Protein Alignment Lar and B0207.1

DIOPT Version :10

• Sequence 1: NP_001260594.1
• Gene: Lar / 35259
• FlyBaseID: FBgn0000464
• Length: 2032
• Species: Drosophila melanogaster
• Sequence 2: NP_491722.2
• Gene: B0207.1 / 181834
• WormBaseID: WBGene00015026
• Length: 564
• Species: Caenorhabditis elegans
• Alignment Length: 620
• Identity: 144/620 - (23%)
• Similarity: 222/620 - (35%)
• Gaps: 165/620 - (26%)

  Fly  1172 HTINELSPFTTYNV-----NVSAIP---SDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEI 1228
            :.::.:.|.||.|:     ||:::|   .:.:..||....:..|:..|:| ..|    |.|..::
 Worm    12 YPMSGVKPSTTPNLANPFPNVNSVPVQNPNPNQIPPAPRPIVNQIQYPKP-TNP----VQNPNKL 71

  Fly  1229 LVILPQASEEYGPISHYYLVV------VPEDKSNLH-----KIPDQFLTDDLLPGRNKPERPNAP 1282
            ...||..:....|.....|..      :|....||:     :||.|.......|    |..|:.|
 Worm    72 STGLPPMTMMLPPTVQEPLPTPVKTPPLPRPPGNLNPVQQPQIPVQRTPPQCPP----PPVPHPP 132

  Fly  1283 YIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLD 1347
            .|....|                                            :..:||
 Worm   133 QITQMAP--------------------------------------------ILPTSP-------- 145

  Fly  1348 MREAPPGERPHRPD----------------PNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVS 1396
               |||...||.|.                |: |..|:....|...:...:.|..||
 Worm   146 ---APPPPIPHPPQRAQMNCLPLPQTFQPLPH-PPVPQQLNQRGSGQAMCVPVAAPL-------- 198

  Fly  1397 TALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVD----MRRLNFQTPGMISHPPI 1457
            .|:|.........||           ||:.:....|||...|.|    :::....|.........
 Worm   199 PAIINPITQHNPVQP-----------PLIPSSDPFGPTVVPPADGSIKLKKKKSVTCDEAEFSGK 252

  Fly  1458 PISEFAN-HIERLKSNDNQKFSQEYE------SIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHS 1515
            ...|..| .|..:.|...:...:||:      ||...|.|.       .|.::|||.|:...|.:
 Worm   253 KKKEIINAWIRHVLSIGIEGLKKEYQDSPNGGSIRSAQVFV-------ANPTRNRYTNIPCCDAT 310

  Fly  1516 RVQLPAVEGVVGSD---YINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRL 1577
            ||:       :..|   ||:||.... .|:...:..|.||:.|..:||||........|||:..:
 Worm   311 RVK-------IDDDPDFYIHANIVSS-AKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEI 367

  Fly  1578 EERTRIKCDQYWPTRGTETYGQI-----FVTITETQE---LATYSIRTFQLCRQGFNDRREIKQL 1634
            .|..:.|...|:|::    .||.     |..||:.|.   ....|:...::.|:| .:...:|.:
 Worm   368 IELGKEKSANYFPSK----LGQAMRIGKFCNITKVQHDDIDKVISMSLLRITREG-QEPVFVKHV 427

  Fly  1635 QFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKII 1699
            .:..|||||||:.....|..|...|:    ...|:::||||||||||...:|...|:.::.....
 Worm   428 HWHNWPDHGVPESYMSPLHLLNIFRS----HQKPILIHCSAGVGRTGTLALILIALQTLRSVDFS 488

  Fly  1700 DIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAII 1734
            .|....|.||.:|...:|||.||:|:|..:||.::
 Worm   489 GIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLV 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lar	NP_001260594.1	I-set	36..129	CDD:400151
		Ig strand B	53..57	CDD:409353
		Ig strand C	66..70	CDD:409353
		Ig strand E	93..97	CDD:409353
		Ig strand F	108..113	CDD:409353
		Ig strand G	122..125	CDD:409353
		Ig	141..228	CDD:472250
		Ig strand B	157..161	CDD:409353
		Ig strand C	170..174	CDD:409353
		Ig strand E	192..196	CDD:409353
		Ig strand F	206..211	CDD:409353
		Ig strand G	218..221	CDD:409353
		IgI_3_RPTP_IIa_LAR_like	237..319	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	244..248	CDD:409401
		Ig strand B	251..259	CDD:409401
		Ig strand C	264..270	CDD:409401
		Ig strand C'	272..274	CDD:409401
		Ig strand D	277..281	CDD:409401
		Ig strand E	286..291	CDD:409401
		Ig strand F	298..305	CDD:409401
		Ig strand G	309..318	CDD:409401
		FN3	322..411	CDD:238020
		FN3	<382..747	CDD:442628
		FN3	712..810	CDD:238020
		FN3	832..898	CDD:214495
		FN3	<867..1269	CDD:442628	25/115 (22%)
		fn3	914..998	CDD:394996
		R-PTPc-LAR-1	1498..1735	CDD:350401	76/248 (31%)
		R-PTP-LAR-2	1784..2021	CDD:350402
B0207.1	NP_491722.2	Atrophin-1	37..>217	CDD:460830	45/263 (17%)
		PTPc	272..520	CDD:214550	80/271 (30%)