Protein Alignment Lar and ZK484.7

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_491758.1
• Gene: ZK484.7 / 191327
• WormBaseID: WBGene00022753
• Length: 344
• Species: Caenorhabditis elegans
• Alignment Length: 351
• Identity: 96/351 - (27%)
• Similarity: 153/351 - (43%)
• Gaps: 63/351 - (17%)

  Fly  1404 VVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRL-NFQTPGMISHPPIPISEFANHIE 1467
            |:::||....|.....|::    ..:..|.|.......::: .|....:...|....:|||   .
 Worm     4 VIQKRRTKKSTQKSKEVSQ----RTVDEGTTAEKKTHRKQIVKFVKNALEKGPAGLRAEFA---A 61

  Fly  1468 RLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQL----PAVEGVVGS 1528
            ..:.||.:|.....|:.|.|               ||||.:|...||:||:|    |       .
 Worm    62 MKRFNDFEKMKAFKEAQEHG---------------KNRYKDVGCLDHNRVKLHPPWP-------H 104

  Fly  1529 DYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYW---- 1589
            |||:||:.........::.||.||.::..|||.||.:.|..:|.|:..:.|:...||..|:
 Worm   105 DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKD 169

  Fly  1590 -PTRGTETYG-QIFVTITETQELATYSIRTFQLCRQGFNDR------REIKQLQFTAWPDHGVPD 1646
             |....|..| :|.|....|.::........::....|...      :::.|..:..|||.|||.
 Worm   170 KPVLEFEEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPT 234

  Fly  1647 HPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERM-------KHEKIIDIYGH 1704
            .....::.|    |.|.|..||.:||||||:||||..::|:.:|:::       :.:||:.
 Worm   235 ADMAIVELL----AKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQ---- 291

  Fly  1705 VTCLRAQRNYMVQTEDQYIFIHDAIL 1730
              .:|.|||..:||:.||:|:|..||
 Worm   292 --KIREQRNNSIQTDQQYLFVHQVIL 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	78/256 (30%)
		R-PTP-LAR-2	1784..2021	CDD:350402
ZK484.7	NP_491758.1	Y_phosphatase	80..316	CDD:459674	79/268 (29%)