DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and IL6ST

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_002175.2 Gene:IL6ST / 3572 HGNCID:6021 Length:918 Species:Homo sapiens


Alignment Length:552 Identity:124/552 - (22%)
Similarity:201/552 - (36%) Gaps:142/552 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 TFSRPPETISEVMLGSNL------NLSCIAVGSPMPHVKWMKGSE-------------------D 274
            ||.:..:.:..:.:.|.|      |||||.........:|..|.|                   |
Human   107 TFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFAD 171

  Fly   275 LTPENEMP----IGRNVLQLINIQ---ESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISE 332
            ...:.:.|    :..:.:..:||:   |:.|  .:...|...|:...|.||:..|.....|..||
Human   172 CKAKRDTPTSCTVDYSTVYFVNIEVWVEAEN--ALGKVTSDHINFD
PVYKVKPNPPHNLSVINSE 234

  Fly   333 VTATSVRLEW---SYKGPEDLQYYVIQYKPKNA---NQAFSEISGIITMYYVVRALSPYTEYEFY 391
            ..::.::|.|   |.|....|:|. |||:.|:|   :|...|.:......:.|:.|.|:|||.|.
Human   235 ELSSILKLTWTNPSIKSVIILKYN-IQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFR 298

  Fly   392 VIAVNNIGRGPPSAPATCTTGDFS--FGGTKMESAPRNV--------QVRTLSSSTMVITWE--P 444
            :..:...|:|..|        |:|  ..|...|..|...        ...|....|:.:.|:  |
Human   299 IRCMKEDGKGYWS--------DWSEEASGIT
YEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLP 355

  Fly   445 PETPNGQVTGYKVYYTTNSNQPEASWNSQMVD---NSELTTVSELTPHAIYTVRVQAYTSMGAGP 506
            |...||::..|:|..|        .|.|.:.:   |:...||:......:.|:.|:....     
Human   356 PFEANGKILDYEVTLT--------RWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVG----- 407

  Fly   507 MSTPVQVKAQQGVPSQPS-NFRAT----DI----GETAVTLQWTKPTHSSENIVHYELYW----- 557
                   |:...|.:.|: :|:||    |:    .:..:.::||.|   .|::..|.|.|     
Human   408 -------KSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP---RESVKKYILEWCVLSD 462

  Fly   558 ----------NDTYANQAHHK-RISNSEAY--TLDGLYPDTLYYIWLAARSQRGEGATTPPIPVR 609
                      .|...::.:.: .::.|:.|  |:..:|.|             |.|:     |..
Human   463 KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYAD-------------GPGS-----PES 509

  Fly   610 TKQY--GAPPRNITAIAT---SSTTISLSWLPPPVERSNGRIIYYKVFF-VEVGREDDEATTMTL 668
            .|.|  .|||.....:.|   ......|.|...||:..||.|..|.:|: ..:|.|  .|..:..
Human   510 IKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNE--TAVNVDS 572

  Fly   669 NMTSIVLDELKRWTEYKIWVLAGTSVG--DGP 698
            :.|...|..|...|.|.:.:.|.|..|  |||
Human   573 SHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGP 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352 21/114 (18%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 19/99 (19%)
fn3 324..404 CDD:278470 25/85 (29%)
FN3 423..514 CDD:238020 18/103 (17%)
FN3 520..610 CDD:238020 21/116 (18%)
FN3 616..707 CDD:238020 26/89 (29%)
FN3 712..810 CDD:238020
FN3 832..907 CDD:238020
FN3 914..1005 CDD:238020
FN3 1012..1101 CDD:238020
fn3 1106..1198 CDD:278470
PTPc 1476..1731 CDD:214550
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
IL6STNP_002175.2 Lep_receptor_Ig 26..112 CDD:283889 2/4 (50%)
FN3 121..215 CDD:304408 18/95 (19%)
FN3 222..321 CDD:238020 30/107 (28%)
WSXWS motif 310..314 2/11 (18%)
FN3 519..599 CDD:214495 21/81 (26%)
Box 1 motif 651..659
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..681
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 722..758
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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