DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptprq

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001357916.1 Gene:Ptprq / 237523 MGIID:1096349 Length:2301 Species:Mus musculus


Alignment Length:2417 Identity:538/2417 - (22%)
Similarity:862/2417 - (35%) Gaps:824/2417 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LSLLVLSLLTWTHP------TIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKN 72
            ::|..:|..|::.|      |.|....||..:     .|.|||. |....:....|.|      |
Mouse    32 ITLSSISATTYSSPVSRTLATNVSKPGPPVFL-----AGERVGS-AGILLSWNTPPNP------N 84

  Fly    73 GKKVS----------GTQSRYT-VLEQPGGISIL--RIEPVRAGRDDAPYE--CVAENGVGDAVS 122
            |:.:|          ..|:.|| |..:|..:.:|  .:.|      ...||  ..|||..|..|.
Mouse    85 GRIISYVVKYKEVCPWMQTAYTRVRAKPDSLEVLLTNLNP------GTTYEIKVAAENSAGIGVF 143

  Fly   123 ADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYW-IKNQT-------K 179
            :|           |..|......|       |..|.:|.:|:.....|:.| :..|.       |
Mouse   144 SD-----------PFLFQTAESAP-------GKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFK 190

  Fly   180 VDMSNPRYSL--KDGFLQIENSREEDQGKYECVAENS--------------------MGTEH--- 219
            :.:.:.|..:  ||..:::|:..   .||.....|||                    :.|.|   
Mouse   191 ISVKHARSGIVVKDVSIKVEDLL---SGKLPECNENSDSFLWSTTSPSPTLSRATPPLRTTHLSN 252

  Fly   220 SKATNLYVKVRRVP-----------------------------PTFSRPPETISEVMLGSNLNLS 255
            :.|.|....|.:.|                             .|..|.||::.|   |...|  
Mouse   253 TLARNKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVRTPESVPE---GPPQN-- 312

  Fly   256 CIA--VGSPMPHVKW-----MKGSEDLTPENEMPIGRNVLQLINIQESANY------------TC 301
            ||.  |......:.|     :.|......|...|.||   .|.|..:...:            ..
Mouse   313 CITGNVTGKAFSISWDPPAIVTGKFSYRVELYGPTGR---ILDNSTKDLRFVFTHLTPFTMYDVY 374

  Fly   302 IAAST---LGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNA- 362
            :||.|   :|...::||.....:|.|..|:||.||.||.:|:.|  :.|......:.||:.|.: 
Mouse   375 VAAETSAGVGPKSNLSVFTPPDVPGAVFDLQIVEVEATEIRVSW--RKPRQPNGIISQYRVKVSV 437

  Fly   363 --------------------NQAFSEISGIIT--------------------------------- 374
                                |....||..::.                                 
Mouse   438 LESGVILENTLLTGQDEYINNPMTPEIMNLVDPMIGFYEGSGEMSSDLHSLASFIYNSHPHDFPA 502

  Fly   375 ---------------------------MYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTG 412
                                       :.||:|.|.|:||:...|.|...:|.|||:.....|  
Mouse   503 RTRVEDQRSPVVVATRNQYMTDIAAEHLSYVIRRLVPFTEHTISVSAFTVMGEGPPTVLTVRT-- 565

  Fly   413 DFSFGGTKMESAPRNVQV---RTLSSSTMVITWEPPETPNGQVTGYKVY---------------- 458
                    .|..|.::|:   :.:|||::::.|:|||.|||::|.|.:|                
Mouse   566 --------REQVPSSIQIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQMTTVD 622

  Fly   459 ----------YT--------------------------TNSNQPEAS-----------------W 470
                      ||                          |..::||:|                 |
Mouse   623 NSFLITGLKKYTRYKMRVAASTHVGESSLSEENDLFVRTPEDEPESSPQDVKVTDVSPSELSLTW 687

  Fly   471 --------------------NSQMVDNSELT--TVSELTPHAIYTVRVQAYTSMGAGPMSTP-VQ 512
                                ::..|.|:..|  |:|:|.|:.:|.:.:|:||.:|.|..|:. :.
Mouse   688 SPPEKPNGIIIAYEVFYQNADALFVKNTSTTNITLSDLKPYTLYNISIQSYTRLGHGNQSSSLLS 752

  Fly   513 VKAQQGVP-SQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRI--SNSE 574
            |:..:.|| |.|.|....:|....:.:.:..|...:..|..|.:|..   .:.:|..|.  :.|.
Mouse   753 VRTSETVPDSAPENITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLK---RSNSHEARTIETTSL 814

  Fly   575 AYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYG--APPRNITAIATSSTTISLSWLPP 637
            ..|:.||...|.|.|.::|.:.:|||..:.||.:.|::..  :||:|.:....|..|:.||| .|
Mouse   815 TLTIGGLKKYTHYVIEVSASTLKGEGVRSMPISILTEEDAPDSPPQNFSVKQLSGVTVMLSW-QP 878

