DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Pxn

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster


Alignment Length:1298 Identity:259/1298 - (19%)
Similarity:429/1298 - (33%) Gaps:381/1298 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 PPEIIRKPQNQGVRVGGVASFY--CAARGDPPPSIVWRKNGKKVSGTQSRYTV-LEQPGGISILR 96
            ||....:|.:|.|.:.|.....  |||.|.|.|.|.|..||:::  .||..:: |:..|.:.:|:
  Fly   364 PPHFTHQPHDQIVALHGSGHVLLDCAASGWPQPDIQWFVNGRQL--LQSTPSLQLQANGSLILLQ 426

  Fly    97 IEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTC 161
            ...:.||    .|.|.|.|.:| :|.|.|.:.:.|       .|.|...|.::.|::|...::.|
  Fly   427 PNQLSAG----TYRCEARNSLG-SVQATARIELKE-------LPEILTAPQSQTIKLGKAFVLEC 479

  Fly   162 KAIGNPTPNIYWIKNQTKVDMSNPRYSLKDGFLQIEN---------SREEDQGKYECVAENSMGT 217
            .|.|||.|.|.|..|...:..:.|.       ||:||         :|:|..|.|.|.|.|..|.
  Fly   480 DADGNPLPTIDWQLNGVPLPGNTPD-------LQLENENTELVVGAARQEHAGVYRCTAHNENGE 537

  Fly   218 EHSKATNLYVKVRR--VPPTFSRPPETISEVMLGSNLNLSCIAVGSPMP----HVKWMKGSEDLT 276
            ...:||   :||.|  .||..:..|..:..: .|:.:.|.|.|   ..|    .:.|......:.
  Fly   538 TSVEAT---IKVERSQSPPQLAIEPSNLVAI-TGTTIELPCQA---DQPEDGLQISWRHDGRLID 595

  Fly   277 PENEMP-------IGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQ-SLPTAPTD--VQIS 331
            |..::.       .|...::.:.|.:...|.|...:..|:..:.::|.:: ::..||.|  |:|:
  Fly   596 PNVQLAEKYQISGAGSLFVKNVTIPDGGRYECQLKNQFGRASASALVTIRNNVDLAPGDRYVRIA 660

  Fly   332 EVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITM-----YYVVRALSPY------ 385
            ...|.. .::.:.....|:   :...:...|...:.|:..:...     ..:.||...|      
  Fly   661 FAEAAK-EIDLAINNTLDM---LFSNRSDKAPPNYGELLRVFRFPTGEARQLARAAEIYERTLVN 721

  Fly   386 ---------------TEYEF-------YVIAVNNIG-----RGPPSAPATCTTGDFSFGGTKMES 423
                           .||||       ::..|..:.     |..|:    ||...|......::.
  Fly   722 IRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREMPN----CTDMCFHSRYRSIDG 782

  Fly   424 APRNVQVRTLSSS-TMVITWEPPETPNG--QVTGYK--VYYTTNSNQPEASWNSQMVDNSELTTV 483
            ...|:|..|..:| |......||...||  ...|:.  :.|:.::.......::.:|...|:|..
  Fly   783 TCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPSARLVSTSLVATKEITPD 847

  Fly   484 SELT--------------PHAIYTVRVQAY------TSMGAGPMSTPVQVKAQQGVPSQP--SNF 526
            :.:|              .|||.:|..:::      .|....|...|::|.     |:.|  .|.
  Fly   848 ARITHMVMQWGQFLDHDLDHAIPSVSSESWDGIDCKKSCEMAPPCYPIEVP-----PNDPRVRNR 907

  Fly   527 RATDI-------GETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPD 584
            |..|:       |....:|.:....| .|.|.....|             |..|:.|.....:..
  Fly   908 RCIDVVRSSAICGSGMTSLFFDSVQH-REQINQLTSY-------------IDASQVYGYSTAFAQ 958

  Fly   585 TLYYIWLAARSQRG---EGATTP----PIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERS 642
            .|..:    .||.|   .|...|    .:|....|.|...|......|.|..:|..   ..|...
  Fly   959 ELRNL----TSQEGLLRVGVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGD---IRVNEQ 1016

  Fly   643 NGRIIYYKVFFVEVGR---------EDDEATTMTLNMTSIVLDELKRWTEYKIWV---------- 688
            .|.:..:.::..|..|         ...:..|:......||..:::..| :|.|:          
  Fly  1017 VGLLAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHIT-FKQWLPLIIGESGME 1080

