DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Ptp52F

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster

Alignment Length:	1608	Identity:	334/1608 - (20%)
Similarity:	577/1608 - (35%)	Gaps:	458/1608 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 IAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAF 366
            :...|:|.:  |:|.:.|.|      .:..|||..|......:....:..|.:.:...:|.:.:.
  Fly    25 VQGQTVGSL--VAVSESQEL------AEKVEVTVVSTVYTLGFSISNEADYSIDKVICRNGSGSE 81

  Fly   367 SEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVR 431
            :|.:..    :|...|:|.|.|...|...:|:...||.:..|.      :..|:.:.....|...
  Fly    82 TEANAA----HVCENLNPCTFYTSVVSFRSNVSGKPPPSDQTI------YAYTEYKQPKTTVTSV 136

  Fly   432 TLSSSTMVITWEPPE---TPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYT 493
            ..:::|:.:||:..:   ..:..:|.....||.         :.|::::....|...|:....:|
  Fly   137 VATANTIKVTWQTNDRACVESFGITAKATDYTK---------SFQLLNDKSSQTFVNLSACLTHT 192

  Fly   494 VRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSEN-IVHYELYW 557
            :.:....:......:....|..|...|.. .....|::......:.|..|  |.:| |.:|...|
  Fly   193 ITLDTRNNASVVVDTDATDVDTQYAEPGD-LVMNVTNLASGITMITWGDP--SEKNCISNYVFKW 254

  Fly   558 --ND--TYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPR 618
              ||  |..||.....:.::|.       .:.:.|:            ||.|:.
  Fly   255 QRNDCGTDQNQDTTTDVPSTET-------TNEIDYV------------TTTPME----------- 289

  Fly   619 NITAIATSSTTISLSWLPPPVERSNGRI------------IY-YKVFFVEVGREDDEATTMTLNM 670
              |...|.|..:...|..   ..|:|::            :| ::||.       :|.:|...:.
  Fly   290 --TTPDTPSDEVKCEWTD---VSSDGKLREYLLTDLQGCDLYTFQVFI-------NENSTAKASQ 342

  Fly   671 TSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPP 735
            |....::           |........|.::|                       |.:|.:|..|
  Fly   343 TFTSAEK-----------LVSAVYEPSPTAYP-----------------------TQLHWTWFSP 373

  Fly   736 LEKDRNGIIRGYHI--HAQELRDEGKG---FLNEPFK-FDVVDTLEFNVTGLQPD-------TKY 787
              ::....:..|.:  .....|.|.|.   ...|.|. ||.:|.....:..:.|:       |||
  Fly   374 --QNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYLVEIVPNQLNGSAGTKY 436

  Fly   788 SIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGEL--RGY 850
            ..|    :..|:...|   |::.|            ::|.| ..|:|:.|:.|  .|.:|  .||
  Fly   437 QEQ----STVGEDQPS---VIQDP------------VVEAE-AYSMEVSWKTP--EYADLCIDGY 479

  Fly   851 RLR-WGVKDQALKEEMLSGPQM-----------------------TKKRFDNLERGVEYEFRVAG 891
            ||. |...|:.::.|.||....                       ||:..|...|.|..|.:.|.
  Fly   480 RLSGWMEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAI 544

  Fly   892 SNHIGI-------GQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYD 949
            .::..:       |.|.:.:.          ..|.......|.:..:.....|.:.||....||
  Fly   545 VDYTKVKLEMKNAGSEFIDLI----------AFNADYNNSCPTIFALFTCNATTQVRNPYAERY- 598

  Fly   950 VQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLI---VETERDMGR 1011
            |:.|.|  .|.         .|..:.|.....|:.:|..|..  ||| |:.::   :.|......
  Fly   599 VEGHSK--QGF---------NASLSPLSPYATYVCKVILYNV--AGP-SEPVVDADMHTTTYFPE 649

  Fly  1012 APMSLQAEATSEQTAEIWWEPVT-SRGKLLGYKIF-------YTMTA----VEDLDDWQTKTVGL 1064
            .|.|:..|.::..:....|:|.| :.|.:..|:.|       |.:.|    ||  .|.:::|.|
  Fly   650 QPESVMLEKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVE--QDTKSETKG- 711

