DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and ptprub

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_009290693.2 Gene:ptprub / 335096 ZFINID:ZDB-GENE-030131-7036 Length:1450 Species:Danio rerio


Alignment Length:1659 Identity:436/1659 - (26%)
Similarity:702/1659 - (42%) Gaps:375/1659 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   458 YYTTNSNQPEASWNSQMVDNSELTTVSELTPHAI---YTV---------RVQAYTSMGAGPMSTP 510
            |...||:|..|...:|::    |.|:||...|.:   |.:         .::.|..:..||:..|
Zfish    69 YMMVNSSQHAAGQRAQLL----LQTLSENDTHCVQFSYFLYSRDGHSPGALRVYVRVNGGPLGIP 129

  Fly   511 V-QVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSE 574
            | .|...:|        |.....|.||:..|..         .|::....|...:.:   |:..:
Zfish   130 VWNVSGSRG--------RQWHQVELAVSTFWPN---------EYQILLEATVDRKGY---IAVDD 174

  Fly   575 AYTLDGLYPDTLYYIWLAARSQR--------GEGATTPPIPVRTKQYGAPPRNITAIATSSTTIS 631
            ...|:  ||     .:.|....|        |:.||                 ...:|....:.:
Zfish   175 ILLLN--YP-----CYKAPHFSRLGDVEVNAGQNAT-----------------FQCVAAGRPSEA 215

  Fly   632 LSWLPPPVERSNGRI--------IYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWV 688
            ..:|   :||.||.:        :....|.|....||.:.....|               |:  .
Zfish   216 EKFL---LERHNGEVSSGGSVKHLGRNRFAVSFQLEDVQKPEQDL---------------YR--C 260

  Fly   689 LAGTSVGDGPRSH-PIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQ 752
            :..:|.|.|..:. .:|::........||.::|   .||.:.:      :.:.|.|:....|..:
Zfish   261 VTQSSRGSGVSNFAELIVKVPPSPIAPPQLLRA---GSTYLII------QLNTNSILGDGPIIRR 316

  Fly   753 ELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDR---SAAIVVKTPGGV 814
            |:  |.:..|....:...|:.:.:.:..|.|||:|.|.| .|||.|:|..   ...::.:|....
Zfish   317 EI--EYRASLAPWSEILGVNMVTYKLWHLDPDTEYHISV-LLTRPGEGGTGPPGPPLISRTKCAE 378

  Fly   815 PVRPTVSLK---IMEREPIVSIELEWERPA------QTYGELRGYRLR----WGVKDQALKEEML 866
            |:|....|:   |..|:    :.|:||.||      .||.....||..    .|..:..::|.:.
Zfish   379 PMRALRGLRASEIQSRQ----LTLQWEVPAFNLTRCHTYSVSLCYRYTTAGGGGGHNTTVRECLA 439

  Fly   867 SGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGG-PPSNITIRFQTP--DV 928
            .....::....:|......:.|:|.:|..|..:....:|||.|..||| .|.::|.   ||  |:
Zfish   440 VEHNTSRFTLRDLPPFHTIQIRLALANTEGKKEGKEVMFQTEEDIPGGIAPESLTF---TPLEDM 501

  Fly   929 LCVTWDPPTREHRNGIITRYDVQFH--KKIDHGL---GSERNMTLRK----AVFTNLEENTEYIF 984
            :.:.|:.|...  ||:||:|::.:.  :..|.|:   |..|.::..|    .:|:||...|.|:.
Zfish   502 IFLKWEEPVEP--NGLITQYEISYQSIESSDPGINVPGPRRTVSKLKNETYHMFSNLHPGTTYLI 564

  Fly   985 RVRAYTKQGAGPFSDKLIVETER-------DMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGY 1042
            .|||.|.:|   |....:.|...       |.|..|..|   :.:|.|..:...|...||..:. 
Zfish   565 SVRARTAKG---FGQTALTEITTNISAPTFDYGDMPSPL---SETENTITVLLRPAQGRGAPVS- 622

  Fly  1043 KIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKP--- 1104
              .|.:...|:......:.:|:.:...:......||...|            ....|..:.|   
Zfish   623 --TYQVVVEEEAGRKVKRELGIQDCFPIPTSHGEAQARGA------------PHYYTAELPPSSL 673

  Fly  1105 -EDVPLNLRAHDVSTHSMTLSWSPPIRLTP-VNYKISFDAMKVFVDSQGFSQTQIVPKREIILKH 1167
             |..|..:.    ..|:....|:.|  |.| .||.:.|.||..|   :|.::...:   .|..|.
Zfish   674 SEATPFTVG----DNHTYNGYWNSP--LDPRKNYLVYFQAMSNF---RGETRINCI---RIARKA 726

