DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and CG42331

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_001189281.1	Gene:	CG42331 / 42948	FlyBaseID:	FBgn0259233	Length:	1615	Species:	Drosophila melanogaster

Alignment Length:	1268	Identity:	230/1268 - (18%)
Similarity:	391/1268 - (30%)	Gaps:	434/1268 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 GGISILRIEPVRAGRDDAPYECVA---------------ENGVGDAVSADATLTIYEGDKTPAGF 139
            |||:   ..||..|.....:.|:.               |||.            :|...|||
  Fly   632 GGIA---ERPVVGGLVGPTFACIIAQQFSNSRRGDRFWYENGG------------FESSFTPA-- 679

  Fly   140 PVITQGPGTRVIEVGHTVLMTCKAIGNPT--PNIY-------------WIKNQTKVDMSNPRYSL 189
                |....|.:.:...:   |:.:|..|  |:|:             .:.:.:.:|:|  .:..
  Fly   680 ----QLHSLRRVSLAQVL---CRTVGGGTLQPHIFIPAEFEDNERQTCGVGSLSPIDLS--PWLE 735

  Fly   190 KDGF------LQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVML 248
            :|.|      .|:....:.:.|..:.:.|:..|..:        :|:.:.|.....|.::|....
  Fly   736 QDPFHNQQVPEQVFTIGQPELGSVQIIKEDKAGFSN--------RVKPIKPQVEVSPSSLSGFHR 792

  Fly   249 GSNLNLSCIA--VGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLIN--IQESANYTCIAASTLGQ 309
            .:|.||:.::  :......|.....:.:.......|:|.     :|  :.:|...|.       .
  Fly   793 PTNENLTKVSDKLDLRRKTVTKKNNTNNRQQTTRKPVGG-----VNNKLDKSPKITL-------N 845

  Fly   310 IDSVSVVKVQS--------LPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAF 366
            |.||:|.:.:.        :...|.:::.|...||:...|......||.:::
  Fly   846 IKSVNVRRPEGSGLKRRVIINNVPVELRSSGGNATAEETEPGNLTDEDDEFH------------- 897

  Fly   367 SEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFG-----GTKMESAPR 426
            .:...::.|..:|..                  |.....|:..|..|.:..     .|:.|...:
  Fly   898 DDAGEVVDMEDIVEV------------------RASKDDPSKLTKTDLNQNRNDSKTTETEQTEK 944

  Fly   427 NVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAI 491
            |..:.....||     :.|:|......  |:.....:..|:.:.:|:::.|....|.:.....|.
  Fly   945 NTTIEPTEDST-----DEPKTERRDAR--KMEPHPAAKTPDKTADSRLLHNQRNRTTTPRDFQAS 1002

  Fly   492 YTVRVQAYTSMGAGP---------------MSTPVQVKAQQGVPSQPS--------NFRATDIG- 532
            .||.::.:|.....|               .:.|:..:.|:.|.:.|:        |.|.|:..
  Fly  1003 STVSLKRFTRQTKAPKVSKPTKRAEELRQYQNRPLYERPQKVVVNGPNADQYEIEINIRQTNKNP 1067

  Fly   533 ----ETAVTLQWT---KPTHSSENIVHYELYWNDT---YANQAHHK---RISNSEAYTLDGLYPD 584
                .|:...|:|   ||.::|....||..|.:.|   ..:..:|:   .|||....|    .|.
  Fly  1068 ASRPSTSDYAQYTTANKPYYNSNYAPHYMDYASTTPIPLPSYGYHQPIGEISNQGVRT----KPP 1128

  Fly   585 TLYYIWLAARSQRGEGATTPPIPVRTKQYGAPP--RNITAIATSS-----------TTISLSWLP 636
            |:.|:     :...:..||      |:   ||.  :|....||:|           ||      |
  Fly  1129 TIIYL-----NDNDDRRTT------TR---APNIFQNFLTFATNSFNPLGIRRPMPTT------P 1173

  Fly   637 PPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSH 701
            .|:.:|:          .|.|:.::......::.:.|:..             .|.|....||
  Fly  1174 SPISQSH----------KEPGQFENNVVHSPISNSHILTG-------------GGPSASYSPR-- 1213

