DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptpro

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_036021846.1 Gene:Ptpro / 19277 MGIID:1097152 Length:1261 Species:Mus musculus


Alignment Length:1332 Identity:297/1332 - (22%)
Similarity:488/1332 - (36%) Gaps:440/1332 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   633 SWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDG 697
            |.|||||.   .:..|:.::::               :|.:|::              |..|...
Mouse   111 STLPPPVV---FKATYHGLYYI---------------ITLVVVN--------------GNVVTKP 143

  Fly   698 PRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRD------ 756
            .||..::             .|..|:.|.||: .:||..|   .|::  :.||..|..:      
Mouse   144 SRSITVL-------------TKPLPVTSVSIY-DYKPSPE---TGVL--FEIHYPEKYNVFSRVN 189

  Fly   757 ----EGKGFLNEPFK----------------------FDVVDTLEFNVTGLQPDTKYSIQVAALT 795
                ||:.|....:|                      |.:|....||.:.|       ::.:.::
Mouse   190 ISYWEGRDFRTMLYKDFFKGKTVFNHWLPGLCYSNITFQLVSEATFNKSTL-------VEYSGVS 247

  Fly   796 RKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQA 860
            .:....|:|..   .|..:.|| .|:|.          :..||.|:.::.|              
Mouse   248 HEPKQHRTAPY---PPRNISVR-FVNLN----------KNNWEEPSGSFPE-------------- 284

  Fly   861 LKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTP-----GGPPSNIT 920
              :..:..||      |::.|...:.|..                :|||..|     |.||||::
Mouse   285 --DSFIKPPQ------DSIGRDRRFHFPE----------------ETPETPPSNVSSGSPPSNVS 325

  Fly   921 IRFQTPDVLCVT-------WDPPTREHRN------GIITRYDVQFHKKIDHGLGSER-------- 964
            ..:..|:.....       ||..:....|      .:...||.:  ..:|.   :|:        
Mouse   326 SAWPDPNSTDYESTSQPFWWDSASAAPENEEDFVSALPADYDTE--TTLDR---TEKPTADPFSA 385

  Fly   965 ---NMTL-------------------RKAVFTN--------------LEENTEYIFRVRAYTKQG 993
               .|||                   |:..||:              |:|..:|...|..::..|
Mouse   386 FPVQMTLSWLPPKPPTAFDGFNILIEREENFTDYLTVDEEAHEFVAELKEPGKYKLSVTTFSSSG 450

  Fly   994 AGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAV------- 1051
            |        .||.:......:|.....|.|     |.|.:|.:.:.:...:..:.||:       
Mouse   451 A--------CETRKSQSAKSLSFYISPTGE-----WIEELTEKPQHVSVHVLSSTTALMSWTSSQ 502

  Fly  1052 EDLDDWQTKTVGLT-----ESADL---------------VNLEKFAQYAVAIAARFKNGLGRLSE 1096
            |:.:......|.||     ||..|               .||...|||.|.:..|....:|..|:
Mouse   503 ENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPVIENLVPGAQYQVVMYLRKGPLIGPPSD 567

  Fly  1097 KVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKR 1161
            .||..|.|..:. :|..:.:...::.|||:.||             :.||             ::
Mouse   568 PVTFAIVPTGIK-DLMLYPLGPTAVVLSWTRPI-------------LGVF-------------RK 605

  Fly  1162 EIILKHYVKTHTINELSPFTTY-----------NVNVSAIPSDYSYRPPTKITVTTQ-------- 1207
            .::...|....|:.  |.:|||           :|.::::...:.|.  .::|:.|.        
Mouse   606 YVVEMFYFNPTTMT--SEWTTYYEIAATVSLTASVRIASLLPAWYYN--FRVTMVTWGDPELSCC 666

  Fly  1208 -------MAAPQPMVKPDFYGVVNGEEILVILPQASEEYG----PISH---YYLVVVPEDKSNLH 1258
                   :.||   |.|:...|.....:|.|    |..||    .:||   .:.:||.|.:..:.
Mouse   667 DSSTISFITAP---VAPEITSVEYFNSLLYI----SWTYGDATTDLSHSRMLHWMVVAEGRKKIK 724

  Fly  1259 KIPDQFLTDDLL---PG-----------------------RNKPERPNAPYIAAKFPQRSIP--- 1294
            |...:.:...:|   ||                       :.:|..|.:.:...| .|.|:.   
Mouse   725 KSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSLPRLVKLEPAPPKSLFAVNK-TQTSVTLLW 788

  Fly  1295 -----------FTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDM 1348
                       |...||||.      |.||:........|..:........|..|..|  .|.| 
Mouse   789 VEEGVADFFEVFCQQLGSGH------NGKLQEPVAVSSHVVTISSLLPATAYNCSVTS--FSHD- 844

  Fly  1349 REAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCK 1413
                        .|:.|....||....:..|.::.:.:..::||.::...|:.|.:::::...  
Mouse   845 ------------TPSVPTFIAVSTMVTEVNPNVVVISVLAILSTLLIGLLLVTLVILRKKHLQ-- 895

  Fly  1414 TPDQAAVTRPLMAADLGAGPTPSD---------PVDMRRLNFQTPGMIS-------------HP- 1455
                       ||.:.|||...:.         |...||..|....::.             :| 
Mouse   896 -----------MARECGAGTFVNFASLEREGKLPYSWRRSVFALLTLLPSCLWTDYLLAFYINPW 949

  Fly  1456 ------------PIPISEFANHIERLKSNDNQKFSQEYESIE-PGQQFTWDNSNLEHNKSKNRYA 1507
                        |:.:.:|.::|:.:..:.:.|||.::|.:: .|.......::|..|:.||||.
Mouse   950 SKNGLKKRKLTNPVQLDDFDSYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYT 1014

  Fly  1508 NVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIV 1572
            |:..||.|||:|.::....|:|||||||..||.....|:||||||.||..|||:|..:.|:..||
Mouse  1015 NILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSHIIV 1079

  Fly  1573 MMTRLEERTRIKCDQYWP-TRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQF 1636
            |:|:..|:.|:|||.||| |.....||.|.|.:...:|...::.|.|::  ...::.:::....:
Mouse  1080 MLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMVSEEEEEDWASRHFRI--NYADEAQDVMHFNY 1142

  Fly  1637 TAWPDHGVPDHPA----PFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEK 1697
            |||||||||  ||    ..|||:...|.......||:|:||||||||||.:|.:|.:|:.::..:
Mouse  1143 TAWPDHGVP--PANAAESILQFVFTVRQQAAKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHE 1205

  Fly  1698 IIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAI 1729
            .:||.|.|:.:|:.|..|||||:||||||..:
Mouse  1206 FVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020
FN3 520..610 CDD:238020
FN3 616..707 CDD:238020 13/73 (18%)
FN3 712..810 CDD:238020 23/129 (18%)
FN3 832..907 CDD:238020 9/74 (12%)
FN3 914..1005 CDD:238020 24/147 (16%)
FN3 1012..1101 CDD:238020 26/115 (23%)
fn3 1106..1198 CDD:278470 16/102 (16%)
PTPc 1476..1731 CDD:214550 110/260 (42%)
PTPc 1503..1731 CDD:238006 103/232 (44%)
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
PtproXP_036021846.1 FN3 479..571 CDD:238020 19/91 (21%)
FN3 575..675 CDD:238020 19/130 (15%)
fn3 770..850 CDD:394996 19/101 (19%)
R-PTPc-O 996..1240 CDD:350462 105/246 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.030

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