DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and Ptprd

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	XP_036019731.1	Gene:	Ptprd / 19266	MGIID:	97812	Length:	1966	Species:	Mus musculus

Alignment Length:	2129	Identity:	996/2129 - (46%)
Similarity:	1307/2129 - (61%)	Gaps:	282/2129 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ARPIAALSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKN 72
            |||   ||||:...|      ...|..||...|.|.:|....||||||.|.|.|||.|.|||.|.
Mouse    12 ARP---LSLLLTFFL------CACAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKK 67

  Fly    73 GKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPA 137
            |||||..:....:....|..|:|||:|:|..||:|.|||||.|.||: :|....||:...|:.|.
Mouse    68 GKKVSNQRFEVVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGE-ISVSTRLTVLREDQIPR 131

  Fly   138 GFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKD----------- 191
            |||.|..||..:|:|...|..|.|.|.|||.|.|.|.|:...||.||....:|.
Mouse   132 GFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPI 196

  Fly   192 -GFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVK----VRRVPPTFSRPPETISEVMLGSN 251
             |.||||.|.|.|||||||||.||.||.:|...||||:    ||||||.||.|| |..|:|.|.:
Mouse   197 RGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPP-TNHEIMPGGS 260

  Fly   252 LNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVV 316
            :|::|:|||||||:||||.|:||||||::||||||||:|.::::||||||:|.||||.|::::.:
Mouse   261 VNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQI 325

  Fly   317 KVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRA 381
            .|::||..|....::|.||||:.|.|....||.:.||:||:||||:.:.:.||.||.|..|.|..
Mouse   326 TVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDGIATTRYSVAG 390

  Fly   382 LSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPE 446
            ||||::|||.|:|||||||||.|.|....|.:     ....||||:||.|.|||:|:::.|:.||
Mouse   391 LSPYSDYEFRVVAVNNIGRGPASEPVLTQTSE-----QAPSSAPRDVQARMLSSTTILVQWKEPE 450

  Fly   447 TPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPV 511
            .||||:.||:||||.:..|...:|....|.:|::||:..|.|...|:|:|.|:||:|.||:|:.:
Mouse   451 EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDI 515

  Fly   512 QVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRIS--NSE 574
            ||..|.|||.||.||:|....||::.|.||.|  .|:.|..|||.:.|  .:|...:||:  ...
Mouse   516 QVITQTGVPGQPLNFKAEPESETSILLSWTPP--RSDTIASYELVYRD--GDQGEEQRITIEPGT 576

  Fly   575 AYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQY--GAPPRNITAIATSSTTISLSWLPP 637
            :|.|.||.|::|||..|:|||.:|.||:|..|..||.|.  .|||::|:..:.|||:|.:||.||
Mouse   577 SYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 641

  Fly   638 PVERSNGRIIYYKVFFVEVGRED---DEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPR 699
            |||:.||.|..|.:.:..|..||   .|...:..:.|..:|::|::||||:|.|.|.|.||.||.
Mouse   642 PVEKQNGIITEYSLKYAAVDGEDFKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPE 706

  Fly   700 SHPIILRTQEDVP-GDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRD-EGKGFL 762
            |..:::||.|||| |.|:.|:...:|:|::.|||:.|:...::|.||||.:|..::.: |.||
Mouse   707 SLSVLIRTDEDVPSGPPRKVEVEAVNATAVKVSWRSPVPNKQHGQIRGYQVHYVKMENGEPKG-- 769

  Fly   763 NEPFKFDVV---------DTLEFN--VTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPV 816
             :|...||:         ||.|.:  ::||||:|.||:.|.|.|.||||.||...:|.|.|.||.
Mouse   770 -QPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 833

  Fly   817 RPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKR----FD 877
            :|.:   ::....:.:..::|..|..|:|.|:||||::|.||.    |.|:..:.::|.    ..
Mouse   834 KPRL---VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDM----EPLTTLEFSEKEDHFTAT 891

  Fly   878 NLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRN 942
            ::.:|..|.||::..|.:|.|:|.||....||..|.|.|.|:.....|...:.::|.||....||
Mouse   892 DIHKGASYVFRLSARNKVGFGEEMVKEISVPEEIPTGFPQNLHSEGTTSTSVQLSWQPPVLAERN 956

