DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptprf

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_006502927.1 Gene:Ptprf / 19268 MGIID:102695 Length:1924 Species:Mus musculus


Alignment Length:2098 Identity:975/2098 - (46%)
Similarity:1278/2098 - (60%) Gaps:252/2098 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 GLQMTAARPIAALSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPS 66
            |.:|....|    :|::|.|:...|     ....|..::.|::|....||||||.|.|.|:|.|.
Mouse     8 GRRMVPLVP----ALVMLGLMAGAH-----GDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPR 63

  Fly    67 IVWRKNGKKVSGTQSRYTVLE-QPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIY 130
            |.|.|.|||||  ..|:.|:| ..|..|:|||:|:|..||:|.|||.|.|.:|: ::..|.|::.
Mouse    64 ITWMKKGKKVS--SQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGE-INTSAKLSVL 125

  Fly   131 EGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKD---- 191
            |.|:.|:|||.|..||..:|:|.|.|..|.|.|.|||.|.|.|.|:...||.:.....:|.    
Mouse   126 EEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLPVDPAASNGRIKQLRSG 190

  Fly   192 -----GFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSN 251
                 |.||||:|.|.|||||||||.||.||.:|...||||:||||.|.||.||.: .|||.|.:
Mouse   191 GSPIRGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS-QEVMPGGS 254

  Fly   252 LNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVV 316
            :||:|:|||:|||:||||.|:|:||.|:|||:|||||:|.|:..||||||:|.|:||.|::.:.|
Mouse   255 VNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQV 319

  Fly   317 KVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRA 381
            .|::||..|.|:.::|.|||||.|.|.....|.:.:|.|||:....:..|.|:.|:.:..|.:..
Mouse   320 TVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGG 384

  Fly   382 LSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPE 446
            |||::||.|.|:|||:|||||||......||:     ....|.||.||.|.||:|||::.|||||
Mouse   385 LSPFSEYAFRVLAVNSIGRGPPSEAVRARTGE-----QAPSSPPRRVQARMLSASTMLVQWEPPE 444

  Fly   447 TPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPV 511
            .|||.|.||:||||.:|.:|.::|:....|...||||..|.|...|::||.|:|::|.||.|..:
Mouse   445 EPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTI 509

  Fly   512 QVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYEL-YWNDTYANQAHHKRISNSEA 575
            |||.|||||:||::|:|....:|.:.|.|..|  ..|.||.||| ||......|.|......:.:
Mouse   510 QVKTQQGVPAQPADFQANAESDTRIQLSWLLP--PQERIVKYELVYWAAEDEGQQHKVTFDPTSS 572

  Fly   576 YTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPPP 638
            |||:.|.|||||:..|||||..|.|..||.:..||.|.  .|||:.:|.::|.|||:.:||:|||
Mouse   573 YTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPP 637

  Fly   639 VERSNGRIIYYKVFFVEVGREDDE---ATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRS 700
            .:..||.|..|.|.:..|..||.:   ...::...:|..|..|::||||::||.|.|.||.||.|
Mouse   638 ADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPES 702

  Fly   701 HPIILRTQEDVP-GDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRD-EGKGFLN 763
            .|:::||.|||| |.|:.|:..|||||::|||||.|:...::|.||||.:....|.: |.:|   
Mouse   703 SPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRG--- 764

  Fly   764 EPFKFDVV-----------DTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVR 817
            :|...||:           :..|..::||.|:|.|||.|||.|.||||.||...||.|.|.||.|
Mouse   765 QPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGR 829

  Fly   818 PTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERG 882
            ||:.:........:   |:|..|.:..|||.||||::...|:|....:..|..........|.:|
Mouse   830 PTMMVSTTAMHTAL---LQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKG 891

  Fly   883 VEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITR 947
            ..|.||:|..|..|.|:|..|...|||..|.|.|.|:.:...|.....:|||||....|||.||.
Mouse   892 ATYVFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVTGLTTSTTELTWDPPVLAERNGHITN 956

  Fly   948 YDVQF---HKKID-HGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVET--- 1005
            |.|.:   :.::: ..:.::.::||     ..|:.:|.|..:|||:|.:||||.|..:...|   
Mouse   957 YTVVYRDINSQLELQNVTNDTHLTL-----LGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPV 1016

  Fly  1006 ERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADL 1070
            |:...:   :.:..|..:.:..:.||...|....:.:||.|...:|| :|....:.:       :
Mouse  1017 EQVFAK---NFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVE-VDGHSMRKL-------I 1070

  Fly  1071 VNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVN 1135
            .:|:...:|:..:..| .:..|.|...|::|..|:.:|                 ..|:   |.:
Mouse  1071 ADLQPNTEYSFVLMNR-GSSAGGLQHLVSIRTAPDLLP-----------------QKPL---PAS 1114

  Fly  1136 YKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPT 1200
                     .|::...||                                               
Mouse  1115 ---------AFIEDGRFS----------------------------------------------- 1123

  Fly  1201 KITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDK--SNL----HK 1259
                                         :.:||. ::...:..:|:||||.|:  .||    ..
Mouse  1124 -----------------------------LSMPQV-QDPSLVRWFYIVVVPIDRVGGNLLAPRWN 1158

