DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and Ptprs

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_006523937.1 Gene:Ptprs / 19280 MGIID:97815 Length:1920 Species:Mus musculus


Alignment Length:2095 Identity:980/2095 - (46%)
Similarity:1281/2095 - (61%) Gaps:267/2095 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 TWTHPTIVD-----------------AAHPPEIIRKPQNQ-GVRVGGVASFYCAARGDPPPSIVW 69
            ||: |::|.                 |..||..||:|::| ||. ||||||.|.|.|||.|.:.|
Mouse     4 TWS-PSVVSVVGPVGLFLVLLARGCLAEEPPRFIREPKDQIGVS-GGVASFVCQATGDPKPRVTW 66

  Fly    70 RKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDK 134
            .|.||||:..:......::..| ::|||:|:|..||:..|||||:|.||: ::..|.||:...|:
Mouse    67 NKKGKKVNSQRFETIDFDESSG-AVLRIQPLRTPRDENVYECVAQNSVGE-ITIHAKLTVLREDQ 129

  Fly   135 TPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVD--MSNPRY-SLKDGFLQI 196
            .|.|||.|..||..:|:|...|..|.|.|.|||.|.|.|.|:...||  .||.|. .|:.|.|||
Mouse   130 LPPGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQI 194

  Fly   197 ENSREEDQGKYECVAENSMGTEHSKATNLYVK----VRRVPPTFSRPPETISEVMLGSNLNLSCI 257
            |:|.|.|||||||||.||.|..:|...||||:    ||||.|.||..|.: .|:|.|.|:|::|:
Mouse   195 ESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMS-HEIMPGGNVNITCV 258

  Fly   258 AVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLP 322
            |||||||:||||:|:||||||::||:|||||:|.::::||||||:|.|:||.|::|:.:.|:|||
Mouse   259 AVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLP 323

  Fly   323 TAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTE 387
            .||....::|.||||:.:.|....|:.:.||||:||.|:.:..:.....|.|..|.:..|||.:|
Mouse   324 KAPGTPVVTENTATSITVTWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 388

  Fly   388 YEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQV 452
            ||.:|.|||:||:||||......||:     ....|||||||.|.||::||::.||.|..|||.:
Mouse   389 YEIWVSAVNSIGQGPPSESVVTRTGE-----QAPASAPRNVQARMLSATTMIVQWEEPVEPNGLI 448

  Fly   453 TGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQ 517
            .||:||||.....|..:|....||:|.||||..|.....|||||.|:||:|.||:|.|:|||.||
Mouse   449 RGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQ 513

  Fly   518 GVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLY 582
            |||.||.|.||....||::.|.|:.|  ..|:::.|||.:.:....:...:....:.|:.::.|.
Mouse   514 GVPGQPMNLRAEAKSETSIGLSWSAP--RQESVIKYELLFREGDRGREVGRTFDPTTAFVVEDLK 576

  Fly   583 PDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPPPVERSNGR 645
            |:|.|...|||||.:|.||.|..:..||.|.  .|||:::...:..||.|.:||.|||.|..||.
Mouse   577 PNTEYAFRLAARSPQGLGAFTAVVRQRTLQAKPSAPPQDVKCTSLRSTAILVSWRPPPPETHNGA 641

  Fly   646 IIYYKVFFVEVGRED---DEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRT 707
            ::.|.|.:..:|.||   .|...:....|.|:|:.|::||||::..:|.|.||.||.|.|:::||
Mouse   642 LVGYSVRYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRT 706

  Fly   708 QEDVP-GDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEG---------KGFL 762
            .|||| ..|:.|:|..||:|:|.|.|:.|....::|.||||.:|  .:|.||         |..:
Mouse   707 DEDVPSAPPRKVEAEALNATAIRVLWRSPTPGRQHGQIRGYQVH--YVRMEGAEARGPPRIKDIM 769

  Fly   763 NEPFKFDVVDTLEFN--VTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIM 825
            ....::::.||.|:.  :|.|||:|.|||.|||.|.||||.||...||.|.|.|..|||:|   :
Mouse   770 LADAQWEMDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLS---V 831

  Fly   826 EREPIVSIELEWERPAQTYGE-LRGYRLRWGVKDQALKEEMLSGPQMTKKRF-DNLERGVEYEFR 888
            ::.|..|:...||.||....: :.||||::|.:|.|.....|:.   .::|| ....:|..|.||
Mouse   832 QQTPEGSLLARWEPPADAAEDPVLGYRLQFGREDAAPATLELAA---WERRFAAPAHKGATYVFR 893

