DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptprm

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_001344554.1 Gene:Ptprm / 19274 MGIID:102694 Length:1486 Species:Mus musculus


Alignment Length:1756 Identity:486/1756 - (27%)
Similarity:713/1756 - (40%) Gaps:478/1756 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   429 QVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAI-- 491
            ||.||:..|     ..|..|:|     .......|.:||.. .:.::    |..:.|...|.|  
Mouse    50 QVNTLTKPT-----SDPWMPSG-----SFMLVNTSGKPEGQ-RAHLL----LPQLKENDTHCIDF 99

  Fly   492 -YTVR---------VQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHS 546
             |.|.         :..|..:..||:..|:     ..:...|                 |:..|.
Mouse   100 HYFVSSKSNAAPGLLNVYVKVNNGPLGNPI-----WNISGDP-----------------TRTWHR 142

  Fly   547 SENIVHYELYWNDTY------ANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPP 605
            :|..:  ..:|.:.|      ....|...::..|...|                   |...|..|
Mouse   143 AELAI--STFWPNFYQVIFEVVTSGHQGYLAIDEVKVL-------------------GHPCTRTP 186

  Fly   606 IPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNM 670
            ..:|.       :|:...|....|...|.:        ||.:.....::: |.:..:|....:.:
Mouse   187 HFLRI-------QNVEVNAGQFATFQCSAI--------GRTVAGDRLWLQ-GIDVRDAPLKEIKV 235

  Fly   671 TSI--------VLDELKRWT-EYKIWVLAGTSVGDGPRSHPIILRTQEDVP-GDPQ--DVKATPL 723
            ||.        |::..||.. :|:..:.  |..|.|..::..::..:..|| ..||  .|.||.|
Mouse   236 TSSRRFIASFNVVNTTKRDAGKYRCMIC--TEGGVGISNYAELVVKEPPVPIAPPQLASVGATYL 298

  Fly   724 NSTSIHVSWKPPLEKDRNGIIRGYHIHAQELR-DEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKY 787
                    |   ::.:.|.|.....|.|:|:. ....|..|:.   ..||:..:.:..|.|||:|
Mouse   299 --------W---IQLNANSINGDGPIVAREVEYCTASGSWNDR---QPVDSTSYKIGHLDPDTEY 349

  Fly   788 SIQVAALTRKGDGDRSA---AIVVKTPGGVPVRPTVSLKIME---REPIVSIELEWERPAQTYGE 846
            .|.| .|||.|:|...:   |:..:|....|:|....|:::|   |:    |.:.|| |.     
Mouse   350 EISV-LLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQ----ITIRWE-PF----- 403

  Fly   847 LRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGT 911
              ||                           |:.|...|...|.....:| |||.|:    .|  
Mouse   404 --GY---------------------------NVTRCHSYNLTVHYGYQVG-GQEQVR----EE-- 432

  Fly   912 PGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNL 976
                               |:|| ....|....||            .|....|::: |.:..|.
Mouse   433 -------------------VSWD-TDNSHPQHTIT------------NLSPYTNVSV-KLILMNP 464

  Fly   977 EENTEYIFRVRAYTKQGAGPFSDKLIVETERDM-GRAPM-SLQAEATSEQTAEIWWEPVTSRGKL 1039
            |...|                |.:|.|:|:.|: |..|. |:|..|..|:....|.||..:.|.:
Mouse   465 EGRKE----------------SQELTVQTDEDLPGAVPTESIQGSAFEEKIFLQWREPTQTYGVI 513

  Fly  1040 LGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKP 1104
            ..|:|.|  .||...|          ...||                 .|..||:|:...     
Mouse   514 TLYEITY--KAVSSFD----------PEIDL-----------------SNQSGRVSKLGN----- 544

  Fly  1105 EDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYV 1169
                        .||.:...                                             
Mouse   545 ------------ETHFLFFG--------------------------------------------- 552

  Fly  1170 KTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEE--ILVIL 1232
                   |.|.|||:..:.|..:. .:.||.....||:::||. |...:|...:|..:  :.|:|
Mouse   553 -------LYPGTTYSFTIRASTAK-GFGPPATNQFTTKISAPS-MPAYEFETPLNQTDNTVTVML 608

  Fly  1233 PQASEEYGPISHYYLVVVPEDKSNLHK---------IPDQFLTDDLLPGRNKPERPNAPYIAAKF 1288
            ..|.....|:|.|.:||..|......|         :|..|....:|..:.        |.||:|
Mouse   609 KPAQSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASILNSQY--------YFAAEF 665

  Fly  1289 PQRSI----PFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAV-------------VDTPQKHLYT 1336
            |..|:    |||  :|....|:.:.|..|...|.|||:.:|.             |.|....:.|
Mouse   666 PADSLQAAQPFT--IGDNKTYNGYWNTPLLPHKSYRIYYQAASRANGETKIDCVRVATKAAIIVT 728

