DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptpru

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_011248512.1 Gene:Ptpru / 19273 MGIID:1321151 Length:1473 Species:Mus musculus


Alignment Length:1760 Identity:438/1760 - (24%)
Similarity:664/1760 - (37%) Gaps:520/1760 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   442 WE----------PPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAI---YT 493
            ||          |.:.|:|      .|...|::|......:.::    ..|:||...|.:   |.
Mouse    59 WEQVRIHPGTRTPEDLPHG------AYLMVNASQHAPGQRAHII----FQTLSENDTHCVQFSYF 113

  Fly   494 VRVQAYTSMGAGPMSTPVQVKAQQGVPSQP------SNFRATDIGETAVTLQW-----------T 541
            :    |:..|..|.:..|.|:...|.....      |:.|.....|.||:..|           .
Mouse   114 L----YSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALI 174

  Fly   542 KPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARS--------QRG 598
            .|.|.....:...|.::...|...|..|:.:.|.    ....:..:....|.|:        ||.
Mouse   175 SPDHKGYIGLDDILLFSYPCAKAPHFSRLGDVEV----NAGQNASFQCMAAGRAAEAEHFFLQRQ 235

  Fly   599 EGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEA 663
            .|...|...||...:    |...|      |..|:                     .|||.:.:.
Mouse   236 SGVLVPAAGVRHISH----RRFLA------TFPLA---------------------SVGRSEQDL 269

  Fly   664 TTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRS------HPIILRTQEDVPGDPQDVKATP 722
                                |:       .|...||.      ..:|::........||.::|.|
Mouse   270 --------------------YR-------CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGP 307

  Fly   723 ------LNSTSIHVSWKPPLEKD-RNGIIRG--YHIHAQELRDEGKGFLNEPFKFDVVDTLEFNV 778
                  ||:.|| :...|.:.|: ...:.||  ..:||..|:                   .:.:
Mouse   308 TYLIIQLNTNSI-IGDGPIVRKEIEYRMARGPWAEVHAVNLQ-------------------TYKL 352

  Fly   779 TGLQPDTKYSIQVAALTRKGDGDR---SAAIVVKTPGGVPVRPTVSL---KIMEREPIVSIELEW 837
            ..|.|||:|.|.| .|||.|||..   ...::.:|....|.|....|   :|..|:    :.|:|
Mouse   353 WHLDPDTEYEISV-LLTRPGDGGTGRPGPPLISRTKCAEPTRAPKGLAFAEIQARQ----LTLQW 412

  Fly   838 E------RPAQTYGELRGYRLR-WGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHI 895
            |      ....||.....||.. .|..:|.::|.:......::....||........|:..:|..
Mouse   413 EPLGYNVTRCHTYAVSLCYRYTLGGSHNQTIRECVKMERGASRYTIKNLLPFRNIHVRLILTNPE 477

  Fly   896 GIGQETVKIFQTPEGTPGGPPSNITIRFQTP--DVLCVTWDPPTREHRNGIITRYDVQFHKKIDH 958
            |..:.....|||.|..|||..:. ::.| ||  |::.:.|:.|  :..||:||:|::.: :.|:.
Mouse   478 GRKEGKEVTFQTDEDVPGGIAAE-SLTF-TPLEDMIFLKWEEP--QEPNGLITQYEISY-QSIES 537

  Fly   959 G------------LGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGR 1011
            .            :...||.|..  ||:||...|.|:|.|||.|                     
Mouse   538 SDPAVNVPGPRRTISKLRNETYH--VFSNLHPGTTYLFSVRART--------------------- 579

  Fly  1012 APMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKF 1076
                                                                             
Mouse   580 ----------------------------------------------------------------- 579

  Fly  1077 AQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFD 1141
                                                                             
Mouse   580 ----------------------------------------------------------------- 579

  Fly  1142 AMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTT 1206
                   |:||.|..:                       |....|:||...||:           
Mouse   580 -------SKGFGQAAL-----------------------TEITTNISAPSFDYA----------- 603

  Fly  1207 QMAAPQPMVKPDFYGVVNGEE---ILVILPQASEEYGPISHYYLVVVPEDKSNLHKIP---DQF- 1264
              ..|.|:          ||.   |.|:|..|.....|||.|.:||..|....|.:.|   |.| 
Mouse   604 --DMPSPL----------GESENTITVLLRPAQGRGAPISVYQVVVEEERPRRLRREPGAQDCFS 656

  Fly  1265 --LTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVV 1327
              ||.:....|.......|. :||.....::|||  :|....|..|.|..||..|.|.|:.:|. 
Mouse   657 VPLTFETALARGLVHYFGAE-LAASSLLEAMPFT--VGDNQTYRGFWNPPLEPRKAYLIYFQAA- 717

