DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lar and Ptprk

DIOPT Version :10

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_006512669.1 Gene:Ptprk / 19272 MGIID:103310 Length:1485 Species:Mus musculus


Alignment Length:1797 Identity:484/1797 - (26%)
Similarity:720/1797 - (40%) Gaps:522/1797 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   412 GDFSFGGTKMESAPRNVQVRT--------LSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEA 468
            |.||.||...:..|.......        :..|.....:.|||.|.|   .|.|..::|.:..|.
Mouse    28 GQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQG---SYMVVDSSNHDPGEK 89

  Fly   469 SWNSQMVDNSELTTVSELTPHAI---YTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQP----SNF 526
            :       ..:|.|:.|...|.|   |.:    |:..|..|.:..:.|:..:|..:.|    :.|
Mouse    90 A-------RLQLPTMKENDTHCIDFSYLL----YSQKGLNPGTLNILVRVNKGPLANPIWNVTGF 143

  Fly   527 RATD--IGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYP--DTLY 587
            ...|  ..|.||:..|     .:|..|.:|.   :....::.:..|.:.:..:    ||  .:.:
Mouse   144 TGRDWLRAELAVSTFW-----PNEYQVIFEA---EVSGGRSGYIAIDDIQVLS----YPCDKSPH 196

  Fly   588 YIWLA-ARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTI-SLSWLPPPVERSNG------ 644
            ::.|. .....|:.||                 ...|||....: :..||    :|.||      
Mouse   197 FLRLGDVEVNAGQNAT-----------------FQCIATGRDAVHNKLWL----QRRNGEDIPVA 240

  Fly   645 --RIIYYKVF-----FVEVGRED---------DEATTMTLNMTSIVLDELKR-----------WT 682
              :.|.::.|     ..||.:.|         .|..:...|...:::.|..|           .|
Mouse   241 QTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPT 305

  Fly   683 EYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGY 747
            ...|.:.|.:.:|||    ||||:..|             ...||  .||.              
Mouse   306 YLLIQLNANSIIGDG----PIILKEVE-------------YRMTS--GSWT-------------- 337

  Fly   748 HIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDR---SAAIVVK 809
            ..||          :|.|         .:.:..|.|||:|.|:| .|||.|:|..   ...::.:
Mouse   338 ETHA----------VNAP---------TYKLWHLDPDTEYEIRV-LLTRPGEGGTGLPGPPLITR 382

  Fly   810 TPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKK 874
            |....|:|...:|||.|.: ...|.::||.        .||                        
Mouse   383 TKCAEPMRTPKTLKIAEIQ-ARRIAVDWES--------LGY------------------------ 414

  Fly   875 RFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTRE 939
               |:.|.  :.|.|....|...|....:                        ..|:..||...:
Mouse   415 ---NITRC--HTFNVTICYHYFRGHNESR------------------------ADCLDMDPKAPQ 450

  Fly   940 HRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVE 1004
            |              .::| |....|::| |.:.||.|...|                |::.|::
Mouse   451 H--------------VVNH-LPPYTNVSL-KMILTNPEGRKE----------------SEETIIQ 483

  Fly  1005 TERDM-GRAPM-SLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTES 1067
            |:.|: |..|: |||..:...:....|.||:...|.:..|::.|  :::...|.           
Mouse   484 TDEDVPGPVPVKSLQGTSFENKIFLNWKEPLEPNGIITQYEVSY--SSIRSFDP----------- 535

  Fly  1068 ADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLT 1132
                        ||.:|.                  |.....||             |:.     
Mouse   536 ------------AVPVAG------------------PPQTVSNL-------------WNS----- 552

  Fly  1133 PVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYN--VNVSAIPSDYS 1195
                                             .|:|..|    |.|.|||.  :..|.:.   .
Mouse   553 ---------------------------------THHVFMH----LHPGTTYQFFIRASTVK---G 577

  Fly  1196 YRPPTKITVTTQMAAPQPMVKPDFYGV-----VNGEEILVILPQASEEYGPISHYYLVVVPEDKS 1255
            :.|.|.|.|||.::||.   .||:.||     .....|.|:|..|..:..|||.|.:||      
Mouse   578 FGPATAINVTTNISAPS---LPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVV------ 633

  Fly  1256 NLHKIPDQFLTDDLLPGRNKPE-----------------RPNAP-YIAAKFPQRSI--PFTFHLG 1300
                       :.|.|.|.|.|                 ...|| |.||:.|..::  |..|.:|
Mouse   634 -----------EQLHPHRTKREAGAMECYQVPVTYQNALSGGAPYYFAAELPPGNLPEPAPFTVG 687

