DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Ptprd

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_038967340.1	Gene:	Ptprd / 313278	RGDID:	1561090	Length:	1940	Species:	Rattus norvegicus

Alignment Length:	2107	Identity:	994/2107 - (47%)
Similarity:	1310/2107 - (62%)	Gaps:	248/2107 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LQMTAAR--PIAALSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPP 65
            :.:|:.|  |:|.|.||:|:...:     ..|..||...|.|.:|....||||||.|.|.|||.|
  Rat     1 MPLTSCRMVPVARLLLLLLAFFLY-----ACAETPPRFTRTPVDQTGVSGGVASFICQATGDPRP 60

  Fly    66 SIVWRKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIY 130
            .|||.|.|||||..:....:....|..|:|||:|:|..||:|.|||||.|.||: :|....||:.
  Rat    61 KIVWNKKGKKVSNQRFEVVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGE-ISVSTRLTVL 124

  Fly   131 EGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKD---- 191
            ..|:.|.|||.|..||..:|:|...|..|.|.|.|||.|.|.|.|:...||.||....:|.
  Rat   125 REDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSE 189

  Fly   192 --------GFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVK----VRRVPPTFSRPPETIS 244
                    |.||||.|.|.|||||||||.||.||.:|...||||:    ||||||.||.|| |..
  Rat   190 SIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPP-TNH 253

  Fly   245 EVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQ 309
            |:|.|.::|::|:|||||||:||||.|:||||||::||||||||:|.::::||||||:|.||||.
  Rat   254 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGV 318

  Fly   310 IDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIIT 374
            |::|:.:.|::||..|....::|.||||:.|.|....||.:.||:||:||||:.:.:.||.||.|
  Rat   319 IEAVAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDGIAT 383

  Fly   375 MYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMV 439
            ..|.|..||||::|||.|:|||||||||.|.|....|.:     ....||||:||.|.|||:|::
  Rat   384 TRYSVAGLSPYSDYEFRVVAVNNIGRGPASEPVLTQTSE-----QAPSSAPRDVQARMLSSTTIL 443

  Fly   440 ITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGA 504
            :.|:.||.||||:.||:||||.:..|...:|....|.:|::||:..|.|...|:|:|.|:||:|.
  Rat   444 VQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 508

  Fly   505 GPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKR 569
            ||:|:.:||..|.|||.||.||:|....||::.|.||.|  .|:.|..|||.:.|  .:|...:|
  Rat   509 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPP--RSDTIASYELVYRD--GDQGEEQR 569

  Fly   570 IS--NSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTI 630
            |:  ...:|.|.||.|::|||..|:|||.:|.||:|..|..||.|.  .|||::|:..:.|||:|
  Rat   570 ITIEPGTSYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 634

  Fly   631 SLSWLPPPVERSNGRIIYYKVFFVEVGRED---DEATTMTLNMTSIVLDELKRWTEYKIWVLAGT 692
            .:||.|||||:.||.|..|.:.:..|..||   .|...:..:.|..:|::|::||||:|.|.|.|
  Rat   635 LVSWQPPPVEKQNGIITEYSLKYAAVDGEDYRPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHT 699

  Fly   693 SVGDGPRSHPIILRTQEDVP-GDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRD 756
            .||.||.|..:::||.|||| |.|:.|:...:|:|::.|||:.|:...::|.||||.:|..::.:
  Rat   700 DVGPGPESLSVLIRTDEDVPSGPPRKVEVEAVNATAVKVSWRSPVPNKQHGQIRGYQVHYVKMEN 764

  Fly   757 -EGKG--------FLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPG 812
             |.||        ..:..::||.....:..::||||:|.||:.|.|.|.||||.||...:|.|.|
  Rat   765 GEPKGQPMLKDVMLADAQWEFDDATEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 829

  Fly   813 GVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKR-- 875
            .||.||.:   ::....:.:..::|..|..|:|.|:||||::|.||.    |.|:..:.::|.
  Rat   830 AVPGRPRL---VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDM----EPLTTLEFSEKEDH 887

  Fly   876 --FDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTR 938
              ..::.:|..|.||::..|.:|.|:|.||....||..|.|.|.|:.....|...:.::|.||..
  Rat   888 FTATDIHKGASYIFRLSARNKVGFGEEMVKEISVPEEVPTGFPQNLHSEGTTSTSVQISWQPPVL 952

