Protein Alignment Lar and PTPN22

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_057051.4
• Gene: PTPN22 / 26191
• HGNCID: 9652
• Length: 807
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 109/290 - (37%)
• Similarity: 154/290 - (53%)
• Gaps: 24/290 - (8%)

  Fly  1749 LQKLLITEPGETISGMEV--EFKKLSNVKMDSSKF--------VTANLPCNKHKNRLVHILPYES 1803
            |||.|.....:.|:..|.  ||.||   |..|:|:        ..|..|.|..|||...||||:.
Human     7 LQKFLDEAQSKKITKEEFANEFLKL---KRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDY 68

  Fly  1804 SRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKE 1868
            |||.|:.|...|.|.|:||:||.|.....||||.|||:.....|||||:||::..|:||.....|
Human    69 SRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYE 133

  Fly  1869 MGREKCFQYW--PHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQ 1931
            ||::||.:||  |.|..:.:..:.|...||.....|.:|..||  ..:..:||:.||.:.:||:.
Human   134 MGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV--KFNSETRTIYQFHYKNWPDH 196

  Fly  1932 GVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVL----DV 1992
            .||.|.:..::.|..|...:|.  ...||.:|||||.||:||...:......:: :|::    .|
Human   197 DVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYTWMLLK-DGIIPENFSV 258

  Fly  1993 FQTVRILRSQRPAMVQTEDQYHFCYRAALE 2022
            |..:|.:|:|||::|||::||...|.|.||
Human   259 FSLIREMRTQRPSLVQTQEQYELVYNAVLE 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401
		R-PTP-LAR-2	1784..2021	CDD:350402	94/242 (39%)
PTPN22	NP_057051.4	PTPc-N22	57..290	CDD:350450	93/237 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..700
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..746