DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lar and K10B4.1

DIOPT Version :9

Sequence 1:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster
Sequence 2:	NP_493669.2	Gene:	K10B4.1 / 187249	WormBaseID:	WBGene00019613	Length:	1294	Species:	Caenorhabditis elegans

Alignment Length:	1192	Identity:	225/1192 - (18%)
Similarity:	353/1192 - (29%)	Gaps:	440/1192 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   752 QELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPV 816
            |:|||..||.::..|.             |:..||.||....:      |....:|.
Worm   241 QDLRDTSKGKISSSFT-------------LESTTKSSIHSLLI------DEHNWVVD-------- 278

  Fly   817 RPTVSLKIMEREPIVSIELEWERPAQTYGELRGY---RLRWGVKDQALKEEMLSGPQMTKK---R 875
                  :|.::.|.:.:||.:|       |.|.:   .|:....:|.|  .:|.|.:..||   |
Worm   279 ------QIQKKFPDMGLELIFE-------EARKFVIAELQHITFEQFL--PILLGDETMKKYDLR 328

  Fly   876 FDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREH 940
            ..:.:.|..:|......|..|........|.|.......|....|..|.|......:..|...|
Worm   329 ASHCDGGSCHEVEANTLNEFGSAVGLFYKFMTSSDKIYNPSLYSTSDFSTSPTSSSSKSPNVAE- 392

  Fly   941 RNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFS------- 998
               ||:       |..|||:          |.::...:..            |.|...
Worm   393 ---IIS-------KGRDHGI----------ATYSQWRKEC------------GGGELKTYEDLID 425

  Fly   999 --DKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTK- 1060
              |..|:::.||:  .|..|..:......||   .||  .|.|||    .|...:..|...:||
Worm   426 LIDSNILKSLRDL--YPDVLDVDLILLGIAE---NPV--YGSLLG----PTFGCIMALQFQKTKF 479

  Fly  1061 ------TVGLTESADLVNLEKFAQYAV-AIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVST 1118
                  |..|||.    .||:..:.:: |:..|.:.          ..|..:||   .:|.|
Worm   480 GDTYWYTNKLTED----QLEEVKKTSISAMMCRHQK----------TSIIQKDV---FKAAD--- 524

  Fly  1119 HSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINE------L 1177
                                :|..:.:|.:|..|::.......|...||  |....::      |
Worm   525 --------------------NFQNIPIFCNSSVFAKPDFSKWVETPEKH--KNEQFDDILGECIL 567

  Fly  1178 SPFTTYNVNVSAIPSDYSYRPPT-----KITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASE 1237
            ..|...|          ..||.|     ..:|..:......:.|.:   .||...:.:||.:|::
Worm   568 EVFEARN----------RQRPATLQEGLHNSVALKSYGSMMLAKDE---AVNEANVSLILLEATK 619

  Fly  1238 EYGPISHYYL-----VVVPED---KSNLHKIPDQFLTDDLLPGR------NKPERPNAPYIAAKF 1288
            :...:.|..|     |.:.||   ||:....|.....|...|.|      |..|.|:   :|..|
Worm   620 KLVKLKHIELDSIQSVNIGEDFGKKSDSQCNPKNLPCDSTNPYRSYTGWCNNLETPS---LANTF 681

  Fly  1289 PQ--RSIPFTFHLG--------------------SGDDYHNFTNRKLEREKRYRIFVRAVVDTPQ 1331
            .:  |.:|..:..|                    |...:|   .:|:|..| |..||
Worm   682 RELRRLLPPAYEDGIDLPRSKTITGSRLPSPRVISNMVHH---AKKIEHVK-YSHFV-------- 734

  Fly  1332 KHLYTSSPFSEFLSLDMREAPPGERP-------HRPDPNWPAEPE-----VSVNRNKDEP-EILW 1383
                  ..|.:|:..|:..:|..:..       .|.|......|.     |.||....|| ..|.
Worm   735 ------MEFGQFIDHDITHSPVDQNSDGTALNCSRCDSGRFVSPSCFPIPVPVNDVHFEPFSCLS 793

