DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and clr-1

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001022209.1 Gene:clr-1 / 3565419 WormBaseID:WBGene00000548 Length:1444 Species:Caenorhabditis elegans


Alignment Length:1453 Identity:376/1453 - (25%)
Similarity:548/1453 - (37%) Gaps:405/1453 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   740 RNGIIRGYH---------IHAQELRDEGKGFLN---EPFKFDVVDTLEFNVTG------------ 780
            |||:.|..|         |...:..|.|.....   .....||.||::|.|..            
 Worm   224 RNGLARRVHEKYSCWELEIKNAQTSDSGSYMCRVTASASDLDVTDTMQFEVKEHARRTHSYWYKR 288

  Fly   781 ----LQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIV---------- 831
                :.|.:..|::.:     .|.|.|....:|   .:.|.|:      ||:.||          
 Worm   289 PKKVMPPSSSSSLKTS-----DDDDDSTPRQIK---NLTVNPS------ERDAIVTWESEGGEDM 339

  Fly   832 SIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIG 896
            :|:|...|...|.|::            ...::.|:.|...|    :|.....|...|:|:|   
 Worm   340 AIDLRLVRRTDTRGQV------------VFSKDNLTSPVSIK----DLRAATPYTLFVSGNN--- 385

  Fly   897 IGQ---ETVKIFQTPEGTPGGPPSNITIRFQTPD--VLC-VTWDPPTREHRNGIITRYDVQFHKK 955
             ||   |..:.|.|.:..| .||....:|.....  :.| |.|..|...  ||.||:|.|.    
 Worm   386 -GQVPFEFTEHFTTKQKRP-FPPKEEDVRVLNSGSALSCEVEWKSPAEP--NGRITKYFVS---- 442

  Fly   956 IDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEA 1020
                                          ||...::..|..:              |..|.|..
 Worm   443 ------------------------------VRGAMRKSDGSLT--------------PDDLPAAV 463

  Fly  1021 TSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVN---------LEKF 1076
            ..::....|                       |.|:..:|..|: ...|..|         |:..
 Worm   464 EVDKRCANW-----------------------DGDENTSKHNGI-NPIDFANEFYSCKFGPLKPN 504

  Fly  1077 AQYAVAIAARFKNGLGRL------SEKVTVRIKPE--DVPLNLRAHDVSTHSMTLSWSPP----- 1128
            ..|.|.:.|  :|..||.      ...||...:|:  :.|..|.:::.||.|:|.. .||     
 Worm   505 RNYTVTVWA--ENSAGRSLPAVFHKNCVTNYAQPDMVETPQPLLSNNHSTFSLTFP-QPPDDING 566

  Fly  1129 ------IRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKH-YVKTHTINELSPFTTYNVN 1186
                  |.:.|:...:|.|               |:||.|.|:.| :.|..|.|           
 Worm   567 PISCYYIAIVPLPANVSLD---------------ILPKSEEIVMHSFSKVFTNN----------- 605

  Fly  1187 VSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEE---YGPISHYYLV 1248
                                                        :||.::||   :..|:..| |
 Worm   606 --------------------------------------------LLPSSAEEKRFFAYIAESY-V 625

  Fly  1249 VVPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQ-----RSIPFTFHLGSGDDYHNF 1308
            .:||:.:    |.|.....||       :..|..|::....:     |.:.:|..|....|....
 Worm   626 QLPEETT----IGDGVRVSDL-------KACNVQYLSRYSSEDLALRRGLKYTGFLIVRVDKEEE 679

  Fly  1309 TNRKLEREKRYRIFVRAVVD---TPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWP----- 1365
            .|||..|........|.::|   :|.....|:||.|..|          .:.|...|.:.     
 Worm   680 LNRKDVRNGADPNIFRNLIDKSVSPTSRTRTASPMSRHL----------RQLHLSGPAYGYSAYF 734

  Fly  1366 ----AEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMA 1426
                .:.|.|   :......:.::||.::  |:.....:.:..|.|:.....|      ..||..
 Worm   735 KPILLDTESS---SSGFGIFMKIILPFLL--FLAFATGVTMFFVNRKGHMLST------WCPLFT 788

  Fly  1427 ADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFT 1491
            .     .|..|.|: |.|..||.|.|....:|......|     .:.:..|:|||||: |..|..
 Worm   789 K-----MTSKDVVE-RTLLKQTFGAIPVDDLPTEYVVRH-----RDTDFLFAQEYESL-PHFQLD 841