  Fly   689 LAGTSVGDGPR--------------------SHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWK 733
            :.|...|..|:                    .:||:.|..|.....||   ...|...:....|:
  Fly  1081 MMGEYQGYNPQLNPSIANEFATAALRFGHTIINPILHRLNETFQPIPQ---GHLLLHKAFFAPWR 1142

  Fly   734 PPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVD-TLEFNVTGLQPDTKYSI--QVAALT 795
            ...|...:.::|              |||..|.|....| .|...:|.....|.:::  .:||:.
  Fly  1143 LAYEGGVDPLMR--------------GFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAIN 1193

  Fly   796 RKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQA 860
            .:...|..      .||....|...:|.:.:         ::|..|   ||:....:|..:|   
  Fly  1194 IQRGRDHG------MPGYNVYRKLCNLTVAQ---------DFEDLA---GEISSAEIRQKMK--- 1237

  Fly   861 LKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQT 925
               |:...|       ||::..:.           ||.::.|      ||...||      .|| 
  Fly  1238 ---ELYGHP-------DNVDVWLG-----------GILEDQV------EGGKVGP------LFQ- 1268

  Fly   926 PDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMT-LRKAVF--------TNLEENTE 981
                |:..: ..|..|:|....|:       :.|:.|...:| :::|.|        .|.::.||
  Fly  1269 ----CLLVE-QFRRLRDGDRLYYE-------NPGVFSPEQLTQIKQANFGRVLCDVGDNFDQVTE 1321

  Fly   982 YIF----------------RVRAYTKQGAG------PFSDKLIVET--------ERDMGRAPMSL 1016
            .:|                .:..|..|..|      ...|..|.:|        :||:|:     
  Fly  1322 NVFILAKHQGGYKKCEDIIGINLYLWQECGRCNSPPAIFDSYIPQTYTKRSNRQKRDLGK----- 1381

  Fly  1017 QAEATSEQTAEIWWEP-----------VTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADL 1070
              |.....|||.:..|           |:...:|:|       :..::|.....|...|.:|.:.
  Fly  1382 --ENDEVATAESYDSPLESLYDVNEERVSGLEELIG-------SFQKELKKLHKKLRKLEDSCNS 1437

  Fly  1071 VNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTL----SWSPPI 1129
            .:.|..||.....||                 .|:.|....|:|.|.....|.    .|||.:
  Fly  1438 ADSEPVAQVVQLAAA-----------------PPQLVSKPKRSHCVDDKGTTRLNNEVWSPDV 1483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 31/96 (32%)
I-set 36..129 CDD:254352 30/95 (32%)
IG_like 146..227 CDD:214653 27/89 (30%)
Ig 159..228 CDD:299845 24/77 (31%)
I-set 234..318 CDD:254352 15/94 (16%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 12/78 (15%)
fn3 324..404 CDD:278470 18/119 (15%)
FN3 423..514 CDD:238020 22/115 (19%)
FN3 520..610 CDD:238020 21/105 (20%)
FN3 616..707 CDD:238020 19/129 (15%)
FN3 712..810 CDD:238020 18/100 (18%)
FN3 832..907 CDD:238020 13/74 (18%)
FN3 914..1005 CDD:238020 23/121 (19%)
FN3 1012..1101 CDD:238020 17/99 (17%)
fn3 1106..1198 CDD:278470 8/28 (29%)
PTPc 1476..1731 CDD:214550
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
PxnNP_523891.2 LRR_RI 51..>161 CDD:238064
leucine-rich repeat 54..77 CDD:275380
LRR_8 55..112 CDD:290566
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..125 CDD:275380
LRR_8 124..184 CDD:290566
leucine-rich repeat 126..149 CDD:275380
LRR_4 148..185 CDD:289563
leucine-rich repeat 150..173 CDD:275380
Ig 240..325 CDD:299845
IG_like 242..325 CDD:214653
I-set 366..450 CDD:254352 28/90 (31%)
Ig 384..451 CDD:143165 24/73 (33%)
I-set 458..546 CDD:254352 29/97 (30%)
Ig 472..536 CDD:299845 22/70 (31%)
I-set 553..644 CDD:254352 15/94 (16%)
Ig 570..643 CDD:299845 11/75 (15%)
An_peroxidase 777..1317 CDD:281139 119/650 (18%)
peroxidasin_like 898..1338 CDD:188658 99/550 (18%)
VWC 1465..1523 CDD:278520 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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