DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Ptprt

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_038961451.1	Gene:	Ptprt / 362263	RGDID:	1309653	Length:	1504	Species:	Rattus norvegicus

Alignment Length:	1657	Identity:	431/1657 - (26%)
Similarity:	675/1657 - (40%)	Gaps:	450/1657 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   570 ISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSW 634
            :..::.:.:|       ::.:.::|.:...||....:.|.....|.|..|::.:.|.      .|
  Rat    99 LKENDTHCID-------FHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTE------GW 150

  Fly   635 LPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPR 699
            :...:..|.....:|:|.|        |:.::..:...|.:||::        |||...     |
  Rat   151 VKAELAISTFWPHFYQVIF--------ESVSLKGHPGYIAVDEVR--------VLAHPC-----R 194

  Fly   700 SHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNE 764
            ..|..||                |.:..::|......:....|   .:..|.:....:..|....
  Rat   195 KAPHFLR----------------LQNVEVNVGQNATFQCIAGG---KWSQHDKLWLQQWNGRDTA 240

  Fly   765 PFKFDVVDTLEFNVTGLQPDT-KYSIQVAALTRKGDG----DRSAAIVVKTPGGVPVRPTVSL-- 822
            .....||:...|:.|....|| :.|:.......:.||    ...|.::||.| ..|:.|...|
  Rat   241 LMVTRVVNHRRFSATVSVADTSQRSVSKYRCVIRSDGGSGVSNYAELIVKEP-PTPIAPPELLAV 304

  Fly   823 ------------KIMEREPIVSIELEWERPAQTYGELR-----GYRLRWGVKDQALKEEMLSGPQ 870
                        .|:...||:..|:|:.....|:.|..     .|:| |
  Rat   305 GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKL-W---------------- 352

  Fly   871 MTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPD-------- 927
                   :|:..||||.||.             :.:..||..|.|...:|.|.:..|
  Rat   353 -------HLDPDVEYEIRVL-------------LTRPGEGGTGPPGPPLTTRTKCADPVHGPQNV 397

  Fly   928 --------VLCVTWDP----PTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENT 980
                    .|.:.|:|    .||.|...:..:|                     :.||...:...
  Rat   398 EIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY---------------------QYVFNQQQYEA 441

  Fly   981 EYIFRVRA-YTKQGAGPF-----------------SDKLIVETERDM-GRAPM-SLQAEATSEQT 1025
            |.:.:..: ||.:|..||                 |::|:|:||.|: |..|: |:|.....|:.
  Rat   442 EEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKI 506

  Fly  1026 AEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVG-LTESADLVNLEKFAQYAVAIAARFKN 1089
            ...|..|..:.|.:..|:|.|             |.|| |..||||
  Rat   507 YIQWKPPNETNGVITLYEINY-------------KAVGSLDPSADL------------------- 539

  Fly  1090 GLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQ 1154
                .|::..|                                   :|:..:...:||.
  Rat   540 ----SSQRGKV-----------------------------------FKLRNETHHLFVG------ 559

  Fly  1155 TQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDF 1219
                                  |.|.|||:..:.|..:. .:.||....:.|:::||. |.:.|.
  Rat   560 ----------------------LYPGTTYSFTIKASTAK-GFGPPVTTRIATKISAPS-MPEYDA 600

  Fly  1220 YGVVNGEE--ILVILPQASEEYGPISHYYLVVVPE---------DKSNLHKIPDQFLTDDLLPGR 1273
            ...:|..:  |.|:|..|.....|:|.|.|||..|         |......:|..:        |
  Rat   601 DSPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSY--------R 657

  Fly  1274 NKPERPNAPYIAAKFPQRSIPFT--FHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQK---- 1332
            |.....:..|.||:....::|.|  |.:|....|:.:.|..|...|.|.|:.:|:.....:
  Rat   658 NASNLDSLHYFAAELKPSNLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKIN 722

  Fly  1333 --HLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSV-NRNKDEPE--------ILWVVL 1386
              .|.|.:|      :...:..||      .|........|. |.|..|||        :..|:.
  Rat   723 CVRLATKAP------MGSAQVTPG------TPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIA 775

  Fly  1387 PLMVSTFIVSTALIVLCVVKRRRQ-----------------------------PCKTPDQAAVTR 1422
            .|::...|:   |.|:..:||||.                             |..:.|:.....
  Rat   776 GLLMFIIIL---LGVMLTIKRRRNAYSYSYYLSQRKLAKKQKETQSGAQREMGPVASTDKPTTKL 837

