DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lar and Ptgs1

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_032995.1	Gene:	Ptgs1 / 19224	MGIID:	97797	Length:	602	Species:	Mus musculus

Alignment Length:	309	Identity:	73/309 - (23%)
Similarity:	109/309 - (35%)	Gaps:	82/309 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1237 EEYGPISHYYLVV--VPED------KSNLHKIPD-QFLTDDLLPGRN---KPERPNA--PYIAAK 1287
            |.:..:|:|..::  ||:|      .....::|| |.|...||..|.   .|:..|.  .:.|..
Mouse   142 ESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDVQLLAQQLLLRREFIPAPQGTNILFAFFAQH 206

  Fly  1288 FPQRSIP--------FTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSS----PF 1340
            |..:...        ||..||.|.|..:.....|||:...|:|    .|...|:.....    |.
Mouse   207 FTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYHLRLF----KDGKLKYQVLDGEVYPPS 267

  Fly  1341 SEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVV 1405
            .|..|:.|| .|||..|.|         :::|.:     |:..::..||:.:.|.......:|.:
Mouse   268 VEQASVLMR-YPPGVPPER---------QMAVGQ-----EVFGLLPGLMLFSTIWLREHNRVCDL 317

  Fly  1406 KRRRQPCKTPDQAAVTRPLMAADLGAGPT-------------------PSDPVDMRRLNFQTPGM 1451
            .:...|....:|...|..|:.    .|.|                   ..||..:.|..||....
Mouse   318 LKEEHPTWDDEQLFQTTRLIL----IGETIKIVIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNR 378

  Fly  1452 ISHPPIPISEFANHI---ERLKSNDNQKFSQEYESIEPGQQFTWDNSNL 1497
            |:      .|| ||:   ..|..|..|..||||..    :||.::.|.|
Mouse   379 IA------MEF-NHLYHWHPLMPNSFQVGSQEYSY----EQFLFNTSML 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020
		FN3	832..907	CDD:238020
		FN3	914..1005	CDD:238020
		FN3	1012..1101	CDD:238020
		fn3	1106..1198	CDD:278470
		PTPc	1476..1731	CDD:214550	8/22 (36%)
		PTPc	1503..1731	CDD:238006
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
Ptgs1	NP_032995.1	EGF_CA	35..72	CDD:238011
Ptgs1	NP_032995.1	prostaglandin_endoperoxide_synthase	92..578	CDD:188648	73/309 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900