  Fly  1492 WDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETF 1556
            ...||.:.|..||||.::.|:|.:||:|..:.|...|||||||:...:::...::|.|.|:..|.
 Worm   842 TVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEKKLFIAAQAPVDATI 906

  Fly  1557 VDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLC 1621
            .|||||.||.::..|||:..|.|:.|.:|.:|||......||.|.|........:.|:||.|.:.
 Worm   907 GDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIA 971

  Fly  1622 RQG-------------------------FNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAL 1661
            ..|                         .|:.|.|.|..||.|.|:..|:.....|:|:.|.|.|
 Worm   972 HIGECGPDVIPNGNGVEYANVPIVKGQFANNSRRILQYHFTNWNDYKAPECSTGLLRFMYRLREL 1036

  Fly  1662 TPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIH 1726
            ....:.||::||||||||||.:|.|||||::...|...:|:..|..||.|||.|||:.:||:||:
 Worm  1037 PQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKANIFEFVCNLRRQRNLMVQSLEQYVFIY 1101

  Fly  1727 DAILEAIICGVTEVPARNLHTHLQKL---------------------------------LITEPG 1758
            .|:.|..:.|.|:...|:...|.|:|                                 :.|..|
 Worm  1102 KALAEWHMYGDTDEDVRDFEDHYQRLCASNRDRAVSFNQQSSTNGSISPRVAIVSSRESMTTSNG 1166

  Fly  1759 ETISGMEVEFKKLS-NVKMD-SSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVN 1821
            ||  |:|.|||||. |:... ||.|...:.  |..|||....:|::..||.|.|..|...|.|:|
 Worm  1167 ET--GLEEEFKKLERNLTTPLSSNFAAKDE--NLLKNRYEAAVPFDKYRVILPPTIGHADSSYIN 1227

  Fly  1822 ASFIDGYRYRSAYIAAQGPVQD-AAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWP------ 1879
            ||.|.||.:  .|||||.||.: .|.|||||:.:.|.|.||||:  .|.......:|||      
 Worm  1228 ASHIKGYFF--DYIAAQDPVSEGTAFDFWRMIADQNVTTVVMLS--DETDWSDVEKYWPIDGSGT 1288

  Fly  1880 --HERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSS----RTVRQFQFIDWPEQG-VPKSG 1937
              |..|.|....|. .::|.:...:.:|....: .:|..|    :.|.|:.:..||... ||||.
 Worm  1289 ECHFGSERNSVNVT-CVSEEHHQDFIIRNLSYS-MKDNESMPANQEVVQYSYTGWPSDSIVPKSA 1351

  Fly  1938 EGFIDFIGQV-HKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRS 2001
            ...::.|..| .:.....|...||.|||..|...||:||.:|::..|.:.|..:||||||:.|:|
 Worm  1352 NSLMNLIEMVLQRQSSLMGSQAPIVVHCRNGSSESGIFICISLLWLRQKAEQRIDVFQTVKGLQS 1416

  Fly  2002 QRPAMVQTEDQYHFCYRAALEYL 2024
            .||.|....:||.|||||..:|:
 Worm  1417 HRPMMFTRFEQYSFCYRALADYI 1439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020
FN3 520..610 CDD:238020
FN3 616..707 CDD:238020
FN3 712..810 CDD:238020 19/97 (20%)
FN3 832..907 CDD:238020 17/77 (22%)
FN3 914..1005 CDD:238020 16/93 (17%)
FN3 1012..1101 CDD:238020 19/103 (18%)
fn3 1106..1198 CDD:278470 21/103 (20%)
PTPc 1476..1731 CDD:214550 106/279 (38%)
PTPc 1503..1731 CDD:238006 95/252 (38%)
PTPc 1763..2022 CDD:214550 102/275 (37%)
PTPc 1791..2022 CDD:238006 90/245 (37%)
clr-1NP_001022209.1 IG_like 175..258 CDD:214653 8/33 (24%)
FN3 403..523 CDD:238020 34/196 (17%)
PTPc 827..1106 CDD:214550 106/279 (38%)
PTPc 853..1106 CDD:238006 95/252 (38%)
PTPc 1169..1437 CDD:214550 102/275 (37%)
PTPc 1198..1437 CDD:238006 90/244 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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