DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Tpo

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_011242158.1	Gene:	Tpo / 22018	MGIID:	98813	Length:	915	Species:	Mus musculus

Alignment Length:	866	Identity:	168/866 - (19%)
Similarity:	272/866 - (31%)	Gaps:	316/866 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1157 IVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYS-YRPPTKITVTTQMAAPQPMVKPDFY 1220
            |:..|:|:....:|:|.|:.        |..|.:..|:: |....:.....::.:|..::  .|:
Mouse    23 ILRSRDILCGKTMKSHVISA--------VETSQLMVDHAVYNTMKRNLKKREVLSPAQLL--SFF 77

  Fly  1221 GVVNGEEILVILPQASEEYGPIS------HYYLVVVPEDKSNLHKIPDQFLTDDL---------- 1269
            .          ||:::.  |.||      ...:.|:..::|       ||.||.|
Mouse    78 K----------LPESTS--GAISRAAEIMETSIQVMKREQS-------QFSTDALSADILGTIAN 123

  Fly  1270 ----LPGRNKPERPNAPYIAAKF------------PQ---------RSIPFTFHLGSGDD----- 1304
                ||....|..|:. .:|.|:            |:         |.:|..:..|....
Mouse   124 LSGCLPFMLPPRCPDT-CLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPKGWNP 187

  Fly  1305 ---YHNFTNRKLEREKRYRIFV--RAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNW 1364
               ||.|....:....|:.|.|  .||.:..|        :|:||                 |.|
Mouse   188 NFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQ--------YSDFL-----------------PVW 227

  Fly  1365 P--AEPEVSVNRNKDEPEILW-----------------VVLPLMVSTFIVSTALIVLCVVKRRRQ 1410
            .  .:.::::..........|                 :.||   |....:||.:..   .|...
Mouse   228 GQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLP---SNSSGTTACLPF---YRSSA 286

  Fly  1411 PCKTPDQAAVTRPLMAAD-----------LGA----GPTP---------SDPVDMRRLN------ 1445
            .|.|.||.|:...|.||:           |.|    |.:|         |....:.|:|
Mouse   287 ACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDA 351

  Fly  1446 ------FQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNK--- 1501
                  |.|......|..|.:   |......:.|.:  :.|..:: ......|..   |||:
Mouse   352 GRAYLPFATAACAPEPGTPRT---NRTPCFLAGDGR--ASEVPAL-AAVHTLWLR---EHNRLAS 407

  Fly  1502 -----SKNRYANVTAYDHSRVQLPAVEGVVG-SDYIN--------ANYCDGYRKHNAYV------ 1546
                 :|:..|| |||..:|..:.|:..::. .|||.        ..|...|..:|..|
Mouse   408 AFKAINKHWSAN-TAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSN 471

  Fly  1547 -----------ATQGP-------------------LQETFVDFWRMCWELKTATIV--MMTRLEE 1579
                       ||..|                   |::.|...||:..|.....||  ::.|..:
Mouse   472 IFSTAAFRFGHATVHPLVRRLNTDFQEHTELPRLQLRDVFFRPWRLIQEGGLDPIVRGLLARAAK 536

  Fly  1580 RTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGV 1644
                          .:..||:.     .:||..   |.|.|...|..|   :..|......|||:
Mouse   537 --------------LQVQGQLM-----NEELTE---RLFVLSNVGTLD---LASLNLQRGRDHGL 576

  Fly  1645 PDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIY------- 1702
            ||: ..:.:|....|..||.|....|.:.|          :::.:::..||...||::
Mouse   577 PDY-NEWREFCGLSRLETPAELNKAIANRS----------MVNKIMDLYKHADNIDVWLGGLAEK 630

  Fly  1703 ---GHVT-----C-----LRAQR--------NYMVQTEDQYIFIHDAILEAIIC---GVTEVP-- 1741
               |..|     |     ::|.|        |..|.|:.|...:....|..:||   |:|.||
Mouse   631 FLPGARTGPLFACIIGKQMKALRDGDRFWWENTNVFTDAQRQELEKHSLPRVICDNTGLTRVPVD 695

  Fly  1742 ARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRV 1806
            |..:....|..   |..|.|..|::|..:.:..:.|...|     |........||.  .||.::
Mouse   696 AFRIGKFPQDF---ESCEDIPSMDLELWRETFPQDDKCVF-----PEEVDNGNFVHC--EESGKL 750

  Fly  1807 YL--TPIHG--IEGSDYVNAS 1823
            .|  :..||  ::|.:.|..:
Mouse   751 VLVYSCFHGYKLQGQEQVTCT 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470	10/41 (24%)
		PTPc	1476..1731	CDD:214550	66/337 (20%)
		PTPc	1503..1731	CDD:238006	61/302 (20%)
		PTPc	1763..2022	CDD:214550	14/65 (22%)
		PTPc	1791..2022	CDD:238006	9/37 (24%)
Tpo	XP_011242158.1	thyroid_peroxidase	161..722	CDD:188657	125/640 (20%)
		CCP	730..783	CDD:153056	11/49 (22%)
		EGF_CA	784..826	CDD:311536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900