DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Ptprb

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:XP_036011586.1 Gene:Ptprb / 19263 MGIID:97809 Length:2361 Species:Mus musculus


Alignment Length:2172 Identity:470/2172 - (21%)
Similarity:752/2172 - (34%) Gaps:735/2172 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 WTHPTIVD----AAHPPEIIRKPQNQGVRVGGVASFYCAA----------RGDPPPSIVWRKNGK 74
            |.||..:|    ..:|.::         :.|.|.:|...:          :.||.|...:..|.:
Mouse   354 WCHPIRIDNFTYGCNPKDL---------QAGTVYNFRIVSLDGEESTLVLQTDPLPPARFEVNRE 409

  Fly    75 KVSGT--QSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAEN---------GVGDAVSADATLT 128
            |.:.|  |.|:|  ...|.:|...::.............|.|:         .:.:..|....:|
Mouse   410 KTASTTLQVRWT--PSSGKVSWYEVQLFDHNNQKIQEVQVQESTTWSQYTFLNLTEGNSYKVAIT 472

  Fly   129 IYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIG-NPTPN---IYW---------------- 173
            ...|:|  ..|||...         |.||....|.:| :|.||   |.|                
Mouse   473 AVSGEK--RSFPVYIN---------GSTVPSPVKDLGISPNPNSLLISWSRGSGNVEQYRLVLMD 526

  Fly   174 ---IKNQTKVDMSNPRYS---LKDGFLQ----------IENSREEDQGKYECVAENSMGTEHSKA 222
               |...|.||..:..|:   |..|.|.          ::|||.:..........|...|...:.
Mouse   527 KGAIVQDTNVDRRDTSYAFHELTPGHLYNLTIVTMASGLQNSRWKLVRTAPMEVSNLKVTNDGRL 591

  Fly   223 TNLYVKVRRVPP--------TFSR-----------PPET---ISEVMLGS--NLNLSCI------ 257
            |:|.||.:: ||        |.|.           ||.|   ..:::.|.  .:.:|||      
Mouse   592 TSLNVKWQK-PPGDVDSYSITLSHQGTIKESKTLAPPVTETQFKDLVPGRLYQVTISCISGELSA 655

  Fly   258 ---AVGSPMPH-VK--------WMK--------------------------------GSE----- 273
               |.|..:|. |:        |||                                |.|     
Mouse   656 EKSAAGRTVPEKVRNLVSYNEIWMKSFTVNWTPPAGDWEHYRIVLFNESLVLLNTTVGKEETHYA 720

  Fly   274 ----DLTPENEMPI----------------GRN----VLQL------------------------ 290
                :|.|..:..|                ||.    ||||                        
Mouse   721 LDGLELIPGRQYEIEVIVESGNLRNSERCQGRTVPLAVLQLRVKHANETSLGITWRAPLGEWEKY 785

  Fly   291 -------------------------INIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQI 330
                                     .::....||.....|..|.:...|.:|.:::|...||:.:
Mouse   786 IISLMDRELLVIHKSLSKDAKEFTFTDLMPGRNYKATVTSMSGDLKQSSSIKGRTVPAQVTDLHV 850

  Fly   331 SEVTAT-SVRLEWSYKGPEDLQYYVIQYKPKNA---NQAFSEISGIITMYYVVRALSPYTEYEFY 391
            :....| |:...|: |...|:::|.:....:|.   |::.|.    .|..|..|||.|.:.|...
Mouse   851 NNQGMTSSLFTNWT-KALGDVEFYQVLLIHENVVVKNESVSS----DTSRYSFRALKPGSLYSVV 910

  Fly   392 VIAVNN---------IGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPET 447
            |..|:.         .||..||          |..|..:.::.||        ..:.::|.|.. 
Mouse   911 VTTVSGGISSRQVVAEGRTVPS----------SVSGVTVNNSGRN--------DYLSVSWLPAP- 956

  Fly   448 PNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELT--TVSELTPHAIYTVRVQAYTSMGAGPMST- 509
              |:|..|.|     |...|...:..::....::  :.|.|||..:|.|.|...:...|....| 
Mouse   957 --GEVDHYVV-----SLSHEGKVDQFLIIAKSVSECSFSSLTPGRLYNVTVTTKSGNYASHSFTE 1014

  Fly   510 ----PVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQ---AHH 567
                |.:|   ||:  ..||...:|.    :.:.|   .|::.:..|||:    |..|:   ...
Mouse  1015 ERTVPDKV---QGI--SVSNSARSDY----LKVSW---VHATGDFDHYEV----TIKNRESFIQT 1063

  Fly   568 KRI--SNSEAYTLDGLYPDTLYYIWLAAR------SQRGEGATTPPIPVRTKQYGAPPRNITAIA 624
            |.|  |.:|...:: |.|..||.:.::.:      |::|.|.|.|          .|.:::|.:.
Mouse  1064 KTIPKSENECEFIE-LVPGRLYSVTVSTKSGQYEASEQGTGRTIP----------EPVKDLTLLN 1117