  Fly   939 EHRNGIITRYDVQFHK------KIDHGL-GSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGP 996
            ..|||:||:|.:.:..      .::|.: .::.:|||     |.|:.:|.|..:|||:|.:|.||
  Rat   953 AERNGVITKYTLLYRDINVPLLPMEHLIVPADTSMTL-----TGLKSDTTYDVKVRAHTSKGPGP 1012

  Fly   997 FSDKLIVET-ERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTK 1060
            :|..:...| ..|......:...:|..:.:..:.||...:....:.:||.|        ||.:
  Rat  1013 YSPSVQFRTLPVDQAVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILY--------DDGK-- 1067

  Fly  1061 TVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSW 1125
               :.|..|                      ||.::|:.|.:|||           .::|..|:
  Rat  1068 ---MVEEVD----------------------GRATQKLIVNLKPE-----------KSYSFVLT- 1095

  Fly  1126 SPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAI 1190
                                   ::|.|...        |:|.|
  Rat  1096 -----------------------NRGNSAGG--------LQHRV--------------------- 1108

  Fly  1191 PSDYSYRPPTKITVTTQMAAPQPM-VKPDFYGVVNGEEILVI-LPQ--ASEEYGPISHYYLVVVP 1251
                           |...||..: .||.|.|..|.:.::.: ||.  |:|.   |..||:::||
  Rat  1109 ---------------TAKTAPDVLRTKPAFIGKTNLDGMITVQLPDVPANEN---IKGYYIIIVP 1155

  Fly  1252 EDKSNLHKI-----PDQFLTDDLLPGRNKPER--------PNAPYIAAKFPQRSIPFTFHLGSGD 1303
            ..||....|     ||:...|:||...::..|        ...|||||.|.  .:|..|.||...
  Rat  1156 LKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFD--VLPTEFTLGDDK 1218

  Fly  1304 DYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSE-FLSLDMREAPPGERPHRPDPNWPAE 1367
            .|..|||::|:..:.|..||.||:|..:..:|.:||:|: .:|:|:            ||. |..
  Rat  1219 HYGGFTNKQLQSGQEYVFFVLAVMDHAESKMYATSPYSDPVVSMDL------------DPQ-PIT 1270

  Fly  1368 PEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAG 1432
            .|        |..::|||.|::...||:...:.:| :.|..:...|..:..:....|..:.....
  Rat  1271 DE--------EEGLIWVVGPVLAVVFIICIVIAIL-LYKSSKPDRKRAESESRKSSLPNSKEVPS 1326

  Fly  1433 PTPSDPVDMRRLNFQTPG--------------MISHPPIPISEFANHIERLKSNDNQKFSQEYES 1483
            ..|:|||::|||||||||              |.|||||||.|.|:||||||:|||.||||||||
  Rat  1327 HHPTDPVELRRLNFQTPGSDDSGYPGNLHFSSMASHPPIPILELADHIERLKANDNLKFSQEYES 1391

  Fly  1484 IEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVAT 1548
            |:|||||||::||||.||.|||||||.|||||||.|.|:||:.||||:||||.|||||.|||:||
  Rat  1392 IDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT 1456

  Fly  1549 QGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATY 1613
            ||.|.|||.|||||.||.::||:||||:||||:|:|||||||:|||||:|.:.||:.:|.|||||
  Rat  1457 QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATY 1521

  Fly  1614 SIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVG 1678
            .:|||.|.:.|.:::||::|.|||||||||||:||.|||.||||.:...||::||::||||||||
  Rat  1522 CVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1586

  Fly  1679 RTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPAR 1743
            ||||:||||:||||:||||.:|||||||.:||||||||||||||||||||:|||:.||.||||||
  Rat  1587 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPAR 1651

  Fly  1744 NLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYL 1808
            ||:.::|||...|.||.::|||:|||:|::.|..:|:|::|||||||.|||||:|:||||:||.|
  Rat  1652 NLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1716

  Fly  1809 TPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREK 1873
            .||.|:|||||:||||:||||.:.||||.|||:.:..|||||||||||||||||||||:||||||
  Rat  1717 QPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREK 1781

