (25%)
R-PTPc-LAR-1 1498..1735 CDD:350401 126/247 (51%)
R-PTP-LAR-2 1784..2021 CDD:350402 74/242 (31%)
ptprz1bXP_073803012.1 None
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.