  Fly   638 PVERSNGRIIYYKVFFVEVGREDDEATTMTLNMT--SIVLDELKRWTEYKIWVLAGTSVGDG-PR 699
            |:| .||.|:||.|:..      |:.:..|:|.|  |:.|.:|....:|..:|.|.|..||| .|
Mouse   879 PLE-PNGIILYYTVYVW------DKVSLKTINATEVSLELSDLDYHADYSAYVTASTRFGDGKTR 936

  Fly   700 SHPIILRTQEDVPGD-PQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLN 763
            |..|..||.|..|.| |:||....|:|:||.:.|.||::.  ||||:.|.::.|   :....|:.
Mouse   937 SSVINFRTPEGEPSDPPKDVHYVNLSSSSIILFWTPPVKP--NGIIQYYSVYYQ---NTSSTFVQ 996

  Fly   764 EPFKFDVVD-----TLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIV-VKTPGGVPVRPTVSL 822
            .....:|..     |:...:..|...:.|:..:.|.|..|:|::|:.:: |.|...:|.....:|
Mouse   997 NFTLLEVTQEPGNVTVSARIYKLAVFSYYTFWLTASTLVGNGNKSSDVIHVYTDQDIPEGGVGNL 1061

  Fly   823 KIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKR----FDNLERGV 883
             ..|.....:|.:.|..|:|..| |..|.:...::....:...   |.:|...    |||||:..
Mouse  1062 -TYESLSSTAINVSWTPPSQPNG-LVFYYVSLNLQQSPPRHRR---PPLTTYENSIYFDNLEKYT 1121

  Fly   884 EYEFRVAGS-------------------------------------------------------- 892
            :|.|::..|                                                        
Mouse  1122 DYIFKITPSTEKGFSETYTAQLHIKTEEDVPDTPPIINTFKNLSSTSILLSWDPPLKPNGAILSY 1186

  Fly   893 -----------------NHI---------------------GIGQETVKIFQTPEGTPGGPPSNI 919
                             |||                     |:|..::..|.|.|..|..||.|:
Mouse  1187 HLTLQGTHANRTFVTSGNHIVLEELSPFTLYSFLAAARTMKGLGPSSILFFYTDESAPLAPPQNL 1251

  Fly   920 TI-------------------------------------------RFQT---------------- 925
            |:                                           .|||                
Mouse  1252 TLINYTSDFVWLTWSPSPLPGGIVKVYSFKIHEHETDTVFYKNISGFQTDAKLAGLEPVSTYSIS 1316

  Fly   926 -------------------------PD----VLCVT---------WDPPTREHRNGIITRYDVQF 952
                                     ||    :.||.         ||||.:  .||||..|.:..
Mouse  1317 VSAFTKVGNGNQFSNVVKFTTQESVPDAVQNIACVARDWQSVSVMWDPPRK--ANGIIIHYMITV 1379

  Fly   953 HKKIDHGLGSERNMTLRKAV--FTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMS 1015
            .       |:...::.|..:  ||.|..||.|||.|||.|..|.|.       |::.::...|.:
Mouse  1380 E-------GNSTKVSPRDPMYTFTKLLANTSYIFEVRASTSAGEGN-------ESQCNVSTLPET 1430

  Fly  1016 LQAEATSEQTAEI--------WWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTK----------TV 1062
            :.:..|:...:.:        |.:|.|..|....||| .|....:...:|:.:          ..
Mouse  1431 VPSVPTNTAFSNVQSTSVTLRWIKPDTILGYFQNYKI-TTQLRAQKCREWEPEECVEHQEVQYLY 1494

  Fly  1063 GLTESADLV-NLEKFAQYAVAIAARFKNGLGRLSEKVTVRI---KPEDVPLNLRAHDVSTHSMTL 1123
            ...::.|.| .|:||..|...:||....|.|..|..::.:.   .|:..|.|:|....|...:.:
Mouse  1495 EANQTEDTVRGLKKFQWYRFQVAASTNAGYGNASSWISTQTLPGPPDGPPENVRVVATSPFGINI 1559

  Fly  1124 SWSPPIRLT-PVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNV-- 1185
            ||:.|..:| |..|.|...:    ||:..|:.:.:....|      .||..||:|..||.|:|  
Mouse  1560 SWNEPAIITGPTFYLIDVKS----VDNDNFNISFVKSNEE------NKTTEINDLEVFTRYSVVI 1614

  Fly  1186 -----NVS------------------AIPSD------------------YSYRPPT--------- 1200
                 |||                  ::|.|                  .|:.||:         
Mouse  1615 TAFVGNVSGAYTDGKSSAEVIITTLESVPKDPPNNMTFQKIPDEVTKFQLSFLPPSQPNGNIQVY 1679

  Fly  1201 ---------------------------------------------------------KITVTTQM 1208
                                                                     ::.:|..:
Mouse  1680 QALVYREDDPTAVQIHNLSIIQKTDTSVIAMLEGLKGGHTYNISVYAINSAGAGPKVQMRITMDI 1744

  Fly  1209 AAP-QPMVKP----DFYG--VVNGEEILVILP--QASEEYGPISHYYLVVV---PEDKSNLHKIP 1261
            .|| :|..||    |..|  :|....|.:.:|  ..::::|||.:..::|.   .:...|:.|..
Mouse  1745 KAPARPKTKPIPIHDATGKLLVTSTTITIRMPICYYNDDHGPIRNVQVLVAEAGAQQDGNVTKWY 1809

