DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptprs

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_035348.2 Gene:Ptprs / 19280 MGIID:97815 Length:1907 Species:Mus musculus


Alignment Length:2082 Identity:980/2082 - (47%)
Similarity:1277/2082 - (61%) Gaps:254/2082 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 TWTHPTIVD-----------------AAHPPEIIRKPQNQ-GVRVGGVASFYCAARGDPPPSIVW 69
            ||: |::|.                 |..||..||:|::| ||. ||||||.|.|.|||.|.:.|
Mouse     4 TWS-PSVVSVVGPVGLFLVLLARGCLAEEPPRFIREPKDQIGVS-GGVASFVCQATGDPKPRVTW 66

  Fly    70 RKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDK 134
            .|.||||:..:......::..| ::|||:|:|..||:..|||||:|.||: ::..|.||:...|:
Mouse    67 NKKGKKVNSQRFETIDFDESSG-AVLRIQPLRTPRDENVYECVAQNSVGE-ITIHAKLTVLREDQ 129

  Fly   135 TPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVD--MSNPRY-SLKDGFLQI 196
            .|.|||.|..||..:|:|...|..|.|.|.|||.|.|.|.|:...||  .||.|. .|:.|.|||
Mouse   130 LPPGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQI 194

  Fly   197 ENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGS 261
            |:|.|.|||||||||.||.|..:|...||||:||||.|.||..|.: .|:|.|.|:|::|:||||
Mouse   195 ESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS-HEIMPGGNVNITCVAVGS 258

  Fly   262 PMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPT 326
            |||:||||:|:||||||::||:|||||:|.::::||||||:|.|:||.|::|:.:.|:|||.||.
Mouse   259 PMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPG 323

  Fly   327 DVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFY 391
            ...::|.||||:.:.|....|:.:.||||:||.|:.:..:.....|.|..|.:..|||.:|||.:
Mouse   324 TPVVTENTATSITVTWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW 388

  Fly   392 VIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYK 456
            |.|||:||:||||......||:     ....|||||||.|.||::||::.||.|..|||.:.||:
Mouse   389 VSAVNSIGQGPPSESVVTRTGE-----QAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYR 448

  Fly   457 VYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPS 521
            ||||.....|..:|....||:|.||||..|.....|||||.|:||:|.||:|.|:|||.|||||.
Mouse   449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPG 513

  Fly   522 QPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTL 586
            ||.|.||....||::.|.|:.|  ..|:::.|||.:.:....:...:....:.|:.::.|.|:|.
Mouse   514 QPMNLRAEAKSETSIGLSWSAP--RQESVIKYELLFREGDRGREVGRTFDPTTAFVVEDLKPNTE 576

  Fly   587 YYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYY 649
            |...|||||.:|.||.|..:..||.|.  .|||:::...:..||.|.:||.|||.|..||.::.|
Mouse   577 YAFRLAARSPQGLGAFTAVVRQRTLQAKPSAPPQDVKCTSLRSTAILVSWRPPPPETHNGALVGY 641

  Fly   650 KVFFVEVGRED---DEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDV 711
            .|.:..:|.||   .|...:....|.|:|:.|::||||::..:|.|.||.||.|.|:::||.|||
Mouse   642 SVRYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDV 706

  Fly   712 P-GDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVV--DT 773
            | ..|:.|:|..||:|:|.|.|:.|....::|.||||.:|  .:|.||......|...|::  |.
Mouse   707 PSAPPRKVEAEALNATAIRVLWRSPTPGRQHGQIRGYQVH--YVRMEGAEARGPPRIKDIMLADA 769

  Fly   774 LEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWE 838
            .|..:|.|||:|.|||.|||.|.||||.||...||.|.|.|..|||:|   :::.|..|:...||
Mouse   770 QEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLS---VQQTPEGSLLARWE 831

  Fly   839 RPAQTYGE-LRGYRLRWGVKDQALKEEMLSGPQMTKKRF-DNLERGVEYEFRVAGSNHIGIGQET 901
            .||....: :.||||::|.:|.|.....|:.   .::|| ....:|..|.||:|.....|:|:|.
Mouse   832 PPADAAEDPVLGYRLQFGREDAAPATLELAA---WERRFAAPAHKGATYVFRLAARGRAGLGEEA 893

  Fly   902 VKIFQTPEGTPGGPP------SNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHG- 959
            ......||..|.|.|      .|::    ...|| :.|.||....|||.|.:|.|...:....| 
Mouse   894 AAALSIPEDAPRGFPQILGAAGNVS----AGSVL-LRWLPPVPAERNGAIIKYTVSVREAGAPGP 953

