DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lar and Y71G12B.31

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_001293450.1	Gene:	Y71G12B.31 / 3565511	WormBaseID:	WBGene00044348	Length:	423	Species:	Caenorhabditis elegans

Alignment Length:	286	Identity:	94/286 - (32%)
Similarity:	138/286 - (48%)	Gaps:	46/286 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1488 QQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPL 1552
            ::.|........:.:.|||:::..|||:.|:|..      .|||||::..|......::|||||:
Worm   154 RRLTRSTDRATRHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPI 212

  Fly  1553 -------QETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR--GTETYGQIFVTI---- 1604
                   :||..|||||..:...|.|||:.:.:|....||.:|||:.  .||.||::.|.:
Worm   213 DSGECIGKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLVCEL 277

  Fly  1605 --------------TETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFL 1655
                          |.:...:|.|.|..:..||  ....::.|.|:..|.|.|.....|.||:||
Worm   278 EEKTWVHREFDVSPTSSYSSSTKSSRKSRASRQ--QSHMKVSQWQYKEWKDTGGAPRIANFLEFL 340

  Fly  1656 RRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTED 1720
            .:.|.  ...:.|::||||||:||||.:|..|:::.|.:.|.||||:..|...|.||..||.|..
Worm   341 LQVRG--RQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVK 403

  Fly  1721 QYIFIHDAILEAIICGVTEVPARNLH 1746
            ||..|:|.|.|.:         ||.|
Worm   404 QYECIYDIIGEYL---------RNYH 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550	90/269 (33%)
		PTPc	1503..1731	CDD:238006	89/254 (35%)
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
Y71G12B.31	NP_001293450.1	PTPc	170..414	CDD:238006	89/253 (35%)
Y71G12B.31	NP_001293450.1	Y_phosphatase	170..412	CDD:278528	88/251 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910