DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptprb

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001416429.1 Gene:Ptprb / 314843 RGDID:1305922 Length:2238 Species:Rattus norvegicus


Alignment Length:2164 Identity:466/2164 - (21%)
Similarity:757/2164 - (34%) Gaps:717/2164 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 WTHPTIVD----AAHPPEIIRKPQNQGVRVGGVASFYCAA----------RGDP-PPS------- 66
            |.||.::|    ...|.::         :.|.:.:|...:          :.|| ||:       
  Rat   305 WCHPILIDNFTYGCDPKDL---------QAGTIYNFRIVSLDGEERSLVLQTDPLPPARLEVNPE 360

  Fly    67 -----------------IVW------RKNGKKV-------SGTQSRYTVLEQPGGISI-LRIEPV 100
                             :.|      .:|.:|:       |.|.|:||.|....|.|. :.|..|
  Rat   361 RTTSTTLQVRWTPSSGKVTWYEVQLFDQNNQKIQEVQVQESATWSQYTFLNLTAGSSYKIGITAV 425

  Fly   101 RAGRDDAPYECVAENG---------VGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHT 156
            ..|:...|   |..||         :|.:.:.::.|..:            ::|||.  :|....
  Rat   426 SGGKRSFP---VYTNGSTGPSPVEDIGISPNPNSLLISW------------SRGPGN--VEQFRL 473

  Fly   157 VLM---------------TCKAIGNPTP-NIYWIKNQTKVDMS----NPRYSL-KDGFLQIENSR 200
            :||               |..|....|| ::|   |.|.|.|:    |.|:.| :...:::.|.:
  Rat   474 MLMDKGAIVQDTNVDKRDTSYAFRGLTPGHLY---NVTIVTMASGLQNSRWKLGRTAPMEVSNLK 535

  Fly   201 EEDQG-----------------KYECVAENSMGTEHSK-----ATNLYVK-----------VRRV 232
            ....|                 .|.....:....:.||     ||.:..|           :|.|
  Rat   536 VTSGGSLTSLNVKWQKPLGVIDSYSITLSHQGTVKESKTLPPRATEIQFKDLVPGRFYQVTIRCV 600

  Fly   233 PPTFSRP--------PETISEVMLGSNLNLSCIAVGSPMPHVKW--------------------- 268
            ....|..        ||.:|.::..:.:.:...||....|...|                     
  Rat   601 SGELSAEKSAMGRTVPEKVSNLVSYNEIWMKSFAVNWTPPAGDWDHYRILLFNDSLVLLNTTVGK 665

  Fly   269 ------MKGSEDLTPENEMPI----------------GRN----VLQL----------------- 290
                  ::|.| |.|..:..:                ||.    ||||                 
  Rat   666 EETHFALEGLE-LIPGRQYEVEVIVESGNLRNSERCQGRTVPLAVLQLRIKQANETSLGITWRAP 729

  Fly   291 --------------------------------INIQESANYTCIAASTLGQIDSVSVVKVQSLPT 323
                                            .|:....||.....|..|.:...:.::.:::|.
  Rat   730 LGEWEKYTISLMDRELFVIHKSLSKDAKEYTFTNLMPGRNYKATVTSMSGDLKQSASIQGRTVPA 794

  Fly   324 APTDVQISEVTAT-SVRLEWSYKGPEDLQYYVIQYKPKNA---NQAFSEISGIITMYYVVRALSP 384
            ..||:::|....| |:...|: |...|:::|.:....:|.   |::.|..|.    :|..|||  
  Rat   795 QVTDLEVSNQGMTSSLFTNWT-KALGDVEFYQVLLIHENVVVKNESVSSDSS----WYSFRAL-- 852

  Fly   385 YTEYEFYVIAVNNIGRGPPS--APATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPET 447
             .....|.:.|..:..|.||  ..|...|...|..|..:.::.||        ..:.::|.|.. 
  Rat   853 -RSGSLYSVVVTTVSGGIPSRQVVAEGRTVPSSVSGVTVNNSGRN--------DYLSVSWLPAP- 907

  Fly   448 PNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQA----YTSMGAGPMS 508
              |:|..|.|..:.:|...::...::.|..   .:.|.|||..:|.|.:..    |.|.......
  Rat   908 --GEVHHYVVTLSHDSKVVQSLITAKFVSE---CSFSSLTPGRLYNVTITTKSGNYESHSFSEER 967

  Fly   509 T-PVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQ---AHHKR 569
            | |.:|   ||:  ..||...:|.    :.:.|   .|::.:..|||:    |..|:   ...|.
  Rat   968 TVPDKV---QGI--SVSNSARSDY----LKVSW---VHATGDFDHYEV----TIKNRDSFIQTKS 1016