  Fly   702 PIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPF 766
                         |..|.:.|: :||..:...|                       |.|||:
  Fly  1214 -------------PPSVHSYPV-ATSSQIGGNP-----------------------GSGFLH--- 1238

  Fly   767 KFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMER--EP 829
                                     |:.:....|...:...|.|..|..  .|.|..|..|  ..
  Fly  1239 -------------------------ASSSAVSAGHFGSISGVATANGAD--STFSFNIRPRPSPD 1276

  Fly   830 IVSIELEWERPAQTYGELRGYRLRWGVKDQAL--KEEML--------SGPQMTKKRFDNLERGVE 884
            :.|:...:.||..:.|....||..:......|  ..|::        ||....::.......|..
  Fly  1277 LGSVVSSYPRPVSSQGGGSSYRPDYAPTQSELYYDRELITDRNPSPFSGSSSAQRPHQQTFYGRS 1341

  Fly   885 YEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITI--RFQTPDVLCVTWD----------PPT 937
            .|.:..|:|...:.....|::...........||:|.  ..||.|.....:|          ..|
  Fly  1342 PELKEVGNNSNELTHTEHKLYLQDYDYASRTLSNLTTDESHQTDDDTDYVYDEDIASNDLDKTKT 1406

  Fly   938 REHR--NGIITRYDVQFHKKIDHGLGSERNMTLRKAV-------FTNLEENTEYIF-----RVRA 988
            |:..  |.:.|       ||.|.. |..|...:|.|.       .|:|::|  |:.     |.|.
  Fly  1407 RKETDLNELTT-------KKFDQD-GYMRPQLMRDATHNSTGYNVTSLDDN--YVMPMLENRTRT 1461

  Fly   989 YTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVED 1053
                       ..:.|..:.|      |...:.|...:::...| .|.||.|...|.    |.|.
  Fly  1462 -----------NYVTEVPKPM------LSTSSRSVTNSKVTVFP-DSLGKQLANDIL----ADEA 1504

  Fly  1054 LDDWQTKTVGLTESADLVNLEKFAQYA-VAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVS 1117
            .||: ....|.||:.  :..:|..|.| ||.|            .:||..|| |.|.|...::.:
  Fly  1505 TDDY-VDANGHTEAR--LKAQKLKQLASVAFA------------PITVLTKP-DRPDNWVIYNKA 1553

  Fly  1118 THSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTT 1182
                  |..||:...|.   ::.|               :.|..|:               |...
  Fly  1554 ------SEEPPLPQPPA---VNMD---------------VAPSGEV---------------PTPI 1579

  Fly  1183 YNVNVSAIPSDYSYR---PPTKIT--VTTQMAA 1210
            .|.|.:.:..|...|   |||::.  |||..||
  Fly  1580 KNFNNAWLKQDLKARPETPPTRLAEEVTTVAAA 1612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	10/53 (19%)
		I-set	36..129	CDD:254352	10/53 (19%)
		IG_like	146..227	CDD:214653	14/101 (14%)
		Ig	159..228	CDD:299845	13/89 (15%)
		I-set	234..318	CDD:254352	16/87 (18%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	13/71 (18%)
		fn3	324..404	CDD:278470	10/79 (13%)
		FN3	423..514	CDD:238020	16/105 (15%)
		FN3	520..610	CDD:238020	24/111 (22%)
		FN3	616..707	CDD:238020	17/103 (17%)
		FN3	712..810	CDD:238020	13/97 (13%)
		FN3	832..907	CDD:238020	15/84 (18%)
		FN3	914..1005	CDD:238020	24/116 (21%)
		FN3	1012..1101	CDD:238020	22/89 (25%)
		fn3	1106..1198	CDD:278470	15/94 (16%)
		PTPc	1476..1731	CDD:214550
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
CG42331	NP_001189281.1	An_peroxidase	183..699	CDD:281139	17/90 (19%)
CG42331	NP_001189281.1	peroxinectin_like	328..696	CDD:188655	17/87 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900