  Fly   889 VAGSNHIGIGQETVKIFQTPEGTPGGPP------SNITIRFQTPDVLCVTWDPPTREHRNGIITR 947
            :|.....|:|:|.......||..|.|.|      .|::    ...|| :.|.||....|||.|.:
Mouse   894 LAARGRAGLGEEAAAALSIPEDAPRGFPQILGAAGNVS----AGSVL-LRWLPPVPAERNGAIIK 953

  Fly   948 YDVQFHKKIDHG------------LGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDK 1000
            |.|...:....|            .|:|..:|||     .|...|.|..||||:|::|.||||..
Mouse   954 YTVSVREAGAPGPATETELAAAAQPGAETALTLR-----GLRPETAYELRVRAHTRRGPGPFSPP 1013

  Fly  1001 LIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLT 1065
            |.....||                       ||:                               
Mouse  1014 LRYRLARD-----------------------PVS------------------------------- 1024

  Fly  1066 ESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIR 1130
                                                      |.|.:...:...|:.|||..|..
Mouse  1025 ------------------------------------------PKNFKVKMIMKTSVLLSWEFPDN 1047

  Fly  1131 L-TPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDY 1194
            . :|..|||.::.:.:.||.:        ..:::|      ||    |.|.|.||..::...|..
Mouse  1048 YNSPTPYKIQYNGLTLDVDGR--------TTKKLI------TH----LKPHTFYNFVLTNRGSSL 1094

  Fly  1195 SYRPPTKITVTT--QMAAPQPMV--KPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKS 1255
            .....| :|..|  .|.:.:|.|  |||     |...|:|.||...... .:.:|::|:||..||
Mouse  1095 GGLQQT-VTARTAFNMLSGKPSVAPKPD-----NDGFIVVYLPDGQSPV-TVQNYFIVMVPLRKS 1152

  Fly  1256 N------LHKIPDQFLTDDLLPGRNKPERPN----------APYIAAKFPQRSIPFTFHLGSGDD 1304
            .      |...|:....::|:...::.:|.:          .|||||:|  ..:|..||.|:...
Mouse  1153 RGGQFPVLLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARF--SILPAVFHPGNQKQ 1215

  Fly  1305 YHNFTNRKLEREKRYRIFVRAVVDTPQKH--LYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAE 1367
            |..|.||.||...||.:||.||:   ||:  .:.:||||:...||           .|||    :
Mouse  1216 YGGFDNRGLEPGHRYVLFVLAVL---QKNEPTFAASPFSDPFQLD-----------NPDP----Q 1262

  Fly  1368 PEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQP-CKTPDQAAVTRPLM-AADLG 1430
            |.|.     .|..::||:.|::...||:   .||:.::..:.:| .|..|....|:.|: .||| 
Mouse  1263 PIVD-----GEEGLIWVIGPVLAVVFII---CIVIAILLYKNKPDSKRKDSEPRTKCLLNNADL- 1318

  Fly  1431 AGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNS 1495
            |...|.|||:|||:|||||||:|||||||::.|.|:||||:||:.|.|||||||:|||||||::|
Mouse  1319 APHHPKDPVEMRRINFQTPGMLSHPPIPITDMAEHMERLKANDSLKLSQEYESIDPGQQFTWEHS 1383

  Fly  1496 NLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFW 1560
            |||.||.|||||||.|||||||.|..:||::|||||||||.||||:.|||:||||||.|||.|||
Mouse  1384 NLEANKPKNRYANVIAYDHSRVILQPLEGIMGSDYINANYVDGYRRQNAYIATQGPLPETFGDFW 1448

  Fly  1561 RMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGF 1625
            ||.||.::||:||||||||::|||||||||.|||||||.|.||:.:|.||||:.:|||.|.:.|.
Mouse  1449 RMVWEQRSATVVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTMELATFCVRTFSLHKNGS 1513

  Fly  1626 NDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSML 1690
            :::||::..|||||||||||::|.|||.||||.:...||::||::||||||||||||:||||:||
Mouse  1514 SEKREVRHFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAML 1578

  Fly  1691 ERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLIT 1755
            ||:|.||.:|:|||||.:|:||||||||||||.|||:|:|||:.||.||||||:|:|::|||...
Mouse  1579 ERIKTEKTVDVYGHVTLMRSQRNYMVQTEDQYGFIHEALLEAVGCGNTEVPARSLYTYIQKLAQV 1643

  Fly  1756 EPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYV 1820
            ||||.::|||:|||:|::.|..:|:|:||:|||||.|||||:|||||||||.|.||.|:|||||:
Mouse  1644 EPGEHVTGMELEFKRLASSKAHTSRFITASLPCNKFKNRLVNILPYESSRVCLQPIRGVEGSDYI 1708

