DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Ptprc

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_612516.2	Gene:	Ptprc / 24699	RGDID:	3451	Length:	1273	Species:	Rattus norvegicus

Alignment Length:	1041	Identity:	304/1041 - (29%)
Similarity:	464/1041 - (44%)	Gaps:	176/1041 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1069 DLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLR--AHDVSTH-SMTLSWSPPIR 1130
            :|.||.:.:|..|.::    ||.....:.:.:.:.|.....||.  ..|:..: |:.|.|....:
  Rat   234 ELKNLPECSQKNVTLS----NGSCTPDKIINLDVPPGTHNFNLTNCTPDIEANTSICLEWKIKNK 294

  Fly  1131 LTPVNYKISFD-----AMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAI 1190
            .|....|||::     .||.|.          :.|...:..|.:...|....:....|| ||..:
  Rat   295 FTCDIQKISYNFRCTPEMKTFA----------LDKHGTLWLHNLTVRTNYTCAAEVLYN-NVILL 348

  Fly  1191 PSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDK- 1254
            ..|.        .|.|....|:.:.........|...::.....||:.:|.|..|  ...|.:|
  Rat   349 KQDR--------RVQTDFGTPEMLPHVQCKNSTNSTTLVSWAEPASKHHGYILCY--KKTPSEKC 403

  Fly  1255 SNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKF-----------PQRSIPFTFHLG-------- 1300
            .||....:.|...:|        ||...|..:.|           |.:...|.....
  Rat   404 ENLANDVNSFEVKNL--------RPYTEYTVSLFAYVIGRVQRNGPAKDCNFRTKAARPGKVNGM 460

  Fly  1301 ----SGDDYHNFT-NRKLE---REKRYRIFVRA---------------VVDTPQKHLYTSSPFSE 1342
                :.|:..|.| |...|   .|.||.:.|::               |||    :||.|:.: |
  Rat   461 KTSRASDNSINVTCNSPYEINGPEARYILEVKSGGSLVKTFNQSTCKFVVD----NLYYSTDY-E 520

  Fly  1343 FLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCV--- 1404
            ||.....    ||        :..:||:.........:.|.:.|..::  .:.|.||:|:..
  Rat   521 FLVYFYN----GE--------YLGDPEIKPQSTSYNSKALIIFLVFLI--IVTSIALLVVLYKIY 571

  Fly  1405 -VKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIER 1468
             ::::|.......|..|.|......:...|..||      |..:|                 .:|
  Rat   572 DLRKKRSSNLDEQQELVERDEEKQLINVDPIHSD------LLLET-----------------YKR 613

  Fly  1469 LKSNDNQKFSQEYESI-EPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYIN 1532
            ..:::.:.|..|::|| ....:|...::....|::||||.::..||::||:|..:.|..||.|||
  Rat   614 KIADEGRLFLAEFQSIPRVFSKFPIKDARKSQNQNKNRYVDILPYDYNRVELSEINGDAGSTYIN 678

  Fly  1533 ANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWP--TRGTE 1595
            |:|.||:::...|:|.|||..||..|||:|.||.|...|||:||.||..|.||.:|||  ..||.
  Rat   679 ASYIDGFKEPRKYIAAQGPRDETVDDFWKMIWEQKATVIVMVTRCEEGNRNKCAEYWPCMEEGTR 743

  Fly  1596 TYGQIFVTITETQELATYSIRTFQLCRQ-----GFNDRREIKQLQFTAWPDHGVPDHPAPFLQFL 1655
            |:..:.|||.:.:....|.|:...:..:     |    ||:..:|||:|||||||:.|...|:..
  Rat   744 TFRDVVVTINDHKRCPDYIIQKLSIAHKKEKATG----REVTHIQFTSWPDHGVPEDPHLLLKLR 804

  Fly  1656 RRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTED 1720
            ||..|.:...|||::|||||||||||.||.||:|||.::.|..:|:||:|..||.||..|||.|.
  Rat   805 RRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLESLEAEGKVDVYGYVVNLRRQRCLMVQVEA 869

  Fly  1721 QYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTAN 1785
            |||.||.|::|....|.|||....||:.||.|...:|....|.:|.|:::|.:.:...::.: .|
  Rat   870 QYILIHQALVEYNQFGETEVNLSELHSCLQNLKKRDPPSDPSPLEAEYQRLPSYRSWRTQHI-GN 933

  Fly  1786 LPCNKHKNRLVHILPYESSRVYLTPIHGI---------------------EGSDYVNASFIDGYR 1829
            ...||.|||..:::||:.:||.|.  |.:                     |.|.|:||||:..|.
  Rat   934 QEENKKKNRSSNVVPYDFNRVPLK--HELEMSKESEAESDESSDEDSDSEETSKYINASFVMSYW 996

  Fly  1830 YRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPI 1894
            .....||||||:::...|||:|:::....::||||:|....:|.|.|||...:.......|:  :
  Rat   997 KPEMMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELMSGDQEVCAQYWGEGKQTYGDMEVM--L 1059

  Fly  1895 AEYNMPQ-YKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1958
            .:.|... |.||.|::..::....|||.|:|...|..:.:|...:..:..|..:.:...:.|.:|
  Rat  1060 KDTNKSSAYILRAFELRHSKRKEPRTVYQYQCTTWKGEELPAEPKDLVTLIQNIKQKLPKSGSEG 1124

  Fly  1959 -------PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFC 2016
                   .|.|||..|..::|:|..|..:||..:.|.|:||||.|:.||..||.||.:.:||.|.
  Rat  1125 MKYHKHASILVHCRDGSQQTGLFCALFNLLESAETEDVVDVFQVVKSLRKARPGMVGSFEQYQFL 1189

  Fly  2017 Y 2017
            |
  Rat  1190 Y 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020	7/31 (23%)
		fn3	1106..1198	CDD:278470	21/99 (21%)
		PTPc	1476..1731	CDD:214550	118/262 (45%)
		PTPc	1503..1731	CDD:238006	112/234 (48%)
		PTPc	1763..2022	CDD:214550	86/284 (30%)
		PTPc	1791..2022	CDD:238006	80/256 (31%)
Ptprc	NP_612516.2	PTP_N	5..27	CDD:289238
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..192
		CD45	203..257	CDD:289344	7/26 (27%)
		FN3	366..431	CDD:238020	16/74 (22%)
		FN3	454..534	CDD:238020	20/96 (21%)
		PTPc	621..880	CDD:214550	118/262 (45%)
		PTPc	649..880	CDD:238006	112/234 (48%)
		Substrate binding. /evidence=ECO:0000250	822..828		5/5 (100%)
		PTPc	913..1194	CDD:214550	86/283 (30%)
		PTPc	939..1194	CDD:238006	80/256 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..984		1/23 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1219..1273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810