Protein Alignment Lar and F36H12.10

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_500756.1
• Gene: F36H12.10 / 185396
• WormBaseID: WBGene00018124
• Length: 398
• Species: Caenorhabditis elegans
• Alignment Length: 347
• Identity: 98/347 - (28%)
• Similarity: 153/347 - (44%)
• Gaps: 59/347 - (17%)

  Fly  1405 VKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERL 1469
            ||:.::  |...:||...|....::    ||:.|        ||     ||.:     ...:.|.
 Worm    54 VKKEKK--KDDGEAAKGDPTNKTNM----TPAPP--------QT-----HPIV-----EQWVLRA 94

  Fly  1470 KSNDNQKFSQEYESI----EPGQQFTWDNSNLEHN--KSKNRYANVTAYDHSRVQL--PAVEGVV 1526
            ......|..:|:..:    .|.......|:|...:  .:||||.:|...|.|.|:|  |:
 Worm    95 LDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSPDIAITKNRYQDVPCQDLSAVKLDQPS----- 154

  Fly  1527 GSDYINANY--CDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYW 1589
            ..:||:|||  |. ......::..||||.:|..:||.|..:.|...|||:.:..|..::||.|||
 Worm   155 PCNYIHANYVGCP-MIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYW 218

  Fly  1590 PTRGTETY----GQIFVTITETQEL---ATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDH 1647
            |....|..    |.:...::.::.:   ....|....|...| .....::.||:|.|||.|||..
 Worm   219 PAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITMLNLTYSG-GQTMSVRHLQWTEWPDRGVPPC 282

  Fly  1648 PAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEK----IIDIYGHVTCL 1708
            ....|:.|...|.    ...|::||||||:||||..:.|:.:||::...|    :.::   |..|
 Worm   283 KLTSLELLSAIRG----SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPEL---VKAL 340

  Fly  1709 RAQRNYMVQTEDQYIFIHDAIL 1730
            |.||.:.:|.:.||:|||..:|
 Worm   341 RDQRAFSIQNDVQYLFIHRVML 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	79/250 (32%)
		R-PTP-LAR-2	1784..2021	CDD:350402
F36H12.10	NP_500756.1	PTPc	101..363	CDD:214550	84/276 (30%)