  Fly  1821 NASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVR 1885
            |||||||||.:.||||.|||:.:..|||||.|||:|||||||||||:|||||||.||||.|||.|
Mouse  1709 NASFIDGYRQQKAYIATQGPLAETTEDFWRALWENNSTIVVMLTKLREMGREKCHQYWPAERSAR 1773

  Fly  1886 YQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKT 1950
            |||:||||:||||||||.||||||||||||.|||||||||.||||||.|||||||||||||||||
Mouse  1774 YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGAPKSGEGFIDFIGQVHKT 1838

  Fly  1951 KEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHF 2015
            ||||||||||:|||||||||:|||||||||||||:||||:|:||||::||:||||||||||:|.|
Mouse  1839 KEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKVLRTQRPAMVQTEDEYQF 1903

  Fly  2016 CYRAALEYLGSFDNY 2030
            |::||||||||||:|
Mouse  1904 CFQAALEYLGSFDHY 1918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 44/94 (47%)
I-set 36..129 CDD:254352 43/93 (46%)
IG_like 146..227 CDD:214653 42/83 (51%)
Ig 159..228 CDD:299845 39/71 (55%)
I-set 234..318 CDD:254352 48/83 (58%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 42/67 (63%)
fn3 324..404 CDD:278470 33/79 (42%)
FN3 423..514 CDD:238020 48/90 (53%)
FN3 520..610 CDD:238020 29/89 (33%)
FN3 616..707 CDD:238020 35/93 (38%)
FN3 712..810 CDD:238020 44/109 (40%)
FN3 832..907 CDD:238020 23/76 (30%)
FN3 914..1005 CDD:238020 34/108 (31%)
FN3 1012..1101 CDD:238020 2/88 (2%)
fn3 1106..1198 CDD:278470 22/92 (24%)
PTPc 1476..1731 CDD:214550 180/254 (71%)
PTPc 1503..1731 CDD:238006 159/227 (70%)
PTPc 1763..2022 CDD:214550 207/258 (80%)
PTPc 1791..2022 CDD:238006 190/230 (83%)
PtprsXP_006523937.1 I-set 33..124 CDD:400151 43/93 (46%)
Ig strand A 33..36 CDD:409353 1/2 (50%)
Ig strand A' 42..45 CDD:409353 1/2 (50%)
Ig strand B 50..57 CDD:409353 4/6 (67%)
Ig strand C 63..68 CDD:409353 1/4 (25%)
Ig strand C' 71..73 CDD:409353 1/1 (100%)
Ig strand D 80..84 CDD:409353 0/3 (0%)
Ig strand E 86..93 CDD:409353 2/7 (29%)
Ig strand F 103..111 CDD:409353 5/7 (71%)
Ig strand G 114..124 CDD:409353 3/10 (30%)
IgI_2_RPTP_IIa_LAR_like 137..226 CDD:409400 45/88 (51%)
Ig strand B 152..156 CDD:409400 1/3 (33%)
Ig strand C 165..169 CDD:409400 1/3 (33%)
Ig strand E 190..194 CDD:409400 2/3 (67%)
Ig strand F 204..209 CDD:409400 4/4 (100%)
Ig strand G 216..219 CDD:409400 0/2 (0%)
IgI_3_RPTP_IIa_LAR_like 239..320 CDD:409401 46/81 (57%)
Ig strand B 253..257 CDD:409401 1/3 (33%)
Ig strand C 266..270 CDD:409401 2/3 (67%)
Ig strand E 287..291 CDD:409401 3/3 (100%)
Ig strand F 299..304 CDD:409401 4/4 (100%)
Ig strand G 312..315 CDD:409401 0/2 (0%)
FN3 323..412 CDD:238020 36/88 (41%)
FN3 419..511 CDD:238020 49/91 (54%)
FN3 516..604 CDD:238020 29/89 (33%)
FN3 612..706 CDD:238020 35/93 (38%)
FN3 714..819 CDD:238020 43/106 (41%)
FN3 929..1017 CDD:238020 32/97 (33%)
FN3 1022..1105 CDD:238020 26/174 (15%)
PTP_tm <1211..1295 CDD:408631 34/109 (31%)
R-PTPc-S-1 1342..1623 CDD:350473 197/280 (70%)
R-PTP-S-2 1625..1914 CDD:350475 226/288 (78%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 422 1.000 Domainoid score I630
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1260 1.000 Inparanoid score I173
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47937
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001053
OrthoInspector 1 1.000 - - otm43194
orthoMCL 1 0.900 - - OOG6_100623
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 1 1.000 - - X953
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.760

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