DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Osmr

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_001005384.1	Gene:	Osmr / 310132	RGDID:	1302983	Length:	962	Species:	Rattus norvegicus

Alignment Length:	1212	Identity:	226/1212 - (18%)
Similarity:	386/1212 - (31%)	Gaps:	430/1212 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 KAIGNP---TPNIYWIKNQTKVDMSN-----PRYSLKD--GFLQIENSREEDQ-----GKYECVA 211
            |.:|.|   ||.|:.:..|:.:..:|     |.:|.::  ...|||.||....     |.|....
  Rat    25 KVLGEPLQLTPEIHTVSLQSALQEANLEWTVPTFSHQELNIVFQIEISRMRTSNTIWVGNYSTTV 89

  Fly   212 ENSMGTEHSKATN--------LYVKVR------RVPP---------------TFSRPPETI---- 243
            ::. .|.|.|.|:        .::::|      :.||               ..|.||:|:
  Rat    90 KHE-ETVHWKWTSDIPLECATHFIRIRAMVDDAQYPPQSSWSNWSSWKEVNAQVSVPPDTLLIFP 153

  Fly   244 SEVML--GSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAAST 306
            .:.:|  |||:.: |:.:|..:.:|......|.:..|
  Rat   154 EDRLLEEGSNVTI-CLMIGQNLYNVSCKLQEEPIRGE---------------------------- 189

  Fly   307 LGQIDS-VSVVKVQS---LPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYV--IQYKPKN---A 362
              |:|| :|::|:.:   |..|.|::....:..|        |.......:|  :..:|||   .
  Rat   190 --QLDSHLSLIKLNNVVFLNNAGTNINCKAMNGT--------KNTFGTVLFVSKVLEEPKNFSCE 244

  Fly   363 NQAFSEIS-----GI-ITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKM 421
            .:.|..::     || .|:.:..:....||.||                         ||.|.:.
  Rat   245 TRDFKTLNCLWEPGIDTTLSWHKQRSQHYTLYE-------------------------SFSGRRE 284

  Fly   422 ESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSEL 486
            .|..||       |.|..||.:..||       |....|..:|..:.|           .::|..
  Rat   285 VSNHRN-------SHTWQITEDSQET-------YNFTLTAENNLRKRS-----------VSISFN 324

  Fly   487 TPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIV 551
            ..|.::                           |..|.:.....:|.|...:.|..|:.....::
  Rat   325 LTHRVH---------------------------PKAPHDVTLKTVGATKAHMTWKVPSRGDYTLL 362

  Fly   552 -HYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYI---------------WLAARSQRGEG 600
             ..||.......:: |:..:..|..|....|.|||.|..               |:..:.:..|.
  Rat   363 CQVELQCEGEVIHE-HNVSVHTSANYLFSDLEPDTEYKACVRCASANHFWKWSDWMQKKFRTPEA 426

  Fly   601 ATTPPI----PVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDD 661
            |.:..:    .|||:.    .|::         ::|.|.|....::||:||.|.: .||......
  Rat   427 APSEALDVWRDVRTEN----GRHV---------VTLFWKPLLKSQANGKIISYNI-VVENEANPT 477

  Fly   662 EATTMTLNM----TSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATP 722
            |:...::..    |::.||    ...|||.:.|..|.|..|.|..::
  Rat   478 ESEQYSVRAPALGTNLSLD----LHPYKIHISANNSAGASPESLVVL------------------ 520

  Fly   723 LNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKY 787
                |.|...:...||...||..|::|..:.:..:..|:        |||....:.|
  Rat   521 ----SSHSGHEEVHEKTIKGIKNGFNISWEPVSGDAIGY--------VVDWCAHSQT-------- 565

  Fly   788 SIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRL 852
                                                  :|     .:|:|:.
  Rat   566 --------------------------------------QR-----CDLQWKN------------- 574

