DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and IGSF9B

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	1671	Identity:	315/1671 - (18%)
Similarity:	522/1671 - (31%)	Gaps:	613/1671 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 THPTIVDAAHPPEIIRKPQNQGVRVGGVASFYC----AARGDPPPSIV-WRKNGKKVS-----GT 79
            |.....:.||  .:..:|:....|.|......|    ...|.|||.:| |.|.|..:.     |.
Human    15 TRGLAAEGAH--GLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGY 77

  Fly    80 QSRYTVLEQPGGISI-----LRIEPVRAGRDDAPYEC----------VAENG--VGDAVSADATL 127
            ...:...|..|..|:     ||:|.||: .|...|||          ...||  |...::|..|.
Human    78 YPPHVDPEYAGRASLHDKASLRLEQVRS-EDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTF 141

  Fly   128 TIYEGDKTPAGFPVITQGPGTRVIEV--GHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLK 190
            |     :||..:           ||.  |.::.|||.|.|||.|.:.|:|..|.:..|. :|.:.
Human   142 T-----ETPPQY-----------IEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASG-KYQVS 189

  Fly   191 DGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLS 255
            ||.|.:.:...||:|.|.|.|.:..| |....|:|.|   :.||....|||.|: |.:..:..|:
Human   190 DGSLTVTSVSREDRGAYTCRAYSIQG-EAVHTTHLLV---QGPPFIVSPPENIT-VNISQDALLT 249

  Fly   256 CIAVGSP--MPHVKWMKGSEDLTPENEMPI-------GRNVLQLINIQESANYTCIAASTLGQID 311
            |.|...|  :.:. |....|::..:|::.:       |..::..:..::|..|||:.:::||:..
Human   250 CRAEAYPGNLTYT-WYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKYTCVPSNSLGRSP 313

  Fly   312 SVSV-------VKVQSLP-------------TAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQ 356
            |.|.       .:|.::|             ..|.|   :|..||.|:  |:..| ..||.
Human   314 SASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVD---AEPPATVVK--WNKDG-RPLQV---- 368

  Fly   357 YKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSF----- 416
              .||......|...|........||..||     .:..|.:|....||||.....|..:
Human   369 --EKNLGWTLMEDGSIRIEEATEEALGTYT-----CVPYNTLGTMGQSAPARLVLKDPPYFTVLP 426

  Fly   417 GGTKMESAPRNVQVRTLSSST--MVITW----EPPETPNGQVTGYKVYYTTNSNQPEASWN---- 471
            |....:.|.|.:.:...::..  .||||    :|..:.:..:....:.:...|.:....|.
Human   427 GWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSKEDHGEWECVAT 491

  Fly   472 ---SQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGE 533
               :.:..::.||.:. .:|||..:||||  .||      |...|..:.|.          |.|.
Human   492 NVVTSITASTHLTVIG-TSPHAPGSVRVQ--VSM------TTANVSWEPGY----------DGGY 537

  Fly   534 TAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRIS-----NSEAYTLDGLYPDTLYYIWLAA 593
            ......|.|                  .|....|..:|     ......:|.|.|:|.|...:.|
Human   538 EQTFSVWMK------------------RAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLA 584

  Fly   594 RSQRGEGATTPPIPVRTKQYG----------APPRNITAIATSSTTISLSWLPP-----PVERSN 643
            :::.|..|.:..:.|.|..:.          .|||.:.|..|....: ||||||     |::|
Human   585 QNKLGTSAFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQQGVL-LSWLPPANHSFPIDR-- 646

  Fly   644 GRIIYYKVF----FVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPII 704
             .|:.::|.    .::.|....|......:::.      ..|.|::                  :
Human   647 -YIMEFRVAERWELLDDGIPGTEGEFFAKDLSQ------DTWYEFR------------------V 686

  Fly   705 LRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFD 769
            |...:|:..:|.::..  ::||.|..  :|.|.:|  |:.|                   |....
Human   687 LAVMQDLISEPSNIAG--VSSTDIFP--QPDLTED--GLAR-------------------PVLAG 726

  Fly   770 VVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKI-MEREPIVSI 833
            :|.|:.|                         .:|||:..|.....|......|: .:::|.:||
Human   727 IVATICF-------------------------LAAAILFSTLAACFVNKQRKRKLKRKKDPPLSI 766

  Fly   834 ELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIG 898
                     |:..            ::|:..:.||.                           :.
Human   767 ---------THCR------------KSLESPLSSGK---------------------------VS 783