  Fly  1260 IPDQFLTDDLL----PGRNKPERPN------APYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLE 1314
            .|::...|:||    .|..|..|..      .||:||:..  .:|.||.||....|..|.||.|.
Mouse  1159 TPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVD--VLPDTFTLGDKKSYRGFYNRPLS 1221

  Fly  1315 REKRYRIFVRAVVDTP--QKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKD 1377
            .:..|:.||.|.:..|  ||. |.|||:|:.:.:                      :|:..:.::
Mouse  1222 PDLSYQCFVLASLKEPMDQKR-YASSPYSDEIVV----------------------QVTPAQQQE 1263

  Fly  1378 EPEILWVVLPLMVSTFIVSTALIVLCVV----KRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDP 1438
            |||:|||..|::....|:   |||:.::    ||...|....:|:...:..:.|.      .|||
Mouse  1264 EPEMLWVTGPVLAVILII---LIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAH------SSDP 1319

  Fly  1439 VDMRRLNFQTPG-----------MISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTW 1492
            |:|||||:||||           |..||||||::.|::|||||:||..|||||||||:|||||||
Mouse  1320 VEMRRLNYQTPGSSAPSCPNISSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTW 1384

  Fly  1493 DNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFV 1557
            :|||.|.||.|||||||.|||||||.|.:::||.|||||||||.|||||.|||:||||||.||..
Mouse  1385 ENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMG 1449

  Fly  1558 DFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCR 1622
            |||||.||.:|||:||||||||::|:|||||||.|||||||.|.||:.:|.|||||::|||.|.:
Mouse  1450 DFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHK 1514

  Fly  1623 QGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVID 1687
            .|.:::||::|.||.||||||||::|.|.|.||||.:|..|.::||::||||||||||||:||||
Mouse  1515 SGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID 1579

  Fly  1688 SMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKL 1752
            :|||||||||.:||||||||:|:||||||||||||:|||:|:|||.:||.|||.||||:.|:|||
Mouse  1580 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKL 1644

  Fly  1753 LITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGS 1817
            ....|||:::.||:|||.|:|.|..:|:||:|||||||.|||||:|:|||.:||.|.||.|:|||
Mouse  1645 GQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGS 1709

  Fly  1818 DYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHER 1882
            ||:||||:||||.:.||||.|||:.::.||||||||||||||:||||||:|||||||.||||.||
Mouse  1710 DYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER 1774

  Fly  1883 SVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQV 1947
            |.||||:||||:||||||||.||||||||||||.|||:|||||.|||||||||:|||||||||||
Mouse  1775 SARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV 1839

  Fly  1948 HKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQ 2012
            |||||||||||||||||||||||:|||||||||||||:||||:|:||||:.||:|||||||||||
Mouse  1840 HKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQ 1904

  Fly  2013 YHFCYRAALEYLGSFDNY 2030
            |..|||||||||||||:|
Mouse  1905 YQLCYRAALEYLGSFDHY 1922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 43/94 (46%)
I-set 36..129 CDD:254352 43/93 (46%)
IG_like 146..227 CDD:214653 41/89 (46%)
Ig 159..228 CDD:299845 37/77 (48%)
I-set 234..318 CDD:254352 49/83 (59%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 40/67 (60%)
fn3 324..404 CDD:278470 34/79 (43%)
FN3 423..514 CDD:238020 46/90 (51%)
FN3 520..610 CDD:238020 37/90 (41%)
FN3 616..707 CDD:238020 37/93 (40%)
FN3 712..810 CDD:238020 46/110 (42%)
FN3 832..907 CDD:238020 24/74 (32%)
FN3 914..1005 CDD:238020 30/94 (32%)
FN3 1012..1101 CDD:238020 16/88 (18%)
fn3 1106..1198 CDD:278470 6/91 (7%)
PTPc 1476..1731 CDD:214550 185/254 (73%)
PTPc 1503..1731 CDD:238006 163/227 (72%)
PTPc 1763..2022 CDD:214550 207/258 (80%)
PTPc 1791..2022 CDD:238006 189/230 (82%)
PtprfXP_006502927.1 I-set 33..124 CDD:369462 43/93 (46%)
Ig2_RPTP_IIa_LAR_like 152..232 CDD:319301 37/79 (47%)
Ig3_RPTP_IIa_LAR_like 252..320 CDD:143216 40/67 (60%)
FN3 325..414 CDD:238020 37/88 (42%)
FN3 421..513 CDD:238020 47/91 (52%)
FN3 518..607 CDD:238020 37/90 (41%)
FN3 615..709 CDD:238020 37/93 (40%)
FN3 716..822 CDD:238020 45/108 (42%)
FN3 827..916 CDD:238020 28/91 (31%)
FN3 925..1013 CDD:238020 29/92 (32%)
FN3 1022..>1081 CDD:238020 12/69 (17%)
PTP_DSP_cys 1352..1627 CDD:391942 196/274 (72%)
R-PTP-F-2 1629..1919 CDD:350477 226/289 (78%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 422 1.000 Domainoid score I630
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1260 1.000 Inparanoid score I173
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47937
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001053
OrthoInspector 1 1.000 - - otm43194
orthoMCL 1 0.900 - - OOG6_100623
Panther 1 1.100 - - O PTHR19134
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 1 1.000 - - X953
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.860

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