DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptgs1

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_058739.4 Gene:Ptgs1 / 24693 RGDID:3439 Length:602 Species:Rattus norvegicus


Alignment Length:483 Identity:98/483 - (20%)
Similarity:152/483 - (31%) Gaps:168/483 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1116 VSTHSMTLSW----------SPPIRLT------PVN-------------YKISFDAMKVFVDSQG 1151
            :|..|::|.:          .||:.||      |||             .:...|..:......|
  Rat     1 MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCDCTRTG 65

  Fly  1152 FS-------------QTQIVPKREIILKHYVKTH-----------TINELSPFTTYNVNVSAIPS 1192
            :|             ::.:.|...  ..|::.||           .|.|:.......|..:.|||
  Rat    66 YSGPNCTIPEIWTWLRSSLRPSPS--FTHFLLTHGYWIWEFVNATFIREVLMRLVLTVRSNLIPS 128

  Fly  1193 DYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVV--VPED-- 1253
                 |||..|....:                          :.|.:..:|:|..::  ||:|  
  Rat   129 -----PPTYNTAHDYI--------------------------SWESFSNVSYYTRILPSVPKDCP 162

  Fly  1254 ----KSNLHKIPD-QFLTDDLLPGRN---KPERPNA--PYIAAKFPQRSIP--------FTFHLG 1300
                .....::|| ..|...||..|.   .|:..|.  .:.|..|..:...        ||..||
  Rat   163 TPMGTKGKKQLPDIHLLAQRLLLRREFIPAPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALG 227

  Fly  1301 SGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSS----PFSEFLSLDMREAPPGERPHRPD 1361
            .|.|..:.....|||:...|:|    .|...|:.....    |..|..|:.|| .|||.      
  Rat   228 HGVDLGHIYGDSLERQYHLRLF----KDGKLKYQVLDGEVYPPSVEQASVLMR-YPPGV------ 281

  Fly  1362 PNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMA 1426
               |.|.:::|.:     |:..::..||:.:.|.......:|.:.:...|....:|...|..|:.
  Rat   282 ---PPEKQMAVGQ-----EVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLIL 338

  Fly  1427 ADLGAGPT-------------------PSDPVDMRRLNFQTPGMISHPPIPISEFANHI---ERL 1469
                .|.|                   ..||..:.|..||....|:      .|| ||:   ..|
  Rat   339 ----IGETIKIIIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIA------LEF-NHLYHWHPL 392

  Fly  1470 KSNDNQKFSQEYESIEPGQQFTWDNSNL 1497
            ..:..|..||||..    :||.::.|.|
  Rat   393 MPDSFQVGSQEYSY----EQFLFNTSML 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020
FN3 520..610 CDD:238020
FN3 616..707 CDD:238020
FN3 712..810 CDD:238020
FN3 832..907 CDD:238020
FN3 914..1005 CDD:238020
FN3 1012..1101 CDD:238020
fn3 1106..1198 CDD:278470 23/134 (17%)
PTPc 1476..1731 CDD:214550 8/22 (36%)
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
Ptgs1NP_058739.4 EGF_CA 35..72 CDD:238011 5/36 (14%)
prostaglandin_endoperoxide_synthase 92..578 CDD:188648 84/390 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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