  Fly   625 TSSTTISLSWLPPPVERSNGRIIYYKV-------------------------------------- 651
            .|:..:.::|     .|:||.:..|:|                                      
Mouse  1118 RSTEDLHVTW-----SRANGDVDQYEVQLLFNDMKVFPHIHLVNTATEYKFTALTPGRHYKILVL 1177

  Fly   652 ------------------------------------------------FFVEVGREDDEATTMTL 668
                                                            :.|...|:|::..:.|:
Mouse  1178 TISGDVQQSAFIEGLTVPSTVKNIHISANGATDRLMVTWSPGGGDVDSYVVSAFRQDEKVDSQTI 1242

  Fly   669 --NMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQED-----VPGDPQD-VKATPLNS 725
              :.:......|:...:|:|.::   ||...       ||.|.|     ||...|. |.|...:|
Mouse  1243 PKHASEHTFHRLEAGAKYRIAIV---SVSGS-------LRNQIDALGQTVPASVQGVVAANAYSS 1297

  Fly   726 TSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLN--EP-----FKFDVVDTLEFNVTGLQP 783
            .|:.|||:..|     |:...|.|..  |.:.|....|  ||     .||:          .|.|
Mouse  1298 NSLTVSWQKAL-----GVAERYDILL--LNENGLLLSNVSEPATARQHKFE----------DLTP 1345

  Fly   784 DTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELR 848
            ..||.:|:..::.......|.|.....|..|     .:|:|.|..... :...|   ..:.|||.
Mouse  1346 GKKYKMQILTVSGGLFSKESQAEGRTVPAAV-----TNLRITENSSRY-LSFGW---TASEGELS 1401

  Fly   849 GYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPG 913
            .|.:.....|:.|:|.....|.:....|.||.:|..|:..:.                    |..
Mouse  1402 WYNIFLYNPDRTLQERAQVDPLVQSFSFQNLLQGRMYKMVIV--------------------THS 1446

  Fly   914 GPPSNITIRF----------------QTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHG-LG 961
            |..||.:..|                .|.|.|..:|.|.:.          |..|::.|.:. .|
Mouse  1447 GELSNESFIFGRTVPAAVNHLKGSHRNTTDSLWFSWSPASG----------DFDFYELILYNPNG 1501

  Fly   962 SERNMTLRKAV----FTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGR---APMSLQAE 1019
            :::.....|.|    |..|....:|..    |....:|..|:|:..|     ||   :|.||.:.
Mouse  1502 TKKENWKEKDVTEWRFQGLVPGRKYTL----YVVTHSGDLSNKVTGE-----GRTAPSPPSLLSF 1557

  Fly  1020 ATSEQTA-----------------EIWW---------EPVTSR---GKLL-----GYKIFYTMTA 1050
            |....|:                 |:.|         .|.:||   |:::     |....:::..
Mouse  1558 ADVANTSLAITWKGPPDWTDYNDFELQWFPGDALTIFNPYSSRKSEGRIVYGLHPGRSYQFSVKT 1622

  Fly  1051 VEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHD 1115
            |.. |.|:|                   |:..|:.             :||.||:.:. ||....
Mouse  1623 VSG-DSWKT-------------------YSKPISG-------------SVRTKPDKIQ-NLHCRP 1653

  Fly  1116 VSTHSMTLSWSPPIRLTPVNYKISFDAMKV---FVDSQGFSQTQIVPKREIILKHYVKTHTINEL 1177
            .::.::..||.||        ...||...:   .:|:|....::.:.|.:.:|       .|..|
Mouse  1654 QNSTAIACSWIPP--------DSDFDGYSIECRKMDTQEIEFSRKLEKEKSLL-------NIMML 1703

  Fly  1178 SPFTTYNVNV--------SAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQ 1234
            .|...|.|::        |.:..|      :.||:..:...|.|.::      ||.:::|:....
Mouse  1704 VPHKRYLVSIKVQSAGMTSEVVED------STITMIDRPPQPPPHIR------VNEKDVLISKSS 1756

  Fly  1235 A---------SEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKP------ERPNAP-- 1282
            .         |:..|.:. |:.|||.|..|          .|:|.|.:..|      .|.||.  
Mouse  1757 INFTVNCSWFSDTNGAVK-YFAVVVREADS----------MDELKPEQQHPLPSYLEYRHNASIR 1810

  Fly  1283 -----YIAAKFPQ----RSIPFTFHLGSGDD---------YHNFTNRKLEREKRYRIFVRAVVDT 1329
                 |.|:|..:    .|..|...||:..|         ...|.:..|:....|||.:||    
Mouse  1811 VYQTNYFASKCAESPDSSSKSFNIKLGAEMDSLGGKCDPSQQKFCDGPLKPHTAYRISIRA---- 1871

