DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Ptprt

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_017172075.1	Gene:	Ptprt / 19281	MGIID:	1321152	Length:	1487	Species:	Mus musculus

Alignment Length:	1646	Identity:	434/1646 - (26%)
Similarity:	676/1646 - (41%)	Gaps:	445/1646 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   570 ISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSW 634
            :..::.:.:|       ::.:.::|.:...||....:.|.....|.|..|::.:.|.      .|
Mouse    99 LKENDTHCID-------FHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTE------GW 150

  Fly   635 LPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPR 699
            :...:..|.....:|:|.|        |:.::..:...|.:||::        |||...     |
Mouse   151 VKAELAISTFWPHFYQVIF--------ESVSLKGHPGYIAVDEVR--------VLAHPC-----R 194

  Fly   700 SHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNE 764
            ..|..||                |.:..::|......:....|   .:..|.:....:..|....
Mouse   195 KAPHFLR----------------LQNVEVNVGQNATFQCIAGG---KWSQHDKLWLQQWNGRDTA 240

  Fly   765 PFKFDVVDTLEFNVTGLQPDT-KYSIQVAALTRKGDG----DRSAAIVVKTPGGVPVRPTVSL-- 822
            .....||:...|:.|....|| :.||.......:.||    ...|.::||.| ..|:.|...|
Mouse   241 LMVTRVVNHRRFSATVSVADTSQRSISKYRCVIRSDGGSGVSNYAELIVKEP-PTPIAPPELLAV 304

  Fly   823 ------------KIMEREPIVSIELEWERPAQTYGELR-----GYRLRWGVKDQALKEEMLSGPQ 870
                        .|:...||:..|:|:.....|:.|..     .|:| |
Mouse   305 GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKL-W---------------- 352

  Fly   871 MTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPD-------- 927
                   :|:..||||.||.             :.:..||..|.|...:|.|.:..|
Mouse   353 -------HLDPDVEYEIRVL-------------LTRPGEGGTGPPGPPLTTRTKCADPVHGPQNV 397

  Fly   928 --------VLCVTWDP----PTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENT 980
                    .|.:.|:|    .||.|...:..:|                     :.||...:...
Mouse   398 EIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY---------------------QYVFNQQQYEA 441

  Fly   981 EYIFRVRA-YTKQGAGPF-----------------SDKLIVETERDM-GRAPM-SLQAEATSEQT 1025
            |.:.:..: ||.:|..||                 |::|:|:||.|: |..|: |:|.....|:.
Mouse   442 EEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKI 506

  Fly  1026 AEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVG-LTESADLVNLEKFAQYAVAIAARFKN 1089
            ...|..|..:.|.:..|:|.|             |.|| |..||||
Mouse   507 YIQWKPPNETNGVITLYEINY-------------KAVGSLDPSADL------------------- 539

  Fly  1090 GLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQ 1154
                .|::..|                                   :|:..:...:||.
Mouse   540 ----SSQRGKV-----------------------------------FKLRNETHHLFVG------ 559

  Fly  1155 TQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQ------- 1212
                                  |.|.|||:..:.|..:. .:.||....:.|:::||.
Mouse   560 ----------------------LYPGTTYSFTIKASTAK-GFGPPVTTRIATKISAPSMPEYDAD 601

  Fly  1213 -PMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPE---------DKSNLHKIPDQFLTD 1267
             |:.:.|       ..|.|:|..|.....|:|.|.|||..|         |......:|..:
Mouse   602 TPLNETD-------TTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSY--- 656

  Fly  1268 DLLPGRNKPERPNAPYIAAKFPQRSIPFT--FHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTP 1330
                 ||.....:..|.||:....::|.|  |.:|....|:.:.|..|...|.|.|:.:|:....
Mouse   657 -----RNASNLDSLHYFAAELKPSNLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKAN 716

  Fly  1331 QK------HLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSV-NRNKDEPE-------- 1380
            .:      .|.|.:|      :...:..||      .|........|. |.|..|||
Mouse   717 GETKINCVRLATKAP------MGSAQVTPG------TPLCLLTTGASTQNSNTVEPEKQVDNTVK 769

