DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Tpo

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_062226.2 Gene:Tpo / 54314 RGDID:3900 Length:914 Species:Rattus norvegicus


Alignment Length:676 Identity:123/676 - (18%)
Similarity:204/676 - (30%) Gaps:252/676 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1305 YHNFTNRKLEREKRYRIFV--RAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWP-- 1365
            ||.|....:....|:.|.|  .||.:..|        :|:||                 |.|.  
  Rat   191 YHGFPLPPVREVTRHLIQVSNEAVTEDDQ--------YSDFL-----------------PVWGQY 230

  Fly  1366 AEPEVSVNRNKDEPEILW-------------VVLPLMVSTFIVSTALIVLCV-VKRRRQPCKTPD 1416
            .:.::::..........|             ...|:.:.:   :::....|: ..|....|.|.|
  Rat   231 IDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPS---NSSRTTACLPFYRSSAACGTGD 292

  Fly  1417 QAAVTRPLMAAD-----------LGA----GPTP---------SDPVDMRRLN------------ 1445
            |.|:...|.||:           |.|    |.:|         |....:.|:|            
  Rat   293 QGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDSGRAYLP 357

  Fly  1446 FQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANV- 1509
            |.:......|..|   .||......:.|.:  :.|..:: ......|..   |||:....:..: 
  Rat   358 FASAACAPEPGAP---HANRTPCFLAGDGR--ASEVPAL-AAVHTLWLR---EHNRLATAFKAIN 413

  Fly  1510 ------TAYDHSRVQLPAVEGVVG-SDYIN--------ANYCDGYRKHNAYV------------- 1546
                  |||..:|..:.|:..::. .|||.        ..|...|..:|..|             
  Rat   414 THWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSNVFSTAAF 478

  Fly  1547 ----ATQGP-------------------LQETFVDFWRMCWE-----LKTATIVMMTRLEERTRI 1583
                ||..|                   |.:.|...||:..|     :....:....:|:.:.::
  Rat   479 RFGHATVHPLVRRLNTDFQDHTELPRLQLHDVFFRPWRLIQEGGLDPIVRGLLARPAKLQVQEQL 543

  Fly  1584 KCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHP 1648
            ..::                :||         |.|.|...|..|   :..|......|||:|.: 
  Rat   544 MNEE----------------LTE---------RLFVLSNVGTLD---LASLNLQRGRDHGLPGY- 579

  Fly  1649 APFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIY----------G 1703
            ..:.:|....|..||.|....|.:.|          :::.::|..||...||::          |
  Rat   580 NEWREFCGLSRLETPAELNKAIANRS----------MVNKIMELYKHADNIDVWLGGLAEKFLPG 634

  Fly  1704 HVT-----C-----LRAQR--------NYMVQTEDQYIFIHDAILEAIIC---GVTEVP--ARNL 1745
            ..|     |     ::|.|        |..|.|:.|...:....|..:||   |:|.||  |..:
  Rat   635 ARTGPLFACIIGKQMKALRDGDRFWWENSHVFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRI 699

  Fly  1746 HTHLQKLLITEPGETISGMEVEF---------KKLSNVKMDSSKFVTANLPCNKHKNRLVHILPY 1801
            ....|..   |..|.|..|::..         |.:...|:|:..||...                
  Rat   700 GKFPQDF---ESCEEIPSMDLRLWRETFPQDDKCVFPEKVDNGNFVHCE---------------- 745

  Fly  1802 ESSRVYL--TPIHG--IEGSDYVNAS 1823
            ||.::.|  :..||  ::|.:.|..:
  Rat   746 ESGKLVLVYSCFHGYKLQGQEQVTCT 771

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020
FN3 520..610 CDD:238020
FN3 616..707 CDD:238020
FN3 712..810 CDD:238020
FN3 832..907 CDD:238020
FN3 914..1005 CDD:238020
FN3 1012..1101 CDD:238020
fn3 1106..1198 CDD:278470
PTPc 1476..1731 CDD:214550 59/339 (17%)
PTPc 1503..1731 CDD:238006 54/312 (17%)
PTPc 1763..2022 CDD:214550 13/74 (18%)
PTPc 1791..2022 CDD:238006 7/37 (19%)
TpoNP_062226.2 An_peroxidase 145..687 CDD:281139 101/571 (18%)
thyroid_peroxidase 161..722 CDD:188657 111/609 (18%)
CCP 730..783 CDD:153056 11/58 (19%)
EGF_CA 784..826 CDD:284955
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 882..907
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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