  Fly   899 QETVKIFQTPEGT---PGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGL 960
            .|:::..:.|..:   .|.|.:...:             .||||.        ::..:||....:
Human   784 PESIRTLRAPSESSDDQGQPAAKRML-------------SPTREK--------ELSLYKKTKRAI 827

  Fly   961 GSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQT 1025
            .|::....:                                                |||.:|.|
Human   828 SSKKYSVAK------------------------------------------------AEAEAEAT 844

  Fly  1026 AEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNG 1090
            ..|   .:.|||.                                             ..||.
Human   845 TPI---ELISRGP---------------------------------------------DGRFV-- 859

  Fly  1091 LGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQT 1155
                       :.|.::..:|::.               |:....:....|....|..|...::.
Human   860 -----------MDPAEMEPSLKSR---------------RIEGFPFAEETDMYPEFRQSDEENED 898

  Fly  1156 QIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPT-------------------K 1201
            .:||.....||        ::|:|.::         |..||.||.                   :
Human   899 PLVPTSVAALK--------SQLTPLSS---------SQESYLPPPAYSPRFQPRGLEGPGGLEGR 946

  Fly  1202 ITVTTQM--AAPQPMVKPDFYGVVN----GE----------------EILVILPQASEEYGPISH 1244
            :..|.|.  .||:|.....:||.::    ||                .::...|..:|  ||..|
Human   947 LQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTE--GPFGH 1009

  Fly  1245 YYLVVVPEDKSNLHKIPDQFLTDDLLP------GRNKPE---RPNAPY-----IAAKFPQR---- 1291
               ..:||:..       :..::..||      |...||   ||..|:     .|..||.:
Human  1010 ---PTIPEENG-------ENASNSTLPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPC 1064

  Fly  1292 SIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGER 1356
            .:|.:....:|          |.|            ..|...|...:.:...|||:..:...|:.
Human  1065 DVPESLQPKAG----------LPR------------GLPPTSLQVPAAYPGILSLEAPKGWAGKS 1107

  Fly  1357 PHR------PDPNW---PAEPEVSVNRNKDEPEILWV-VLPLM----------VSTFIVSTALIV 1401
            |.|      |...|   |.:|.||..:.:...:.:.: |||..          .|||.:.|..
Human  1108 PGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQGMGIPVLPYPEPAEPGAHGGPSTFGLDTRW-- 1170

  Fly  1402 LCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQT------------PGMIS- 1453
               .:.:.:|..:|.||....|.: ..:...|:...|:....|:.:|            ||::.
Human  1171 ---YEPQPRPRPSPRQARRAEPSL-HQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPGLLQQ 1231

  Fly  1454 --------HPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFT 1491
                    .||..:| |:........:.:|.......|..|...||
Human  1232 AEMSEITLQPPAAVS-FSRKSTPSTGSPSQSSRSGSPSYRPAMGFT 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	30/120 (25%)
		I-set	36..129	CDD:254352	30/119 (25%)
		IG_like	146..227	CDD:214653	29/82 (35%)
		Ig	159..228	CDD:299845	26/68 (38%)
		I-set	234..318	CDD:254352	22/99 (22%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	16/83 (19%)
		fn3	324..404	CDD:278470	20/79 (25%)
		FN3	423..514	CDD:238020	21/103 (20%)
		FN3	520..610	CDD:238020	16/94 (17%)
		FN3	616..707	CDD:238020	20/99 (20%)
		FN3	712..810	CDD:238020	16/97 (16%)
		FN3	832..907	CDD:238020	7/74 (9%)
		FN3	914..1005	CDD:238020	8/90 (9%)
		FN3	1012..1101	CDD:238020	11/88 (13%)
		fn3	1106..1198	CDD:278470	14/91 (15%)
		PTPc	1476..1731	CDD:214550	4/16 (25%)
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653	25/85 (29%)
		Ig	41..115	CDD:143165	22/74 (30%)
		I-set	139..225	CDD:254352	33/103 (32%)
		IGc2	153..210	CDD:197706	22/57 (39%)
		I-set	229..321	CDD:254352	22/93 (24%)
		Ig	235..321	CDD:299845	20/87 (23%)
		IG_like	331..414	CDD:214653	25/99 (25%)
		Ig	<353..414	CDD:299845	21/74 (28%)
		IG_like	426..505	CDD:214653	11/78 (14%)
		Ig	442..505	CDD:299845	8/62 (13%)
		FN3	510..601	CDD:238020	28/126 (22%)
		FN3	617..699	CDD:238020	22/109 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817		15/127 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081		38/212 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810