DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and ptprz1b

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_009298311.1	Gene:	ptprz1b / 553019	ZFINID:	ZDB-GENE-050506-100	Length:	1457	Species:	Danio rerio

Alignment Length:	1344	Identity:	368/1344 - (27%)
Similarity:	564/1344 - (41%)	Gaps:	291/1344 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   853 RWGVKDQALKEEMLSG--PQMTKKRF------------DNLERGVEYEFRVAGSNHIGIGQETVK 903
            |:| |..|::|..|..  |:.|:|.|            :|:|       .:...|.:||.:..::
Zfish   207 RFG-KSSAVEEFSLLALLPENTEKYFMYNGSLTAPPCSENVE-------WIVFKNTVGISETQLE 263

  Fly   904 IF-----------------------------------------QTPEGTPGGPPSNITIRFQTPD 927
            :|                                         :.|.......|.|:....|...
Zfish   264 VFCEVMTIQQAGYAMLTDYLQNNYREQQQQFMGQVFSSYTGTEEVPAPMCSSEPQNVQADSQNFT 328

  Fly   928 VLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRK------AVFTNLEENTEYIFRV 986
            .:.|||:.| |...:.:|.||.|.:.:.  .|....:...|..      |:..||..|:.|:.:|
Zfish   329 GIVVTWERP-RAVYDTVIERYSVTYQRL--QGQNPPKQQYLTDGDQDVGAIIHNLLANSSYVVQV 390

  Fly   987 RAYTKQG-AGPFSDKLIVETE-RDMGRAPMSLQAEATSEQTAEIWWEPVTSR---GKLLGYKIFY 1046
            .|....| .|..||::||:.. .|....|......|.||:..|......:|:   |:.|
Zfish   391 VALCMNGLTGKMSDQVIVDMPFEDPVNEPDPYGDLAESEEYNEEHTSAPSSKPPPGRFL------ 449

  Fly  1047 TMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNL 1111
                :.|    ...::.:|.|.|              ...|...:.| :..:|||.|
Zfish   450 ----IRD----SGSSISITTSTD--------------QPGFLFPVSR-TTPITVRRK-------- 483

  Fly  1112 RAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQG-FSQTQIVPKREIILKHYVKTHTIN 1175
                 .|...:|| .||::......:....|.::..|..| |.|:..| ..::..:..:.:.|.|
Zfish   484 -----ITEESSLS-QPPVQNKSRKNETKRPANRLLPDDSGHFPQSNTV-VTDVYYEDVLNSSTTN 541

  Fly  1176 ELSPFTTYNVNVSAIPSDYSYRPP---------TKITVTTQMAAPQPMV----KPDFYGV----- 1222
             ::|....|:.:.......|..||         ...|..:.::|...::    :|.|..|
Zfish   542 -ITPTINNNLLIDQNTEKASTSPPKQPANESSTANATTGSSLSASMKIISQTTQPLFNDVFVTAT 605

  Fly  1223 -VNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAA 1286
             .|.|.:|::                    .|.::|::...:..|..|..|            :|
Zfish   606 SFNNERVLMV--------------------SDATSLYESSTRSPTIILEEG------------SA 638

  Fly  1287 KFPQRSIPFTFHLGSGDD-YHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMRE 1350
            .||.......|. |||.. :....:|:.|.|:.......|.....|:..:...| |.|.....||
Zfish   639 HFPPSDGQGEFS-GSGSAIFLEELDREWELEQTRTAPKNADPRKTQEENHEGLP-STFFFESERE 701

  Fly  1351 APPGERPHRPD----PNWPAEPEVS-------VNRNKDEPEILWVVLP----------------- 1387
            |....:|...|    ..|.||.:..       :::.:|.|  :.:::|
Zfish   702 ASSTYKPQNQDFLSWVTWSAESDSGSGQGGSMISQTEDIP--IQLIIPKLNIQEENHAEASNSSP 764

  Fly  1388 ---------------LMVSTFIVSTALIVLCVV---------KRRRQPCKTPDQAAVTRPLMAAD 1428
                           .:|...|||| |.|||:|         :|..|          |......|
Zfish   765 ESRVGMVGGTETEKRAVVPLAIVST-LTVLCLVVLVGILIYWRRCFQ----------TAHFYVED 818