  Fly   570 ISNSE-AYTLDGLYPDTLYYIWLAAR------SQRGEGATTPPIPVRTKQYGAPPRNITAIATSS 627
            |..|| ......|.|..||.|.:..:      |::|.|.|.|          .|.:|:|.:..|:
  Rat  1017 IPKSENECVFARLVPGRLYSITVTTKSGQYEASEQGTGRTIP----------EPVKNLTLLNRST 1071

  Fly   628 TTISLSWLPPPVERSNGRIIYYKV----------------------------------------- 651
            ..:.::|     .|:||.:..|:|                                         
  Rat  1072 EDLHVTW-----SRANGDVDQYEVQLLFNDMKVFPPIYLVNTATEYQFSALTPGRHYKILVLTIS 1131

  Fly   652 ---------------------------------------------FFVEVGREDD--EATTMTLN 669
                                                         :.|...|:|:  |:.|:..:
  Rat  1132 GDVQQPAFIEGLTVPSTVKNIHISANGATDRLTVTWSPGGGDVDSYVVSAFRQDEKVESHTLPKH 1196

  Fly   670 MTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKAT--------PLNST 726
            .:......|:....|:|.::   ||...       ||.|.||.|  |.|.|:        ..:|.
  Rat  1197 GSEHTFHRLEAGATYRIAIV---SVSGS-------LRNQIDVLG--QTVPASVHGVVADNAYSSN 1249

  Fly   727 SIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLN--EP-----FKFDVVDTLEFNVTGLQPD 784
            |:.|||:..|     |:...|.|..  |.:.|....|  ||     .||:          .|.|.
  Rat  1250 SLTVSWQKAL-----GMAERYDILL--LSENGVLLSNTSEPATVKQHKFE----------DLTPG 1297

  Fly   785 TKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRG 849
            .||.:|:  ||..| |..|..  |:|.|........:|:|.|... ..:...|   ..:.|||..
  Rat  1298 KKYKMQI--LTVSG-GLFSKE--VETEGRTVPAAVTNLRITENSS-RHLSFSW---TASEGELSW 1353

  Fly   850 YRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIG-IGQETVKIFQTPEGTPG 913
            |.:.....|:.|:|.....|.:....|.||.:|..|:..:.  .|.| :..|:....:|......
  Rat  1354 YNIFLYNPDKTLQERAQVDPLVQSFSFQNLLQGRMYKMVIV--THSGELSNESFIFGRTVPAAVN 1416

  Fly   914 ---GPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTN 975
               |...|:|      |.|..:|.|.:.          |..|::.|.:.....:....|:     
  Rat  1417 HLKGSNRNMT------DSLWFSWSPASG----------DFDFYELILYNPNGTKKENWRE----- 1460

  Fly   976 LEENTEYIF-------RVRAYTKQGAGPFSDKLIVETERDMGR---APMSLQAEATSEQTA---- 1026
             ::.||:.|       :...|....:|..|:|:..|     ||   :|.||.:.|....|:    
  Rat  1461 -KDVTEWRFQGLIPGRKYTLYVVTHSGDLSNKVTGE-----GRTAPSPPSLLSFADVANTSLAIT 1519

  Fly  1027 -------------EIWWEP------------VTSRGKLL-----GYKIFYTMTAVEDLDDWQTKT 1061
                         |:.|.|            ..|.|:::     |....:::..|.. |.|:|  
  Rat  1520 WKGPPDWTDYNDFELQWLPGDALTVFNPYSSKKSEGRIVNGLRPGRSYQFSVKTVSG-DSWKT-- 1581

  Fly  1062 VGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWS 1126
                             |:..|:.             :||.||:.:. ||.....::.::..||.
  Rat  1582 -----------------YSKPISG-------------SVRTKPDKIQ-NLHCRPQNSTAIACSWI 1615

  Fly  1127 PPIRLTPVNYKISFDAMKV---FVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNV- 1187
            ||        ...||...:   .:|:|....::.:.|.:.:|       .|..|.|...|.|:: 
  Rat  1616 PP--------DSDFDGYSIECRKMDTQEIEFSRKLEKEKSLL-------NIMMLVPHRRYLVSIK 1665

  Fly  1188 -------SAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQA---------S 1236
                   |.:..|      :.||:..:...|.|.::      ||.:::|:.....         |
  Rat  1666 VQSAGVTSEVVED------STITMIDRPPPPPPHIR------VNEKDVLISKSSINFTVNCSWFS 1718

  Fly  1237 EEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKP------ERPNAP-------YIAAKF 1288
            :..|.:. |:.|||.|..|          .|:|.|.:..|      .|.||.       |.|:|.
  Rat  1719 DTNGAVK-YFAVVVREADS----------MDELRPEQQHPLPSYLEYRHNASIRVYQTNYFASKC 1772

