DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and ptprma

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001018143.1 Gene:ptprma / 386769 ZFINID:ZDB-GENE-031113-24 Length:974 Species:Danio rerio


Alignment Length:914 Identity:185/914 - (20%)
Similarity:304/914 - (33%) Gaps:263/914 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 SADATLTIY-EGDKTPAGFPVIT-QGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSN 184
            |:...:.|| :.:.:|.|.||.. .||..      ||......|:....||.|.:  ..:|..|.
Zfish   110 SSPGQMLIYVKENSSPLGQPVWNYSGPAM------HTWQQVELAVSTFWPNFYQL--VFEVVASG 166

  Fly   185 PRYSLKDGFLQIEN-SREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVML 248
            .|     |.|.::. ||   || ::|     |.|.|      ::.::.|            ||..
Zfish   167 DR-----GLLAVKGISR---QG-HQC-----MNTPH------FLHIKGV------------EVNA 199

  Fly   249 GSNLNLSCIAVGSPMPHVK---WMK--GSEDLTPENEMPIG----RNVLQLINI--QESANYTCI 302
            .......|...|.|..|:.   |::  |..:...::..|:.    .....::|.  .:|..|.||
Zfish   200 RQTATFQCTINGQPKDHLNYKLWLQGIGGREAVMKDSKPVNSRRYTGSFDILNTTKADSGRYRCI 264

  Fly   303 AASTLG-QIDSVS--VVKVQSLPTAPTDVQISEVTATSVRLEW---SYKGPEDLQYYVIQYKPKN 361
            ..|..| .:.|..  |||...:|.||.  |::.|.||.:.::.   |..|...:....::|  :.
Zfish   265 VRSDSGVGVSSYGALVVKQPPIPIAPP--QLTAVGATYLWIQLNANSINGDGPIVEKEVEY--RT 325

  Fly   362 ANQAFSEISGIITMYYVVRALSPYTEYEFYVIAV--NNIGRGPPSAPATCTT--GDFSFGGTKME 422
            .:.:..::..:....:.:..|.|.|||:..|:..  |..|.|.|..|....|  .|...|     
Zfish   326 VSGSLIDLQPVDKPNHKIGHLDPDTEYQISVLLTRPNEGGTGAPGPPLRARTKCADPMHG----- 385

  Fly   423 SAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYK----------VYYTTNSNQPEASWNSQMVD- 476
              ||.:.|..:.|..:.:.|||        .||.          |.|..:||..|.....|..| 
Zfish   386 --PRQLTVVDIKSKQLTVRWEP--------FGYNVTRCYSYNLTVQYRYSSNGKEDRREEQCFDL 440

  Fly   477 --NSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQ-PSNFRATDIGETAVTL 538
              .:...|:..|.|....::|:......| ...|..:||...:.||.. |.:....:..|..:||
Zfish   441 HSPAPQHTIRNLPPFTNVSIRLVLRNREG-DKDSPELQVLTDEDVPGPVPQDSIQGNTYEEKITL 504

  Fly   539 QWTKPTHSSENIVHYELYWN-----DTYANQAHHK----RISNSEAYTLDGLYPDTLYYIWLAAR 594
            :|.:|.|:...|..||:::.     |...|.::..    :.||..::...||||.:.|...:.|.
Zfish   505 RWREPLHTYGIIKQYEIFYKAMSSFDPEFNLSNQSGKVLKSSNETSHLFTGLYPGSTYSFTIRAS 569

  Fly   595 SQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGRE 659
            :.:|              ||.|     ||...:|.||...:|                    |.|
Zfish   570 TVKG--------------YGPP-----AIRQFTTKISSPRMP--------------------GYE 595

  Fly   660 DDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLN 724
            .:.....|.:..:::|                                      .|...:..|::
Zfish   596 QESPLNQTDSTVTVML--------------------------------------KPAQSRGAPVS 622