  Fly  1337 --SSPFSEFLSLDMREAP---PGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVS 1396
              ::|:       :|.||   .|:......|....|||...:..   .:|..|:..:::...|. 
Mouse   729 QLTTPY-------IRIAPAAGDGQLTGAVTPKPVPEPEKQTDHT---VKIAGVIAGILLFVIIF- 782

  Fly  1397 TALIVLCVVKRRRQPCKTPDQAAVTRPLMA----------ADLGAG------------------P 1433
              |.|:.|:|:|:...|..:..:.||..|.          |:.|..                  .
Mouse   783 --LGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMGTHNLNGRSVS 845

  Fly  1434 TPS-------------------DPVDMRRLNFQTPGMIS-------------------------- 1453
            :||                   ||.....:..:|..|.|                          
Mouse   846 SPSSFTMKTNTLSTSVPNSYYPDPFVPTAILDETHTMASDTSSLAQPHTYKKREAADVPYQTGQL 910

  Fly  1454 HPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQ 1518
            ||.|.:::...||.::|..:...|.:||||...||...||::..:.|:.||||.|:.|||||||:
Mouse   911 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVR 975

  Fly  1519 LPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRI 1583
            |..:||...|||||.||.|||.:.|.|:|||||:|||..|||||.|...||:|:|:|.|.|..|:
Mouse   976 LQMLEGDNNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRV 1040

  Fly  1584 KCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHP 1648
            ||.:|||. .||.|..|.||:.:|:.||.|.||||.:.::|.::.|||:|..||.|||||||.|.
Mouse  1041 KCCKYWPD-DTEIYKDIKVTLIDTELLAEYVIRTFAVEKRGIHEIREIRQFHFTGWPDHGVPYHA 1104

  Fly  1649 APFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRN 1713
            ...|.|:|:.::.:||.:||::||||||.|||||:||||.||:..:.|.::|||..|..||::|.
Mouse  1105 TGLLGFVRQVKSKSPPNAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRV 1169

  Fly  1714 YMVQTEDQYIFIHDAILEAIICGVTEVPA---RNLHTHLQKLLITEPGETISGMEVEFKKLSNVK 1775
            .|||||:||:|||||||||.:||.|.:||   |:|:..:.||   :|....|.::.||:.|:.|.
Mouse  1170 NMVQTEEQYVFIHDAILEACLCGDTSIPASQVRSLYYDMNKL---DPQTNSSQIKEEFRTLNMVT 1231

  Fly  1776 -----MDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYI 1835
                 .|.|   .|.||.|..|||.:.|||.:....:|..|.| |.|:|:||:.:|.|:..||:|
Mouse  1232 PTLRVEDCS---IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFI 1292

  Fly  1836 AAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRY---QYYVVDPIAEY 1897
            ..|.|:.:..:||||::.:::.|.||||..:..  .:.|.||||.....|:   |...|....|.
Mouse  1293 VTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEE 1355

  Fly  1898 NMPQYKLREFKVTDARDGSSRTVRQFQFIDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPI 1960
            ::.....|.:..:..:|| .|.|:||||:.|| .:..|.|...|:..|.||.|.:|:: |.:|..
Mouse  1356 DIISRIFRIYNASRPQDG-HRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRT 1419

  Fly  1961 TVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLG 2025
            .|||..|.||||.|..:|||.|.::::..:|||..|:.||:.:|.||...|||.|||..|||||.
Mouse  1420 VVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1484

  Fly  2026 S 2026
            |
Mouse  1485 S 1485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020 21/96 (22%)
FN3 520..610 CDD:238020 12/95 (13%)
FN3 616..707 CDD:238020 17/99 (17%)
FN3 712..810 CDD:238020 30/104 (29%)
FN3 832..907 CDD:238020 15/74 (20%)
FN3 914..1005 CDD:238020 15/90 (17%)
FN3 1012..1101 CDD:238020 21/89 (24%)
fn3 1106..1198 CDD:278470 8/91 (9%)
PTPc 1476..1731 CDD:214550 138/254 (54%)
PTPc 1503..1731 CDD:238006 128/227 (56%)
PTPc 1763..2022 CDD:214550 99/268 (37%)
PTPc 1791..2022 CDD:238006 89/235 (38%)
PtprmNP_001344554.1 MAM 22..182 CDD:214533 31/189 (16%)
ig 192..274 CDD:278476 17/92 (18%)
FN3 282..361 CDD:214495 29/93 (31%)
FN3 383..467 CDD:214495 30/162 (19%)
fn3 499..574 CDD:306538 24/173 (14%)
PTPc 933..1187 CDD:214550 138/254 (54%)
PTPc 1249..1481 CDD:238006 89/235 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.