Protein Alignment Lar and Ptp36E

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_609872.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Alignment Length: 649
• Identity: 195/649 - (30%)
• Similarity: 306/649 - (47%)
• Gaps: 102/649 - (15%)

  Fly  1435 PSDPVDMR----------------RLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYES 1483
            |:.|:|:|                :|.|||...:.      |....|  .||.|
  Fly    79 PNGPIDIRHFLKLCDLRRKFPVLYKLEFQTAAKVE------SNTCRH--ALKKN----------- 124

  Fly  1484 IEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVAT 1548
                        |||    ||:......||::||.|..|.|:..|||:||:|.|...|.|||:.|
  Fly   125 ------------NLE----KNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVT 173

  Fly  1549 QGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGT--ETYGQIFVTITETQELA 1611
            |||::||...:|||.|:...:.|||:|:..:..::.|.||||....  |.||.||:.|...::||
  Fly   174 QGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLA 238

  Fly  1612 TYSIRTFQLC----RQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALT-------PPE 1665
            .:.||||:|.    :|...|.|.|.|..:|.|..|..|...| .|:|.||.|.:.       ...
  Fly   239 NFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFSNA-LLEFRRRVRLVVGNIIKDEDDM 302

  Fly  1666 SGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAIL 1730
            .||::||||.|.||:|.|:.||:.||..:.|:..:::|::..||..|..:|:..:||.||:|.:.
  Fly   303 RGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLE 367

  Fly  1731 EAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPC------- 1788
            |.||||.|..|...|...|:.......|..::..:.|:.::..   .:.:|...:  |
  Fly   368 EHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICK---QTPRFTIGD--CAGGHRAD 427

  Fly  1789 NKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLW 1853
            |:.|||.|..:|.::.|.|||...|...:||:|:.|:|||.....||..:.|::....:||.:::
  Fly   428 NREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVY 492

  Fly  1854 EHNSTIVVMLTKLKEMGREKCFQYWPHERSVR-----YQYYVVDPIAEYNMPQYKLREFKV---- 1909
            :...:.||:|.:.....::.. .:||::..:.     :..:.|...:..|:.|:   |||:
  Fly   493 DQECSAVVVLCQPPSQSQQYP-SFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQW---EFKINKKI 553

  Fly  1910 ---TDARDG---SSRTVRQFQFIDWP-EQGVPKSGEGFIDFIGQVH--KTKEQFGQDGPITVHCS 1965
               |:...|   .:|||:.||...|| ...||.|....:..:..|.  :.|..:   ||:.|...
  Fly   554 VSLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVDY---GPVCVVSP 615

  Fly  1966 AGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDN 2029
            .|..|:||:...:..:|::...|.:||||.|:.:|..||.:|:...:|.:||...|.|:..|.|
  Fly   616 DGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFLN 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	96/249 (39%)
		R-PTP-LAR-2	1784..2021	CDD:350402	70/261 (27%)
Ptp36E	NP_609872.1	Y_phosphatase	125..368	CDD:459674	96/247 (39%)
		Y_phosphatase	428..671	CDD:459674	69/249 (28%)