  Fly  1065 TESADLVNLEKFAQYAVAIAARFKNGLGRLSEKV---TVRIKPEDV---------PLNLRAHDVS 1117
            ..|.:...|....:|.:.:||:...|:|..:|.|   |:....:.|         |:|..|  |.
  Fly   712 DPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLTQGPVNNNA--VY 774

  Fly  1118 THSMTLSWSPPIR------------------LTPVNYKISFDAMKVFVDS---QG---FSQTQIV 1158
            ..::|::|..|.:                  ..||:::     .:|.:|:   ||   :::|::.
  Fly   775 EANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFE-----RRVELDTGNKQGRMSYTETEMQ 834

  Fly  1159 PKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVV 1223
            |:.:..::..||...:.:||         |::|..:            |..|..|.:..|
  Fly   835 PQFDYTVEVSVKNRDVEQLS---------SSVPGSW------------QSPAGLPTIPSD----- 873

  Fly  1224 NGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDD---------LLPGRNKPERP 1279
              |.|..:.....|...|           .|:.:.::|...:|..         ::..:|....|
  Fly   874 --ELIKQMRANVEETSNP-----------TKTAIVRLPADIMTSASGDIKWMALMISQKNCAGVP 925

  Fly  1280 NAPY-IAAKFPQ-------------------------------------------RSIPFTFHLG 1300
            :..| :::.:|:                                           ..|.||..|.
  Fly   926 HLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWHPEPVQRQRRDGEVTSDEEIVFTIGLD 990

  Fly  1301 SGDDYH-NFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNW 1364
            ...:.. .:.|..|..:..|.:.||         |:|:|.:|:...|                |:
  Fly   991 KCSEVQKTYCNGPLLPDTDYNVVVR---------LFTASGYSDAAVL----------------NF 1030

  Fly  1365 PAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADL 1429
            ..:..:.|..      ||..|...::..|::  .|.||.|.||                 :|...
  Fly  1031 KTKAAIKVTL------ILVSVCSCLLLAFVL--GLTVLWVRKR-----------------LAWKR 1070

  Fly  1430 GAGPTPSDPV-DMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIE-PGQQFTW 1492
            .:|....||. ::...||         .|..:|.|.         .:|.::|::.|. ...:.::
  Fly  1071 DSGQGIEDPFGNVIAKNF---------AIFYTEVAK---------PEKLAREFKEITVVALELSY 1117

  Fly  1493 DNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFV 1557
            ..|.|  ...|||||::..||.:||.|..  ...|||||||::.||:.:...|:|||||..|:.:
  Fly  1118 SASEL--GCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVM 1178

  Fly  1558 DFWRMCWELKTATIVMMTRLEERTRIKCDQYWP--TRGTETYGQIFVTITETQELATYSIRTFQL 1620
            |||||..:.....||.:|:..|...|||.:|:|  .||      :.|||...:.|..|......:
  Fly  1179 DFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG------LTVTIKSKEVLELYDRTELTV 1237

  Fly  1621 CRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIV 1685
            ....:..:.::....|..|||||||:.|...:.|:::.:|...|...|::|||||||||||.:|.
  Fly  1238 VHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIG 1302

  Fly  1686 IDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI 1733
            :|.:::|:|.|..|:|:..|..||.||..||||:.||.|::....|.:
  Fly  1303 LDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352	4/15 (27%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	4/14 (29%)
		fn3	324..404	CDD:278470	15/79 (19%)
		FN3	423..514	CDD:238020	11/93 (12%)
		FN3	520..610	CDD:238020	19/94 (20%)
		FN3	616..707	CDD:238020	15/103 (15%)
		FN3	712..810	CDD:238020	21/110 (19%)
		FN3	832..907	CDD:238020	24/107 (22%)
		FN3	914..1005	CDD:238020	20/93 (22%)
		FN3	1012..1101	CDD:238020	26/103 (25%)
		fn3	1106..1198	CDD:278470	22/124 (18%)
		PTPc	1476..1731	CDD:214550	95/257 (37%)
		PTPc	1503..1731	CDD:238006	90/229 (39%)
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	25/103 (24%)
		PTPc	1100..1345	CDD:214550	95/254 (37%)
		PTPc	1125..1348	CDD:238006	90/230 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443573
Domainoid	1	1.000	145	1.000	Domainoid score	I1146
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2866
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940