  Fly  1168 YVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEI---- 1228
            ..|.|                           .:....||.:....::    .||..|..:    
Zfish   727 ACKDH---------------------------QRALEVTQRSEEMGLI----LGVCAGGLVVLIL 760

  Fly  1229 ----LVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFP 1289
                ::|:.:...:|...|:|     |....|::|.|..:          :.|:.|.        
Zfish   761 LLGAIIIIIKKGRDYYSYSYY-----PRKPGNMNKTPITY----------RQEKSNM-------- 802

  Fly  1290 QRSIPFTFHLGSGDDYHNFTNRK-LEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPP 1353
                     :||.:  .:||::. |:.::|..:   :.:||     :|.|..|            
Zfish   803 ---------MGSME--RSFTDQSTLQEDERMAL---SFMDT-----HTCSTRS------------ 836

  Fly  1354 GERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQA 1418
                         :|..|:|.                     |::|:                  
Zfish   837 -------------DPRSSMNE---------------------SSSLL------------------ 849

  Fly  1419 AVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYES 1483
                         |.:|......:...:.| |.: ||.:.:::...||.::|:.:...|.|||||
Zfish   850 -------------GGSPRRQCGRKGSPYHT-GQL-HPAVRVADLLQHINQMKTAEGYGFKQEYES 899

  Fly  1484 IEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCD------GYRKH 1542
            ...|    || .|.:.:|:|.|:..:..||..||:|..:.|...||||||||.|      ||.:.
Zfish   900 FFDG----WD-INKKKDKTKGRHDTLMGYDRHRVKLHPLLGDPNSDYINANYIDIRINREGYHRS 959

  Fly  1543 NAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITET 1607
            |.::|||||.|||..|||||.|:....:|||:|:|.|..|:||.:|||.. :|.||.|.:|:.:|
Zfish   960 NHFIATQGPKQETVYDFWRMVWQENCFSIVMITKLVEVGRVKCCKYWPDE-SEMYGDIKITLLKT 1023

  Fly  1608 QELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVH 1672
            :.||.|::|||.|.|:|::.:.|:.|..||:||:||||.|....|.|:||.:..||.::|||:||
Zfish  1024 ETLAEYTVRTFALERRGYSAKHEVCQFHFTSWPEHGVPYHATGLLAFIRRVKTSTPLDAGPVVVH 1088

  Fly  1673 CSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGV 1737
            ||.|.||||||||:|.||:..:.|.::|||..|..|.::|..|:|||:||||||||||||.:||.
Zfish  1089 CSVGAGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRINMIQTEEQYIFIHDAILEACLCGE 1153

  Fly  1738 TEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNV--KMDSSKFVTANLPCNKHKNRLVHILP 1800
            |.:|........:::|..:.....|.:..||:.|::|  .:|..:...|.||.|:.|||.:.:||
Zfish  1154 TAIPVNEFALAYKEMLRVDSQSNSSQLREEFQTLNSVTPHLDVEECSIALLPRNREKNRSMDVLP 1218

  Fly  1801 YESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTK 1865
            .:.:..:|....| |.::|:||:.:|.:...:|:|....|:.....||||:::::..|.||||.:
Zfish  1219 PDRALAFLVTTEG-ESNNYINAALMDSFHRPAAFIVTPHPLPGTTSDFWRLVFDYGCTSVVMLNQ 1282

  Fly  1866 LKEMGRE-KCFQYWPHERSVRY---QYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFI 1926
            |.:.... .|.||||.....:|   |...:...|:.::.....|...||..::| ...|.||||:
Zfish  1283 LNQSNSAWPCVQYWPEPGLQQYGPMQVEFLSMSADEDIITRLFRVKNVTRLQEG-QLVVCQFQFL 1346

  Fly  1927 DWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVL 1990
            .|.. :.||.|.:.|::.:..|.|.:.:.| :|...|||..|.||||.:...:|::|.:||:.::
Zfish  1347 RWSAYRDVPDSKKAFLNLLASVQKWQRECG-EGRTVVHCLNGGGRSGTYCASNILMEMIQYQNIV 1410

  Fly  1991 DVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL 2024
            |||..|:.||:.:|.||:|.:||.|||...||||
Zfish  1411 DVFYAVKTLRNAKPNMVETLEQYRFCYELVLEYL 1444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628 58/318 (18%)
FN3 712..810 CDD:238020 24/100 (24%)
FN3 832..898 CDD:214495 16/75 (21%)
FN3 <867..1269 CDD:442628 89/433 (21%)
fn3 914..998 CDD:394996 28/95 (29%)
R-PTPc-LAR-1 1498..1735 CDD:350401 121/242 (50%)
R-PTP-LAR-2 1784..2021 CDD:350402 82/241 (34%)
ptprubXP_009290693.2 None
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.