Protein Alignment Lar and IA-2

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Alignment Length: 1068
• Identity: 229/1068 - (21%)
• Similarity: 371/1068 - (34%)
• Gaps: 328/1068 - (30%)

  Fly  1176 ELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYG 1240
            :|.|    |:..:..|:...:..|.......:...|:|..:.|:|               .:..|
  Fly   260 QLPP----NLCANLAPTPPEFGDPASALAYVRFTPPEPEAELDYY---------------EQPAG 305

  Fly  1241 PISHY----------------YLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFP 1289
            |...|                ||..:.:|:..|...|.:......:.|..:..:.:||.|.
  Fly   306 PAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAPSIM---- 366

  Fly  1290 QRSIPFTFHLGSGDDYHNFTNRKLEREK----------------RYRIFVRAVVDTPQKHLYTSS 1338
                         |.:.:...:::|||:                |..::.......|....|...
  Fly   367 -------------DAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRK 418

  Fly  1339 PFSEFLSLDMREA-----------------------PPGE-----RPHRPDPNWP---------- 1365
            |.::..::|..||                       ||.|     ..:.||...|
  Fly   419 PAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRG 483

  Fly  1366 --------AEPEVSVNRNKDEPEILWVVLPLM---VSTFIVSTALIVLCVVKRRRQPCK--TPDQ 1417
                    .:|:.|..|.....:.|....||.   |.|.:.:|..:    ||||....|  .|..
  Fly   484 GLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDATPEL----VKRRPASFKQLDPYD 544

  Fly  1418 AAVTRPLMAADLGA---------------------------------------------GPTPSD 1437
            .::.:..||.:.|.                                             |....:
  Fly   545 VSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADE 609

  Fly  1438 PVDMR--------------RLNFQTPGMISHPP-IPISEFANHIERLKSNDNQKFSQEYESIEPG 1487
            |.:::              ||:.:.||.:..|| :..:|.:|.:|..|:: .||.....|.:.
  Fly   610 PENVKQSLLANMLGFARHERLDVKKPGPLLGPPSLGSAELSNQLETEKAH-KQKGHGNKEVLP-- 671

  Fly  1488 QQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPL 1552
            .....::.:..|.|.|......:|.||:       ...|.::|:             :|..:.|
  Fly   672 AHIKGNDEDDAHKKKKVMKQQHSAEDHA-------PHTVDTEYV-------------HVFVKNP- 715

  Fly  1553 QETFVDFW----RMCWELKTATIVM-----MTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQ 1608
                :|.|    |:..||:....:.     :|..:.....:.:...|.|  :|.|.:..||.|.:
  Fly   716 ----IDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPER--KTAGDVARTINENR 774

  Fly  1609 ELATYSIRT--FQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIV 1671
            .:.....|.  |.:...|..|  .||.||     |..|..            ..:...|.||.:.
  Fly   775 GVKNNIQRRVGFYVLHAGVGD--VIKDLQ-----DPSVSS------------SRIELAEQGPDVT 820

  Fly  1672 HCS----AGVGRTGCYIVIDSMLERMKHEKIID--------IYGHVTCLRAQRNYMVQTEDQYIF 1724
            |..    ||.|.....::..:::...:|::..|        |.|..||          ::|
  Fly   821 HIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETC----------SKD---- 871

  Fly  1725 IHDAILEAIICG-------------------------VTEV--------PARNLHTH-------L 1749
             :..:..|.:.|                         :|.:        |:....|.       |
  Fly   872 -YQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPAL 935

  Fly  1750 QKLLITEPGETISGME----------VEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESS 1804
            ..:.|:.....:|.||          .|::.|...:.:.|....|:.|.....||....|||:.|
  Fly   936 TNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHS 1000

  Fly  1805 RVYLTPIHGIEGSDYVNASFIDGYRYRS-AYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKE 1868
            ||.|..:...||.||||||.|..:..|: ||:|||||:......||:|:||..:.::|.|.:|:|
  Fly  1001 RVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQE 1065

  Fly  1869 MGREKCFQYWPHERSVRYQYYVVDPIAEYN-MPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQG 1932
            .|...|.:|||.|.:..|..|.|..::|:. ...|.:|.|.:.:.|...:|||.||.|:.||..|
  Fly  1066 NGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMG 1130

  Fly  1933 VPKSGEGFIDFIGQVHKTKEQFGQDG-PITVHCSAGVGRSGVFITLSIVLERMQYEGV--LDVFQ 1994
            ||...:..:||..:|:|:..  |:.. ||.||.|||.||:||:|.|.:|||||. :|.  :|:..
  Fly  1131 VPAQAKALLDFRRKVNKSYR--GRRSCPIVVHGSAGAGRTGVYILLDLVLERMN-KGAREIDIAA 1192

  Fly  1995 TVRILRSQRPAMVQTEDQYHFCYRAALE 2022
            |:..||.||..:|.|..|:.|...|..|
  Fly  1193 TLEHLRDQRAGVVATRQQFEFVLMAVAE 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628	17/108 (16%)
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	48/259 (19%)
		R-PTP-LAR-2	1784..2021	CDD:350402	97/241 (40%)
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	19/109 (17%)
		PTP_DSP_cys	942..1225	CDD:475123	104/282 (37%)