DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptprm

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_038939045.1 Gene:Ptprm / 29616 RGDID:620776 Length:1531 Species:Rattus norvegicus


Alignment Length:1860 Identity:503/1860 - (27%)
Similarity:735/1860 - (39%) Gaps:551/1860 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   373 ITMYYVVRA---------LSPYTEYEFYVIAVNNIGRG-----PPSAPATC-----TTGDFSFGG 418
            :.:.::|||         .|.|.||           ||     |.|   ||     ...||::  
  Rat    16 LMLAFLVRAAEICAFVSGFSVYREY-----------RGCLFEEPYS---TCGYSQADDDDFNW-- 64

  Fly   419 TKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTV 483
                     .||.||:..|     ..|..|:|     .......|.:||.. .:.::    |..:
  Rat    65 ---------EQVNTLTKPT-----SDPWMPSG-----SFMLVNTSGKPEGQ-RAHLL----LPQL 105

  Fly   484 SELTPHAI---YTVR---------VQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAV 536
            .|...|.|   |.|.         :..|..:..||:..|:     ..:...|             
  Rat   106 KENDTHCIDFHYFVSSKSNAAPGLLNVYVKVNNGPLGNPI-----WNISGDP------------- 152

  Fly   537 TLQWTKPTHSSENIVHYELYWNDTY------ANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARS 595
                |:..|.:|..|  ..:|.:.|      ....|...::..|...|                 
  Rat   153 ----TRTWHRAELAV--STFWPNFYQVIFEVVTSGHQGYLAIDEVKVL----------------- 194

  Fly   596 QRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGRED 660
              |...|..|..:|.       :|:...|....|...|.:        ||.:.....::: |.:.
  Rat   195 --GHPCTRTPHFLRI-------QNVEVNAGQFATFQCSAI--------GRTVAGDRLWLQ-GIDV 241

  Fly   661 DEATTMTLNMTSI--------VLDELKRWT-EYKIWVLAGTSVGDGPRSHPIILRTQEDVP-GDP 715
            .:|....:.:||.        |::..||.. :|:..:  .|..|.|..::..::..:..|| ..|
  Rat   242 RDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP 304

  Fly   716 Q--DVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELR-DEGKGFLNEPFKFDVVDTLEFN 777
            |  .|.||.|        |   ::.:.|.|.....|.|:|:. ....|..|:.   ..||:..:.
  Rat   305 QLASVGATYL--------W---IQLNANSINGDGPIVAREVEYCTASGSWNDR---QPVDSTSYK 355

  Fly   778 VTGLQPDTKYSIQVAALTRKGDGDRSA---AIVVKTPGGVPVRPTVSLKIME---REPIVSIELE 836
            :..|.|||:|.|.| .|||.|:|...:   |:..:|....|:|....|:::|   |:    |.:.
  Rat   356 IGHLDPDTEYEISV-LLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQ----ITIR 415

  Fly   837 WERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQET 901
            || |.       ||                           |:.|...|...|.....:| |||.
  Rat   416 WE-PF-------GY---------------------------NVTRCHSYNLTVRYCYQVG-GQEQ 444

  Fly   902 VKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNM 966
            |:    .|                     |:|| ....|....||            .|....|:
  Rat   445 VR----EE---------------------VSWD-MDNSHPQHTIT------------NLSPYTNV 471

  Fly   967 TLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDM-GRAPM-SLQAEATSEQTAEIW 1029
            :: |.:..|.|...|                |.:|.|:|:.|: |..|. |:|..|..|:....|
  Rat   472 SV-KLILMNPEGRKE----------------SQELTVQTDEDLPGAVPTESIQGSAFEEKIFLQW 519

  Fly  1030 WEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRL 1094
            .||..:.|.:..|:|.|  .||...|          ...||                 .|..||:
  Rat   520 REPTQTYGVITLYEITY--KAVSSFD----------PEIDL-----------------SNQSGRV 555

  Fly  1095 SEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVP 1159
            |:...                 .||.:...                                   
  Rat   556 SKLGN-----------------ETHFLFFG----------------------------------- 568

  Fly  1160 KREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVN 1224
                             |.|.|||:..:.|..:. .:.||.....||:::||. |...:|...:|
  Rat   569 -----------------LYPGTTYSFTIRASTAK-GFGPPATNQFTTKISAPS-MPAYEFETPLN 614

  Fly  1225 GEE--ILVILPQASEEYGPISHYYLVVVPEDKSNLHK---------IPDQFLTDDLLPGRNKPER 1278
            ..:  :.|:|..|.....|:|.|.:||..|......|         :|..|....:|..:.    
  Rat   615 QTDNTVTVLLKPAQSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASILNSQY---- 675

  Fly  1279 PNAPYIAAKFPQRSI----PFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAV------------- 1326
                |.||:||..|:    |||  :|....|:.:.|..|...|.|||:.:|.             
  Rat   676 ----YFAAEFPADSLQAAQPFT--IGDNKTYNGYWNTPLLPHKSYRIYYQAASRANGETKIDCVR 734