  Fly   960 -----------LGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAP 1013
                       .|:|..:|||     .|...|.|..||||:|::|.||||..|.....||     
Mouse   954 ATETELAAAAQPGAETALTLR-----GLRPETAYELRVRAHTRRGPGPFSPPLRYRLARD----- 1008

  Fly  1014 MSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQ 1078
                              ||:                                            
Mouse  1009 ------------------PVS-------------------------------------------- 1011

  Fly  1079 YAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRL-TPVNYKISFDA 1142
                                         |.|.:...:...|:.|||..|... :|..|||.::.
Mouse  1012 -----------------------------PKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG 1047

  Fly  1143 MKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTT- 1206
            :.:.||.:        ..:::|      ||    |.|.|.||..::...|.......| :|..| 
Mouse  1048 LTLDVDGR--------TTKKLI------TH----LKPHTFYNFVLTNRGSSLGGLQQT-VTARTA 1093

  Fly  1207 -QMAAPQPMV--KPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSN------LHKIPD 1262
             .|.:.:|.|  |||     |...|:|.||...... .:.:|::|:||..||.      |...|:
Mouse  1094 FNMLSGKPSVAPKPD-----NDGFIVVYLPDGQSPV-TVQNYFIVMVPLRKSRGGQFPVLLGSPE 1152

  Fly  1263 QFLTDDLLPGRNKPERPN----------APYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREK 1317
            ....::|:...::.:|.:          .|||||:|  ..:|..||.|:...|..|.||.||...
Mouse  1153 DMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARF--SILPAVFHPGNQKQYGGFDNRGLEPGH 1215

  Fly  1318 RYRIFVRAVVDTPQKH--LYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPE 1380
            ||.:||.||:   ||:  .:.:||||:...||           .|||    :|.|.     .|..
Mouse  1216 RYVLFVLAVL---QKNEPTFAASPFSDPFQLD-----------NPDP----QPIVD-----GEEG 1257

  Fly  1381 ILWVVLPLMVSTFIVSTALIVLCVVKRRRQP-CKTPDQAAVTRPLM-AADLGAGPTPSDPVDMRR 1443
            ::||:.|::...||:   .||:.::..:.:| .|..|....|:.|: .||| |...|.|||:|||
Mouse  1258 LIWVIGPVLAVVFII---CIVIAILLYKNKPDSKRKDSEPRTKCLLNNADL-APHHPKDPVEMRR 1318

  Fly  1444 LNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYAN 1508
            :|||||||:|||||||::.|.|:||||:||:.|.|||||||:|||||||::||||.||.||||||
Mouse  1319 INFQTPGMLSHPPIPITDMAEHMERLKANDSLKLSQEYESIDPGQQFTWEHSNLEANKPKNRYAN 1383

  Fly  1509 VTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVM 1573
            |.|||||||.|..:||::|||||||||.||||:.|||:||||||.|||.|||||.||.::||:||
Mouse  1384 VIAYDHSRVILQPLEGIMGSDYINANYVDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATVVM 1448

  Fly  1574 MTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTA 1638
            ||||||::|||||||||.|||||||.|.||:.:|.||||:.:|||.|.:.|.:::||::..||||
Mouse  1449 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTMELATFCVRTFSLHKNGSSEKREVRHFQFTA 1513

  Fly  1639 WPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYG 1703
            |||||||::|.|||.||||.:...||::||::||||||||||||:||||:||||:|.||.:|:||
Mouse  1514 WPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKTEKTVDVYG 1578

  Fly  1704 HVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEF 1768
            |||.:|:||||||||||||.|||:|:|||:.||.||||||:|:|::|||...||||.::|||:||
Mouse  1579 HVTLMRSQRNYMVQTEDQYGFIHEALLEAVGCGNTEVPARSLYTYIQKLAQVEPGEHVTGMELEF 1643

  Fly  1769 KKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSA 1833
            |:|::.|..:|:|:||:|||||.|||||:|||||||||.|.||.|:|||||:|||||||||.:.|
Mouse  1644 KRLASSKAHTSRFITASLPCNKFKNRLVNILPYESSRVCLQPIRGVEGSDYINASFIDGYRQQKA 1708

  Fly  1834 YIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYN 1898
            |||.|||:.:..|||||.|||:|||||||||||:|||||||.||||.|||.||||:||||:||||
Mouse  1709 YIATQGPLAETTEDFWRALWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1773

  Fly  1899 MPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVH 1963
            ||||.||||||||||||.|||||||||.||||||.|||||||||||||||||||||||||||:||
Mouse  1774 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGAPKSGEGFIDFIGQVHKTKEQFGQDGPISVH 1838

