DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lar and Osmr

DIOPT Version :9

Sequence 1:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster
Sequence 2:NP_035149.2 Gene:Osmr / 18414 MGIID:1330819 Length:971 Species:Mus musculus


Alignment Length:1095 Identity:213/1095 - (19%)
Similarity:361/1095 - (32%) Gaps:352/1095 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   581 LYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGR 645
            |:|..|..: |:.|:.|.| ....|:|:      .|..:..:.......::|.|..|.:......
Mouse     7 LHPAFLLAV-LSLRASRSE-VLEEPLPL------TPEIHKVSFQLKLQEVNLEWTVPALTHEELN 63

  Fly   646 IIYYKVFFVEVGREDDEATTMTLN-MTSIVLDELKRWTEYKIWVLAGTSVGDGPR---SHPIILR 706
            :|    |.:|:.|.:...|....| .|::..:|..||.    |      ..|.|.   .|.|.:|
Mouse    64 MI----FQIEISRLNISNTIWVENYSTTVKREEAVRWN----W------TSDIPLECVKHFIRIR 114

  Fly   707 TQEDVPGDPQDVKATPLNSTSIHVSWKP-----PLEKDRNGII-------RGYHI-----HAQEL 754
            ...|      |.|:.|.:|.....|||.     .:|.|::.|.       .|.::     :.|.:
Mouse   115 ALVD------DTKSLPQSSWGNWSSWKEVNAKVSVEPDKSLIFPKDKVLEEGSNVTICLMYGQNV 173

  Fly   755 RDEGKGFLNEPFKFDVVDT----LEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAI-----VVKT 810
            .:......:||...:.:|:    |:.|......||..:|...|  .||.......:     |::.
Mouse   174 YNVSCKLQDEPIHGEQLDSHVSLLKLNNVVFLSDTGTNINCQA--TKGPKRIFGTVLFVSKVLEE 236

  Fly   811 PGGVPVRPTVSLKIME--REPIVSIELEWERPA-QTYG---------ELRGYR--LRWGVKDQAL 861
            |..|... |...|.::  .||.|...|.|.:.. |.|.         |:..||  ..|.:.:.: 
Mouse   237 PKNVSCE-TRDFKTLDCSWEPGVDTTLTWRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGS- 299

  Fly   862 KEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKI-FQTPEGTPGGPPSNITIRFQT 925
             :||                   |.|.:...|.  :.:.:|.| |..........|.::|::...
Mouse   300 -QEM-------------------YNFTLTAENQ--LRKRSVNINFNLTHRVHPKAPQDVTLKIIG 342

  Fly   926 PDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHG-LGSERNMTLRKA---VFTNLEENTEYIFRV 986
            .....:||    :.|.:|  ..|.:....|:.:| :..|.|:::..:   :|::|:.:|:|...|
Mouse   343 ATKANMTW----KVHSHG--NNYTLLCQVKLQYGEVIHEHNVSVHMSANYLFSDLDPDTKYKAFV 401

  Fly   987 RAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIW---------------WEPV--- 1033
            |..:......:||    .|:::..      ..|....|..::|               |:|:   
Mouse   402 RCASANHFWKWSD----WTQKEFS------TPETAPSQALDVWRQVWSENGRRIVTLFWKPLLKS 456

  Fly  1034 TSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLG----RL 1094
            .:.||::.|.|     .||:    :.|.   |||      |.:..:|.|::......|.    |:
Mouse   457 QANGKIISYNI-----VVEN----EAKP---TES------EHYCVWAPALSTNLSLDLQPYKIRI 503

  Fly  1095 SEKVTVRIKPEDVPLNLRAHDVSTH-------------SMTLSWSPPIRLTPVNYKISFDAMKVF 1146
            :...::...||.  |.:.::| |.|             :..:||.|          :|.|.|...
Mouse   504 TANNSMGASPES--LMVLSND-SGHEEVKEKTIKGIKDAFNISWEP----------VSGDTMGYV 555

  Fly  1147 VDSQGFSQTQIVPKREIILKHY-----VKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTT 1206
            ||....||.|   :.::..|:.     ..|.|.::..|...||..:.....::..|...|....|
Mouse   556 VDWCAHSQDQ---RCDLQWKNLGPNTTSTTITSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYT 617

  Fly  1207 QMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQ-------F 1264
            |..||          :||        |:....|...:.:.|           :.||.       |
Mouse   618 QELAP----------LVN--------PKVEIPYSTPNSFVL-----------RWPDYDSDFQAGF 653

  Fly  1265 LTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDT 1329
            :...|:..::|..:.|.|:.....|..|:...:.: :|.:....|...|:.|..|..||     |
Mouse   654 IKGYLVYVKSKEMQCNQPWERTLLPDNSVLCKYDI-NGSETKTLTVENLQPESLYEFFV-----T 712

  Fly  1330 PQKHLYTSS---PFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVS 1391
            |    |||:   |...|..:    ..|..|.|.                     :|.::||:   
Mouse   713 P----YTSAGPGPNETFTKV----TTPDARSHM---------------------LLQIILPM--- 745

  Fly  1392 TFIVSTALIV------------------------LCVVKRRRQP--------CKTPDQAAVTRPL 1424
            |..|..::||                        |.::|.::.|        | .||...|....
Mouse   746 TLCVLLSIIVCYWKSQWVKEKCYPDIPNPYKSSILSLIKSKKNPHLIMNVKDC-IPDVLEVINKA 809

  Fly  1425 MAAD---LGAG--------------PTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSN 1472
            ..:.   :|:|              ||..|               |..|:|...|.|.     :.
Mouse   810 EGSKTQCVGSGKLHIEDVPTKPPIVPTEKD---------------SSGPVPCIFFENF-----TY 854

  Fly  1473 DNQKFSQEYESIEPGQQFTWDNSNLEHN----KSKNRYANVTAYDHSRVQLPAVE 1523
            |...|......:.||..     .:..|.    ...|::.||...|:.:   |.||
Mouse   855 DQSAFDSGSHGLIPGPL-----KDTAHQLGLLAPPNKFQNVLKNDYMK---PLVE 901

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020
FN3 520..610 CDD:238020 9/28 (32%)
FN3 616..707 CDD:238020 19/94 (20%)
FN3 712..810 CDD:238020 24/123 (20%)
FN3 832..907 CDD:238020 16/87 (18%)
FN3 914..1005 CDD:238020 19/94 (20%)
FN3 1012..1101 CDD:238020 20/110 (18%)
fn3 1106..1198 CDD:278470 21/109 (19%)
PTPc 1476..1731 CDD:214550 11/52 (21%)
PTPc 1503..1731 CDD:238006 7/21 (33%)
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
OsmrNP_035149.2 LIFR_D2 30..137 CDD:375455 29/132 (22%)
fn3 332..413 CDD:394996 17/86 (20%)
WSXWS motif. /evidence=ECO:0000250 412..416 2/7 (29%)
FN3 437..512 CDD:214495 17/92 (18%)
FN3 622..730 CDD:238020 29/150 (19%)
Box 1 motif. /evidence=ECO:0000250 767..775 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 949..971
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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