  Fly   943 GIITRYDVQFHK------KIDHGL-GSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDK 1000
            |:||:|.:.:..      .::|.: .::.:|||     |.|:.:|.|..:|||:|.:|.||:|..
Mouse   957 GVITKYTLLYRDINVPLLPMEHLIVPADTSMTL-----TGLKSDTTYDVKVRAHTSKGPGPYSPS 1016

  Fly  1001 LIVET-ERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGL 1064
            :...| ..|......:...:|..:.:..:.||...:....:.:||.|        ||.:     :
Mouse  1017 VQFRTLPVDQAVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILY--------DDGK-----M 1068

  Fly  1065 TESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPI 1129
            .|..|                      ||.::|:.|.:|||           .::|..|:
Mouse  1069 VEEVD----------------------GRATQKLIVNLKPE-----------KSYSFVLT----- 1095

  Fly  1130 RLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDY 1194
                               ::|.|...        |:|.|
Mouse  1096 -------------------NRGNSAGG--------LQHRV------------------------- 1108

  Fly  1195 SYRPPTKITVTTQMAAPQPM-VKPDFYGVVNGEEILVI-LPQ--ASEEYGPISHYYLVVVPEDKS 1255
                       |...||..: .||.|.|..|.:.::.: ||.  |:|.   |..||:::||..||
Mouse  1109 -----------TAKTAPDVLRTKPAFIGKTNLDGMITVQLPDVPANEN---IKGYYIIIVPLKKS 1159

  Fly  1256 NLHKI-----PDQFLTDDLLPGRNKPER--------PNAPYIAAKFPQRSIPFTFHLGSGDDYHN 1307
            ....|     ||:...|:||...::..|        ...|||||.|.  .:|..|.||....|..
Mouse  1160 RGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFD--VLPTEFTLGDDKHYGG 1222

  Fly  1308 FTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSE-FLSLDMREAPPGERPHRPDPNWPAEPEVS 1371
            |||::|:..:.|..||.||:|..:..:|.:||:|: .:|:|:            ||. |...|
Mouse  1223 FTNKQLQSGQEYVFFVLAVMDHAESKMYATSPYSDPVVSMDL------------DPQ-PITDE-- 1272

  Fly  1372 VNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPS 1436
                  |..::|||.|::...||:...:.:| :.|..:...|..:..:....|..:.......|:
Mouse  1273 ------EEGLIWVVGPVLAVVFIICIVIAIL-LYKSSKPDRKRAESESRKSSLPNSKEVPSHHPT 1330

  Fly  1437 DPVDMRRLNFQTP----------------------------------------GMISHPPIPISE 1461
            |||::||||||||                                        ||.|||||||.|
Mouse  1331 DPVELRRLNFQTPALSSNSVPYASLIGSVSSLSSQTTTQSIYDNNSLPRFARKGMASHPPIPILE 1395

  Fly  1462 FANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVV 1526
            .|:||||||:|||.|||||||||:|||||||::||||.||.|||||||.|||||||.|.|:||:.
Mouse  1396 LADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIP 1460

  Fly  1527 GSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPT 1591
            ||||:||||.|||||.|||:||||.|.|||.|||||.||.::||:||||:||||:|:|||||||:
Mouse  1461 GSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS 1525

  Fly  1592 RGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLR 1656
            |||||:|.:.||:.:|.|||||.:|||.|.:.|.:::||::|.|||||||||||:||.|||.|||
Mouse  1526 RGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLR 1590

  Fly  1657 RCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQ 1721
            |.:...||::||::||||||||||||:||||:||||:||||.:|||||||.:|||||||||||||
Mouse  1591 RVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQ 1655

  Fly  1722 YIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANL 1786
            |||||||:|||:.||.||||||||:.::|||...|.||.::|||:|||:|::.|..:|:|::|||
Mouse  1656 YIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANL 1720

  Fly  1787 PCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRM 1851
            ||||.|||||:|:||||:||.|.||.|:|||||:||||:||||.:.||||.|||:.:..||||||
Mouse  1721 PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAETTEDFWRM 1785