  Fly  1384 VVLPL-------------MVSTFIVSTALI--VLCVVKRRR----------QPCKTPDQAAVTRP 1423
            .|..|             .||.::..:.:.  ..|...|.|          |..:.|....:|
Worm   794 FVRSLPAQKTLGYRNQMNQVSAYLDGSVMYGSTKCEGDRLRTFQDGKMKTTQTSRAPRHYGIT-- 856

  Fly  1424 LMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIP---ISEFANHIERLKSNDNQKFSQEYE--- 1482
            |..:|                ..:..|.:|.|..|   ..:..|..:.|....:..|.:|:|
Worm   857 LSQSD----------------ESEQDGCVSAPDAPCFIAGDDRNSQQTLLIAVHSVFHREHERIT 905

  Fly  1483 ----SIEPGQQFTWDNSNLEHNKSK---NRYANVTAYDHSRVQLPAVEGVVGSDYIN-------- 1532
                .|.|    .||:..:.....|   ..:|::...::    ||.   ::|...|:
Worm   906 TTLKEINP----NWDDEKIYQETRKLISAEFAHIVYNEY----LPI---IIGQKLIDDYDLRPRQ 959

  Fly  1533 ANYCDGYRKHNAYV----ATQG------------PLQETFVDFWRMCWELKTATIVM-------- 1573
            ..|.|||...:|.:    ||..            |:|||..|         .||.|:
Worm   960 DGYYDGYENCDASILQPFATAAFRFGHSTVTRFTPMQETVHD---------PATCVVDLASDFLN 1015

  Fly  1574 MTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELAT-----YSIRTFQLCRQGFNDR----- 1628
            |:::.:              .|...||...:....::.|     .:||.|.     |:||
Worm  1016 MSKIYD--------------NEAVEQILGGMHGKHQMMTDRFVDDAIRNFL-----FSDRGRRGT 1061

  Fly  1629 -REIKQLQFTAWPDHGVPDHPAPFLQFLRRC--------------------RALTPPESGPVIVH 1672
             .::..:......|||:|    |:..:...|                    .|:......|..:.
Worm  1062 GLDLISINIQRGRDHGIP----PYNHYRSFCGLSRLTSFYSIFSDINQDGLTAIGKVYESPDDID 1122

  Fly  1673 CSAG-----------VGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIF-- 1724
            ...|           ||.|...|:.: ...|:|              :..|.|....||...|
Worm  1123 LFTGIVSEKTIPGGIVGPTAACIIAE-QFRRLK--------------KCDRFYYENGEDHSKFSA 1172

  Fly  1725 -----IHDAILEAIICGVTEVP 1741
                 :....:.|:||..|:||
Worm  1173 SQLKEVRKTSMSALICANTKVP 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020	14/57 (25%)
		FN3	832..907	CDD:238020	18/80 (23%)
		FN3	914..1005	CDD:238020	17/99 (17%)
		FN3	1012..1101	CDD:238020	22/96 (23%)
		fn3	1106..1198	CDD:278470	15/97 (15%)
		PTPc	1476..1731	CDD:214550	59/345 (17%)
		PTPc	1503..1731	CDD:238006	52/311 (17%)
		PTPc	1763..2022	CDD:214550
		PTPc	1791..2022	CDD:238006
K10B4.1	NP_493669.2	An_peroxidase	93..509	CDD:281139	75/357 (21%)
		An_peroxidase_like	94..>321	CDD:265428	26/121 (21%)
		An_peroxidase_like	224..508	CDD:265428	75/356 (21%)
		An_peroxidase	662..1191	CDD:281139	110/625 (18%)
		peroxinectin_like	807..1190	CDD:188655	78/458 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900