DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and Ptp10D

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster


Alignment Length:1971 Identity:436/1971 - (22%)
Similarity:715/1971 - (36%) Gaps:587/1971 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   329 QISEVTATSVRLE-----------WSY-----------------------KGPEDLQYYVIQYKP 359
            |:|:.| |.:||:           ||.                       .|.:|...|.:.|.|
  Fly     4 QLSKAT-TRIRLKRQKAVPQHRWLWSLAFLAAFTLKDVRCADLAISIPNNPGLDDGASYRLDYSP 67

  Fly   360 ------KNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGG 418
                  .|...|..||...|..   .||| |.|:|.|::...|.......:...|.||.      
  Fly    68 PFGYPEPNTTIASREIGDEIQF---SRAL-PGTKYNFWLYYTNFTHHDWLTWTVTITTA------ 122

  Fly   419 TKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNS--QMVDNSELT 481
               ...|.|:.|:..|....:|.|.||  ..|..|.:|: .....::..:|:|.  |:.||:...
  Fly   123 ---PDPPSNLSVQVRSGKNAIILWSPP--TQGSYTAFKI-KVLGLSEASSSYNRTFQVNDNTFQH 181

  Fly   482 TVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKP--- 543
            :|.||||.|.|  :||||| :..|..|.....:.....|:.|..|......||.:.:.|..|   
  Fly   182 SVKELTPGATY--QVQAYT-IYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPA 243

  Fly   544 ---TH---------SSENIVHYELYWNDTYANQAHHKRISNSEAYTL-------DGL-YPDTLYY 588
               ||         :::::::.|.........||..|.:....||.:       |.: .|.|..|
  Fly   244 GIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQY 308

  Fly   589 ------------------------IWLA--------------ARSQR------------------ 597
                                    :|.|              |.::|                  
  Fly   309 RTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDFRD 373

  Fly   598 ----------------GEGATTP--------PIPVRTKQYGAPPRNITAIATSST-TISLSWLPP 637
                            |:..:.|        |:||         ||:.:|....| |:.::|...
  Fly   374 IAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPV---------RNLRSINDDKTNTMIITWEAD 429

  Fly   638 PVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLA--------GTSV 694
            |....:    .|::.:.|:...:.:.:|:|.:.|...|:.|.....|.:.|.|        .||:
  Fly   430 PASTQD----EYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSI 490

  Fly   695 GDGPR-SHPII------------------------------------LRTQED------------ 710
            ....| |.|||                                    ||||:.            
  Fly   491 FVVTRPSSPIIEDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQP 555

  Fly   711 --------------------------VPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHI 749
                                      .|..|:::....:.|.|:.|.|.||    .:|....|.|
  Fly   556 GAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPP----ESGEFTEYSI 616

  Fly   750 HAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGV 814
            ..:  .|..:.::..|    .|.:.|.::|.:....||:|||          .:.:..|::|  |
  Fly   617 RYR--TDSEQQWVRLP----SVRSTEADITDMTKGEKYTIQV----------NTVSFGVESP--V 663

  Fly   815 P------VRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTK 873
            |      |.|.....|::.....:|.|||.:|.   |.:..|.|:|...|.       .|...||
  Fly   664 PQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPE---GRVESYILKWWPSDN-------PGRVQTK 718

  Fly   874 KRFDN---------------LERGVEYEFRVAGSNH------IGIGQETVKIFQTPEGTPGGPPS 917
            ...:|               |..||:|:|.:..:::      ..:...|:.:.|:......|...
  Fly   719 NVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKE 783

  Fly   918 NITIRFQTPDVLCVTWDPPTREHRNGIITRY---DVQFHKKIDHGLGSER--NMTLRKAVFTNLE 977
            :      ..|.:.:::.|..:......|.|:   |.:...|       |:  |.|.||..||.|.
  Fly   784 D------ERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDK-------EKLANDTDRKVTFTGLV 835

  Fly   978 ENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEI---WWEPVTSRGKL 1039
            ...  ::.:..:|..| |..|  |.::.:..:...|:: |..||:....||   |..|   :|:.
  Fly   836 PGR--LYNITVWTVSG-GVAS--LPIQRQDRLYPEPIT-QLHATNITDTEISLRWDLP---KGEY 891

  Fly  1040 LGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAAR--FKNGLGRLSEKVTVRI 1102
            ..:.|.| :||    |:...:.:.......:.:|.....|...:..|  .::.:.|.|..::...
  Fly   892 NDFDIAY-LTA----DNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASF 951

  Fly  1103 KP-EDVPLNL-RAH--DVSTHSMTLSWSPP------------IRLTPVNYKISFDAMKVFVDSQG 1151
            .. |.||..: |.|  ||....:...||.|            |..|.:| .::...|:.|...:.
  Fly   952 TTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNIN-NLTDAGMQDFESEEA 1015

  Fly  1152 FSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSA-----IPSDYSYRPPTKITVTTQMAAP 1211
            |.                   .|..|.|..||...:.|     ...:..||....|     :|.|
  Fly  1016 FG-------------------VIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPI-----LAPP 1056

