DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptp4E

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster


Alignment Length:1730 Identity:391/1730 - (22%)
Similarity:639/1730 - (36%) Gaps:460/1730 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   352 YYVIQYKP------KNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCT 410
            :|.|.|.|      .|.....|:|...|..   .||| |.|||.|::...|:..|...:.....|
  Fly    88 FYRIDYSPPFGFPEPNTTIPASDIGKDIKF---SRAL-PGTEYNFWLYYTNSTHREQLTWTVNIT 148

  Fly   411 TGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQP-EASWNSQM 474
            |.         ...|.|:.|:..||.:..|||.||  .:|:.:|:::.....::.| |.|::.:.
  Fly   149 TA---------PDPPANLSVQLRSSKSAFITWRPP--GSGRYSGFRIRVLGLTDLPFERSYSLEG 202

  Fly   475 VDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQ 539
            .:..:| :..||||...|  :|||| |:..|..|.....:.....|:.|..|......||.:.:.
  Fly   203 NETLQL-SAKELTPGGSY--QVQAY-SVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVL 263

  Fly   540 WTKP------TH---------SSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYI 589
            |..|      ||         :.:::::.|.........||..|           ||.|...|.|
  Fly   264 WQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFK-----------GLVPGREYNI 317

  Fly   590 WLAARSQRGEGATTPPIPVRTKQYGAPPR--NIT--AIATSSTTISLSWLPPPV----------- 639
            .:...|:    ..|..:|...:....|.|  |:|  ...|:|::..:.|.||..           
  Fly   318 SVQTVSE----DETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVML 378

  Fly   640 ----------ERSNGRIIYYKV-FFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTS 693
                      ..:||..:|:.. ..:|.||..:.       :...:.|.:..|            
  Fly   379 STSRRIFNVPRAANGDSVYFDYPDILEPGRTYEV-------VVKTIADNVNSW------------ 424

  Fly   694 VGDGPRSHPIILRTQEDVPGDPQDVKA----TPLNSTSIHVSWKPPLEKDRNGIIR-GYH--IHA 751
                |.|..:.||        |:.|::    ....|.::|:||: |.|..|....| .||  .:|
  Fly   425 ----PASGEVTLR--------PRPVRSLGGFLDDRSNALHISWE-PAETGRQDSYRISYHEQTNA 476

  Fly   752 QELRDEGKGFLNEPFKFDV-------VDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVK 809
            .|:          |..|.|       .:..|:.:..|....:|.|.|.||: ||....::.|...
  Fly   477 SEV----------PAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALS-KGVASNASDITRY 530

  Fly   810 TPGGVPVRPTVSLKIMEREPI-VSIELEWERPAQTYGELRGYRLRWGVKDQ--ALKEEMLSGPQM 871
            |      ||...| |.|...| ..:.|.|.      .::...:.|:.|..|  ..:||.......
  Fly   531 T------RPAAPL-IQELRSIDQGLMLSWR------SDVNSRQDRYEVHYQRNGTREERTMATNE 582

  Fly   872 TKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQT--PEGTPGGPPSNITIRFQTPDVLCVTWD 934
            |......|..|..||.:|...:| |:..|....||.  |:     ||.|:|::....:::.:.|.
  Fly   583 TSLTIHYLHPGSGYEVKVHAISH-GVRSEPHSYFQAVFPK-----PPQNLTLQTVHTNLVVLHWQ 641

  Fly   935 PPTREHRNGIITRY---------------------DVQFHKK-------IDHGLGS--------- 962
            .|.....:..:.||                     |:.:.::       :..|:.|         
  Fly   642 APEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVT 706

  Fly   963 --------------ERNMTLR----------------------KAVFTN---------------- 975
                          .||:||.                      :..|.|                
  Fly   707 MPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPI 771

  Fly   976 --LEENTEYIFRVRAYT---KQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTS 1035
              |....:|.|.|:|.:   :.|....|.:.:...:.|:      ..|.|..||..:   |.:| 
  Fly   772 EDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDV------FIANAGHEQGQD---ETIT- 826

  Fly  1036 RGKLLGYKIFYTMTAVE----DLDDWQTKTVGLTESADLVN-LEKFAQYAVAIAARFKN------ 1089
                    :.||.|..:    |:..:......:.:...|.| .|:...::.....:..|      
  Fly   827 --------LSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTV 883

  Fly  1090 --GLGRLSEKVTVRIKPEDVPL-NLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQG 1151
              |:..|..:...|:.|  :|: :|:|..|:...:||.|:     .|......|:...:..|.:.
  Fly   884 SGGVASLPVQRLYRLHP--LPISDLKAIQVAAREITLHWT-----APAGEYTDFELQYLSADEEA 941

