DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Ptpre

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_001303607.1	Gene:	Ptpre / 19267	MGIID:	97813	Length:	719	Species:	Mus musculus

Alignment Length:	727	Identity:	295/727 - (40%)
Similarity:	421/727 - (57%)	Gaps:	59/727 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1336 TSSPFSEFL----SLDMREAPPGERPHRPDPNW------PAEPEVSVNRNKDEPEILWVVLPLMV 1390
            |..||...|    ||.:..|..|......:.||      |.:|..|      :|.:.|::|||::
Mouse    20 TMEPFCPLLLASFSLSLARAGQGNDTTPTESNWTSTTAGPPDPGAS------QPLLTWLLLPLLL 78

  Fly  1391 STFIVSTALIVL-----CVVKR--RRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQT 1448
            ..|:::......     .||..  ::.|....::....|.::.:...:||.
Mouse    79 LLFLLAAYFFRFRKQRKAVVSSNDKKMPNGILEEQEQQRVMLLSRSPSGPK-------------- 129

  Fly  1449 PGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQ-QFTWDNSNLEHNKSKNRYANVTAY 1512
                ...|||:......|....::|.::|.:|:.|:..|. |.|::.:|.|.|:.||||.|:...
Mouse   130 ----KFFPIPVEHLEEEIRVRSADDCKRFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPN 190

  Fly  1513 DHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRL 1577
            ||.||.|..|:|:..||||||:|.|||::.|.::|.|||.|||..|||||.||.::|||||:|.|
Mouse   191 DHCRVILSQVDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQRSATIVMLTNL 255

  Fly  1578 EERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTF----QL---CRQGFNDRREIKQLQ 1635
            :||...||.||||.:|..|||.|.|.:.:...|..|:||.|    ||   |:.    .|.:.||.
Mouse   256 KERKEEKCYQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIHPQLPDSCKA----PRLVSQLH 316

  Fly  1636 FTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIID 1700
            ||:|||.|||..|...|:||::.:.|.|..:||::|||||||||||.:||||:|::.:..|:.:|
Mouse   317 FTSWPDFGVPFTPIGMLKFLKKVKTLNPSHAGPIVVHCSAGVGRTGTFIVIDAMMDMIHSEQKVD 381

  Fly  1701 IYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGME 1765
            ::..|:.:|.||..||||:.||.||:.|:||..:.|.||:...:|..|||.|..|.......|:|
Mouse   382 VFEFVSRIRNQRPQMVQTDVQYTFIYQALLEYYLYGDTELDVSSLERHLQTLHSTATHFDKIGLE 446

  Fly  1766 VEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRY 1830
            .||:||:||::......|.|||.|..|.|::.|:||:.:||.|:...|.|.:||:|||||||||.
Mouse   447 EEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEFTDYINASFIDGYRQ 511

  Fly  1831 RSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIA 1895
            :..::|.|||:....||||||:||..|..:||||:::|..::||:||||.|.||.:....::..:
Mouse   512 KDYFMATQGPLAHTVEDFWRMVWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGDITIEIKS 576

  Fly  1896 EYNMPQYKLREFKVT-----DARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1955
            :.......:|:|.||     ..::...|.||||.|..|||.|:|..|:|.||.|..|.|.::|.|
Mouse   577 DTLSEAISVRDFLVTFKQPLARQEEQVRMVRQFHFHGWPEVGIPAEGKGMIDLIAAVQKQQQQTG 641

  Fly  1956 QDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAA 2020
             :.|||||||||.||:|.||.||.:|||::.||:|||||.|:.||.|||.||||.:||.|||:..
Mouse   642 -NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV 705

  Fly  2021 LEYLGSFDNYTN 2032
            .:::..|.:|.|
Mouse   706 QDFIDIFSDYAN 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550	125/262 (48%)
		PTPc	1503..1731	CDD:238006	116/234 (50%)
		PTPc	1763..2022	CDD:214550	126/263 (48%)
		PTPc	1791..2022	CDD:238006	113/235 (48%)
Ptpre	NP_001303607.1	PTPc	154..412	CDD:214550	125/261 (48%)
		PTPc	180..412	CDD:238006	116/235 (49%)
		PTPc	444..707	CDD:214550	126/263 (48%)
		PTPc	472..707	CDD:238006	113/235 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710