  Fly  1262 DQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGD------DYHNFTNRKLEREKRYR 1320
            |.:. :...|.......||.|.|..|.........:.:|:.:      :.....|..|:.:|:|.
Mouse  1810 DAYF-NKARPYFTNEGFPNPPCIEGKTKFSGNEEIYVIGADNACMIPGNEEKICNGPLKPKKQYL 1873

  Fly  1321 IFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDE--PEILW 1383
            ...||   |.....:|.|.:|                         :|..::.....|  .||:.
Mouse  1874 FKFRA---TNVMGQFTDSEYS-------------------------DPIKTLGEGLSERTVEIIL 1910

  Fly  1384 VVLPLMVSTFIVSTALIVLCVVKRRRQPCKT--PDQAAV-------TRPLMAADLGAGPTPSDPV 1439
            .|...::|..::.||:.....::::::...|  |..|.:       .:.:..|||..    .|..
Mouse  1911 SVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPRDAEIIDTKFKLDQLITVADLEL----KDER 1971

  Fly  1440 DMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPG-QQFTWDNSNLEHNKSK 1503
            ..|.|:::.    |..|:....|..|:|.|.:|:|.||.:|:..:... |..:..:::|..|::|
Mouse  1972 LTRLLSYRK----SIKPVSKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAK 2032

  Fly  1504 NRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKT 1568
            ||:.|:..|:::||:|.|...:.|||||||:|..||...|.::||||||..|..|||||.||.:.
Mouse  2033 NRFPNIKPYNNNRVKLIADVSIPGSDYINASYVSGYLCPNEFIATQGPLPGTVGDFWRMVWETRA 2097

  Fly  1569 ATIVMMTRLEERTRIKCDQYWP--TRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREI 1631
            .|:||:|:..|:.||:|.||||  .:....:|.|.:|.........::||..::.|.|  |...:
Mouse  2098 KTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDILITKLMEDIQIDWTIRDLKIERHG--DCMTV 2160

  Fly  1632 KQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHE 1696
            :|..||.||:||||::..|.:.|::..|.....::.|::|||||||||||.:|.:|.:.:.:...
Mouse  2161 RQCNFTGWPEHGVPENTTPLIHFVKLVRTSRAHDATPMVVHCSAGVGRTGVFIALDHLTQHIHDH 2225

  Fly  1697 KIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI--------ICGVTEVPARNLHTHLQKLL 1753
            ..:||||.|..||::|..|||...||||:|..||:.:        :|.|.       ::.|||: 
Mouse  2226 DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGGHQPVCFVN-------YSTLQKM- 2282

  Fly  1754 ITEPGETISGME 1765
                 :::..||
Mouse  2283 -----DSLDAME 2289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 27/108 (25%)
I-set 36..129 CDD:254352 26/107 (24%)
IG_like 146..227 CDD:214653 22/113 (19%)
Ig 159..228 CDD:299845 19/101 (19%)
I-set 234..318 CDD:254352 24/105 (23%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 19/89 (21%)
fn3 324..404 CDD:278470 29/160 (18%)
FN3 423..514 CDD:238020 36/185 (19%)
FN3 520..610 CDD:238020 24/92 (26%)
FN3 616..707 CDD:238020 34/93 (37%)
FN3 712..810 CDD:238020 29/104 (28%)
FN3 832..907 CDD:238020 23/172 (13%)
FN3 914..1005 CDD:238020 36/189 (19%)
FN3 1012..1101 CDD:238020 22/107 (21%)
fn3 1106..1198 CDD:278470 30/135 (22%)
PTPc 1476..1731 CDD:214550 103/257 (40%)
PTPc 1503..1731 CDD:238006 97/229 (42%)
PTPc 1763..2022 CDD:214550 2/3 (67%)
PTPc 1791..2022 CDD:238006
PtprqNP_001357916.1 FN3 57..151 CDD:238020 29/122 (24%)
FN3 308..393 CDD:238020 19/89 (21%)
fn3 399..>441 CDD:365830 14/43 (33%)
FN3 570..654 CDD:238020 17/83 (20%)
fn3 668..744 CDD:365830 14/75 (19%)
FN3 762..850 CDD:238020 23/90 (26%)
fn3 857..934 CDD:365830 30/84 (36%)
FN3 951..1049 CDD:238020 28/102 (27%)
FN3 1056..1137 CDD:238020 19/85 (22%)
FN3 1152..1233 CDD:238020 5/80 (6%)
FN3 1247..1337 CDD:238020 7/89 (8%)
FN3 1342..1421 CDD:238020 30/94 (32%)
FN3 1432..1535 CDD:238020 21/103 (20%)
FN3 1542..1638 CDD:238020 27/105 (26%)
FN3 1645..1734 CDD:238020 4/88 (5%)
UP_III_II 1759..1928 CDD:297589 37/197 (19%)
R-PTPc-Q 2033..2256 CDD:350464 94/224 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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