  Fly  1429 LGAGPTPSDPVDMRRLNFQTPGMI---SHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQ- 1489
            ..:....|.|        .||.::   .:..:|:.:|..|:..|.:  |.|||:|:|.::...:
Zfish   819 TNSARAISAP--------STPLLLPTEDNEALPVKDFVKHVADLHA--NHKFSKEFEILKESYEE 873

  Fly  1490 ---------FTWDNSNLEHNKSKNRYANVTAYDHSRVQLPA---VEGVVGSDYINANYCDGYRKH 1542
                     .|.|:||...|||||||.|:.|||||||:|..   .:|..| |||||||.||:.:.
Zfish   874 IQGCTADMGITTDSSNHPDNKSKNRYINILAYDHSRVKLSQNSDKDGKTG-DYINANYVDGFNQP 937

  Fly  1543 NAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITET 1607
            .||:|.||||:.:..|||||.||.....|||:|.|.|:.|.|||||||....|.||...||:..:
Zfish   938 KAYIAAQGPLKGSLEDFWRMIWEQNVGVIVMITNLVEKGRRKCDQYWPLENQEDYGCFLVTLKSS 1002

  Fly  1608 QELATYSIRTFQL--------CRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPP 1664
            :.||.|::|||.|        .::|.:..|.:....:|.|||.|||::..|.|.|:|........
Zfish  1003 RTLAYYTLRTFTLRNVQIKKGSQKGRSQERTVLHFHYTQWPDMGVPEYTLPLLSFIRTSSQARTA 1067

  Fly  1665 ESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAI 1729
            |.|||:|||||||||||.||||||||:::|.|..::|.|.:..:|.||||:||||:||:|||||:
Zfish  1068 EMGPVVVHCSAGVGRTGTYIVIDSMLKQIKEENTVNIMGFLKHIRTQRNYLVQTEEQYVFIHDAL 1132

  Fly  1730 LEAIICGVTEVPARNLHTHLQKLLITEP-GETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKN 1793
            :|||....|.|.:..:||::..||...| |:|  .:|.:||.:|......|.:.||....|..||
Zfish  1133 VEAIRSKETLVSSSLIHTYVSGLLTPGPAGKT--PLEKQFKLVSQSCAKQSDYTTALKESNVSKN 1195

  Fly  1794 RLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNST 1858
            |...::|.|.|||.|:...| |.|||:|||::.|:.....:|..|.|:.:...|||||:|:||:.
Zfish  1196 RTACLMPVERSRVSLSAAAG-ESSDYINASYLLGFHQSREFIVTQNPLPNTIHDFWRMIWDHNTQ 1259

  Fly  1859 IVVMLTKLKEMGREKCFQYWP-HERSVRYQYYVV-----DPIAEYNMPQYKLREFKVTDARDGSS 1917
            |:|.|.....|..|....||| .:..:..:.:.|     |.:...|.....::.|.:...:|...
Zfish  1260 IIVSLPDTHNMSSEAECVYWPTKDEPISCETFTVSFRDEDSLNLSNEEPVLVQHFILEALKDDYV 1324

  Fly  1918 RTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLE 1982
            ..|.|||...||:...|.|  ...:.|..:.  :|...::||:.:|...|...:|:|..|..::.
Zfish  1325 LEVHQFQSPRWPDPDSPIS--NCFELINIIR--EESSRREGPVLIHDGCGGSSAGLFCALVTLVN 1385

  Fly  1983 RMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026
            ::..|..:||:||.|::...||.:....:||.|.|:|.|..:.:
Zfish  1386 QLDEENSVDVYQTARMINLMRPGVFNDVEQYQFLYKAILSLVST 1429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020	16/108 (15%)
		FN3	914..1005	CDD:238020	27/97 (28%)
		FN3	1012..1101	CDD:238020	15/91 (16%)
		fn3	1106..1198	CDD:278470	16/92 (17%)
		PTPc	1476..1731	CDD:214550	132/275 (48%)
		PTPc	1503..1731	CDD:238006	120/238 (50%)
		PTPc	1763..2022	CDD:214550	80/264 (30%)
		PTPc	1791..2022	CDD:238006	72/236 (31%)
ptprz1b	XP_009298311.1	alpha_CARP_receptor_like	47..300	CDD:239396	16/100 (16%)
		fn3	315..393	CDD:278470	20/80 (25%)
		PTPc	859..1134	CDD:214550	132/275 (48%)
		PTPc	896..1134	CDD:238006	120/238 (50%)
		PTPc	1166..1424	CDD:214550	80/262 (31%)
		PTPc	1194..1424	CDD:238006	72/234 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940