Protein Alignment Lar and Ptpn7

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_796055.1
• Gene: Ptpn7 / 320139
• MGIID: 2156893
• Length: 359
• Species: Mus musculus
• Alignment Length: 352
• Identity: 117/352 - (33%)
• Similarity: 170/352 - (48%)
• Gaps: 40/352 - (11%)

  Fly  1410 QPCKTPDQAAVTRPLMAADLGAGPTPSDP------VDMRR-------LNFQTPGMISHPPIPI-- 1459
            |.|:...:|.:....:.||:...|....|      :..||       |:.|:.|.:.    ||
Mouse     3 QACEGRSRAQLPTLSLGADMTQPPPTKAPAKKHVRLQERRGSSVALMLDVQSLGTVE----PICS 63

  Fly  1460 ----SEFANHIERLKSNDNQKFSQEYESIEPGQ---QFTWDNSN--------LEHNKSKNRYANV 1509
                .|...|..|...:...:::.:::...|.|   :|....||        :..:.||:||..:
Mouse    64 VNTPREVTLHFLRTAGHPLTRWTLQHQPPSPKQLEEEFLKIPSNFVNPEDLDIPGHASKDRYKTI 128

  Fly  1510 TAYDHSRVQLPAVEGVVGSDYINANYCDGY-RKHNAYVATQGPLQETFVDFWRMCWELKTATIVM 1573
            .....|||.|...:....||||||||..|| .|...|:|||||:..|..|||.|.|:...:.|||
Mouse   129 LPNPQSRVCLGRAQSQEDSDYINANYIRGYDGKEKVYIATQGPMPNTVADFWEMVWQEDVSLIVM 193

  Fly  1574 MTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTA 1638
            :|:|.| .:.||..||||. .|.||...:.|.:.:|...|::|  ||..|...:.|.:|.:.|:|
Mouse   194 LTQLRE-GKEKCVHYWPTE-EEAYGPFQIRIQDMKEHPEYTVR--QLTIQHQQECRSVKHILFSA 254

  Fly  1639 WPDHGVPDHPAPFLQFLRRCRA-LTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIY 1702
            ||||..|:...|.|:.:..... .|...|||::||||||:|||||:|......:::|....:||.
Mouse   255 WPDHQTPESAGPLLRLVAEVETPETAANSGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDIL 319

  Fly  1703 GHVTCLRAQRNYMVQTEDQYIFIHDAI 1729
            |.|..||..|..|:||.:||.|:|..:
Mouse   320 GIVCQLRLDRGGMIQTAEQYQFLHHTL 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	95/234 (41%)
		R-PTP-LAR-2	1784..2021	CDD:350402
Ptpn7	NP_796055.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		7/29 (24%)
		Interaction with MAP kinases. /evidence=ECO:0000250	38..51		2/12 (17%)
		PTPc-N7	105..349	CDD:350460	97/246 (39%)