  Fly  1328 DTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVST 1392
                .||...:..:.............:||            :.|::..:|..::..:....::.
Mouse   718 ----SHLKGETRLNCIRIARKAACKESKRP------------LEVSQRSEEMGLILGICAGGLAV 766

  Fly  1393 FIVSTALIVLCVVKRR---------------------RQPCKTPDQAAVTRPLM----------- 1425
            .|:....|::.:.|.|                     ||. ||...:||.|...           
Mouse   767 LILLLGAIIVIIRKGRDRYAYSYYPKPVNMTKATVNYRQE-KTHMMSAVDRSFTDQSTLQEDERL 830

  Fly  1426 -----------------------AADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIE 1467
                                   |:.| .|.:|..|...:...:.| |.: ||.:.:::...||.
Mouse   831 GLSFMDAPGYSPRGDQRSGGVTEASSL-LGGSPRRPCGRKGSPYHT-GQL-HPAVRVADLLQHIN 892

  Fly  1468 RLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYIN 1532
            ::|:.:...|.|||||...|    ||.:..:......|...|:|||...|:|..:.....:|||:
Mouse   893 QMKTAEGYGFKQEYESFFEG----WDATKKKDKLKGGRQEPVSAYDRHHVKLHPMLADPDADYIS 953

  Fly  1533 ANYCD------GYRKHNAYVATQ-------------GPLQETFVDFWRMCWELKTATIVMMTRLE 1578
            |||.|      ||.:.|.::|||             ||..|...|||||.|:.:.|:|||:|:|.
Mouse   954 ANYIDIRINRQGYHRSNHFIATQGDLAQGQAPSAPPGPKPEMIYDFWRMVWQEQCASIVMITKLV 1018

  Fly  1579 ERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHG 1643
            |..|:||.:||| ..::.||.|.:|:.:|:.||.|.:|||.|.|:|::.|.|::|..|||||:||
Mouse  1019 EVGRVKCSRYWP-EDSDMYGDIKITLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHG 1082

  Fly  1644 VPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCL 1708
            ||.|....|.|:||.:|.|||::||:::|||||.||||||||:|.||:..:.|.::|||..|..|
Mouse  1083 VPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTL 1147

  Fly  1709 RAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSN 1773
            .::|..|:|||:||||||||||||.:||.|.:|........::::..:|....|.:..||:.|::
Mouse  1148 CSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVNEFKATYREMIRIDPQSNSSQLREEFQTLNS 1212

  Fly  1774 V--KMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIA 1836
            |  .:|..:...|.||.|:.|||.:.:||.:....:|....| :.::|:||:..|.|...:|:|.
Mouse  1213 VTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISSDG-DPNNYINAALTDSYTRSAAFIV 1276

  Fly  1837 AQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGRE-KCFQYWPHERSVRYQYYVVDPIAEYNMP 1900
            ...|:|....||||:::::..|.:|||.:|.:.... .|.||||.....:|....|:.::.....
Mouse  1277 TLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFVSGTANE 1341

  Fly  1901 QYKLREFKVTDARDGSSR------TVRQFQFIDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDG 1958
            ....|.|:|    ..|||      .||.|||:.|.. :..|.|.:.|:..:.:|.|.:.:.| ||
Mouse  1342 DLVSRVFRV----QNSSRLQEGHLLVRHFQFLRWSAYRDTPDSRKAFLHLLAEVDKWQAESG-DG 1401

  Fly  1959 PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY 2023
            ...|||..|.||||.|...:.|||.::...::|||...:.||:.:|.||:|.|||||||..||||
Mouse  1402 RTVVHCLNGGGRSGTFCACATVLEMIRCHSLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1466

  Fly  2024 LGSFD 2028
            |.:.:
Mouse  1467 LEALE 1471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628 64/357 (18%)
FN3 712..810 CDD:238020 28/109 (26%)
FN3 832..898 CDD:214495 15/72 (21%)
FN3 <867..1269 CDD:442628 69/424 (16%)
fn3 914..998 CDD:394996 27/97 (28%)
R-PTPc-LAR-1 1498..1735 CDD:350401 118/255 (46%)
R-PTP-LAR-2 1784..2021 CDD:350402 84/244 (34%)
PtpruXP_011248512.1 MAM 31..194 CDD:214533 28/148 (19%)
IG_like 204..290 CDD:214653 20/147 (14%)
fn3 299..373 CDD:394996 26/94 (28%)
FN3 <355..>632 CDD:442628 87/492 (18%)
fn3 502..585 CDD:394996 29/246 (12%)
PTP_DSP_cys 951..1174 CDD:475123 110/223 (49%)
R-PTPc-U-2 1259..1465 CDD:350485 74/210 (35%)
Blue background indicates that the domain is not in the aligned region.

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