  Fly  1964 CSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFD 2028
            |||||||:|||||||||||||:||||:|:||||::||:||||||||||:|.||::||||||||||
Mouse  1839 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKVLRTQRPAMVQTEDEYQFCFQAALEYLGSFD 1903

  Fly  2029 NY 2030
            :|
Mouse  1904 HY 1905

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151 43/93 (46%)
Ig strand B 53..57 CDD:409353 3/3 (100%)
Ig strand C 66..70 CDD:409353 0/3 (0%)
Ig strand E 93..97 CDD:409353 1/3 (33%)
Ig strand F 108..113 CDD:409353 3/4 (75%)
Ig strand G 122..125 CDD:409353 0/2 (0%)
Ig 141..228 CDD:472250 45/89 (51%)
Ig strand B 157..161 CDD:409353 1/3 (33%)
Ig strand C 170..174 CDD:409353 1/3 (33%)
Ig strand E 192..196 CDD:409353 2/3 (67%)
Ig strand F 206..211 CDD:409353 4/4 (100%)
Ig strand G 218..221 CDD:409353 0/2 (0%)
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401 46/81 (57%)
Ig strand A 237..239 CDD:409401 1/1 (100%)
Ig strand A' 244..248 CDD:409401 1/3 (33%)
Ig strand B 251..259 CDD:409401 3/7 (43%)
Ig strand C 264..270 CDD:409401 4/5 (80%)
Ig strand C' 272..274 CDD:409401 0/1 (0%)
Ig strand D 277..281 CDD:409401 2/3 (67%)
Ig strand E 286..291 CDD:409401 3/4 (75%)
Ig strand F 298..305 CDD:409401 5/6 (83%)
Ig strand G 309..318 CDD:409401 2/8 (25%)
FN3 322..411 CDD:238020 36/88 (41%)
FN3 <382..747 CDD:442628 159/370 (43%)
FN3 712..810 CDD:238020 44/100 (44%)
FN3 832..898 CDD:214495 21/67 (31%)
FN3 <867..1269 CDD:442628 95/431 (22%)
fn3 914..998 CDD:394996 31/101 (31%)
R-PTPc-LAR-1 1498..1735 CDD:350401 165/236 (70%)
R-PTP-LAR-2 1784..2021 CDD:350402 195/236 (83%)
PtprsNP_035348.2 I-set 33..124 CDD:400151 43/93 (46%)
Ig strand B 50..54 CDD:409570 3/3 (100%)
Ig strand C 63..67 CDD:409570 0/3 (0%)
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000269|PubMed:19833921, ECO:0000269|PubMed:21454754 68..72 2/3 (67%)
Ig strand E 86..93 CDD:409570 2/7 (29%)
Ig strand F 104..109 CDD:409570 3/4 (75%)
Ig strand G 117..120 CDD:409570 0/2 (0%)
IgI_2_RPTP_IIa_LAR_like 137..226 CDD:409400 45/88 (51%)
Ig strand A' 143..147 CDD:409400 1/3 (33%)
Ig strand B 150..159 CDD:409400 3/8 (38%)
Ig strand C 164..170 CDD:409400 3/5 (60%)
Ig strand C' 172..174 CDD:409400 0/1 (0%)
Ig strand D 183..187 CDD:409400 1/3 (33%)
Ig strand E 190..195 CDD:409400 3/4 (75%)
Ig strand F 204..211 CDD:409400 6/6 (100%)
Ig strand G 214..225 CDD:409400 4/10 (40%)
IgI_3_RPTP_IIa_LAR_like 235..316 CDD:409401 46/81 (57%)
Ig strand A 235..237 CDD:409401 1/1 (100%)
Ig strand A' 241..245 CDD:409401 1/3 (33%)
Ig strand B 248..256 CDD:409401 3/7 (43%)
Ig strand C 261..267 CDD:409401 4/5 (80%)
Ig strand C' 269..271 CDD:409401 0/1 (0%)
Ig strand D 274..278 CDD:409401 2/3 (67%)
Ig strand E 283..288 CDD:409401 3/4 (75%)
Ig strand F 295..302 CDD:409401 5/6 (83%)
Ig strand G 306..315 CDD:409401 2/8 (25%)
FN3 309..815 CDD:442628 217/514 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..711 10/19 (53%)
FN3 916..1004 CDD:238020 32/97 (33%)
FN3 1009..1092 CDD:238020 26/174 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1286..1313 9/27 (33%)
R-PTPc-S-1 1329..1610 CDD:350473 197/280 (70%)
R-PTP-S-2 1612..1901 CDD:350475 226/288 (78%)

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