  Fly  1852 LWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGS 1916
            |||||||||||||||:|||||||.||||.|||.||||:||||:||||||||.||||||||||||.
Mouse  1786 LWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1850

  Fly  1917 SRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVL 1981
            |||||||||.||||||||||||||||||||||||||||||||||:|||||||||:||||||||||
Mouse  1851 SRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVL 1915

  Fly  1982 ERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNY 2030
            |||:||||:|:||||::||:||||||||||||.||||||||||||||:|
Mouse  1916 ERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEYLGSFDHY 1964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845	46/93 (49%)
		I-set	36..129	CDD:254352	45/92 (49%)
		IG_like	146..227	CDD:214653	42/92 (46%)
		Ig	159..228	CDD:299845	39/80 (49%)
		I-set	234..318	CDD:254352	50/83 (60%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	42/67 (63%)
		fn3	324..404	CDD:278470	42/79 (53%)
		FN3	423..514	CDD:238020	43/90 (48%)
		FN3	520..610	CDD:238020	38/91 (42%)
		FN3	616..707	CDD:238020	38/93 (41%)
		FN3	712..810	CDD:238020	42/110 (38%)
		FN3	832..907	CDD:238020	25/78 (32%)
		FN3	914..1005	CDD:238020	29/97 (30%)
		FN3	1012..1101	CDD:238020	13/88 (15%)
		fn3	1106..1198	CDD:278470	7/91 (8%)
		PTPc	1476..1731	CDD:214550	186/254 (73%)
		PTPc	1503..1731	CDD:238006	164/227 (72%)
		PTPc	1763..2022	CDD:214550	210/258 (81%)
		PTPc	1791..2022	CDD:238006	193/230 (84%)
Ptprd	XP_036019731.1	I-set	31..123	CDD:400151	45/92 (49%)
		Ig strand A'	39..43	CDD:409353	1/3 (33%)
		Ig strand B	46..55	CDD:409353	6/8 (75%)
		Ig strand C	61..66	CDD:409353	3/4 (75%)
		Ig strand C'	69..72	CDD:409353	2/2 (100%)
		Ig strand D	75..83	CDD:409353	0/7 (0%)
		Ig strand E	84..94	CDD:409353	5/9 (56%)
		Ig strand F	102..110	CDD:409353	6/7 (86%)
		Ig strand G	113..123	CDD:409353	3/10 (30%)
		IgI_2_RPTP_IIa_LAR_like	135..234	CDD:409400	45/98 (46%)
		Ig strand B	151..155	CDD:409400	1/3 (33%)
		Ig strand C	164..168	CDD:409400	1/3 (33%)
		Ig strand E	198..202	CDD:409400	2/3 (67%)
		Ig strand F	212..217	CDD:409400	4/4 (100%)
		Ig strand G	224..227	CDD:409400	0/2 (0%)
		IgI_3_RPTP_IIa_LAR_like	247..328	CDD:409401	48/81 (59%)
		Ig strand B	261..265	CDD:409401	1/3 (33%)
		Ig strand C	274..278	CDD:409401	2/3 (67%)
		Ig strand E	295..299	CDD:409401	3/3 (100%)
		Ig strand F	307..312	CDD:409401	4/4 (100%)
		Ig strand G	320..323	CDD:409401	0/2 (0%)
		FN3	331..420	CDD:238020	45/88 (51%)
		FN3	427..519	CDD:238020	44/91 (48%)
		FN3	524..612	CDD:238020	38/91 (42%)
		FN3	620..714	CDD:238020	38/93 (41%)
		FN3	721..827	CDD:238020	41/108 (38%)
		FN3	832..927	CDD:238020	29/101 (29%)
		FN3	930..1021	CDD:238020	28/95 (29%)
		FN3	1031..>1092	CDD:238020	17/106 (16%)
		R-PTPc-D-1	1388..1671	CDD:350472	207/282 (73%)
		R-PTP-D-2	1672..1963	CDD:350476	231/290 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	422	1.000	Domainoid score	I630
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1260	1.000	Inparanoid score	I173
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47937
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001053
OrthoInspector	1	1.000	-	-		otm43194
orthoMCL	1	0.900	-	-		OOG6_100623
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	1	1.000	-	-		X953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860