  Fly  1301 SGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWP 1365
            ....|..|.|..|...|.|.|:.:|:          ||...|..:..:|.|.......       
Mouse   688 DNRTYKGFWNPPLAPRKGYNIYFQAM----------SSVEKETKTQCVRIATKAAATE------- 735

  Fly  1366 AEPEVSVNRNKDEPEILWVV-LPLMVSTFIVSTALIVLCVVKR----RRQPC------------- 1412
             ||||..:..|....::.:. :...:..||:...::::.|.||    ||..|             
Mouse   736 -EPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVIVIVKKRYICWRRHICIRNIRRSYYSYSY 799

  Fly  1413 ------KTPDQAAVTRPLMAADLGA---------------------------GP-TPSDP----- 1438
                  |..|....||..|...:.|                           .| .|:||     
Mouse   800 YLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRLPNDPLVPTA 864

  Fly  1439 -------------------VDMRRL-------NFQTPGMISHPPIPISEFANHIERLKSNDNQKF 1477
                               :|:.|.       .:|| |.: ||.|.:::...||..:|::|:..|
Mouse   865 VLVPITDENHSATAESSRLLDVPRYLCEGTESPYQT-GQL-HPAIRVADLLQHINLMKTSDSYGF 927

  Fly  1478 SQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYC------ 1536
            .:||||...||..:||.:..:.|::||||.|:.|||||||.|..||....||||||||.      
Mouse   928 KEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYR 992

  Fly  1537 DGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIF 1601
            |||::.:.|:|||||:.||..|||||.|:.::|.|||:|.|.|..|:||.:|||. .||.||...
Mouse   993 DGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFK 1056

  Fly  1602 VTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPES 1666
            ||..|.:.||.|.:|||.|.|:|:|:.||:||..||.|||||||.|....|.|:||.:...||.:
Mouse  1057 VTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSA 1121

  Fly  1667 GPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE 1731
            ||::||||||.||||||||||.||:..:.|.::|||..|..||::|..|||||:|||||||||||
Mouse  1122 GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE 1186

  Fly  1732 AIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNV--KMDSSKFVTANLPCNKHKNR 1794
            |.:||.|.:|..........::..:.....|.::.||:.|::|  ::.:.....|.||.|..|||
Mouse  1187 ACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNR 1251

  Fly  1795 LVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTI 1859
            .:.:||.:....:|..|.| |.|:|:||:.:|.||..:|:|..|.|:.:..:||||:::::..|.
Mouse  1252 FMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1315

  Fly  1860 VVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIA---EYNMPQYKLREFKVTDARDGSSRTVR 1921
            :|||.::..  .:.|.||||.|..:||....|:.::   :.::.....|...:|..::| ...|:
Mouse  1316 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEG-YLMVQ 1377

  Fly  1922 QFQFIDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPITVHCSAGVGRSGVFITLSIVLERM 1984
            |||::.| ..:.||.|...|:..|.||.|.:|:..: :|...:||..|.||||:|..:.||:|.:
Mouse  1378 QFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMV 1442

  Fly  1985 QYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026
            :.:.|:|||..|:.||:.:|.||:..:||.|||..|||||.|
Mouse  1443 KRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628 76/388 (20%)
FN3 712..810 CDD:238020 20/100 (20%)
FN3 832..898 CDD:214495 10/65 (15%)
FN3 <867..1269 CDD:442628 73/410 (18%)
fn3 914..998 CDD:394996 13/83 (16%)
R-PTPc-LAR-1 1498..1735 CDD:350401 136/242 (56%)
R-PTP-LAR-2 1784..2021 CDD:350402 85/241 (35%)
PtprkXP_006512669.1 MAM 31..191 CDD:214533 37/185 (20%)
IG_like 201..287 CDD:214653 18/106 (17%)
Ig strand B 211..215 CDD:409353 2/20 (10%)
Ig strand C 225..231 CDD:409353 2/9 (22%)
Ig strand E 252..256 CDD:409353 0/3 (0%)
Ig strand F 266..271 CDD:409353 0/4 (0%)
fn3 293..370 CDD:394996 30/129 (23%)
FN3 <458..>670 CDD:442628 69/349 (20%)
fn3 487..582 CDD:394996 30/195 (15%)
PTP_DSP_cys 911..1189 CDD:475123 149/278 (54%)
R-PTPc-K-2 1275..1480 CDD:350484 72/207 (35%)
Blue background indicates that the domain is not in the aligned region.

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