  Fly  1874 CFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGE 1938
            |.||||.|||.||||:||||:||||||||.||||||||||||.|||||||||.||||||||||||
  Rat  1782 CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGE 1846

  Fly  1939 GFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQR 2003
            ||||||||||||||||||||||:|||||||||:|||||||||||||:||||:|:||||::||:||
  Rat  1847 GFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQR 1911

  Fly  2004 PAMVQTEDQYHFCYRAALEYLGSFDNY 2030
            ||||||||||.||||||||||||||:|
  Rat  1912 PAMVQTEDQYQFCYRAALEYLGSFDHY 1938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	46/93 (49%)
		I-set	36..129	CDD:254352	45/92 (49%)
		IG_like	146..227	CDD:214653	42/92 (46%)
		Ig	159..228	CDD:299845	39/80 (49%)
		I-set	234..318	CDD:254352	51/83 (61%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	43/67 (64%)
		fn3	324..404	CDD:278470	42/79 (53%)
		FN3	423..514	CDD:238020	43/90 (48%)
		FN3	520..610	CDD:238020	38/91 (42%)
		FN3	616..707	CDD:238020	38/93 (41%)
		FN3	712..810	CDD:238020	38/107 (36%)
		FN3	832..907	CDD:238020	25/78 (32%)
		FN3	914..1005	CDD:238020	29/97 (30%)
		FN3	1012..1101	CDD:238020	13/88 (15%)
		fn3	1106..1198	CDD:278470	7/91 (8%)
		PTPc	1476..1731	CDD:214550	186/254 (73%)
		PTPc	1503..1731	CDD:238006	164/227 (72%)
		PTPc	1763..2022	CDD:214550	210/258 (81%)
		PTPc	1791..2022	CDD:238006	193/230 (84%)
Ptprd	XP_038967340.1	I-set	31..123	CDD:400151	45/92 (49%)
		Ig strand A'	39..43	CDD:409353	1/3 (33%)
		Ig strand B	46..55	CDD:409353	6/8 (75%)
		Ig strand C	61..66	CDD:409353	3/4 (75%)
		Ig strand C'	69..72	CDD:409353	2/2 (100%)
		Ig strand D	75..83	CDD:409353	0/7 (0%)
		Ig strand E	84..94	CDD:409353	5/9 (56%)
		Ig strand F	102..110	CDD:409353	6/7 (86%)
		Ig strand G	113..123	CDD:409353	3/10 (30%)
		IgI_2_RPTP_IIa_LAR_like	135..234	CDD:409400	45/98 (46%)
		Ig strand B	151..155	CDD:409400	1/3 (33%)
		Ig strand C	164..168	CDD:409400	1/3 (33%)
		Ig strand E	198..202	CDD:409400	2/3 (67%)
		Ig strand F	212..217	CDD:409400	4/4 (100%)
		Ig strand G	224..227	CDD:409400	0/2 (0%)
		IgI_3_RPTP_IIa_LAR_like	247..328	CDD:409401	49/81 (60%)
		Ig strand B	261..265	CDD:409401	1/3 (33%)
		Ig strand C	274..278	CDD:409401	2/3 (67%)
		Ig strand E	295..299	CDD:409401	3/3 (100%)
		Ig strand F	307..312	CDD:409401	4/4 (100%)
		Ig strand G	320..323	CDD:409401	0/2 (0%)
		FN3	331..420	CDD:238020	45/88 (51%)
		FN3	427..519	CDD:238020	44/91 (48%)
		FN3	524..612	CDD:238020	38/91 (42%)
		FN3	620..714	CDD:238020	38/93 (41%)
		fn3	721..820	CDD:394996	34/98 (35%)
		FN3	832..927	CDD:238020	30/101 (30%)
		FN3	930..1021	CDD:238020	28/95 (29%)
		FN3	1031..>1092	CDD:238020	17/106 (16%)
		R-PTPc-D-1	1362..1645	CDD:350472	207/282 (73%)
		R-PTP-D-2	1646..1937	CDD:350476	231/290 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	422	1.000	Domainoid score	I609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H88669
Inparanoid	1	1.050	1249	1.000	Inparanoid score	I163
OMA	1	1.010	-	-		QHG47937
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		otm45268
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.970