Protein Alignment Lar and ptprn2

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_001122139.2
• Gene: ptprn2 / 325033
• ZFINID: ZDB-GENE-030131-3758
• Length: 1027
• Species: Danio rerio
• Alignment Length: 1099
• Identity: 238/1099 - (21%)
• Similarity: 392/1099 - (35%)
• Gaps: 306/1099 - (27%)

  Fly   696 DGPRSHPIILR-TQEDVP---GDPQDVKATPLNSTSIHVSWKPPLEKDRNGI----IRGYHIHAQ 752
            :|.|:|.:.:: ....:|   |.| |::.|.....|...|:. ..|:||:|:    ::.|.....
Zfish   165 NGLRNHKVFIQPPSAQIPFLQGRP-DLQTTVAQLPSGRSSFS-GFEQDRSGVPLAELQQYQAGPM 227

  Fly   753 ELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGG--VP 815
            ..:|.|||......::                  :|:|....|:          :.|.||.  .|
Zfish   228 RAQDPGKGQTQGKLRY------------------FSLQRTPATK----------IEKLPGASRQP 264

  Fly   816 VRPTVSLKIME--------REPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMT 872
            .:|.:...:::        :|.:.:::.::..               ||.:| |..:.::...:|
Zfish   265 PKPQIEKLLLKSSASSPAHKEALSTVDEKFID---------------GVVNQ-LGRQSVNVDTLT 313

  Fly   873 KKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPG-----GPPSNITIRFQTPDVLCVT 932
            .|..|.|.:.:....||..      |:|.||   ..:.|.|     ..||....:.:..:
Zfish   314 PKDLDKLSKVITQALRVVD------GEEKVK---GRDATQGEIEVKREPSQELHQMEKAE----- 364

  Fly   933 WDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPF 997
             |.||.:     :|:.:...||..|    .::....:...|.:....||           .|.|.
Zfish   365 -DGPTHK-----VTQTEETAHKSED----KDKGFISQLLEFLDRNSGTE-----------SAHPP 408

  Fly   998 SDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTV 1062
            .:..:....:....:|:....|....:|.:       ....|:..|:......||.:|....:.:
Zfish   409 QESFLGYINQPNAGSPLRASLENVQSRTTQ-------REVDLMKKKMEPDTLDVEPVDAEVEQWM 466

  Fly  1063 GLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSP 1127
            ..:|.:..|..|         |...|....:..:|..|..|...|.:|:..:. |.|.
Zfish   467 HSSEGSPQVKAE---------AQTDKEPQKQSMDKEEVEKKGVRVEVNIATYS-SPHD------- 514

  Fly  1128 PIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPS 1192
                ....|.|:.|::..   .||.:..:|:.:|  :..|......::.|.|..|:.:
Zfish   515 ----GDFGYIITEDSLST---DQGLNLMEILAER--VRLHVTDFLQLSVLGPAVTFRL------- 563

  Fly  1193 DYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLV----VVPED 1253
                ||..:...|.|:|    .|..:..|.:..|..|.||.....:.|.::|..||    |.|.:
Zfish   564 ----RPNARNISTAQLA----RVAVEQKGQLEKESGLRILEAGLSDRGKLNHIPLVKQSQVEPGN 620

  Fly  1254 KSNLHKIPDQFLTDDLLPG--------RNKPERPNAPYIAAKFPQRSIPFTFHLGSGDD------ 1304
            ...|..:...|:.  |:.|        |::........:|              |.|:|
Zfish   621 FLILVVVSMVFIV--LVLGMSGALYCLRHRSHHKLKEKLA--------------GLGNDTGHDAT 669

  Fly  1305 --YHNFTNRKL-----EREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDP 1362
              |.:...:::     ||.:|..:|      .|......:|..|:|....|:.  |..|  ....
Zfish   670 AAYQDLCRQRMAVQTSERGERSEVF------HPSHTSRINSVSSQFSDGPMQS--PSAR--SSTS 724

  Fly  1363 NWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAA 1427
            :|..||.   ..|.|                 :||..::|
Zfish   725 SWSEEPS---QTNMD-----------------ISTGHMIL------------------------- 744

  Fly  1428 DLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESI-----EP- 1486
                                            |...:|::     :..:..:|:|::     ||
Zfish   745 --------------------------------SYMEDHLQ-----NKDRLDKEWEALCSYQAEPA 772

  Fly  1487 ----GQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINAN-YCDGYRKHNAYV 1546
                ||:        |.|..:||...|..|||||..|........||||||: ..|...::.||:
Zfish   773 VCAVGQE--------EQNVQRNRPHGVLVYDHSRFILKLENNQSRSDYINASPIMDHDPRNPAYI 829

  Fly  1547 ATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVT-ITETQEL 1610
            :.||||..|..|||:|.||.....|||:|.|.|....:|.||||..|::.|....|. ::|....
Zfish   830 SAQGPLPSTVADFWQMVWESGCVVIVMLTPLAENGLKQCHQYWPDEGSDLYHIYEVNLVSEHIWC 894

  Fly  1611 ATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSA 1675
            ..:.:|:|.|.....|:.|.:.|..|.:|.|..||:.....|.|.|:........|.|:|||||.
Zfish   895 DDFLVRSFYLKNVQTNETRTVTQFHFLSWMDQNVPESARTLLDFRRKVNKCYRGRSCPIIVHCSD 959

  Fly  1676 GVGRTGCYIVIDSMLERM-KHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI 1733
            |.||:|.||:||.:|.:| |..|.|||...:..||.||:.||||:||:.|...|:.|.:
Zfish   960 GAGRSGTYILIDMVLNKMAKGAKEIDIAATLEHLRDQRSGMVQTKDQFEFALTAVAEEV 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628	14/58 (24%)
		FN3	712..810	CDD:238020	19/104 (18%)
		FN3	832..898	CDD:214495	10/65 (15%)
		FN3	<867..1269	CDD:442628	76/410 (19%)
		fn3	914..998	CDD:394996	14/83 (17%)
		R-PTPc-LAR-1	1498..1735	CDD:350401	95/239 (40%)
		R-PTP-LAR-2	1784..2021	CDD:350402
ptprn2	NP_001122139.2	None