  Fly  1327 VDTPQKHLYT--SSPFSEFLSLDMREAP---PGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVL 1386
            |.|....:.|  ::|:       :|.||   .|:......|....|||...:..   .:|..|:.
  Rat   735 VATKAAIIVTQLTTPY-------IRIAPAAGDGQLTGAVTPKPVPEPEKGTDHT---VKIAGVIA 789

  Fly  1387 PLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMA----------ADLGAG--------- 1432
            .:::...|.   |.|:.|:|:|:...|..:..:.||..|.          |:.|..         
  Rat   790 GILLFVIIF---LGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMD 851

  Fly  1433 -------------------------------PTPSDP-----VDMRRL----NFQTPGMIS---- 1453
                                           |.|..|     ....||    |.:|..|.|    
  Rat   852 THNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILGAQQTRLSVPINDETHTMASDTSS 916

  Fly  1454 ----------------------HPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSN 1496
                                  ||.|.:::...||.::|..:...|.:||||...||...||::.
  Rat   917 LAQPHTYKKREAADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAK 981

  Fly  1497 LEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWR 1561
            .:.|:.||||.|:.|||||||:|..:||...|||||.||.|||.:.|.|:|||||:|||..||||
  Rat   982 KDENRMKNRYGNIIAYDHSRVRLQMLEGDNSSDYINGNYIDGYHRPNHYIATQGPMQETVYDFWR 1046

  Fly  1562 MCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTF-------- 1618
            |.|...||:|:|:|.|.|..|:||.:|||. .||.|..|.||:.:|:.||.|.||||        
  Rat  1047 MVWYENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIDTELLAEYVIRTFAVEKGGAG 1110

  Fly  1619 ---------QLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCS 1674
                     ::.::|.::.|||:|..||.|||||||.|....|.|:|:.::.:||.:||::||||
  Rat  1111 GEANCSPSREVPQRGIHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPNAGPLVVHCS 1175

  Fly  1675 AGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTE 1739
            ||.|||||:||||.||:..:.|.::|||..|..||::|..|||||:||:|||||||||.:||.|.
  Rat  1176 AGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTS 1240

  Fly  1740 VPA---RNLHTHLQKLLITEPGETISGMEVEFKKLSNVK-----MDSSKFVTANLPCNKHKNRLV 1796
            :||   |:|:..:.||   :|....|.::.||:.|:.|.     .|.|   .|.||.|..|||.:
  Rat  1241 IPASQVRSLYYDMNKL---DPQTNSSQIKEEFRTLNMVTPTLRVEDCS---IALLPRNHEKNRCM 1299

  Fly  1797 HILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVV 1861
            .|||.:....:|..|.| |.|:|:||:.:|.|:..||:|..|.|:.:..:||||::.:::.|.||
  Rat  1300 DILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVV 1363

  Fly  1862 MLTKLKEMGREKCFQYWPHERSVRY---QYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQF 1923
            ||..:..  .:.|.||||.....|:   |...|....|.::.....|.:..:..:|| .|.|:||
  Rat  1364 MLNDVDP--TQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNASRPQDG-HRMVQQF 1425

  Fly  1924 QFIDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPITVHCSAGVGRSGVFITLSIVLERMQY 1986
            ||:.|| .:..|.|...|:..|.||.|.:|:: |.:|...|||..|.||||.|..:|||.|.:::
  Rat  1426 QFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1490

  Fly  1987 EGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026
            :..:|||..|:.||:.:|.||...|||.|||..|||||.:
  Rat  1491 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNA 1530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470 10/44 (23%)
FN3 423..514 CDD:238020 21/102 (21%)
FN3 520..610 CDD:238020 13/95 (14%)
FN3 616..707 CDD:238020 17/99 (17%)
FN3 712..810 CDD:238020 30/104 (29%)
FN3 832..907 CDD:238020 15/74 (20%)
FN3 914..1005 CDD:238020 15/90 (17%)
FN3 1012..1101 CDD:238020 21/89 (24%)
fn3 1106..1198 CDD:278470 8/91 (9%)
PTPc 1476..1731 CDD:214550 138/271 (51%)
PTPc 1503..1731 CDD:238006 128/244 (52%)
PTPc 1763..2022 CDD:214550 99/268 (37%)
PTPc 1791..2022 CDD:238006 89/235 (38%)
PtprmXP_038939045.1 FN3 298..377 CDD:214495 29/93 (31%)
FN3 399..493 CDD:238020 34/188 (18%)
fn3 515..590 CDD:394996 24/173 (14%)
R-PTPc-M-1 946..1235 CDD:350481 144/289 (50%)
R-PTPc-M-2 1321..1526 CDD:350483 78/207 (38%)
MAM 42..198 CDD:214533 39/227 (17%)
ig 208..290 CDD:395002 17/92 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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