  Fly  1423 PLMAADLG-------------------AGPT---------PSDPVDMR--RLNFQTPGMISHPPI 1457
            .....|.|                   :.||         ..|||:|.  |..||       |.|
  Rat   838 STNRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQ-------PAI 895

  Fly  1458 PISEFANHIERLKSNDNQKFSQEYE-----------------SIEPGQQFTWDNSNLEHNKSKNR 1505
            .:::...||.::|......|.:|||                 ::..||..:||.:..:.|::|||
  Rat   896 RVADLLQHITQMKRGQGYGFKEEYEDSYKTTNFGGILEQELQALPEGQTASWDTAKEDENRNKNR 960

  Fly  1506 YANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTAT 1570
            |.|:.:||||||:|..::|...||||||||.|||.:...|:|||||:|||..|||||.|:..:|:
  Rat   961 YGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSAS 1025

  Fly  1571 IVMMTRLEERTR--------------------IKCDQYWPTRGTETYGQIFVTITETQELATYSI 1615
            |||:|.|.|..|                    :||.:|||. .||.||.|.||:.||:.||.|.|
  Rat  1026 IVMVTNLVEVGRHPAEHTVGTATLGRAASPGMVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVI 1089

  Fly  1616 RTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRT 1680
            |||.:.::|:::.||::...||:|||||||.:....|.|:|:.:.|.|||:||::||||||.|||
  Rat  1090 RTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRT 1154

  Fly  1681 GCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPA--- 1742
            ||:|.||:||:..::|.::||:..|..|||||..:||||:||:|:|||||||.:||.|.:|.
  Rat  1155 GCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEF 1219

  Fly  1743 RNLHTHLQKLLITEPGETISGMEVEFKKLSNV--KMDSSKFVTANLPCNKHKNRLVHILPYESSR 1805
            |:|:.::.:|   :|....|.::.||:.|:.|  ::.........||.|..|||.:.:||.:...
  Rat  1220 RSLYYNISRL---DPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCL 1281

  Fly  1806 VYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMG 1870
            .:|..:.| |.|:|:||:.:|.::..:|::..|.|:.:...||||:::::|.:.||||.::..
  Rat  1282 PFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT-- 1343

  Fly  1871 REKCFQYWPHERSVRY---QYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPE-Q 1931
            .:.|.||||.:.|..|   |...|....:.::.....|...:...:|| .|.|:..|:|.||. :
  Rat  1344 AQLCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDG-YRIVQHLQYIGWPAYR 1407

  Fly  1932 GVPKSGEGFIDFIGQVHKTKEQF-GQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQT 1995
            ..|.|....:..:.::.|.:|:: |::|...|||..|.||||.|..:..|.|.:|.:.::|||..
  Rat  1408 DTPPSKRSLLKAVRRLEKWQEEYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHI 1472

  Fly  1996 VRILRSQRPAMVQTEDQYHFCYRAALEYLGSF 2027
            |:.||:.:..||:|.:||.|.|..|||||.||
  Rat  1473 VKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020	5/39 (13%)
		FN3	616..707	CDD:238020	18/90 (20%)
		FN3	712..810	CDD:238020	16/102 (16%)
		FN3	832..907	CDD:238020	14/79 (18%)
		FN3	914..1005	CDD:238020	22/128 (17%)
		FN3	1012..1101	CDD:238020	19/90 (21%)
		fn3	1106..1198	CDD:278470	9/91 (10%)
		PTPc	1476..1731	CDD:214550	134/291 (46%)
		PTPc	1503..1731	CDD:238006	125/247 (51%)
		PTPc	1763..2022	CDD:214550	82/265 (31%)
		PTPc	1791..2022	CDD:238006	75/235 (32%)
Ptprt	XP_038961451.1	MAM	36..193	CDD:214533	21/122 (17%)
		Ig	200..285	CDD:416386	16/103 (16%)
		fn3	298..364	CDD:394996	17/89 (19%)
		FN3	394..484	CDD:238020	18/110 (16%)
		fn3	506..581	CDD:394996	25/174 (14%)
		R-PTPc-T-1	953..1209	CDD:350478	129/256 (50%)
		R-PTPc-T-2	1294..1499	CDD:350482	66/207 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810