DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and LIFR

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_016864951.1 Gene:LIFR / 3977 HGNCID:6597 Length:1115 Species:Homo sapiens


Alignment Length:1256 Identity:243/1256 - (19%)
Similarity:407/1256 - (32%) Gaps:406/1256 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 PPSIVWRKNGKK--VSGTQSRYTVLEQPGG--------------------ISILRIEPVRAGRDD 106
            |.:.:|:..|:.  ::.....|..|::|..                    |.:..:..|.:.:..
Human     2 PEAALWKPRGRTDCIAQMMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKG 66

  Fly   107 APYE--CVAENGVGDAVSADATLTIYEGD-KTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPT 168
            ||::  ||..|           |.::... |.|:|     .|.||. .||         .|.|.:
Human    67 APHDLKCVTNN-----------LQVWNCSWKAPSG-----TGRGTD-YEV---------CIENRS 105

  Fly   169 PNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAENSM---GTEHSKATNLYVKVR 230
            .:.|.::   |..:..|..|               .|.|| :..||:   |:..||.|.....|.
Human   106 RSCYQLE---KTSIKIPALS---------------HGDYE-ITINSLHDFGSSTSKFTLNEQNVS 151

  Fly   231 RVPPTFSRPPETISEVMLGSNLNLSCIAV-----GSPMPH---VKWMKGSEDLTPENEMPIGR-N 286
            .:|.|    ||.::   |.::.:.|.:.:     ||..||   |.|           |:.:.| .
Human   152 LIPDT----PEILN---LSADFSTSTLYLKWNDRGSVFPHRSNVIW-----------EIKVLRKE 198

  Fly   287 VLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRL------EWSYK 345
            .::|:.: .:.|.|.....||......|.:.::..      :...|:......|      |||..
Human   199 SMELVKL-VTHNTTLNGKDTLHHWSWASDMPLECA------IHFVEIRCYIDNLHFSGLEEWSDW 256

  Fly   346 GPEDLQYYVIQYKPKNANQAFSEISGI----------ITMYYVVRALSPYT-------EYEFYVI 393
            .|    ...|.:.|.:..:.|.:...|          ::...|:.||..:|       :.|...|
Human   257 SP----VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAI 317

  Fly   394 AVNNIGRGPPSAPATCTTGDFSFGGTKM-----ESAPRNVQVRTLSSSTMVITWEPPETPNGQVT 453
            .:.||.....|......|.:.:..||.:     ...|:.:...|.....::.:|.|     |:||
Human   318 KIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP-----GRVT 377

  Fly   454 GY----KVYYT---------TNSNQPEASWNS------QMVDNSELTTVSELTPHAIYTVRVQAY 499
            ..    ...||         ....:.||..|.      ||:.|.|           ||...:.|:
Human   378 ALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQE-----------IYNFTLNAH 431

  Fly   500 TSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSE--NIVHYELYWNDTYA 562
            ..:|....:..|.: .::..|..|::|:..||..|||.|.|..|.:.::  .:...|:..:::..
Human   432 NPLGRSQSTILVNI-TEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQ 495

  Fly   563 NQAH--HKRISNSE-AYTLDGLYPDTLY---------YIWLAAR-SQRGEGATTPPIPVR----T 610
            .|.:  .|.:.||. ...||.|.|.|||         ..|..:: |.:.:..||...|.:    .
Human   496 EQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTW 560

  Fly   611 KQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMT-----LNM 670
            :::.:..:|:.          :.|.|.|:..:||:|:.|.|..    ..|:|..:::     .:.
Human   561 REWSSDGKNLI----------IYWKPLPINEANGKILSYNVSC----SSDEETQSLSEIPDPQHK 611

  Fly   671 TSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPP 735
            ..|.||:    .:|.|.|:|..|||..|   |..:.:.| :|.|  |:|                
Human   612 AEIRLDK----NDYIISVVAKNSVGSSP---PSKIASME-IPND--DLK---------------- 650

  Fly   736 LEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDG 800
                           .:::...|||.|                               ||...|.
Human   651 ---------------IEQVVGMGKGIL-------------------------------LTWHYDP 669

  Fly   801 DRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEM 865
            :.:...|:|........|.:              ::|.:                         :
Human   670 NMTCDYVIKWCNSSRSEPCL--------------MDWRK-------------------------V 695

  Fly   866 LSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLC 930
            .|....|....|....|:.|.|.:.|..:.|.......|....|..|...| |.|:...:.|.:.
Human   696 PSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAP-NFTVEDTSADSIL 759

  Fly   931 VTWDPPTREHRNGIITRY---------DVQFHKKIDHGLGSER--------NMTLRKAVFTNLEE 978
            |.|:....|...|.:..|         |....:.::.|....:        ..|||.|   :|:.
Human   760 VKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIA---DLQG 821

  Fly   979 NTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYK 1043
            .|.|...:||||..|.||.....:|..|..:|.....|...|.:     :....|||   :|.|:
Human   822 KTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVA-----VIVGVVTS---ILCYR 878

  Fly  1044 IFYTMTAVEDLDDWQTKTVGLTESADLVNLE--KFAQYAVAIAARFKNGLGRLSEKVTVRIKP-- 1104
                      ..:|..:|.    ..|:.|.|  |..|:..::.    .|...|.   |:.:.|  
Human   879 ----------KREWIKETF----YPDIPNPENCKALQFQKSVC----EGSSALK---TLEMNPCT 922

  Fly  1105 ----------------EDV----PLNLRAHDVS----THSMTLSWSPPI----RLTPVNYKISFD 1141
                            ||.    |:..|..|.|    .:.:.:|:.|||    ...|...:....
Human   923 PNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPNPAADEAGGT 987

  Fly  1142 AMKVFVDSQGFSQTQIVPKRE 1162
            |..:::|.|...|.|..|:.|
Human   988 AQVIYIDVQSMYQPQAKPEEE 1008

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 14/88 (16%)
I-set 36..129 CDD:254352 14/88 (16%)
IG_like 146..227 CDD:214653 19/83 (23%)
Ig 159..228 CDD:299845 15/71 (21%)
I-set 234..318 CDD:254352 19/92 (21%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 15/76 (20%)
fn3 324..404 CDD:278470 18/102 (18%)
FN3 423..514 CDD:238020 21/109 (19%)
FN3 520..610 CDD:238020 28/108 (26%)
FN3 616..707 CDD:238020 23/95 (24%)
FN3 712..810 CDD:238020 12/97 (12%)
FN3 832..907 CDD:238020 10/74 (14%)
FN3 914..1005 CDD:238020 26/107 (24%)
FN3 1012..1101 CDD:238020 17/90 (19%)
fn3 1106..1198 CDD:278470 17/69 (25%)
PTPc 1476..1731 CDD:214550
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
LIFRXP_016864951.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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