Protein Alignment Lar and F10G8.1

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_001251277.1
• Gene: F10G8.1 / 184322
• WormBaseID: WBGene00008661
• Length: 346
• Species: Caenorhabditis elegans
• Alignment Length: 327
• Identity: 94/327 - (28%)
• Similarity: 151/327 - (46%)
• Gaps: 58/327 - (17%)

  Fly  1463 ANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVG 1527
            |..:...:.||.:|.....|:.|.|               ||||.:|...|::||:|   ||...
 Worm    58 AEFVGMRRFNDFEKMKAFKEAQEAG---------------KNRYKDVGCLDNNRVKL---EGPWP 104

  Fly  1528 SDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR 1592
            .:||:|||.........::.||.||::|..|||.||::.|...|.|:....|:...||.:|:|::
 Worm   105 HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK 169

  Fly  1593 GTETY-----GQIFVTITETQELATYSIR--------TFQLCRQGFNDR-REIKQLQFTAWPDHG 1643
            ..:..     ||......|:.  .|||.|        ..::..:|..:: |:.....:..|||.|
 Worm   170 KGDVMDFDEGGQKISVKCESS--VTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG 232

  Fly  1644 VPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCL 1708
            ||......|:.|...|    |..||::||||||:||||..::::.:::::...:||| .|....:
 Worm   233 VPAADMAVLELLENAR----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIID-DGEKILV 292

  Fly  1709 R--AQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPG--ETISGMEVEFK 1769
            :  .|||..:||:.||:|:|..|               |:...:|.|:.|.|  |.......::|
 Worm   293 KICEQRNNSIQTDAQYLFVHQVI---------------LNYFRKKKLMDESGVQEAYDAFLEQYK 342

  Fly  1770 KL 1771
            |:
 Worm   343 KV 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	79/252 (31%)
		R-PTP-LAR-2	1784..2021	CDD:350402
F10G8.1	NP_001251277.1	Y_phosphatase	83..317	CDD:459674	79/258 (31%)