  Fly  1152 FSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNV-----SAIPSDYSYRPPTKITVTTQMAAP 1211
            ....|.|.|...|        |:..|.|:..|...|     |...:|::     .::|:|.|.:.
  Fly   942 PQLLQNVTKNTEI--------TLQGLRPYHNYTFTVVVRSGSIQGTDFA-----DVSVSTLMRSS 993

  Fly  1212 QPMV-----------KPDFY---GVVNGEEILVILPQASEEYGPISHYYLVVVPEDKS---NLHK 1259
            .|:.           |.|::   .|..||.......:.:|::|||.::.:.....|.:   :.::
  Fly   994 APISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYE 1058

  Fly  1260 IP---DQFLTDDLLPGRNKPERPNA----------------PYIAAKFPQRS------------I 1293
            .|   .|...|.|:||.:...|..|                |.:|...|:.|            |
  Fly  1059 FPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTI 1123

  Fly  1294 PFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHL----------YT-------SSPFS 1341
            ..:|..|...:.|...       :.|.|.:...|......|          ||       ..|::
  Fly  1124 EISFRQGYFSNAHGMV-------RSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYN 1181

  Fly  1342 EFL--------------------SLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEIL---- 1382
            .||                    :.|..:|.....|.|....:    .:.:....||.:..    
  Fly  1182 PFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTY----RIKIRAFTDEDKFTDTVY 1242

  Fly  1383 ----------WVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSD 1437
                      .|::...||..::...::|:...:.|.|..:...:.|    .|..:|.|.|.   
  Fly  1243 SSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLA----RMQDELAALPE--- 1300

  Fly  1438 PVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIE-PGQQFTWDNSNLEHNK 1501
                   .:.||    :.|:.:.:|:.|...:.::.:.:||:|:|.:: .|:......:||..|:
  Fly  1301 -------GYITP----NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNR 1354

  Fly  1502 SKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWEL 1566
            .|||:.|:..|||||.:|..|:...|||||||||..|:.....::.|||||..|..:|||||||.
  Fly  1355 PKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWES 1419

  Fly  1567 KTATIVMMTRLEERTRIKCDQYWPT-RGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRRE 1630
            .:..|||:||..|:.|.|||||||. |....||.|.|.:........:||..|.:.|.  .:.|.
  Fly  1420 NSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRI 1482

  Fly  1631 IKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKH 1695
            ::...||.|||.|||:.|...::|:|..|.:...:..|:||||||||||:|.:|.:|.:|:.:..
  Fly  1483 MRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHK 1547

  Fly  1696 EKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTH------LQKLLI 1754
            ...:||:|.|..:|.:|.:|||||.||:.||..:| |::.|...:.|.:|..|      :.|:.:
  Fly  1548 SDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEGKEHLLADSLELHANDGYEVTKIYL 1611

  Fly  1755 TEPGETISG-MEVEFKKLSNVKMDSSKFVTANLPCNKHKN 1793
            ....:|..| :.:........|:|      |:|..||.::
  Fly  1612 ERQPQTKMGTLPIRASLAMAEKLD------ADLMTNKDED 1645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470 18/57 (32%)
FN3 423..514 CDD:238020 28/91 (31%)
FN3 520..610 CDD:238020 21/104 (20%)
FN3 616..707 CDD:238020 20/116 (17%)
FN3 712..810 CDD:238020 27/111 (24%)
FN3 832..907 CDD:238020 17/76 (22%)
FN3 914..1005 CDD:238020 24/184 (13%)
FN3 1012..1101 CDD:238020 16/101 (16%)
fn3 1106..1198 CDD:278470 21/97 (22%)
PTPc 1476..1731 CDD:214550 108/256 (42%)
PTPc 1503..1731 CDD:238006 100/228 (44%)
PTPc 1763..2022 CDD:214550 7/32 (22%)
PTPc 1791..2022 CDD:238006 0/3 (0%)
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020 28/96 (29%)
fn3 247..328 CDD:278470 18/95 (19%)
fn3 343..417 CDD:278470 13/80 (16%)
fn3 443..525 CDD:278470 24/93 (26%)
FN3 548..611 CDD:238020 15/69 (22%)
FN3 620..706 CDD:238020 12/90 (13%)
fn3 708..796 CDD:278470 12/87 (14%)
fn3 824..886 CDD:278470 9/70 (13%)
fn3 902..978 CDD:278470 20/88 (23%)
fn3 1013..1092 CDD:278470 16/78 (21%)
UP_III_II 1106..>1248 CDD:297589 21/152 (14%)
PTPc 1329..1582 CDD:214550 108/254 (43%)
PTPc 1355..1582 CDD:238006 100/228 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45443518
Domainoid 1 1.000 163 1.000 Domainoid score I1235
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm2866
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR19134
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
65.970

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