  Fly  1330 PQKHLYTSSPFSEFLSLDMREAPPGERPHRPDP--NWPAEPEVSVNRNKDEPEILWVVLPLMVST 1392
                      |::....|::|.   .:|...|.  :.|...|       .|| :..|:..:....
Mouse  1872 ----------FTQLFDEDLKEF---TKPLYSDTFFSMPITTE-------SEP-LFGVIEGVSAGL 1915

  Fly  1393 FIVS--TALIVLCVVKRRRQPCKTPDQAAVT----RPLMAADLGAGPTPSDPVDMRRLNFQTPGM 1451
            |::.  .||:...:.:::....:....|.::    ||| :..|..|              |....
Mouse  1916 FLIGMLVALVAFFICRQKASHSRERPSARLSIRRDRPL-SVHLNLG--------------QKGNR 1965

  Fly  1452 ISHPPIPISEFANHIERLKSNDNQKFSQEYESI-EPGQQFTWDNSNLEHNKSKNRYANVTAYDHS 1515
            .:..||.|::|..|..:|:::.|...|:|||.: :.|:..:.|.:.|..|:.||||.|:..||.|
Mouse  1966 KTSCPIKINQFEGHFMKLQADSNYLLSKEYEDLKDVGRSQSCDIALLPENRGKNRYNNILPYDAS 2030

  Fly  1516 RVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEER 1580
            ||:|..|:....||||||:|..|......|:||||||..|..|||:|.||.....|||:|:..|:
Mouse  2031 RVKLCNVDDDPCSDYINASYIPGNNFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEK 2095

  Fly  1581 TRIKCDQYWPT-RGTETYGQIFVTITETQELATYSIRTFQLC-RQGFNDRREIKQLQFTAWPDHG 1643
            .|:|||.|||. :....||.:.:.:.....|..::||.|::| .:..:..|.|:...:|.|||||
Mouse  2096 GRVKCDHYWPADQDPLYYGDLILQMVSESVLPEWTIREFKICSEEQLDAHRLIRHFHYTVWPDHG 2160

  Fly  1644 VPDHPAPFLQFLRRCRAL--TPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVT 1706
            ||:.....:||:|..|..  ..|.:||.:|||||||||||.::.:|.:|:::..:..:||||.|.
Mouse  2161 VPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVH 2225

  Fly  1707 CLRAQRNYMVQTEDQYIFIHDAILEAI 1733
            .||..|.:|||||.||:::|..:.:.:
Mouse  2226 DLRLHRVHMVQTECQYVYLHQCVRDVL 2252

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845 18/114 (16%)
I-set 36..129 CDD:254352 17/113 (15%)
IG_like 146..227 CDD:214653 25/116 (22%)
Ig 159..228 CDD:299845 22/104 (21%)
I-set 234..318 CDD:254352 33/235 (14%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 27/197 (14%)
fn3 324..404 CDD:278470 22/92 (24%)
FN3 423..514 CDD:238020 20/97 (21%)
FN3 520..610 CDD:238020 23/100 (23%)
FN3 616..707 CDD:238020 19/178 (11%)
FN3 712..810 CDD:238020 27/105 (26%)
FN3 832..907 CDD:238020 14/74 (19%)
FN3 914..1005 CDD:238020 22/111 (20%)
FN3 1012..1101 CDD:238020 18/122 (15%)
fn3 1106..1198 CDD:278470 19/102 (19%)
PTPc 1476..1731 CDD:214550 107/259 (41%)
PTPc 1503..1731 CDD:238006 99/231 (43%)
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
PtprbXP_036011586.1 Ricin_B_lectin <22..93 CDD:395527
Herpes_BLLF1 <158..>352 CDD:282904
FN3 398..483 CDD:238020 17/88 (19%)
fn3 492..560 CDD:394996 15/67 (22%)
fn3 579..658 CDD:394996 17/79 (22%)
fn3 681..742 CDD:394996 5/60 (8%)
fn3 757..835 CDD:394996 8/77 (10%)
fn3 844..917 CDD:394996 20/77 (26%)
fn3 932..1010 CDD:394996 21/103 (20%)
fn3 1020..1096 CDD:394996 21/92 (23%)
fn3 1109..1182 CDD:394996 9/77 (12%)
fn3 1196..1269 CDD:394996 9/75 (12%)
fn3 1285..1365 CDD:394996 24/96 (25%)
fn3 1375..1448 CDD:394996 19/101 (19%)
fn3 1473..1536 CDD:394996 15/76 (20%)
fn3 1550..1632 CDD:394996 16/101 (16%)
fn3 1644..1723 CDD:394996 17/94 (18%)
PTP_tm 1761..1931 CDD:408631 43/205 (21%)
R-PTPc-B 2019..2246 CDD:350465 97/226 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

Return to query results.
Submit another query.