Protein Alignment Lar and T28F4.3

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_492100.1
• Gene: T28F4.3 / 189059
• WormBaseID: WBGene00012138
• Length: 490
• Species: Caenorhabditis elegans
• Alignment Length: 362
• Identity: 95/362 - (26%)
• Similarity: 157/362 - (43%)
• Gaps: 41/362 - (11%)

  Fly  1445 NFQTPGMISHPPIPISEFANHIER---------------LK----SNDNQKF--SQEYESIEPGQ 1488
            |.|..|.|......:.:.|:..|:               ||    ||..::|  ::||:.
 Worm    15 NSQDEGSIQPDKTQLDDVADDAEKKSEKSSNCMIWSQNVLKKAKISNMTREFRNNKEYKP----- 74

  Fly  1489 QFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYC---DGYRKHNAYVATQG 1550
              ....|..|....||||.::...|.:||.|.  |....:|||:|::.   ||::    :::|||
 Worm    75 --NVTTSISEKMMDKNRYRHIFCGDDNRVVLK--ERDPSNDYIHASWMVMPDGFQ----FISTQG 131

  Fly  1551 PLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITE-TQEL-ATY 1613
            |::.|..|||.|.:..|...|||:.:..|..:.||.:|:.....:.||...|.:.| |.|| ...
 Worm   132 PIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVELWNPV 196

  Fly  1614 SIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVG 1678
            .:...|:.::....:..:....:..|.|...|..|||.::..:  ..|....|.|::||||||||
 Worm   197 KVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYK--AVLNKSSSKPIVVHCSAGVG 259

  Fly  1679 RTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPAR 1743
            ||..::.|......::....:|:...:..||..|...||::.||:::...::|..|.........
 Worm   260 RTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKIIKRNA 324

  Fly  1744 NLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSK 1780
            |..:.|:|........|.:.||.|.|:....|.:..|
 Worm   325 NYESLLKKYADVTRKVTAAIMEEEEKRRQRKKREEEK 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	70/241 (29%)
		R-PTP-LAR-2	1784..2021	CDD:350402
T28F4.3	NP_492100.1	PTPc	58..312	CDD:214550	75/268 (28%)