  Fly  1289 -----PQRSI-PFTFHLGSGDD---------YHNFTNRKLEREKRYRIFVRAVVDTPQKHL--YT 1336
                 |.||. .|...||...|         ...|.:..|:....|||.:||......:.|  :|
  Rat  1773 AESPDPDRSSKSFNIKLGGEMDSLGGKCDPSQQKFCDGPLKPHTAYRISIRAFTQLFDEGLKEFT 1837

  Fly  1337 SSPFSE-FLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVS--TA 1398
            ...:|: |.|:.:                         ..:.|| :..|:..:....|::.  .|
  Rat  1838 KPLYSDTFFSMPI-------------------------TTESEP-LFGVIEGVSAGLFLIGMLVA 1876

  Fly  1399 LIVLCVVKRRRQPCKTPDQAAVT----RPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPI 1459
            |:...:.:::....:....|.::    ||| :..|..|              |.....:..||.|
  Rat  1877 LVAFFICRQKASHSRERSSARLSIRRDRPL-SVHLNLG--------------QKGNRKTSCPIKI 1926

  Fly  1460 SEFANHIERLKSNDNQKFSQEYESI-EPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVE 1523
            ::|..|..:|:::.|...|:|||.: :.|:..:.|.:.|..|:.||||.|:..||.|||:|..|:
  Rat  1927 NQFEGHFMKLQADSNYLLSKEYEDLKDVGRSQSCDIALLPENRGKNRYNNILPYDASRVKLCNVD 1991

  Fly  1524 GVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQY 1588
            ....||||||:|..|......|:||||||..|..|||:|.||.....|||:|:..|:.|:|||.|
  Rat  1992 DDPCSDYINASYIPGNNFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEKGRVKCDHY 2056

  Fly  1589 WPT-RGTETYGQIFVTITETQELATYSIRTFQLC-RQGFNDRREIKQLQFTAWPDHGVPDHPAPF 1651
            ||. :....||.:.:.:.....|..::||.|::| .:..:..|.::...:|.|||||||:.....
  Rat  2057 WPADQDPLYYGDLILQMVSESVLPEWTIREFKICSEEQLDAHRLLRHFHYTVWPDHGVPETTQSL 2121

  Fly  1652 LQFLRRCRAL--TPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNY 1714
            :||:|..|..  ..|.:||.:|||||||||||.::.:|.:|:::..:..:||||.|..||..|.:
  Rat  2122 IQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLRLHRVH 2186

  Fly  1715 MVQTEDQYIFIHDAILEAI 1733
            |||||.||:::|..:.:.:
  Rat  2187 MVQTECQYVYLHQCVRDVL 2205

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151 26/150 (17%)
Ig strand B 53..57 CDD:409353 1/3 (33%)
Ig strand C 66..70 CDD:409353 1/33 (3%)
Ig strand E 93..97 CDD:409353 1/4 (25%)
Ig strand F 108..113 CDD:409353 1/4 (25%)
Ig strand G 122..125 CDD:409353 0/2 (0%)
Ig 141..228 CDD:472250 25/129 (19%)
Ig strand B 157..161 CDD:409353 2/18 (11%)
Ig strand C 170..174 CDD:409353 1/3 (33%)
Ig strand E 192..196 CDD:409353 0/3 (0%)
Ig strand F 206..211 CDD:409353 1/4 (25%)
Ig strand G 218..221 CDD:409353 0/2 (0%)
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401 23/185 (12%)
Ig strand A 237..239 CDD:409401 1/1 (100%)
Ig strand A' 244..248 CDD:409401 1/3 (33%)
Ig strand B 251..259 CDD:409401 0/7 (0%)
Ig strand C 264..270 CDD:409401 2/32 (6%)
Ig strand C' 272..274 CDD:409401 0/1 (0%)
Ig strand D 277..281 CDD:409401 1/3 (33%)
Ig strand E 286..291 CDD:409401 4/57 (7%)
Ig strand F 298..305 CDD:409401 2/6 (33%)
Ig strand G 309..318 CDD:409401 0/8 (0%)
FN3 322..411 CDD:238020 24/94 (26%)
FN3 <382..747 CDD:442628 93/477 (19%)
FN3 712..810 CDD:238020 31/112 (28%)
FN3 832..898 CDD:214495 16/66 (24%)
FN3 <867..1269 CDD:442628 87/469 (19%)
fn3 914..998 CDD:394996 16/90 (18%)
R-PTPc-LAR-1 1498..1735 CDD:350401 99/240 (41%)
R-PTP-LAR-2 1784..2021 CDD:350402
PtprbNP_001416429.1 None
Blue background indicates that the domain is not in the aligned region.

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