  Fly  1381 ILWVVLPLMVSTFIVSTALIVLCVVKRRRQPC--------------KTPDQAAVTR---PLMAAD 1428
            :..|:..|::...|:   |.|:..:||||...              :...|:...|   |:.:.|
Mouse   770 MAGVIAGLLMFIIIL---LGVMLTIKRRRNAYSYSYYLSQRKLAKKQKETQSGAQREMGPVASTD 831

  Fly  1429 -----LGAG--------------------------PT---------PSDPVDMR--RLNFQTPGM 1451
                 ||..                          ||         ..|||:|.  |..||
Mouse   832 KPTAKLGTNRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQ---- 892

  Fly  1452 ISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSR 1516
               |.|.:::...||.::|......|.:|||::..||..:||.:..:.|::||||.|:.:|||||
Mouse   893 ---PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSR 954

  Fly  1517 VQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERT 1581
            |:|..::|...||||||||.|||.:...|:|||||:|||..|||||.|:..:|:|||:|.|.|..
Mouse   955 VRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVG 1019

  Fly  1582 R--------------------IKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFN 1626
            |                    :||.:|||. .||.||.|.||:.||:.||.|.||||.:.::|::
Mouse  1020 RHPAEHTVGTATLGRAASPGMVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYH 1083

  Fly  1627 DRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLE 1691
            :.||::...||:|||||||.:....|.|:|:.:.|.|||:||::||||||.|||||:|.||:||:
Mouse  1084 EIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLD 1148

  Fly  1692 RMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPA---RNLHTHLQKLL 1753
            ..::|.::||:..|..|||||..:||||:||:|:|||||||.:||.|.:|.   |:|:.::.:|
Mouse  1149 MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRL- 1212

  Fly  1754 ITEPGETISGMEVEFKKLSNV--KMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEG 1816
              :|....|.::.||:.|:.|  ::.........||.|..|||.:.:||.:....:|..:.| |.
Mouse  1213 --DPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ES 1274

  Fly  1817 SDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHE 1881
            |:|:||:.:|.::..:|::..|.|:.:...||||:::::|.:.||||.::..  .:.|.||||.:
Mouse  1275 SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQLCMQYWPEK 1337

  Fly  1882 RSVRY---QYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPE-QGVPKSGEGFID 1942
            .|..|   |...|....:.::.....|...:...:|| .|.|:..|:|.||. :..|.|....:.
Mouse  1338 TSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDG-YRIVQHLQYIGWPAYRDTPPSKRSLLK 1401

  Fly  1943 FIGQVHKTKEQF-GQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAM 2006
            .:.::.|.:||: |::|...|||..|.||||.|..:..|.|.:|.:.::|||..|:.||:.:..|
Mouse  1402 VVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNM 1466

  Fly  2007 VQTEDQYHFCYRAALEYLGSF 2027
            |:|.:||.|.|..|||||.||
Mouse  1467 VETLEQYKFVYEVALEYLSSF 1487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020	5/39 (13%)
		FN3	616..707	CDD:238020	18/90 (20%)
		FN3	712..810	CDD:238020	17/102 (17%)
		FN3	832..907	CDD:238020	14/79 (18%)
		FN3	914..1005	CDD:238020	22/128 (17%)
		FN3	1012..1101	CDD:238020	19/90 (21%)
		fn3	1106..1198	CDD:278470	9/91 (10%)
		PTPc	1476..1731	CDD:214550	134/274 (49%)
		PTPc	1503..1731	CDD:238006	125/247 (51%)
		PTPc	1763..2022	CDD:214550	83/265 (31%)
		PTPc	1791..2022	CDD:238006	76/235 (32%)
Ptprt	XP_017172075.1	MAM	36..193	CDD:214533	21/122 (17%)
		fn3	298..364	CDD:365830	17/89 (19%)
		FN3	394..484	CDD:238020	18/110 (16%)
		fn3	506..581	CDD:365830	25/174 (14%)
		R-PTPc-T-1	936..1192	CDD:350478	129/256 (50%)
		R-PTPc-T-2	1277..1482	CDD:350482	67/207 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810