  Fly   853 RWGVKDQALKEEMLSGPQMTKK--RFDNLERGVEYEFRVAGSNHIGIGQETVKIFQ-----TPEG 910
                          .||.:|..  ..|..|.||.|.||:...:    .:|.|::.:     |.|.
  Rat   575 --------------VGPNITSTIITSDAFEPGVRYNFRIFERS----VEENVRLVEKQRGYTQEL 621

  Fly   911 TPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQF-HKKIDHGLGSERNMTLRKAVF- 973
            .|...| .:||...||:...:.|.....:.::|.|..|.|.. .|::......||.:...|:|.
  Rat   622 APSVNP-GVTIHNLTPNSFSLKWQDYASDFQSGFIKGYLVYLKSKELQCNPNWERTVLSDKSVLC 685

  Fly   974 --------------TNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQ 1024
                          .||...:.|.|.|..||..|.|| ::.....|..|: |:.|.||...
  Rat   686 KYDVDDPETKTLTVENLRPESLYEFLVTPYTSAGQGP-NETYTKVTTPDV-RSHMLLQIIL---- 744

  Fly  1025 TAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKN 1089
                   |:| .|..|...:.|          |:::.|......|:.|     .|..:|.:..|:
  Rat   745 -------PMT-LGVFLSIIVCY----------WKSQWVKEKCYPDIPN-----PYKSSILSLIKS 786

  Fly  1090 GLGRLSEKVTVRIK---PEDVPLNLRAHDVST--------HSMTLSWSPPIRLTPVNYKISFDAM 1143
               :.:..:.:.:|   |:.:.:..:|....|        |:..:...||  |.|.....|....
  Rat   787 ---KKNPHLIMNVKDCIPDVLEVINKAEGSKTQCVGSGKLHTEDVPTKPP--LVPTEKDSSGPMP 846

  Fly  1144 KVFVDSQGFSQTQIVPKREIILKHYVKT--HTINELSPFTTYNVNVSAIPSDY------SYRPPT 1200
            .||:::..:.|:.........:...:|.  |.:..|:|   .|...:.:.:||      |....|
  Rat   847 FVFLENFTYDQSAFDSGSHGFIPGPLKNTPHQLGLLAP---PNKLQNVLENDYMKSLVESPTEET 908

  Fly  1201 KITVTTQMAAPQPMVKPDFYGVVNGEEILVI---LPQASEEY 1239
            .:...:|:|:|          :...::.||.   :|....||
  Rat   909 SLIYVSQLASP----------ICGDKDSLVTNPPMPVHGSEY 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653	21/87 (24%)
		Ig	159..228	CDD:299845	21/88 (24%)
		I-set	234..318	CDD:254352	18/105 (17%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	12/68 (18%)
		fn3	324..404	CDD:278470	16/90 (18%)
		FN3	423..514	CDD:238020	15/90 (17%)
		FN3	520..610	CDD:238020	20/109 (18%)
		FN3	616..707	CDD:238020	23/94 (24%)
		FN3	712..810	CDD:238020	13/97 (13%)
		FN3	832..907	CDD:238020	14/81 (17%)
		FN3	914..1005	CDD:238020	25/106 (24%)
		FN3	1012..1101	CDD:238020	15/88 (17%)
		fn3	1106..1198	CDD:278470	19/107 (18%)
		PTPc	1476..1731	CDD:214550
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
Osmr	NP_001005384.1	FN3	231..>276	CDD:304408	10/44 (23%)
		fn3	333..414	CDD:278470	15/81 (19%)
		WSXWS motif. /evidence=ECO:0000250	413..417		0/3 (0%)
		FN3	440..519	CDD:238020	24/96 (25%)
		fn3	539..607	CDD:278470	20/157 (13%)
		FN3	623..731	CDD:238020	26/109 (24%)
		Box 1 motif. /evidence=ECO:0000250	768..776		2/12 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..840		5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910