  Fly   725 STSIHVSWKPPLEKDRNG-IIRGYHI--HAQELRDEGKGFLNEPFKFD-------VVDTLEFNV- 778
            ...:.|..:.|....|.. |:|.|.|  |.|.:     ...|.|:.|.       :...|.|.| 
Zfish   623 VYQVVVEEERPRRSQRAAEILRCYPIPVHFQNV-----SAFNSPYYFSAEFPAARIQAPLPFTVG 682

  Fly   779 ----------TGLQPDTKYSIQVAAL-TRKGD--------GDRSAAIVVK-TPGGVPVRPTVS-- 821
                      ..|.|...||:...|: |..|:        ..::|.||.: |...|.:.|...  
Zfish   683 DNRTYEGYWNLPLLPHKSYSVYYQAVSTANGETKIDCVRVATKAAIIVTQLTTPYVRIAPAAGDS 747

  Fly   822 --LKIMEREP-IVSIELEWERPAQTYGELRG-------------------------YRLRWGVKD 858
              .....|:| .|..|.:.:...:..|.:.|                         |.|:...| 
Zfish   748 QLTGAATRKPDAVEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRRSYHSYTYYLKLAKK- 811

  Fly   859 QALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTP--EGTPGGPPSNITI 921
               ::|.||.   |::....:...::..:...|::    ..|.:....|.  .|.|...||:.|:
Zfish   812 ---RKETLSS---TRQEMTVMVNSMDKSYAEQGTS----CDEAISFMDTHNLNGRPVSSPSSFTL 866

  Fly   922 RFQT 925
            :..|
Zfish   867 KTNT 870

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151 1/6 (17%)
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353 1/2 (50%)
Ig 141..228 CDD:472250 22/88 (25%)
Ig strand B 157..161 CDD:409353 0/3 (0%)
Ig strand C 170..174 CDD:409353 2/3 (67%)
Ig strand E 192..196 CDD:409353 2/3 (67%)
Ig strand F 206..211 CDD:409353 1/4 (25%)
Ig strand G 218..221 CDD:409353 1/2 (50%)
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401 20/95 (21%)
Ig strand A 237..239 CDD:409401 0/1 (0%)
Ig strand A' 244..248 CDD:409401 2/3 (67%)
Ig strand B 251..259 CDD:409401 1/7 (14%)
Ig strand C 264..270 CDD:409401 2/8 (25%)
Ig strand C' 272..274 CDD:409401 0/1 (0%)
Ig strand D 277..281 CDD:409401 0/3 (0%)
Ig strand E 286..291 CDD:409401 0/4 (0%)
Ig strand F 298..305 CDD:409401 3/6 (50%)
Ig strand G 309..318 CDD:409401 3/10 (30%)
FN3 322..411 CDD:238020 21/93 (23%)
FN3 <382..747 CDD:442628 81/392 (21%)
FN3 712..810 CDD:238020 27/128 (21%)
FN3 832..898 CDD:214495 11/90 (12%)
FN3 <867..1269 CDD:442628 11/61 (18%)
fn3 914..998 CDD:394996 4/12 (33%)
R-PTPc-LAR-1 1498..1735 CDD:350401
R-PTP-LAR-2 1784..2021 CDD:350402
ptprmaNP_001018143.1 MAM 27..183 CDD:99706 24/89 (27%)
IG_like 193..275 CDD:214653 17/93 (18%)
Ig strand B 203..207 CDD:409353 0/3 (0%)
Ig strand C 219..233 CDD:409353 2/13 (15%)
Ig strand F 260..265 CDD:409353 2/4 (50%)
FN3 293..377 CDD:238020 17/85 (20%)
FN3 <346..>568 CDD:442628 59/237 (25%)
fn3 502..577 CDD:394996 21/88 (24%)
PTP_DSP_cys 934..>955 CDD:475123
Blue background indicates that the domain is not in the aligned region.

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