  Fly  1212 QP---MVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGR 1273
            :|   :|..:.|...:..:|.......|::.|.:..|.::|..:|..|...:             
  Fly  1057 RPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGL------------- 1108

  Fly  1274 NKPERPN----------APYIAA----KFPQRSIPFTFHLGSGD-DYH--NFTNRKLEREKRYRI 1321
               |.|:          .||.|.    .|..||:. .|.:|:.: |.|  .:.|..|:....||:
  Fly  1109 ---EMPSWLDVQSYSVWLPYQAIDPYYPFENRSVE-DFTIGTENCDNHKIGYCNGPLKSGTTYRV 1169

  Fly  1322 FVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVL 1386
            .|||.....:   :|.:.:|                      :|      :..::|...:   ::
  Fly  1170 KVRAFTGADK---FTDTAYS----------------------FP------IQTDQDNTSL---IV 1200

  Fly  1387 PLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGM 1451
            .:.|...|:...|:.|...||||..|:     ..|:...|.|                |...|..
  Fly  1201 AITVPLTIILVLLVTLLFYKRRRNNCR-----KTTKDSRAND----------------NMSLPDS 1244

  Fly  1452 I--SHPPIPISEFANHIERLKSNDNQKFSQEYESIE-PGQQFTWDNSNLEHNKSKNRYANVTAYD 1513
            :  .:.||.|..||.|...:.::.:.:||:|:|.:: .|:......::|..|:.|||:.|:..||
  Fly  1245 VIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYD 1309

  Fly  1514 HSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLE 1578
            |||.:|..|:...|||||||||..|:.....::.|||||..|..||||||||..:..|||:||..
  Fly  1310 HSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCF 1374

  Fly  1579 ERTRIKCDQYWPTRGTET-YGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDH 1642
            |:.|.|||||||...... ||.|.|.|......|.:.:..|.|||.  :::|.::...||.|||.
  Fly  1375 EKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRG--SEQRILRHFHFTTWPDF 1437

  Fly  1643 GVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTC 1707
            |||:.|...::|:|..|.....|..|::|||||||||:|.:|.:|.:|:::.....:||:|.|..
  Fly  1438 GVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYA 1502

  Fly  1708 LRAQRNYMVQTEDQYIFIHDAILEAIICGVTEV--PARNLHTHL----QKLLITEPGETISGME- 1765
            :|.:|.:|||||.|||.||..:| |::.|...:  |||.:|.:.    |::.:.|.|:.::.:| 
  Fly  1503 MRKERVWMVQTEQQYICIHQCLL-AVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEG 1566

  Fly  1766 ---------VEFKKLSN----VKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGS 1817
                     .|.:.:.:    :..|..:.:|::. ...|    .|:.|..|...:     |..|.
  Fly  1567 HLSHHDLQQAEAEAIDDENAAILHDDQQPLTSSF-TGHH----THMPPTTSMSSF-----GGGGG 1621

  Fly  1818 DYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLK--------------- 1867
            .:.|....|    | ..:..|.              ::|:::|::|...|               
  Fly  1622 GHTNVDAPD----RXHSVVNQS--------------DNNNSVVIVLVDNKPSSMICKDSKGGNID 1668

  Fly  1868 ----EMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVT------DARDGSSRTVRQ 1922
                :..:::..|..|::..  :....:..|..||..|::.:...:|      |.::..|.    
  Fly  1669 VLESQQQQQQQQQQQPNQGG--HNITTISAINGYNTLQHRRKSQLITFSSSSCDIKNSLSH---- 1727

  Fly  1923 FQFIDWPE----QGVPKSGEG 1939
             ::|:...    .|.|.||.|
  Fly  1728 -EYINGSNGSAANGPPSSGSG 1747

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020 27/121 (22%)
FN3 <382..747 CDD:442628 104/553 (19%)
FN3 712..810 CDD:238020 22/97 (23%)
FN3 832..898 CDD:214495 19/86 (22%)
FN3 <867..1269 CDD:442628 87/456 (19%)
fn3 914..998 CDD:394996 18/88 (20%)
R-PTPc-LAR-1 1498..1735 CDD:350401 106/237 (45%)
R-PTP-LAR-2 1784..2021 CDD:350402 29/185 (16%)
Ptp10DNP_996413.2 fn3 124..205 CDD:394996 29/86 (34%)
fn3 220..304 CDD:394996 15/83 (18%)
FN3 278..>734 CDD:442628 86/500 (17%)
FN3 583..671 CDD:238020 25/109 (23%)
fn3 787..850 CDD:394996 16/72 (22%)
fn3 866..935 CDD:394996 17/77 (22%)
fn3 959..1043 CDD:394996 19/103 (18%)
PTP_tm 1083..1187 CDD:465889 27/145 (19%)
R3-PTPc 1301..1522 CDD:350396 100/222 (45%)
Blue background indicates that the domain is not in the aligned region.

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